T6347 |
Ki16198
|
355025-13-7
|
98%
|
|
Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μ...
|
T7393 |
ONO-7300243
|
638132-34-0
|
98%
|
|
ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 µM).
|
T22812 |
GRI977143
|
325850-81-5
|
98%
|
|
GRI977143 is a selective and non-lipid agonist of LPA2 (EC50 = 3.3 μM). GRI977143 inhibits the activation of caspases 3, 7, 8, and 9 and and reduces DNA fragment...
|
T14335 |
ASP6432
|
1282549-08-9
|
98%
|
|
ASP6432 is an antagonist of type 1 lysophosphatidic acid receptor (LPA1). For human LPA1 and rat LPA1, the IC50s are 11 nM and 30 nM , respectively.
|
T23438 |
TC LPA5 4
|
1393814-38-4
|
98%
|
|
TC LPA5 4 is a LPA5 receptor antagonist.
|
T22070 |
DBIBB
|
1569309-92-7
|
98%
|
|
DBIBB is a specific nonlipid agonist of the type 2 G protein coupled receptor for lysophosphatidic acid (LPA2). DBIBB mitigates the gastrointestinal radiation sy...
|
T11875 |
LPA2 antagonist 2
|
36840-10-5
|
98%
|
|
LPA2 antagonist 2 is >480-fold more selective than LPA3 (IC50 of 13.85 μM).LPA2 antagonist 2 is a selective LPA2 antagonist with an IC50 of 28.3 nM and a Ki of 2...
|
T9699 |
TAK-615
|
1664335-55-0
|
98%
|
|
TAK-615 is commonly used to study pulmonary fibrosis and is a negative allosteric modulator of LPA1 receptors.
|
T15796 |
LX-1031
|
945976-76-1
|
98%
|
|
LX-1031 is an effective inhibitor of tryptophan 5-hydroxylase. LX-1031 decreases serotonin (5-HT) synthesis peripherally.
|
T21654 |
1-Oleoyl lysophosphatidic acid sodium
|
325465-93-8
|
|
|
1-Oleoyl lysophosphatidic acid sodium salt is an Endogenous agonist of LPA1 and LPA2
|
T22835 |
H2L5186303
|
139262-76-3
|
97.23%
|
|
H2L5186303 is an LPA2 antagonist and can be used in studies about asthma treatment.
|
T7689 |
Tetradecyl Phosphonate
|
4671-75-4
|
98%
|
|
Tetradecyl phosphonate is a pan-antagonist of lysophosphatidic acid 1 (LPA1), LPA2, and LPA3 receptors.
|
T6108 |
Ki16425
|
355025-24-0
|
98.54%
|
|
Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively.
|
T4016 |
BMS-986020
|
1257213-50-5
|
98.61%
|
|
BMS-986020 is a selective antagonist of LPA1.
|
T12684 |
Radioprotectin-1
|
1622006-09-0
|
99.43%
|
|
Radioprotectin-1 is a selective agonist of LPA2 with EC50 of 25 nM for murine LPA2 GPCR and exerts radioprotective and radiomitigative action.
|
T22834 |
H2L 5765834
|
420841-84-5
|
99.47%
|
|
H2L 5765834 is a lysophosphatidic acid receptors antagonist
|
T4278 |
AM966
|
1228690-19-4
|
99.49%
|
|
AM966, a excellent affinity, specific, oral LPA1(IC50=17 nM) antagonist, suppresses LPA-stimulated intracellular calcium release.
|
T2000 |
AM095
|
1345614-59-6
|
99.62%
|
|
AM095 is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively.
|
T4521 |
Edg-2 receptor inhibitor 1
|
1195941-38-8
|
99.64%
|
|
Edg-2 receptor inhibitor 1 is an Edg-2 receptor inhibitor extracted (IC50: <0.1 μM).
|
T10293 |
AM095 free acid
|
1228690-36-5
|
99.9%
|
|
AM095 (free acid) is a potent LPA1 receptor antagonist (IC50s: 0.98 and 0.73 μM for recombinant human or mouse LPA1).
|