photosensitizer

Compound 11, also known as Antitumor Photosensitizer-2, is a potent photosensitizer with remarkable photodynamic anti-tumor properties and minimal skin photo-toxicity, representing a promising candidate for photodynamic therapy research [1].

Compound PS-I (Photosensitizer-4) is an effective photosensitizer that can efficiently kill cancer cells and inhibit tumor growth under light exposure.

Photosensitizer-1 (Compound CLB-13) hydrochloride is a photosensitizer [1].

Photosensitizer-2 (compound 1), an organic D-π-A sensitizer, exhibits antitumor properties and potent phototoxicity due to an acrylic acid moiety. It demonstrates significant activity against HeLa cells, with IC 50 values of 20.9 ± 4.5 μM (dark) and 0.046 ± 0.012 μM (irradiation) [1].

Antimicrobial Photosensitizer-1 demonstrates significant potential as an effective agent for treating infections caused by pathogenic microorganisms, with notable antimicrobial efficacy observed in S. aureus-infected mouse wound models [1].

Photosensitizer-3 is a photosensitizer that, when exposed to near-infrared light excitation, exhibits powerful selective killing effects on transfected HEK cells and affibody-targeted A431 cancer cells [1].

Antitumor Photosensitizer-4 (compound 10b), a conjugate of dasatinib and imatinib, serves as a potent tyrosine kinase inhibitor (TKI) targeting ABCG2. This photosensitizer (PS) induces apoptosis and reactive oxygen species (ROS) production, while demonstrating significant phototoxicity against both HepG2 and B16-F10 cells [1].

Photosensitizer-1 (Compound CLB-13) is a photosensitizer [1] .

Antitumor Photosensitizer-1 (Compound 8) is a potent photosensitizer with remarkable photodynamic anti-tumor properties and minimal skin photo-toxicity, positioning it as a promising new candidate for photodynamic therapy research [1].

Antitumor Photosensitizer-3 (Compound I), a chlorin derivative, effectively induces apoptosis and necrosis in tumor cells upon exposure to 650 nm laser irradiation. This compound demonstrates reduced skin phototoxicity compared to the positive reference m-THPC in vivo [1].

Verteporfin (BPD-MA) is a YAP inhibitor that inhibits YAP-TEAD interactions. Verteporfin is also a photosensitizer used in photodynamic therapy. Verteporfin also induces apoptosis and inhibits autophagy.

Bithionol (Actamer), formerly marketed as an active ingredient in various topical drug products, was shown to be a potent photosensitizer with the potential to cause serious skin disorders. Approvals of the NDA's for bithionol drug products were withdrawn on October 24, 1967.

Hematoporphyrin dihydrochloride (Hematoporphyrin IX dihydrochloride) is a substrate for affinity chromatography of heme-binding proteins.

4-N-Nonyloxyphenol (4-nonoxyphenol), a heterogeneous photosensitizer based on kaolinite nanotubes, is a widely used pesticide and endocrine disruptor for the photodegradation of phenol-based pesticides.

MFCD01917484 (ETHYL 2-AMINO-4-(4-METHOXYPHENYL)-3-THIOPHENECARBOXYLATE) is a derivative of thiophene that possesses a variety of properties, including the ability to act as a ligand, catalyst and photosensitizer. It has been used as a model compound for biochemical and physiological studies as well as drug discovery and development.

Octocrylene (Octocrilene) is used as an ingredient in sunscreens and cosmetics. This organic compound can penetrate into the skin where it acts as a photosensitizer. This results in an increased production of free radicals under illumination.

3-methoxy-9H-carbazole is a photosensitizer, a natural compound from Klauseneria heptaphylla and Klauseneria indica.3-methoxy-9H-carbazole has anti-breast cancer activity and induces apoptosis.

PPA-904 FA is a cationic photosensitizer with broad-spectrum antimicrobial activity for use in photodynamic studies (PDT) studies, which can be used to study chronic leg ulcers and diabetic foot ulcers.

GPLGIAGQ acetate is a MMP2-cleavable polypeptide. GPLGIAGQ acetate can be used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy.

PPA-904, a specific phenothiazine photosensitizer, is used in photodynamic therapy (PDT).

Chlorin E6 (CE6) is a second-generation photosensitizer with antitumor activity when used in combination with irradiation. In a mouse model of implanted fibrosarcoma, Chlorin E6 (2.5-10 mg kg, i.v., 50-200 J cm2 irradiation) resulted in complete tumor disappearance after varying degrees of irradiation. Agents including Chlorin E6 were tested in a Phase I clinical study in patients with early superficial squamous cell carcinoma of bronchial origin with favorable results (40 mg m2, IV, 100 J cm2 laser irradiation). In a Phase II clinical trial in patients with early stage lung cancer, the same mode of administration resulted in a complete response in 82.9% of patients. Chlorin E6 has been investigated as a nanotechnology drug delivery tool.

Methyl pyropheophorbide-a (MPPa) is a chlorine photosensitizer and a derivative of chlorophyll a. It is photodynamically active, induces apoptosis and inhibits tumor growth, and can be used in photodynamic therapy (PDT) of cancer.

Benz-AP, a potent photosensitizer, generates singlet oxygen inversely related to Human carboxylesterase 2 (hCES2) activity, showcasing enhanced photocytotoxicity in cancer cells within low hCES2 environments. Moreover, upon Two-photon excitation (TPE), Benz-AP induces the production of reactive oxygen species (ROS), effectively killing cancer cells and tumor spheroids [1].

Talaporfin is a photosensitizer used in photodynamic therapy.

