FXR

The bile acid receptor (BAR), also known as farnesoid X receptor (FXR) or NR1H4 (nuclear receptor subfamily 1, group H, member 4) is a nuclear receptor that is encoded by the NR1H4 gene in humans.FXR is expressed at high levels in the liver and intestine. Chenodeoxycholic acid and other bile acids are natural ligands for FXR. Similar to other nuclear receptors, when activated, FXR translocates to the cell nucleus, forms a dimer (in this case a heterodimer with RXR) and binds to hormone response elements on DNA, which up- or down-regulates the expression of certain genes.

Cat. No.	Product name	CAS No.	Purity
TN4628	Nelumol A	77836-86-3	98%
TN4628	Nelumol A, and nelumal A show a potency comparable to the endogenous ligand, they may as a valuable potential novel lead compound in the search for FXR agonists....
T11426	Gly-β-MCA	66225-78-3	98%
T11426	Gly-β-MCA, a bile acid, is a sable, intestine-selective, and oral bioactive farnesoid X receptor (FXR) inhibitor.
T15818	LY367385	198419-91-9	98%
T15818	LY367385 is a highly effective and selective mGluR1a antagonist. LY367385 has neuroprotective, anticonvulsant, and antiepileptic effects. Compared with > 100 μM ...
T13093	Tauro-β-muricholic acid sodium	145022-92-0	98%
T13093	Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).
T1789	Obeticholic Acid	459789-99-2	98%
T1789	Obeticholic acid is a Farnesoid X Receptor Agonist. The mechanism of action of obeticholic acid is as a Farnesoid X Receptor Agonist.
T11428	Glyco-Obeticholic acid	863239-60-5	98%
T11428	Glyco-Obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an agonist of the farnesoid X receptor (FXR).
TQ0252	BAR502	1612191-86-2	98%
TQ0252	BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).
T7886	Nidufexor	1773489-72-7	98%
T7886	Nidufexor is an agonist for the farnesoid X receptor (FXR).
T15806	LY2562175	1103500-20-4	98%
T15806	LY2562175 is an effective and selective FXR agonist (EC50: 193 nM).
T6690	T0901317	293754-55-9	98%
T6690	T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).
T4379	Tropifexor	1383816-29-2	98%
T4379	Tropifexor is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.
T2015	Fexaramine	574013-66-4	98%
T2015	Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.
T2939	Forskolin	66575-29-9	98%
T2939	Forskolin, a potent activator of the adenylate cyclase (EC50: 0.5 μM), can increase the cAMP level. It is extracted from the plant Coleus forskohlii.
T27460	GSK2324	1020567-30-9	98%
T27460	GSK2324 is a potent FXR agonist for the treatment of NAFLD by controlling hepatic lipids through reduced uptake and selective reduction of fatty acid synthesis.
T31587	DY268	1609564-75-1	98%
T31587	DY-268 is a compound based on trisubstituted pyrazolamide without any FXR agonist activity and cytotoxicity and can be used as an effective FXR antagonist (IC50 ...
T5574	Guggulsterone	95975-55-6	98%
T5574	Guggulsterone E&Z is a 3-hydroxy steroid. It has a role as an androgen.
T7436	Cilofexor	1418274-28-8	98%
T7436	Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.
T2233	GW 4064	278779-30-9	98%
T2233	GW 4064 is an effective farnesoid X receptor (FXR) agonist (EC50 =65 nM).
T8895	Altenusin	31186-12-6	98%
T8895	Altenusin is a natural nonsteroidal fungal metabolite, as a novel selective agonist of FXR with an EC50 value of 3.2 ± 0.2 μM.
T2968	Hyodeoxycholic acid	83-49-8	98%
T2968	Hyodeoxycholic Acid has been used in trials studying the treatment of Hypercholesterolemia.