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MEK

MEK is a member of the MAPK signaling cascade that is activated in melanoma. When MEK is inhibited, cell proliferation is blocked and apoptosis (controlled cell death) is induced.
Cat. No. Product name CAS No. Purity Chemical Structure
TN3397 Alpinumisoflavone 34086-50-5 98%
Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is e...
TN1462 Cajanin 32884-36-9 98%
Cajanin has potential hypolipidemic effects,possibly via up-regulating the ABCA1 protein expression,subsequently resulting in increased macrophage cholesterol ef...
T2610 BMS-599626 714971-09-2 98%
BMS-599626 has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.
T13782 MS432 T13782 98%
MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.
T10675 MEK-IN-1 870600-45-6 98%
MEK-IN-1 is a MEK inhibitor from patent WO2008076415A1.
TN3711 Corylifol C 775351-91-2 98%
Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration 50% values for epidermal growth factor receptor...
T7030 Anemarsaponin B 139051-27-7 98%
Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity,...
T15193 EBI-1051 1801896-05-8 98%
EBI-1051 is a highly potent and orally efficacious inhibitor of MEK (IC50: 3.9 nM).
TN4166 Griffipavixanthone 219649-95-3 98%
Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mito...
T16114 Pavinetant 941690-55-7 98%
Pavinetant is an antagonist of the neurokinin-3 receptor (NK3R).
TN5201 Uncarinic acid E 277751-61-8 98%
Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resul...
TN3525 Boehmenan 57296-22-7 98%
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
T11993 MEK inhibitor 334951-92-7 98%
MEK inhibitor is a potent MEK inhibitor with antitumor potency.
T21980 PD 198306 212631-61-3 98%
PD 198306 is a selective inhibitor of MAPK/ERK-kinase (MEK) with antihyperalgesic effects. PD 198306 reduces the Streptozocin-induced increase in the level of ac...
T7610 GW284543 790186-68-4 98%
GW284543 is a selective inhibitor of MEK5 .
T21635 PD184161 212631-67-9
PD184161 is a novel, orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner[1].
T9321 Zapnometinib 303175-44-2
zapnometinib is a MEK inhibitor.
T6636 Refametinib 923032-37-5 100%
Refametinib (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM).
T6785 BI-847325 1207293-36-4 97.54%
BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.
T7742 GW 284543 hydrochloride 179246-08-3 98%
GW 284543 hydrochloride is a selective inhibitor of MEK5 .
Alpinumisoflavone
TN3397
Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is e...
Cajanin
TN1462
Cajanin has potential hypolipidemic effects,possibly via up-regulating the ABCA1 protein expression,subsequently resulting in increased macrophage cholesterol ef...
BMS-599626
T2610
BMS-599626 has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.
MS432
T13782
MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.
MEK-IN-1
T10675
MEK-IN-1 is a MEK inhibitor from patent WO2008076415A1.
Corylifol C
TN3711
Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration 50% values for epidermal growth factor receptor...
anemarsaponin B
T7030
Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity,...
EBI-1051
T15193
EBI-1051 is a highly potent and orally efficacious inhibitor of MEK (IC50: 3.9 nM).
Griffipavixanthone
TN4166
Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mito...
Pavinetant
T16114
Pavinetant is an antagonist of the neurokinin-3 receptor (NK3R).
Uncarinic acid E
TN5201
Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resul...
Boehmenan
TN3525
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
MEK inhibitor
T11993
MEK inhibitor is a potent MEK inhibitor with antitumor potency.
PD 198306
T21980
PD 198306 is a selective inhibitor of MAPK/ERK-kinase (MEK) with antihyperalgesic effects. PD 198306 reduces the Streptozocin-induced increase in the level of ac...
GW284543
T7610
GW284543 is a selective inhibitor of MEK5 .
PD184161
T21635
PD184161 is a novel, orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner[1].
zapnometinib
T9321
zapnometinib is a MEK inhibitor.
Refametinib
T6636
Refametinib (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM).
BI-847325
T6785
BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.
GW 284543 hydrochloride
T7742
GW 284543 hydrochloride is a selective inhibitor of MEK5 .
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