Chlorin e6 trimethyl ester, a derivative of methyl pheophorbide-a, is an effective photosensitizer for photodynamic therapy (PDT).

Thymolphthalexon (tetrasodium) is an organic thioxanthone derivative used as a biochemical assay reagent due to its potent antioxidant properties. It is crucial in researching free radical response, oxidative stress, and aging. Additionally, Thymolphthalexon serves as a photosensitizer in photodynamic therapy for treating cancer and various other diseases.

PSDalpha, an ERα degrader consisting of a photosensitizer (PS), triphenylamine benzothiadiazole (TB), and 17β-estradiol connected via an acetylene bond, demonstrates superior anti-proliferative effects on MCF-7 cells. Its peak absorption wavelength in the visible region is 465 nm [1].

Sinoporphyrin sodium significantly suppressed cell proliferation, promoted early apoptotic response, triggered collapse of F-actin filaments and inhibited cell migration. Sinoporphyrin sodium potentially a treatment for cancer. Sinoporphyrin sodium is als

TBTDC serves as a multifunctional organic photosensitizer exhibiting aggregation-induced emission characteristics, optimal for in vivo bioimaging and photodynamic research applications.

[Ru(DIP)2TAP]Cl2, a Ruthenium(II) polypyridyl compound, serves as a photosensitizer and is utilized in photodynamic therapy (PDT) research.

Antibacterial agent 140 chloride, a first-of-its-kind Ru-based AIEgen photosensitizer, shows promise in detecting and treating Gram-positive bacteria (G+). It effectively discriminates against and exterminates G+ by interacting with lipoteichoic acids (LTA), displaying robust antibacterial activity under light irradiation [1].

Cercosporin, produced by the plant pathogen Cercospora kikuchii and the elsinochromes, is a potent photosensitizer with a short activation wavelength. Cercosporin contains perylene quinone structural features essential for PKC activity (IC50: 0.6-1.3 μM).

HPPH (Photochlor) (Photochlor) is a second-generation photosensitizer. It is used as photodynamic therapy (PDT) agent.

Mal-Pc, a phthalocyanine-based molecular photosensitizer featuring maleimides, interacts with GSH to diminish its levels and decrease aggregation, enhancing the ROS (Reactive Oxygen Species)-dependent efficacy of photodynamic therapy (PDT) in targeting cancer cells [1].

PH 1008 is a porphyrin photosensitizer that may be useful as a diagnostic tool.

Fagopyrine is a DNA topoisomerase I (Topo I) inhibitor and a photosensitizer used in tumor research.

Fimaporfin, also known as TPCS2a, is a potent chlorin-based photosensitizer, Fimaporfin is consisted of a mixture of three isomers A, B and C (25%,50%,25%). Fimaporfin has been developed by di-imide reduction of disulfonated tetraphenyl porphine (TPPS(2a)

Methylene Violet 3RAX, a phenazine dye, is utilized for staining cell mitochondria and has the capability to alter DNA's molecular structure, disrupt DNA modules, and promote reactive singlet oxygen generation. It inhibits human erythrocyte AChE and human plasma BChE, with Ki values of 1.58 and 0.51 μM, respectively, highlighting its potential as a photosensitizer for mitochondrial targeting in photodynamic therapy (PDT) [1] [2].

ICy-OH, a iodinated photosensitizer, serves as a potent anticancer agent, capable of deep tissue imaging (λ ex =640 nm, λ em =690-740 nm) and selectively triggering cell death in pancreatic cancer cells through the cell pyroptosis pathway [1].

TH9402 is a dibrominated rhodamine derivative and potent photosensitizer and useful in photodynamic therapy. TH9402 eradicates multiple myeloma (MM) and BC cell lines, while sparing more than 50% of normal pluripotential blood stem cells from healthy volu

Suftalan Zine is a potential photosensitizer for the treatment of cancer.

Pyropheophorbide-a (Ppa) shows promise as a photosensitizer in tumor photodynamic therapy (PDT).

Antifungal agent 87(10) is a highly potent PDT antimycotic photosensitizer (PDT-IC₅₀ = 1 nM for T. rubrum) [1].

NFh-ALP is an alkaline phosphatase (ALP)-activated photosensitizer. When activated by ALP in cells, NFh-ALP generates singlet oxygen (1O2) under stimulation at 808 nm, effectively killing tumor cells by inducing apoptosis. It also exhibits good biocompatibility. The maximum absorption wavelength of NFh-ALP is approximately 656 nm.

Purpurin 18 methyl ester, a derivative of chlorophyll-a, serves as a photosensitizer for photodynamic therapy (PDT), exhibiting the ability to induce cancer cell apoptosis [1].

Br-DAPI is a water-soluble, cell-permeable, DNA-binding photosensitizer.

2-Selenouracil is a specialized photosensitizer for photodynamical therapy.

Redaporfin, also known as F-2BMet or LUZ-11, is a photosensitizer for Photodynamic Therapy (PDT) of cancer. Redaporfin showed a high efficacy in the treatment of male BALB/c mice with subcutaneously implanted colon (CT26) tumours. Vascular-PDT with 1.5 mg

GPLGIAGQ TFA, is an MMP2-cleaved polypeptide that is used as a stimulus-sensitive connector in both liposomes and micelle nanoceroses for targeted therapy of tumors triggered by MMP2.

GPLGIAGQ, a MMP2-cleavable polypeptide, functions as a stimulus-sensitive linker in liposomal and micellar nanocarriers for MMP2-triggered tumor targeting.