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Guanylate cyclase

Guanylate cyclase (also known as guanyl cyclase, guanylyl cyclase, or GC) is a lyase enzyme that converts guanosine triphosphate (GTP) to cyclic guanosine monophosphate (cGMP) and pyrophosphate. It is often part of the G protein signaling cascade that is activated by low intracellular calcium levels and inhibited by high intracellular calcium levels. In response to calcium levels, guanylate cyclase synthesizes cGMP from GTP. cGMP keeps cGMP-gated channels open, allowing for the entry of calcium into the cell.
Cat. No. Product name CAS No. Purity Chemical Structure
T34648 Sinitrodil 143248-63-9 98%
Sinitrodil is a guanylate cyclase stimulant that may be used in the treatment of myocardial ischemia and angina pectoris.
T6968 Riociguat 625115-55-1 98%
Riociguat is a stimulator of guanylate cyclase which causes relaxation of vascular smooth muscle and is used to treat severe pulmonary arterial hypertension.
T1984 Cinaciguat 329773-35-5 98%
Cinaciguat (BAY 58-2667) is the first of a new class of soluble guanylate cyclase (sGC) activators in Clinicalal development for acute decompensated heart failur...
T17226 Vericiguat 1350653-20-1 98%
Vericiguat is a potent and orally available guanylate cyclase stimulator.
T21607 Ataciguat 254877-67-3 98%
Ataciguat (HMR-1766) is a potent and specific soluble guanylate cyclase (sGC) activator.
T67734 MCUF-651 2747162-85-0 98%
MCUF-651 is a guanylyl cyclase A receptor positive allosteric modulators, EC50=0.45 μM.
T21712 BAY 41-8543 256498-66-5 98%
BAY 41-8543 is a nitric oxide (NO)-independent stimulator of soluble guanylyl cyclase (sGC).
T4381 Lificiguat 170632-47-0 98%
YC-1 is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha).
T16344 NS-2028 204326-43-2 98%
NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor (IC50: 30 nM and 200 nM for basal and NO-stimulated enzyme activity). It is commonly used ...
T16383 Olinciguat 1628732-62-6 98%
Olinciguat is an oral guanylate cyclase (sGC) stimulator. It also has concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a wh...
T7201 Nelociguat 625115-52-8 98%
Nelociguat(BAY60-4552) is a soluble guanylate cyclase stimulator (sGC stimulator). Soluble guanylate cyclase (sGC) is a key enzyme in the nitric oxide (NO) signa...
T16569 Praliciguat 1628730-49-3 98%
Praliciguat stimulates sGC in HEK-293 cells (EC50: 197 nM). Praliciguat is an effective and orally active soluble guanylate cyclase stimulator. It also enhances ...
T21576 LY83583 91300-60-6 98%
LY83583 is a soluble guanylate cyclase competitive inhibitor with IC50 of 2 µM.
T19777 ODQ 41443-28-1 98%
ODQ is an effective and selective soluble guanylyl cyclase (sGC) inhibitor.
T11852 Linaclotide 851199-59-2 98%
Linaclotide developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation, and is a potent and selective guan...
T0006 Methylene Blue trihydrate 7220-79-3 98%
Methylene blue is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue...
T9080 Plecanatide 467426-54-6 98%
Plecanatide acetate is an analogue of Uroguanylin. It is an orally active guanylate cyclase-C (GC-C) receptor agonist.
T6991 Nitroprusside disodium dihydrate 13755-38-9 98%
Sodium Nitroprusside Dihydrate is a potent vasodilator working through releasing NO spontaneously in blood.
T16808 Runcaciguat 1402936-61-1 98%
Runcaciguat is a soluble guanylate cyclase stimulator. Runcaciguat combines with selective partial adenosine A1 receptor agonists and can be used in studies abou...
T6888 Methylene Blue 61-73-4 98%
Methylene Blue(IC50 of 1.9 μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.
Sinitrodil
T34648
Sinitrodil is a guanylate cyclase stimulant that may be used in the treatment of myocardial ischemia and angina pectoris.
Riociguat
T6968
Riociguat is a stimulator of guanylate cyclase which causes relaxation of vascular smooth muscle and is used to treat severe pulmonary arterial hypertension.
Cinaciguat
T1984
Cinaciguat (BAY 58-2667) is the first of a new class of soluble guanylate cyclase (sGC) activators in Clinicalal development for acute decompensated heart failur...
Vericiguat
T17226
Vericiguat is a potent and orally available guanylate cyclase stimulator.
Ataciguat
T21607
Ataciguat (HMR-1766) is a potent and specific soluble guanylate cyclase (sGC) activator.
MCUF-651
T67734
MCUF-651 is a guanylyl cyclase A receptor positive allosteric modulators, EC50=0.45 μM.
BAY 41-8543
T21712
BAY 41-8543 is a nitric oxide (NO)-independent stimulator of soluble guanylyl cyclase (sGC).
Lificiguat
T4381
YC-1 is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha).
NS-2028
T16344
NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor (IC50: 30 nM and 200 nM for basal and NO-stimulated enzyme activity). It is commonly used ...
Olinciguat
T16383
Olinciguat is an oral guanylate cyclase (sGC) stimulator. It also has concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a wh...
Nelociguat
T7201
Nelociguat(BAY60-4552) is a soluble guanylate cyclase stimulator (sGC stimulator). Soluble guanylate cyclase (sGC) is a key enzyme in the nitric oxide (NO) signa...
Praliciguat
T16569
Praliciguat stimulates sGC in HEK-293 cells (EC50: 197 nM). Praliciguat is an effective and orally active soluble guanylate cyclase stimulator. It also enhances ...
LY83583
T21576
LY83583 is a soluble guanylate cyclase competitive inhibitor with IC50 of 2 µM.
ODQ
T19777
ODQ is an effective and selective soluble guanylyl cyclase (sGC) inhibitor.
Linaclotide
T11852
Linaclotide developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation, and is a potent and selective guan...
Methylene Blue trihydrate
T0006
Methylene blue is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue...
Plecanatide
T9080
Plecanatide acetate is an analogue of Uroguanylin. It is an orally active guanylate cyclase-C (GC-C) receptor agonist.
Nitroprusside disodium dihydrate
T6991
Sodium Nitroprusside Dihydrate is a potent vasodilator working through releasing NO spontaneously in blood.
Runcaciguat
T16808
Runcaciguat is a soluble guanylate cyclase stimulator. Runcaciguat combines with selective partial adenosine A1 receptor agonists and can be used in studies abou...
Methylene Blue
T6888
Methylene Blue(IC50 of 1.9 μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.
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