Guanylate cyclase

Guanylate cyclase (also known as guanyl cyclase, guanylyl cyclase, or GC) is a lyase enzyme that converts guanosine triphosphate (GTP) to cyclic guanosine monophosphate (cGMP) and pyrophosphate. It is often part of the G protein signaling cascade that is activated by low intracellular calcium levels and inhibited by high intracellular calcium levels. In response to calcium levels, guanylate cyclase synthesizes cGMP from GTP. cGMP keeps cGMP-gated channels open, allowing for the entry of calcium into the cell.

Cat. No.	Product name	CAS No.	Purity
T34648	Sinitrodil	143248-63-9	98%
T34648	Sinitrodil is a guanylate cyclase stimulant that may be used in the treatment of myocardial ischemia and angina pectoris.
T6968	Riociguat	625115-55-1	98%
T6968	Riociguat is a stimulator of guanylate cyclase which causes relaxation of vascular smooth muscle and is used to treat severe pulmonary arterial hypertension.
T1984	Cinaciguat	329773-35-5	98%
T1984	Cinaciguat (BAY 58-2667) is the first of a new class of soluble guanylate cyclase (sGC) activators in Clinicalal development for acute decompensated heart failur...
T17226	Vericiguat	1350653-20-1	98%
T17226	Vericiguat is a potent and orally available guanylate cyclase stimulator.
T21607	Ataciguat	254877-67-3	98%
T21607	Ataciguat (HMR-1766) is a potent and specific soluble guanylate cyclase (sGC) activator.
T67734	MCUF-651	2747162-85-0	98%
T67734	MCUF-651 is a guanylyl cyclase A receptor positive allosteric modulators, EC50=0.45 μM.
T21712	BAY 41-8543	256498-66-5	98%
T21712	BAY 41-8543 is a nitric oxide (NO)-independent stimulator of soluble guanylyl cyclase (sGC).
T4381	Lificiguat	170632-47-0	98%
T4381	YC-1 is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha).
T16344	NS-2028	204326-43-2	98%
T16344	NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor (IC50: 30 nM and 200 nM for basal and NO-stimulated enzyme activity). It is commonly used ...
T16383	Olinciguat	1628732-62-6	98%
T16383	Olinciguat is an oral guanylate cyclase (sGC) stimulator. It also has concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a wh...
T7201	Nelociguat	625115-52-8	98%
T7201	Nelociguat(BAY60-4552) is a soluble guanylate cyclase stimulator (sGC stimulator). Soluble guanylate cyclase (sGC) is a key enzyme in the nitric oxide (NO) signa...
T16569	Praliciguat	1628730-49-3	98%
T16569	Praliciguat stimulates sGC in HEK-293 cells (EC50: 197 nM). Praliciguat is an effective and orally active soluble guanylate cyclase stimulator. It also enhances ...
T21576	LY83583	91300-60-6	98%
T21576	LY83583 is a soluble guanylate cyclase competitive inhibitor with IC50 of 2 µM.
T19777	ODQ	41443-28-1	98%
T19777	ODQ is an effective and selective soluble guanylyl cyclase (sGC) inhibitor.
T11852	Linaclotide	851199-59-2	98%
T11852	Linaclotide developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation, and is a potent and selective guan...
T0006	Methylene Blue trihydrate	7220-79-3	98%
T0006	Methylene blue is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue...
T9080	Plecanatide	467426-54-6	98%
T9080	Plecanatide acetate is an analogue of Uroguanylin. It is an orally active guanylate cyclase-C (GC-C) receptor agonist.
T6991	Nitroprusside disodium dihydrate	13755-38-9	98%
T6991	Sodium Nitroprusside Dihydrate is a potent vasodilator working through releasing NO spontaneously in blood.
T16808	Runcaciguat	1402936-61-1	98%
T16808	Runcaciguat is a soluble guanylate cyclase stimulator. Runcaciguat combines with selective partial adenosine A1 receptor agonists and can be used in studies abou...
T6888	Methylene Blue	61-73-4	98%
T6888	Methylene Blue(IC50 of 1.9 μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.