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MEK

MEK is a member of the MAPK signaling cascade that is activated in melanoma. When MEK is inhibited, cell proliferation is blocked and apoptosis (controlled cell death) is induced.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T2610 BMS-599626 714971-09-2 98.73%
BMS-599626
BMS-599626 (AC480) has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.
T78209 Nedometinib 2252314-46-6 98%
Nedometinib
Nedometinib, a tyrosine kinase inhibitor, specifically targets MEK1 and exhibits antineoplastic effects. It is utilized in research related to dermatosis, cutane...
T79048 MEK-IN-6 hydrate 2845153-35-5 98%
MEK-IN-6 hydrate
MEK-IN-6 hydrate (compound 69), a MEK inhibitor, exhibits an IC50 value of 2 nM in A375 cells [1].
T79143 MS934 2756323-15-4 98%
MS934
MS934, a novel VHL-recruiting MEK 1/2 degrader, exhibits potent anti-proliferative effects on HT-29 cell growth, achieving a GI50 of 0.023 μM. It holds potential...
T80638 Glycinexylidide 18865-38-8 98%
Glycinexylidide
Glycinexylidide (GX), the active metabolite of the local anesthetic Lidocaine, exhibits properties significant in inhibiting sodium channels with complex voltage...
T11993 MEK inhibitor 334951-92-7 98%
MEK inhibitor
MEK inhibitor is a potent MEK inhibitor with antitumor potency.
T10675 MEK-IN-1 870600-45-6 98%
MEK-IN-1
MEK-IN-1 is a MEK inhibitor.
TN1953 Morusinol 62949-93-3 98%
Morusinol
Morusinol is a flavonoid extracted from the root bark of Morus alba. Morusinol has antiplatelet and anticancer activities, inhibits arterial thrombosis in vivo, ...
TN3525 Boehmenan 57296-22-7 98%
Boehmenan
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
T15193 EBI-1051 1801896-05-8 98%
EBI-1051
EBI-1051 is a highly potent and orally efficacious inhibitor of MEK (IC50: 3.9 nM).
TN4166 Griffipavixanthone 219649-95-3 98%
Griffipavixanthone
Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mito...
TN5201 Uncarinic acid E 277751-61-8 98%
Uncarinic acid E
Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resul...
TN3711 Corylifol C 775351-91-2 98%
Corylifol C
Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration 50% values for epidermal growth factor receptor...
TN3397 Alpinumisoflavone 34086-50-5 98%
Alpinumisoflavone
Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is e...
T13782 MS432 T13782 98%
MS432
MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.
T14055 5Z-7-Oxozeaenol 253863-19-3 98%
5Z-7-Oxozeaenol
5Z-7-Oxozeaenol (FR148083) is a potent, irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 with IC50 of 8.1 nM for TAK...
T16114 Pavinetant 941690-55-7 98%
Pavinetant
Pavinetant is a small molecule orally active and selective neurokinin-3 (NK3) receptor antagonist for the treatment of hot flashes and polycystic ovarian syndrom...
T22677 Cobimetinib racemate 934662-91-6 98%
Cobimetinib racemate
Cobimetinib racemate (Cobimetinib (racemate)) (GDC-0973 racemate) is a selective inhibitor of MEK.Cobimetinib racemate is also known as a mitogen-activated prote...
T21332 U0126 109511-58-2 98%
U0126
U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 μM respectively. U0126 inhi...
TN1462 Cajanin 32884-36-9 98%
Cajanin
Cajanin has potential hypolipidemic effects,possibly via up-regulating the ABCA1 protein expression,subsequently resulting in increased macrophage cholesterol ef...
BMS-599626
T2610
BMS-599626 (AC480) has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.
Nedometinib
T78209
Nedometinib, a tyrosine kinase inhibitor, specifically targets MEK1 and exhibits antineoplastic effects. It is utilized in research related to dermatosis, cutane...
MEK-IN-6 hydrate
T79048
MEK-IN-6 hydrate (compound 69), a MEK inhibitor, exhibits an IC50 value of 2 nM in A375 cells [1].
MS934
T79143
MS934, a novel VHL-recruiting MEK 1/2 degrader, exhibits potent anti-proliferative effects on HT-29 cell growth, achieving a GI50 of 0.023 μM. It holds potential...
Glycinexylidide
T80638
Glycinexylidide (GX), the active metabolite of the local anesthetic Lidocaine, exhibits properties significant in inhibiting sodium channels with complex voltage...
MEK inhibitor
T11993
MEK inhibitor is a potent MEK inhibitor with antitumor potency.
MEK-IN-1
T10675
MEK-IN-1 is a MEK inhibitor.
Morusinol
TN1953
Morusinol is a flavonoid extracted from the root bark of Morus alba. Morusinol has antiplatelet and anticancer activities, inhibits arterial thrombosis in vivo, ...
Boehmenan
TN3525
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
EBI-1051
T15193
EBI-1051 is a highly potent and orally efficacious inhibitor of MEK (IC50: 3.9 nM).
Griffipavixanthone
TN4166
Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mito...
Uncarinic acid E
TN5201
Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resul...
Corylifol C
TN3711
Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration 50% values for epidermal growth factor receptor...
Alpinumisoflavone
TN3397
Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is e...
MS432
T13782
MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.
5Z-7-Oxozeaenol
T14055
5Z-7-Oxozeaenol (FR148083) is a potent, irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 with IC50 of 8.1 nM for TAK...
Pavinetant
T16114
Pavinetant is a small molecule orally active and selective neurokinin-3 (NK3) receptor antagonist for the treatment of hot flashes and polycystic ovarian syndrom...
Cobimetinib racemate
T22677
Cobimetinib racemate (Cobimetinib (racemate)) (GDC-0973 racemate) is a selective inhibitor of MEK.Cobimetinib racemate is also known as a mitogen-activated prote...
U0126
T21332
U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 μM respectively. U0126 inhi...
Cajanin
TN1462
Cajanin has potential hypolipidemic effects,possibly via up-regulating the ABCA1 protein expression,subsequently resulting in increased macrophage cholesterol ef...
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TargetMol