Search Result

Search Results for " sgc "

Targets

Compounds

Natural Products

Cat No.	Product Name	Synonyms	Targets
T12885	SGC-AAK1-1		AAK1 (AP2 associated kinase 1)
	SGC-AAK1-1 is a potent and selective inhibitor of AAK1 (AP2 associated kinase 1) (IC50 of 270 nM and a Ki of 9 nM),and is a chemical probe.		AAK1 (AP2 associated kinase 1)
T6668	SGC-CBP30		Epigenetic Reader Domain , Histone Acetyltransferase
	SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).		Epigenetic Reader Domain , Histone Acetyltransferase
T9568	SGC-SMARCA-BRDVIII		Epigenetic Reader Domain
	SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3) and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM and 13 nM, respectively.		Epigenetic Reader Domain
T5169	SGC-GAK-1		Serine/threonin kinase
	SGC-GAK-1 is a selective cyclin G-associated kinase (GAK) inhibitor (Ki: 3.1 nM).		Serine/threonin kinase
T40131	SGC-CK2-1	SGC-CK2-1
	SGC-CK2-1 is an ATP-competitive chemical compound that acts as a highly potent and cell-active CK2 inhibitor. It demonstrates excellent selectivity towards both isoforms of human CK2, with IC50 values of 36 nM for CK2α a...
T34630	SGC-AAK1-1N	SGCAAK11N,SGCAAK1-1N,SGC-AAK11N
	SGC-AAK1-1N is a potent and selective inhibitor of AAK1 (AP2 associated kinase 1) with an IC 50 of 1.8 μM [1].
T34631	SGC-GAK-1N	SGC-GAK1N,SGCGAK1N,SGCGAK-1N
	SGC-GAK-1N is a negative control for SGC-GAK-1.
T36976	SGC 6870
	Potent and selective protein arginine methyltransferase 6 (PRMT6) inhibitor (IC50 = 77 nM). Exhibits selectivity over all other PRMTs and 23 methyltransferases. In HEK293T cells overexpressing PRMT6, inhibits asymmetric ...
T37467	SGC 6870N
	Negative control for SGC 6870 (Cat. No. 7182). SGC 6870N is the (S)-enantiomer, which is inactive on PRMT6.
T12886	SGC-iMLLT		Histone Methyltransferase
	SGC-iMLLT is a potent and selective MLLT1/3-histone interactions inhibitor(IC50 = 0.26 μM),and is a first-in-class chemical probe displaying cellular target engagement of MLLT1(Kd = 0.129 μM) and MLLT3(Kd = 0.077 μM).		Histone Methyltransferase
T69551	SGC-STK17B-1
	SGC-STK17B-1 is a potent and selective inhibitor of STK17B/DRAK2 kinase.
T34629	SGC3027N	SGC-3027N,SGC 3027N
	SGC3027N is a negative control for SGC3027 (GLXC-12451).
T3084	SGC707		Histone Methyltransferase
	SGC707 is a potent, selective, and cell-active allosteric inhibitor of PRMT3.		Histone Methyltransferase
T7089	SGC2085		Histone Methyltransferase
	SGC2085 is an effective and selective coactivator-associated arginine methyltransferase 1 (CARM1) inhibitor (IC50: 50 nM).		Histone Methyltransferase
T79542	SGC-UBD253		HDAC
	SGC-UBD253 is a potent antagonist of the HDAC6-UBD interaction and may be utilized in cancer research [1].		HDAC
T62471	SGC agonist 1
	SGC agonist 1 is a potent soluble guanylate cyclase (SGC) agonist. SGC agonist 1 is able to increase solubility and has high cell permeability.
T62909	SGC agonist 2
	SGC agonist 2 is a potent soluble guanylate cyclase (SGC) agonist. SGC agonist 2 has potential for cardiovascular disease (heart failure, angina, pulmonary hypertension, myocardial infarction) and fibrotic disease (renal...
T3082	SGC0946		Histone Methyltransferase
	SGC0946 is a highly effective and specific DOT1L methyltransferase inhibitor (IC50: 0.3 nM); selectively kill mixed lineage leukemia cells.		Histone Methyltransferase
