FXR

The bile acid receptor (BAR), also known as farnesoid X receptor (FXR) or NR1H4 (nuclear receptor subfamily 1, group H, member 4) is a nuclear receptor that is encoded by the NR1H4 gene in humans.FXR is expressed at high levels in the liver and intestine. Chenodeoxycholic acid and other bile acids are natural ligands for FXR. Similar to other nuclear receptors, when activated, FXR translocates to the cell nucleus, forms a dimer (in this case a heterodimer with RXR) and binds to hormone response elements on DNA, which up- or down-regulates the expression of certain genes.

Cat No.	product name
T1789	Obeticholic Acid	Obeticholic acid is a Farnesoid X Receptor Agonist. The mechanism of action of obeticholic acid is as a Farnesoid X Receptor Agonist.
T2015	Fexaramine	Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.
T2202	Lithocholic acid	Lithocholic acid is a bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubil...
T2233	GW 4064	GW 4064 is an effective farnesoid X receptor (FXR) agonist (EC50 =65 nM).
T2968	Hyodeoxycholic acid	Hyodeoxycholic Acid has been used in trials studying the treatment of Hypercholesterolemia.
T6053	Turofexorate Isopropyl	Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM
T6690	T0901317	T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).
T4379	Tropifexor	Tropifexor is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.
T5264	Androsterone	Androsterone is a metabolic product of testosterone and can activate Farnesoid X Receptor (FXR).
T7436	Cilofexor	Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.
T7886	Nidufexor	Nidufexor is a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis.
TQ0252	BAR502	BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).
T8471	Vonafexor	Vonafexor is a farnesoid X receptor (FXR, NR1H4) agonist, with anti-HBV effects
T13093	Tauro-β-muricholic acid sodium	Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).
T11426	Gly-β-MCA	Gly-β-MCA may be a candidate for the treatment of metabolic disorders. Gly-β-MCA, a bile acid, is a potent, sable, intestine-selective and oral bioactive f...
T15818	LY367385	LY367385 is a highly effective and selective mGluR1a antagonist. LY367385 has neuroprotective, anticonvulsant, and antiepileptic effects. Compared with > 100 μ...
T12583L	(-)-PX20606 trans isomer	(-)-PX20606 trans isomer is an agonist of FXR (EC50s: 18 and 29 nM for FXR in FRET and M1H assay, respectively).
TN4628	Nelumol A	Nelumol A, and nelumal A show a potency comparable to the endogenous ligand, they may as a valuable potential novel lead compound in the search for FXR agonists...

Cat No.

product name

T1789

Obeticholic Acid

Obeticholic acid is a Farnesoid X Receptor Agonist. The mechanism of action of obeticholic acid is as a Farnesoid X Receptor Agonist.

T2015

Fexaramine

Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.

T2202

Lithocholic acid

Lithocholic acid is a bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubil...

T2233

GW 4064

GW 4064 is an effective farnesoid X receptor (FXR) agonist (EC50 =65 nM).

T2968

Hyodeoxycholic acid

Hyodeoxycholic Acid has been used in trials studying the treatment of Hypercholesterolemia.

T6053

Turofexorate Isopropyl

Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM

T6690

T0901317

T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).

T4379

Tropifexor

Tropifexor is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.

T5264

Androsterone

Androsterone is a metabolic product of testosterone and can activate Farnesoid X Receptor (FXR).

T7436

Cilofexor

Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.

T7886

Nidufexor

Nidufexor is a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis.

TQ0252

BAR502

BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).

T8471

Vonafexor

Vonafexor is a farnesoid X receptor (FXR, NR1H4) agonist, with anti-HBV effects

T13093

Tauro-β-muricholic acid sodium

Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).

T11426

Gly-β-MCA

Gly-β-MCA may be a candidate for the treatment of metabolic disorders. Gly-β-MCA, a bile acid, is a potent, sable, intestine-selective and oral bioactive f...

T15818

LY367385

LY367385 is a highly effective and selective mGluR1a antagonist. LY367385 has neuroprotective, anticonvulsant, and antiepileptic effects. Compared with > 100 μ...

T12583L

(-)-PX20606 trans isomer

(-)-PX20606 trans isomer is an agonist of FXR (EC50s: 18 and 29 nM for FXR in FRET and M1H assay, respectively).

TN4628

Nelumol A

Nelumol A, and nelumal A show a potency comparable to the endogenous ligand, they may as a valuable potential novel lead compound in the search for FXR agonists...