uric

Uric Acid (Lithic acid) is an oxidation product of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.

Uric acid sodium, scavengers of oxygen radicals, is a potent and common antioxidant that helps maintain stable blood pressure and resist oxidative stress. Uric acid sodium, which removes reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, has an inhibitory effect on lipid peroxidation and is associated with the pathogenesis of gout joint disease and the formation of calcium oxalate stones.

Thiobarbituric acid (NSC-4733) has Antibacterial Activity.

Lauric Acid (Dodecylic acid),which is found naturally in various plant and animal fats and oils, is a saturated medium-chain fatty acid with a 12-carbon backbone. It is a major component of coconut oil and palm kernel oil.

1-Methyluric acid (1-Methylurate) acts on the bladder mucosa and increases the levels of insulin, triglycerides, cholesterol, and blood glucose.

Roburic acid and phenethyl-trans-ferulate inhibit COX-1 and COX-2.

Erythrocentauric acid is a natural product from Gentiana macrophylla.

Dehydroeburicoic acid monoacetate (3-O-Acetyldehydroeburicoic acid) is a triterpenoid of lanolin isolated from Wolfiporia cocos.

Clematomandshurica saponin B shows significant inhibitory activity on cyclooxygenase-2 (IC50 = 2.58 microM).

α-Muricholic acid is the most abundant primary bile acid in rodents.

Venturicidin A is a macrolide antibiotic.

Clemomandshuricoside B is a natural product for research related to life sciences. The catalog number is TN6587 and the CAS number is 905294-48-6.

ω-Muricholic acid (ω-MCA) is a murine-specific secondary bile acid.

Lauric Acid Diethanolamide (Lauric diethanolamide) is a marine derived natural products found in Bacillus sp.

Tauro-β-muricholic acid (TβMCA), a trihydroxylated bile acid, acts as a competitive and reversible FXR antagonist (IC 50 = 40 μM) and exhibits antiapoptotic effects by inhibiting bile acid-induced hepatocellular apoptosis and preserving mitochondrial membrane potential [1] [2].

Auriculasin is a natural product of Derris, Fabaceae. The catalog number is TN3471 and the CAS number is 60297-37-2. Auriculasin can be used as a reference standard.

7-Methyluric Acid is a natural product for research related to life sciences. The catalog number is T37856 and the CAS number is 612-37-3.

17-hydroxy Venturicidin A is a macrolide fungal metabolite originally isolated from Streptomyces. It has antibiotic activity against M. luteus, B. subtilis, and S. aureus and antifungal activity against V. dahlia, Fusarium, and C. tropicalis in a disc assay.

Clematiunicinoside E is a natural product from Clematis uncinata.

Polyphenol metabolite.

Nicotinuric acid is an acyl glycine which is normally minor metabolites of fatty acids. Acyl glycines are produced through the action of glycine N-acyltransferase.

1,3,7-Trimethyluric acid is a purine alkaloid that occurs as a minor metabolite of caffeine in humans. As an antioxidant, it has shown an ability to scavenge hydroxyl radicals as well as protective potential against lipid peroxidation in erythrocyte membranes

Kadsuric acid is a natural product of Schisandra, Schisandraceae. The catalog number is TN5933 and the CAS number is 62393-88-8. Kadsuric acid can be used as a reference standard.

1,3,9-Trimethyluric acid exhibits in vitro cytotoxic activity against breast cancer (MCF-7), human neuroblastoma (SHSY5Y), human non-small cell lung cancer (A549) and human liver cancer (HEPG2) with IC50 value in the range of 1-3 uM. 1,3,9-Trimethyluric a

Daurichromenic acid is a terpenophenol with a potent anti-HIV activity.

Kadsuric acid 3-methylester is a natural product from Kadsura longipedunculata Finet.et Gagnep.

4-Aminohippuric Acid is the glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity.

1,3-Dimethyluric acid is a product of theophylline metabolism in man. It is one of the purine components in urinary calculi.