T4013	SGC2085 HCl		Histone Methyltransferase
	SGC2085 is a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectivity over other PRMTs. CARM1 is an important positive modulat...		Histone Methyltransferase
T69580	SGC6870
	SGC6870 is a novel potent, selective, and cell-active inhibitor of PRMT6 with IC50 of 77 ± 6 nM, being selective over all other PRMTs and 23 methyltransferases.
T7900	BAY-474		c-Met/HGFR
	BAY-474 is an inhibitor of tyrosine-protein kinase c-Met. It acts as an epigenetics probe		c-Met/HGFR
T12887	SGC3027		Others
	SGC3027 is an inhibitor of histone methyltransferase,also is a first potent, selective and cell active chemical probe for PRMT7.		Others
T21607	Ataciguat	HMR-1766	Others , Guanylate cyclase
	Ataciguat (HMR-1766) (HMR-1766) is a potent and specific soluble guanylate cyclase (sGC) activator.		Others , Guanylate cyclase
T21712	BAY 41-8543		Others , Guanylate cyclase
	BAY 41-8543 is a nitric oxide (NO)-independent stimulator of soluble guanylyl cyclase (sGC).		Others , Guanylate cyclase
T12670	(Rac)-MGV354	MGV354	Others
	(Rac)-MGV354 (MGV354) is the racemate of MGV354. MGV354 is a soluble activator of guanylate cyclase (sGC)(EC50s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively).		Others
T0942	Quinacrine dihydrochloride	Mepacrine dihydrochloride,SN-390,Quinacrine 2HCl	Apoptosis , Mitophagy , DNA , Phospholipase , Parasite , Autophagy , Histamine Receptor
	Quinacrine dihydrochloride (Mepacrine dihydrochloride) is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities.
T5858	Sertindole	Lu 23-174	Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Autophagy
	Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively)
T0006	Methylene Blue trihydrate	Methylthionine chloride,Basic blue 9,Methylene Blue	Guanylate cyclase , Microtubule Associated , NO Synthase , Parasite , Monoamine Oxidase
	Methylene Blue trihydrate (Basic blue 9) is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene Blue trihydrate...
T16569	Praliciguat	IW-1973	Others , Guanylate cyclase
	Praliciguat (IW-1973) stimulates sGC in HEK-293 cells (EC50: 197 nM). Praliciguat is an effective and orally active soluble guanylate cyclase stimulator. It also enhances NO signaling and acts as a vasodilator.		Others , Guanylate cyclase
T16383	Olinciguat	IW-1701	Guanylate cyclase
	Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator. It also has concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole-cell assay.		Guanylate cyclase
T4381	Lificiguat	YC-1	Others , Guanylate cyclase , HIF
	Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha).		Others , Guanylate cyclase , HIF
T7201	Nelociguat	BAY60-4552	Guanylate cyclase
	Nelociguat (BAY60-4552)(BAY60-4552) is a soluble guanylate cyclase stimulator (sGC stimulator). Soluble guanylate cyclase (sGC) is a key enzyme in the nitric oxide (NO) signalling pathway.		Guanylate cyclase
T19777	ODQ		Apoptosis , Others , Guanylate cyclase
	ODQ is an effective and selective soluble guanylyl cyclase (sGC) inhibitor.		Apoptosis , Others , Guanylate cyclase
T16344	NS-2028		Others , Guanylate cyclase
	NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor (IC50: 30 nM and 200 nM for basal and NO-stimulated enzyme activity). It is commonly used in the research of nitric oxide signaling pathways. NS-2028...		Others , Guanylate cyclase
T10473	BAY-678		Others
	BAY-678 is a human neutrophil elastase (HNE; IC50: 20 nM) inhibitor with oral bioactivity, potency and selectivity.BAY-678 is a chemical probe recommended by the Structural Genomics Consortium (SGC).		Others
T6775	BAY 41-2272		Guanylate cyclase
	BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator.		Guanylate cyclase
T77729	MY-1076		Apoptosis , YAP
	MY-1076 is a potent YAP inhibitor with antigastric cancer activity.MY-1076 dose-dependently induced G2/M phase block, induced YAP degradation and apoptosis, and inhibited microtubule protein polymerization.MY-1076 inhibi...		Apoptosis , YAP
T1984	Cinaciguat	BAY 58-2667	Guanylate cyclase
	Cinaciguat (BAY 58-2667) (BAY 58-2667) is the first of a new class of soluble guanylate cyclase (sGC) activators in Clinicalal development for acute decompensated heart failure.		Guanylate cyclase
T8506	THPP-1		PDE
	THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively).		PDE
T12661	(Rac)-BI 703704		Others
	(Rac)-BI 703704 is a potent activator of soluble guanylyl cyclase (sGC).		Others
T36981	GSK 591 dihydrochloride
	Potent and selective PRMT5 inhibitor (IC50 = 4 nM). Selective for PRMT5 over a panel of other PRMTs and lysine methyltransferases. Inhibits proliferation of mantle cell lymphoma (MCL) in vitro. To request the negative...
T10471	BAY 60-2770		Others
	BAY 60-2770 is a selective and orally active soluble guanylyl cyclase (sGC) activator with antifibrotic effect. It increases the activity of sGC in a nitric oxide-independent manner.		Others
T69543	CFM-1571(free base)
	CFM 1571 is the free base of CFM 1571 Hydrochloride (C291720), which acts as a soluble guanylyl cyclase (sGC) activator while ignoring adenylyl cyclase.
T10536	BI 703704		Others
	BI 703704, a soluble guanylate cyclase (sGC) activator, inhibits the progression of diabetic nephropathy in the ZSF1 rat [1].		Others
T12888	MGV354		Others
	MGV354 is a soluble activator of guanylate cyclase(sGC) with EC 50 s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively [1] [2].		Others
T73332	BI-685509
	BI-685509 is a potent and orally active sGC activator. BI-685509 restores cyclic guanosine monophosphate (cGMP) and improves functionality of nitric oxide (NO) pathways. BI-685509 can be used in research of chronic kidne...
T32242	IWP-051	IWP051
	IWP-051 is a potent, orally active sGC stimulator (EC50 = 290nM). IWP-051 showed >99% plasma protein binding, high metabolic stability, high permeability, and no efflux in a Caco-2 model of intestinal absorption. IWP-...
T10473L	BAY-677		Others
	BAY-677, serving as an inactive control for BAY-678, is distinguished by BAY-678's capabilities as an orally bioavailable, selective, and cell-permeable inhibitor of human neutrophil elastase (HNE), showcasing a high pot...		Others
T62971	Tubulin polymerization-IN-16
	Tubulin aggregation-IN-16 (compound 5g) is a potent inhibitor of tubulin aggregation. 16 effectively disrupts microtubule/tubulin dynamics and induces cell cycle arrest at G2/M phase in SGC-7901 cells.
T72057	H1k		CDK
	H1k is an eudistomin Y fluorescent derivative and lysosome-targeted antiproliferative agent that dose-dependently increases autophagy signalling and down-regulates the expression of cyclin-dependent kinase (CDK1) and cyc...		CDK

