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Immunology / Inflammation LTR

LTR

LTR retrotransposons are class I transposable element characterized by the presence of Long Terminal Repeats (LTRs) directly flanking an internal coding region. As retrotransposons, they mobilize through reverse-transcription of their mRNA and integration of the newly created cDNA into another location. Their mechanism of retrotransposition is shared with retroviruses, with the difference that most LTR-retrotransposons do not form infectious particles that leave the cells and therefore only replicate inside their genome of origin.
Cat No. product name
T0694 Pranlukast Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction t...
T1257 Ubenimex Ubenimex competitively inhibits many aminopeptidases, including B, N and leucine aminopeptidases. Ubenimex is a microbial metabolite and dipeptide with potentia...
T1677 Montelukast Montelukast is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked ...
T1677L Montelukast sodium Montelukast is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked ...
T3148 Verlukast sodium MK-571 is a selective, orally active antagonist of the CysLT1 receptor. MK571 is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor used to demonstrate t...
T3715 Acebilustat Acebilustat (ZK322) is an effective and specific leukotriene B4 hydrolase inhibitor.
T3738 3-(4-Hydroxyphenyl)-1-propanol 3-(4-hydroxyphenyl)-1-propanol is a member of the class of compounds known as 1-hydroxy-2-unsubstituted benzenoids.
T4114 Diffractaic Acid Diffractaic Acid can inhibit LTB4 biosynthesis in A-23187-stimulated bovine PMNL cells with activity value of 8 μM.
T4192 hnps-PLA Inhibitor Hnps-PLA Inhibitor is an inhibitor of human nonpancreatic secretory Phospholipase A (hnps-PLA).
T7841 MK 571 MK 571 is an orally active antagonist of CysLT1 receptor .
T10208 A-69412 A-69412 is a reversible, specific inhibitor of the hydrophilic 5-lipoxygenase. It has the potential to treat ulcerative colitis and asthma, and possibly other i...
T10917 LTB4-IN-1 LTB4-IN-1 with IC50 of 70 nM is an inhibitor of leukotriene synthesis (LTB4).
T14210 Amelubant Amelubant (BIIL 284) is a prodrug of active metabolites BIIL 260 and BIIL 315. Anti-inflammatory activity[1]. Amelubant (BIIL 284) is a potent, oral and long ac...
T15002 CP-105696 CP-105696 is a selective antagonist of Leukotriene B4 Receptor (IC50: 8.42 nM).
T15182 DW-1350 DW-1350 is an antagonist of LTB4 receptor.
T11487L Fiboflapon sodium Fiboflapon sodiumis a potent and orally bioavailable 5-lipoxygenase-activating protein (FLAP) inhibitor with a potency of 2.9 nM in FLAP binding, an IC50 of 76 ...
T11487 Fiboflapon Fiboflapon  is a potent and orally bioavailable 5-lipoxygenase-activating protein (FLAP) inhibitor with a potency of 2.9 nM in FLAP binding, an IC50 of 76 nM f...
T13295 Veliflapon Veliflapon is an orally active and selective inhibitor of 5-lipoxygenase activating protein (FLAP) . Veliflapon inhibits the synthesis of the leukotrienes B4 an...
T15813 LY309887 LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (Ki: 6.5 nM). It also has antitumor activity.
T15815 LY3295668 LY3295668 is an effective and orally active and highly specific inhibitor of Aurora-A kinase (Ki: 0.8 nM and 1038 nM for AurA and AurB, respectively).
T16395 ONO4057 ONO4057 is an antagonist of the Leukotriene B4 receptor (IC50: 0.7±0.3 μM).
T17191 Bunaprolast Bunaprolast shows significant inhibition of lipoxygenase and TXB2 release. Bunaprolast is a potent inhibitor of LTB4 production in human whole blood.
TN3983 Ergosta-7,22-dien-3-one Ergosta-7,22-dien-3-one shows pro-inflammatory property, it can stimulate nitric oxide production, induce the expression of genes, and induce the production of ...
TN5164 trans-Hinokiresinol Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphyl...
Pranlukast
T0694CAS 103177-37-3
Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction t...