Hippuric acid (2-Benzamidoacetic acid) is an acyl glycine formed by the conjugation of benzoic acid with glycine. Hippuric acid) is a normal component of urine and is typically increased with increased consumption of phenolic compounds (tea, wine, fruit juices). These phenols are converted to benzoic acid which is then converted to hippuric acid and excreted in the urine.

Salicyluric acid (2-Hydroxy Hippuric Acid) is a metabolite of Salicylic Acid.

Muricarpone B is a natural product for research related to life sciences. The catalog number is TN5705 and the CAS number is 886226-15-9.

3-Hydroxyhippuric acid is an acyl glycine, which are normally minor metabolites of fatty acids.

1. Dauricine has pulmonary toxicity, can produce pulmonary injury in CD-1 mice by the metabolism of Dauricine mediated by CYP3A. 2. Dauricinec can pass the blood-brain barrier, and that P-glycoprotein has an important role in the transportation of Dauricine across the blood-brain barrier. 3. Dauricine may has anti-tumor effect, can inhibit tumor cells in urinary system and colon cancer cell proliferation, invasion; induce cell apoptosis by suppressing NF-kappaB activity and the expression profile of its downstream genes.

β-Muricholic acid (β-MCA) is a murine-specific primary bile acid.[1],[2] Dietary administration of β-MCA reduces HMG-CoA reductase activity in liver microsomes from mice fed a high cholesterol and cholic acid diet.[3] Dietary administration of β-MCA also dissolves 100% of gallstones in a gallstone-susceptible mouse model of diet-induced cholesterol gallstones.[4]

Dauricumine is a natural product for research related to life sciences. The catalog number is TN6081 and the CAS number is 345641-00-1.

Eburicoic acid (ZINC4655149) exhibits anti-inflammatory and antioxidant activity thereby protecting the liver from CCl4-induced hepatic damage and can be used in studies about anti-liver cancer.

Xanthine (Isoxanthine) is a product on the pathway of purine degradation. Xanthine is subsequently converted to uric acid by the action of the Xanthine oxidase enzyme. Xanthine is found in most body tissues and fluids in various organisms. Biologically Xanthine is produced from guanine by cypin (guanine deaminase). Furthermore, Xanthines act as antagonists for adenosine receptors, with selectivity depending on whether there are substitution of alkyl groups.

Hypoxanthine (Purin-6-ol), also known as purine-6-ol or Hyp. Hypoxanthine is a naturally occurring purine derivative and a reaction intermediate in the metabolism of adenosine and in the formation of nucleic acids by the nucleotide salvage pathway. Under normal circumstances hypoxanthine is readily converted to uric acid.hypoxanthine is first oxidized to xanthine, which is further oxidized to uric acid by xanthine oxidase.

Alloxan is an acidic compound formed by the oxidation of URIC ACID.

Purine (7H-Imidazo(4,5-d)pyrimidine) is a heterocyclic aromatic organic compound, consisting of a pyrimidine ring fused to an imidazole ring. Two of the bases in nucleic acids, adenine and guanine, are purines. Purines from food (or from tissue turnover) are metabolised by several enzymes, including xanthine oxidase, into uric acid. High levels of uric acid can predispose to gout when the acid crystalises in joints; this phenomenon only happens in humans and some animal species (e.g. dogs) that lack an intrinsic uricase enzyme that can further degrade uric acid.

Allantoic acid, a byproduct of uric acid degradation, is implicated in purine metabolism [1][2][3].

Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways and metabolic in the brain based on the particular disease and clinical condition model. According to the reports, Citric acid trilithium salt tetrahydrate was used as a mood stabilizer when treating bipolar mood disorders (BD) and lower the risk of self-harm in BD patient. In addition,Citric acid trilithium salt tetrahydrate has been the choice drug in the therapy of acute manic episodes.Citric acid trilithium salt tetrahydrate also could dissolve uric acid crystals in urine achieved from patients with gout. Besides,Citric acid trilithium salt tetrahydrate have some dose-dependent side-effects. The the main side-effects of Lithium Citrate is the tendency to inhibit the prostatic acid phosphatase enzyme (PAP), which result in the accumulation of PAP.