T10675 |
MEK-IN-1 |
MEK-IN-1 is a MEK inhibitor from patent WO2008076415A1. |
T11993 |
MEK inhibitor |
MEK inhibitor is a potent MEK inhibitor with antitumor potency. |
T13782 |
MS432 |
MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2. |
T15193 |
EBI-1051 |
EBI-1051 is a highly potent and orally efficacious inhibitor of MEK (IC50: 3.9 nM). |
T16114 |
Pavinetant |
Pavinetant is an antagonist of the neurokinin-3 receptor (NK3R). |
T2125 |
TrametinibHOT |
Trametinib is an ATP-noncompetitive inhibitor of MEK 1/2 (IC50s: 0.7/0.9 nM). It shows low inhibition for more than 180 kinases, including B-Raf, c-Raf, and MEK...
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T21295 |
BIX 02189 |
BIX02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM). |
T2327 |
Pelitinib |
Pelitinib (EKB-569) is an effective irreversible EGFR inhibitor (IC50: 38.5 nM). |
T2416 |
BIX02189 |
BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM. |
T2443 |
CI-1040HOT |
CI-1040 (PD184352) is an ATP non-competitive MEK1/2 inhibitor (IC50: 17 nM). |
T2508 |
Binimetinib |
Binimetinib (MEK162, ARRY-162, ARRY-438162) is an orally available inhibitor of MEK1/2 (IC50: 12 nM) in a cell-free assay. |
T2610 |
BMS 599626 |
BMS-599626 has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies. |
T2623 |
PD 98059HOT |
PD98059 is a non-ATP competitive MEK inhibitor (IC50: 2/50 μM for MEK1/MEK2). |
T2708 |
SL-327 |
SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier. |
T2P2806 |
Hederacolchiside A1 |
Hederacolchiside A1 shows anti-leishmanial activity, it exhibits a strong antiproliferative activity on all stages of development of the parasite by altering me...
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T3001 |
Honokiol |
Honokiol is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2. |
T3623 |
Cobimetinib |
Cobimetinib is a selective inhibitor of mitogen-activated protein kinase kinase (MEK) (IC50: 0.9 nM). Cobimetinib specifically binds to and inhibits the catalyt...
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T3S0137 |
Bavachalcone |
Bavachalcone has antibiotic or anticancer activities, it may be useful as a therapeutic drug for bone resorption-associated diseases.Bavachalcone can protect th...
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T5412 |
RO4987655 |
RO4987655 is an orally active and highly selective MEK inhibitor (IC50: 5.2 nM for MEK1/MEK2). |
T5857 |
Trametinib DMSO solvate |
Trametinib DMSO solvate is a Highly Potent and Selective MEK Inhibitor that specifically inhibits MEK1/2(IC50 :2 nM) |
T5S0689 |
Demethylwedelolactone |
Demethylwedelolactone has trypsin inhibitory effect, it exerts anti-invasive growth effect on breast cancer cells. |
T5S2361 |
Epiberberine |
1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK...
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T6057 |
URMC-099 |
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM...
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T6066 |
SCH772984HOT |
SCH 772984 is a potent inhibitor of ERK1/ERK2 (IC50: 4/1 nM) and has only weak inhibitory for other 300 tested kinases. |
T6083 |
AZD8330 |
AZD8330 is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1. |
T6131 |
Pimasertib |
Pimasertib is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. |
T6152 |
PD318088 |
PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binding simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-b...
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T6189 |
PD0325901HOT |
PD0325901 is a specific and non-ATP-competitive MEK inhibitor (IC50: 0.33 nM). |
T6218 |
SelumetinibHOT |
Selumetinib (AZD6244) is an effective, specific inhibitor of MEK1 and ERK1/2 phosphorylation (IC50: 14/10 nM). |
T6223 |
U0126-EtOHHOT |
U0126-EtOH is a non-ATP competitive specific inhibitor of MEK1/2 (IC50: 0.07/0.06 μM). |
T6324 |
BIX02188 |
BIX02188 is a specific MEK5 inhibitor (IC50: 4.3 nM), also inhibits ERK5 catalytic activity (IC50: 810 nM), and does not inhibit closely related kinases MEK1/2,...
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T6419 |
BMS-536924 |
BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/...
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T6636 |
Refametinib |
Refametinib (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM). |
T6692 |
TAK-733 |
MEK Inhibitor TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. |
T6785 |
BI-847325 |
BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively. |
T6843 |
GDC-0623 |
GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1. |
T7190 |
Actein |
Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblas...
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T7610 |
GW284543 |
GW284543 is a selective inhibitor of MEK5 . |
T7742 |
GW 284543 hydrochloride |
GW 284543 hydrochloride is a selective inhibitor of MEK5 . |
TN1459 |
Bufarenogin |
Bufarenogin has inhibitory activity on human kidney Na(+)/K(+)-ATPase, it has cytotoxicity against HepG2 and MCF-7 human cancer cells. |
TN1462 |
Cajanin |
Cajanin has potential hypolipidemic effects,possibly via up-regulating the ABCA1 protein expression,subsequently resulting in increased macrophage cholesterol e...
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TN1819 |
Kaempferol 3-neohesperidoside |
Kaempferol 3-neohesperidoside has insulin-like properties in terms of glucose lowering, it stimulates glucose uptake in the rat soleus muscle via the PI3K and P...
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TN2151 |
Rhamnocitrin |
Rhamnocitrin can enhance the immune function, improve the formation of spleen cells of mice serum hemolysin of chicken red blood cell immune. |
TN3397 |
Alpinumisoflavone |
Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is ...
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TN3525 |
Boehmenan |
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity i...
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TN3711 |
Corylifol C |
Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration 50% values for epidermal growth factor recepto...
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TN4166 |
Griffipavixanthone |
Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mit...
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TN5201 |
Uncarinic acid E |
Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resu...
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