FXR

The bile acid receptor (BAR), also known as farnesoid X receptor (FXR) or NR1H4 (nuclear receptor subfamily 1, group H, member 4) is a nuclear receptor that is encoded by the NR1H4 gene in humans.FXR is expressed at high levels in the liver and intestine. Chenodeoxycholic acid and other bile acids are natural ligands for FXR. Similar to other nuclear receptors, when activated, FXR translocates to the cell nucleus, forms a dimer (in this case a heterodimer with RXR) and binds to hormone response elements on DNA, which up- or down-regulates the expression of certain genes.

Cat No.	product name
T2202	Lithocholic acid	Lithocholic acid is a bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubili...
T2233	GW 4064	GW 4064 is an effective farnesoid X receptor (FXR) agonist (EC50 =65 nM).
T7886	Nidufexor	Nidufexor is an agonist for the farnesoid X receptor (FXR).
T6053	Turofexorate Isopropyl	Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM
T4379	Tropifexor	Tropifexor is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.
T2015	Fexaramine	Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.
T2968	Hyodeoxycholic acid	Hyodeoxycholic Acid has been used in trials studying the treatment of Hypercholesterolemia.
T6690	T0901317	T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).
TQ0252	BAR502	BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).
T0847	Chenodeoxycholic acid	Chenodiol is a bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbe...
T1789	Obeticholic Acid	Obeticholic acid is a Farnesoid X Receptor Agonist. The mechanism of action of obeticholic acid is as a Farnesoid X Receptor Agonist.
T2939	Forskolin	Forskolin, a potent activator of the adenylate cyclase (EC50: 0.5 μM), can increase the cAMP level. It is extracted from the plant Coleus forskohlii.
T7436	Cilofexor	Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.
T6344	Sevelamer hydrochloride	Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.
T8471	Vonafexor	Vonafexor is a farnesoid X receptor (FXR, NR1H4) agonist, with anti-HBV effects
T5574	Guggulsterone	Guggulsterone E&Z is a 3-hydroxy steroid. It has a role as an androgen.
T8895	Altenusin	Altenusin is a natural nonsteroidal fungal metabolite, as a novel selective agonist of FXR with an EC50 value of 3.2 ± 0.2 μM.
T13093	Tauro-β-muricholic acid sodium	Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).
T13092	Tauro-Obeticholic acid	Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR).
T12583L	(-)-PX20606 trans isomer	(-)-PX20606 trans isomer is an agonist of FXR (EC50s: 18 and 29 nM for FXR in FRET and M1H assay, respectively).
T11428	Glyco-Obeticholic acid	Glyco-Obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an agonist of the farnesoid X receptor (FXR).
T11426	Gly-β-MCA	Gly-β-MCA, a bile acid, is a sable, intestine-selective, and oral bioactive farnesoid X receptor (FXR) inhibitor.
TN4628	Nelumol A	Nelumol A, and nelumal A show a potency comparable to the endogenous ligand, they may as a valuable potential novel lead compound in the search for FXR agonists....
T31587	DY268	DY-268 is a compound based on trisubstituted pyrazolamide without any FXR agonist activity and cytotoxicity and can be used as an effective FXR antagonist (IC50 ...
T15818	LY367385	LY367385 is a highly effective and selective mGluR1a antagonist. LY367385 has neuroprotective, anticonvulsant, and antiepileptic effects. Compared with > 100 μM ...
T15806	LY2562175	LY2562175 is an effective and selective FXR agonist (EC50: 193 nM).
T29078	Ursodeoxycholic acid sodium	Ursodeoxycholic acid sodium 是一种天然存在的次级胆汁酸，具有抗炎和细胞保护活性。Ursodeoxycholic acid sodium 作为信号分子，通过与胆汁酸激活受体相互作用发挥其作用，包括 G 蛋白偶联胆汁酸受体 5 (TGR5) 和法尼醇 X 受体 (FXR)。