Home Tools
Log in
Cart

FXR

The bile acid receptor (BAR), also known as farnesoid X receptor (FXR) or NR1H4 (nuclear receptor subfamily 1, group H, member 4) is a nuclear receptor that is encoded by the NR1H4 gene in humans.FXR is expressed at high levels in the liver and intestine. Chenodeoxycholic acid and other bile acids are natural ligands for FXR. Similar to other nuclear receptors, when activated, FXR translocates to the cell nucleus, forms a dimer (in this case a heterodimer with RXR) and binds to hormone response elements on DNA, which up- or down-regulates the expression of certain genes.
Cat No. product name
T2202 Lithocholic acid Lithocholic acid is a bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubili...
T2233 GW 4064 GW 4064 is an effective farnesoid X receptor (FXR) agonist (EC50 =65 nM).
T7886 Nidufexor Nidufexor is an agonist for the farnesoid X receptor (FXR).
T6053 Turofexorate Isopropyl Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM
T4379 Tropifexor Tropifexor is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.
T2015 Fexaramine Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.
T2968 Hyodeoxycholic acid Hyodeoxycholic Acid has been used in trials studying the treatment of Hypercholesterolemia.
T6690 T0901317 T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).
TQ0252 BAR502 BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).
T0847 Chenodeoxycholic acid Chenodiol is a bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbe...
T1789 Obeticholic Acid Obeticholic acid is a Farnesoid X Receptor Agonist. The mechanism of action of obeticholic acid is as a Farnesoid X Receptor Agonist.
T2939 Forskolin Forskolin, a potent activator of the adenylate cyclase (EC50: 0.5 μM), can increase the cAMP level. It is extracted from the plant Coleus forskohlii.
T7436 Cilofexor Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.
T6344 Sevelamer hydrochloride Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.
T8471 Vonafexor Vonafexor is a farnesoid X receptor (FXR, NR1H4) agonist, with anti-HBV effects
T5574 Guggulsterone Guggulsterone E&Z is a 3-hydroxy steroid. It has a role as an androgen.
T8895 Altenusin Altenusin is a natural nonsteroidal fungal metabolite, as a novel selective agonist of FXR with an EC50 value of 3.2 ± 0.2 μM.
T13093 Tauro-β-muricholic acid sodium Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).
T13092 Tauro-Obeticholic acid Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR).
T12583L (-)-PX20606 trans isomer (-)-PX20606 trans isomer is an agonist of FXR (EC50s: 18 and 29 nM for FXR in FRET and M1H assay, respectively).
T11428 Glyco-Obeticholic acid Glyco-Obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an agonist of the farnesoid X receptor (FXR).
T11426 Gly-β-MCA Gly-β-MCA, a bile acid, is a sable, intestine-selective, and oral bioactive farnesoid X receptor (FXR) inhibitor.
TN4628 Nelumol A Nelumol A, and nelumal A show a potency comparable to the endogenous ligand, they may as a valuable potential novel lead compound in the search for FXR agonists....
T31587 DY268 DY-268 is a compound based on trisubstituted pyrazolamide without any FXR agonist activity and cytotoxicity and can be used as an effective FXR antagonist (IC50 ...
T15818 LY367385 LY367385 is a highly effective and selective mGluR1a antagonist. LY367385 has neuroprotective, anticonvulsant, and antiepileptic effects. Compared with > 100 μM ...
T15806 LY2562175 LY2562175 is an effective and selective FXR agonist (EC50: 193 nM).
T29078 Ursodeoxycholic acid sodium Ursodeoxycholic acid sodium 是一种天然存在的次级胆汁酸,具有抗炎和细胞保护活性。Ursodeoxycholic acid sodium 作为信号分子,通过与胆汁酸激活受体相互作用发挥其作用,包括 G 蛋白偶联胆汁酸受体 5 (TGR5) 和法尼醇 X 受体 (FXR)。
Lithocholic acid
T2202
Lithocholic acid is a bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubili...
GW 4064
T2233
GW 4064 is an effective farnesoid X receptor (FXR) agonist (EC50 =65 nM).
Nidufexor
T7886
Nidufexor is an agonist for the farnesoid X receptor (FXR).
Turofexorate Isopropyl
T6053
Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM
Tropifexor
T4379
Tropifexor is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.
Fexaramine
T2015
Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.
Hyodeoxycholic acid
T2968
Hyodeoxycholic Acid has been used in trials studying the treatment of Hypercholesterolemia.
T0901317
T6690
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).
BAR502
TQ0252
BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).
Chenodeoxycholic acid
T0847
Chenodiol is a bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbe...
Obeticholic Acid
T1789
Obeticholic acid is a Farnesoid X Receptor Agonist. The mechanism of action of obeticholic acid is as a Farnesoid X Receptor Agonist.
Forskolin
T2939
Forskolin, a potent activator of the adenylate cyclase (EC50: 0.5 μM), can increase the cAMP level. It is extracted from the plant Coleus forskohlii.
Cilofexor
T7436
Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.
Sevelamer hydrochloride
T6344
Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.
Vonafexor
T8471
Vonafexor is a farnesoid X receptor (FXR, NR1H4) agonist, with anti-HBV effects
Guggulsterone
T5574
Guggulsterone E&Z is a 3-hydroxy steroid. It has a role as an androgen.
Altenusin
T8895
Altenusin is a natural nonsteroidal fungal metabolite, as a novel selective agonist of FXR with an EC50 value of 3.2 ± 0.2 μM.
Tauro-β-muricholic acid sodium
T13093
Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).
Tauro-Obeticholic acid
T13092
Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR).
(-)-PX20606 trans isomer
T12583L
(-)-PX20606 trans isomer is an agonist of FXR (EC50s: 18 and 29 nM for FXR in FRET and M1H assay, respectively).
Glyco-Obeticholic acid
T11428
Glyco-Obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an agonist of the farnesoid X receptor (FXR).
Gly-β-MCA
T11426
Gly-β-MCA, a bile acid, is a sable, intestine-selective, and oral bioactive farnesoid X receptor (FXR) inhibitor.
Nelumol A
TN4628
Nelumol A, and nelumal A show a potency comparable to the endogenous ligand, they may as a valuable potential novel lead compound in the search for FXR agonists....
DY268
T31587
DY-268 is a compound based on trisubstituted pyrazolamide without any FXR agonist activity and cytotoxicity and can be used as an effective FXR antagonist (IC50 ...
LY367385
T15818
LY367385 is a highly effective and selective mGluR1a antagonist. LY367385 has neuroprotective, anticonvulsant, and antiepileptic effects. Compared with > 100 μM...
LY2562175
T15806
LY2562175 is an effective and selective FXR agonist (EC50: 193 nM).
Ursodeoxycholic acid sodium
T29078
Ursodeoxycholic acid sodium 是一种天然存在的次级胆汁酸,具有抗炎和细胞保护活性。Ursodeoxycholic acid sodium 作为信号分子,通过...