Compounds

SGC-AAK1-1

T12885

Synonym:

Target: AAK1 (AP2 associated kinase 1)

SGC-CBP30

T6668

Synonym:

Target: Epigenetic Reader Domain, Histone Acetyltransferase

SGC-SMARCA-BRDVIII

T9568

Synonym:

Target: Epigenetic Reader Domain

SGC-GAK-1

T5169

Synonym:

Target: Serine/threonin kinase

Synonym: SGCAAK11N,SGCAAK1-1N,SGC-AAK11N

Target:

SGC-GAK-1N

T34631

Synonym: SGC-GAK1N,SGCGAK1N,SGCGAK-1N

Target: Histone Methyltransferase

Synonym: SGC-3027N,SGC 3027N

Target: Histone Methyltransferase

SGC2085

T7089

Synonym:

Target: Histone Methyltransferase

Target: Histone Methyltransferase

SGC2085 HCl

T4013

Synonym:

Target: Histone Methyltransferase

Target: Others, Guanylate cyclase

BAY 41-8543

T21712

Synonym:

Target: Others, Guanylate cyclase

Quinacrine dihydrochloride

T0942

Synonym: Mepacrine dihydrochloride,SN-390,Quinacrine 2HCl

Target: Apoptosis, Mitophagy, DNA, Phospholipase, Parasite, Autophagy, Histamine Receptor

Sertindole

T5858

Synonym: Lu 23-174

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, Autophagy

Methylene Blue trihydrate

T0006

Synonym: Methylthionine chloride,Basic blue 9,Methylene Blue

Target: Guanylate cyclase, Microtubule Associated, NO Synthase, Parasite, Monoamine Oxidase

Praliciguat

T16569

Synonym: IW-1973

Target: Others, Guanylate cyclase

Olinciguat

T16383

Synonym: IW-1701

Target: Guanylate cyclase

Lificiguat

T4381

Synonym: YC-1

Target: Others, Guanylate cyclase, HIF

Nelociguat

T7201

Synonym: BAY60-4552

Target: Guanylate cyclase

ODQ

T19777

Synonym:

Target: Apoptosis, Others, Guanylate cyclase

NS-2028

T16344

Synonym:

Target: Others, Guanylate cyclase

Target: Guanylate cyclase

MY-1076

T77729

Synonym:

Target: Apoptosis, YAP

Cinaciguat

T1984

Synonym: BAY 58-2667

Target: Guanylate cyclase

GSK 591 dihydrochloride

Tubulin polymerization-IN-16

Cat No.	Product Name	Synonyms	Targets
TN2755	2-Desoxy-4-epi-pulchellin		Anti-infection
	2-Desoxy-4-epi-pulchellin has potent in vitro cytotoxicities against the K562, MCF-7, Hela, DU145, U937, H1975, SGC-7901, A549, MOLT-4, and HL60 cell lines with IC50 values ranging from 0.10 to 46.7uM, while it shows sig...		Anti-infection
T3S2312	Poncirin	Isosakuranetin-7-neohesperidoside	Apoptosis , Others
	1. Poncirin (Isosakuranetin-7-neohesperidoside) shows a significant in vitro inhibitory effect on the growth of the human gastric cancer cells, SGC-791, in a dose-dependent manner. 2. Poncirin prevents adipogenesis, enha...		Apoptosis , Others
T3S2344	β,β-Dimethylacrylshikonin	Dimethylacrylshikonin,β, β-Dimethylacrylshikonin	ERK , HIF/HIF Prolyl-Hydroxylase
	1. β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combined with IR treatment significant...		ERK , HIF/HIF Prolyl-Hydroxylase
TN4340	Ivangustin		PARP
	Ivangustin exhibits remarkable cytotoxicity against HEp2, SGC-7901 and HCT116 human cancer cell lines.		PARP
T75451	Cytoglobosin C
	Cytoglobosin C, a derivative of cytochalasan, demonstrates significant cytotoxic effects on SGC-7901 and A549 cell lines, with an inhibitory concentration (IC50) of less than 10 μM [1].
TN4960	Schleicheol 1		Others
	Schleicheol 1 has antitumor activity, it possesses inhibitory activity against SGC-7901 cell line.		Others
TN3740	Cyclocommunol		PAFR
	Cyclocommunol exhibits cytotoxicity against hepatocellular carcinoma (SMMC-7721) and gastric carcinoma (BGC-823 and SGC-7901) cell lines. It also shows strong inhibition of arachidonic acid (AA)- and collagen-induced pla...		PAFR
TN3429	Aphagranin A		Others
	Aphagranin A exhibits strong antiproliferative activity against the growth of six lines of human cancer cells (MCF-7, A549, HepG2, Bel-7402, SGC-7901, and BGC-823.		Others
TN4239	Hydroxytanshinone IIA		Others
	Hydroxytanshinone ⅡA has good antiproliferative effect on SGC-7901,HeLa, and HepG 2 cell, the values of IC50 are 4.18, 6.08 and10.20 uM, respectively; it has tumor cell proliferation inhibition significantly stronger tha...		Others
TN5264	Xanthoxyletin		TNF , NOS , ROS , COX , Antifection
	Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties, it also has anticancer, and anti-inflammatory activities. It shows an inhibitory effect on iNOS protein expression at 10 microM, it also can...		TNF , NOS , ROS , COX , Antifection