Ubenimex
T1257CAS 58970-76-6
Ubenimex competitively inhibits many aminopeptidases, including B, N and leucine aminopeptidases. Ubenimex is a microbial metabolite and dipeptide with potentia...
Montelukast
T1677CAS 158966-92-8
Montelukast is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked ...
Montelukast sodium
T1677LCAS 151767-02-1
Montelukast is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked ...
Verlukast sodium
T3148CAS 115103-85-0
MK-571 is a selective, orally active antagonist of the CysLT1 receptor. MK571 is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor used to demonstrate t...
Acebilustat
T3715CAS 943764-99-6
Acebilustat (ZK322) is an effective and specific leukotriene B4 hydrolase inhibitor.
3-(4-Hydroxyphenyl)-1-propanol
T3738CAS 10210-17-0
3-(4-hydroxyphenyl)-1-propanol is a member of the class of compounds known as 1-hydroxy-2-unsubstituted benzenoids.
Diffractaic Acid
T4114CAS 436-32-8
Diffractaic Acid can inhibit LTB4 biosynthesis in A-23187-stimulated bovine PMNL cells with activity value of 8 μM.
hnps-PLA Inhibitor
T4192CAS 185298-58-2
Hnps-PLA Inhibitor is an inhibitor of human nonpancreatic secretory Phospholipase A (hnps-PLA).
MK 571
T7841CAS 115104-28-4
MK 571 is an orally active antagonist of CysLT1 receptor .
A-69412
T10208CAS 123606-23-5
A-69412 is a reversible, specific inhibitor of the hydrophilic 5-lipoxygenase. It has the potential to treat ulcerative colitis and asthma, and possibly other i...
LTB4-IN-1
T10917CAS 133012-00-7
LTB4-IN-1 with IC50 of 70 nM is an inhibitor of leukotriene synthesis (LTB4).
Amelubant
T14210CAS 346735-24-8
Amelubant (BIIL 284) is a prodrug of active metabolites BIIL 260 and BIIL 315. Anti-inflammatory activity[1]. Amelubant (BIIL 284) is a potent, oral and long ac...
CP-105696
T15002CAS 158081-99-3
CP-105696 is a selective antagonist of Leukotriene B4 Receptor (IC50: 8.42 nM).
DW-1350
T15182CAS 491577-61-8
DW-1350 is an antagonist of LTB4 receptor.
Fiboflapon sodium
T11487LCAS 1196070-26-4
Fiboflapon sodiumis a potent and orally bioavailable 5-lipoxygenase-activating protein (FLAP) inhibitor with a potency of 2.9 nM in FLAP binding, an IC50 of 76 ...
Fiboflapon
T11487CAS 936350-00-4
Fiboflapon  is a potent and orally bioavailable 5-lipoxygenase-activating protein (FLAP) inhibitor with a potency of 2.9 nM in FLAP binding, an IC50 of 76 nM f...
Veliflapon
T13295CAS 128253-31-6
Veliflapon is an orally active and selective inhibitor of 5-lipoxygenase activating protein (FLAP) . Veliflapon inhibits the synthesis of the leukotrienes B4 an...
LY309887
T15813CAS 127228-54-0
LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (Ki: 6.5 nM). It also has antitumor activity.
LY3295668
T15815CAS 1919888-06-4
LY3295668 is an effective and orally active and highly specific inhibitor of Aurora-A kinase (Ki: 0.8 nM and 1038 nM for AurA and AurB, respectively).
ONO4057
T16395CAS 134578-96-4
ONO4057 is an antagonist of the Leukotriene B4 receptor (IC50: 0.7±0.3 μM).
Bunaprolast
T17191CAS 99107-52-5
Bunaprolast shows significant inhibition of lipoxygenase and TXB2 release. Bunaprolast is a potent inhibitor of LTB4 production in human whole blood.
Ergosta-7,22-dien-3-one
TN3983CAS 32507-77-0
Ergosta-7,22-dien-3-one shows pro-inflammatory property, it can stimulate nitric oxide production, induce the expression of genes, and induce the production of ...
trans-Hinokiresinol
TN5164CAS 17676-24-3
Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphyl...