TN3397 |
Alpinumisoflavone
|
34086-50-5
|
98%
|
|
Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is e...
|
TN1462 |
Cajanin
|
32884-36-9
|
98%
|
|
Cajanin has potential hypolipidemic effects,possibly via up-regulating the ABCA1 protein expression,subsequently resulting in increased macrophage cholesterol ef...
|
T2610 |
BMS-599626
|
714971-09-2
|
98%
|
|
BMS-599626 has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.
|
T13782 |
MS432
|
T13782
|
98%
|
|
MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.
|
T10675 |
MEK-IN-1
|
870600-45-6
|
98%
|
|
MEK-IN-1 is a MEK inhibitor from patent WO2008076415A1.
|
TN3711 |
Corylifol C
|
775351-91-2
|
98%
|
|
Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration 50% values for epidermal growth factor receptor...
|
T7030 |
Anemarsaponin B
|
139051-27-7
|
98%
|
|
Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity,...
|
T15193 |
EBI-1051
|
1801896-05-8
|
98%
|
|
EBI-1051 is a highly potent and orally efficacious inhibitor of MEK (IC50: 3.9 nM).
|
TN4166 |
Griffipavixanthone
|
219649-95-3
|
98%
|
|
Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mito...
|
T16114 |
Pavinetant
|
941690-55-7
|
98%
|
|
Pavinetant is an antagonist of the neurokinin-3 receptor (NK3R).
|
TN5201 |
Uncarinic acid E
|
277751-61-8
|
98%
|
|
Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resul...
|
TN3525 |
Boehmenan
|
57296-22-7
|
98%
|
|
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
|
T11993 |
MEK inhibitor
|
334951-92-7
|
98%
|
|
MEK inhibitor is a potent MEK inhibitor with antitumor potency.
|
T21980 |
PD 198306
|
212631-61-3
|
98%
|
|
PD 198306 is a selective inhibitor of MAPK/ERK-kinase (MEK) with antihyperalgesic effects. PD 198306 reduces the Streptozocin-induced increase in the level of ac...
|
T7610 |
GW284543
|
790186-68-4
|
98%
|
|
GW284543 is a selective inhibitor of MEK5 .
|
T21635 |
PD184161
|
212631-67-9
|
|
|
PD184161 is a novel, orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner[1].
|
T9321 |
Zapnometinib
|
303175-44-2
|
|
|
zapnometinib is a MEK inhibitor.
|
T6636 |
Refametinib
|
923032-37-5
|
100%
|
|
Refametinib (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM).
|
T6785 |
BI-847325
|
1207293-36-4
|
97.54%
|
|
BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.
|
T7742 |
GW 284543 hydrochloride
|
179246-08-3
|
98%
|
|
GW 284543 hydrochloride is a selective inhibitor of MEK5 .
|