T2610 |
BMS-599626
|
714971-09-2
|
98.73%
|
|
BMS-599626 has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.
|
T11993 |
MEK inhibitor
|
334951-92-7
|
98%
|
|
MEK inhibitor is a potent MEK inhibitor with antitumor potency.
|
T10675 |
MEK-IN-1
|
870600-45-6
|
98%
|
|
MEK-IN-1 is a MEK inhibitor from patent WO2008076415A1.
|
TN1953 |
Morusinol
|
62949-93-3
|
98%
|
|
Morusinol is a flavonoid extracted from the root bark of Morus alba. Morusinol has antiplatelet and anticancer activities, inhibits arterial thrombosis in vivo, ...
|
TN3525 |
Boehmenan
|
57296-22-7
|
98%
|
|
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
|
T15193 |
EBI-1051
|
1801896-05-8
|
98%
|
|
EBI-1051 is a highly potent and orally efficacious inhibitor of MEK (IC50: 3.9 nM).
|
TN4166 |
Griffipavixanthone
|
219649-95-3
|
98%
|
|
Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mito...
|
TN5201 |
Uncarinic acid E
|
277751-61-8
|
98%
|
|
Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resul...
|
TN3711 |
Corylifol C
|
775351-91-2
|
98%
|
|
Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration 50% values for epidermal growth factor receptor...
|
TN3397 |
Alpinumisoflavone
|
34086-50-5
|
98%
|
|
Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is e...
|
T13782 |
MS432
|
T13782
|
98%
|
|
MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.
|
T14055 |
5Z-7-Oxozeaenol
|
253863-19-3
|
98%
|
|
5Z-7-Oxozeaenol, a natural anti-protozoan compound from fungal origin, acting as a potent irreversible and selective inhibitor of TAK1 and VEGF-R2, with IC50s of...
|
T16114 |
Pavinetant
|
941690-55-7
|
98%
|
|
Pavinetant is a small molecule orally active and selective neurokinin-3 (NK3) receptor antagonist for the treatment of hot flashes and polycystic ovarian syndrom...
|
T22677 |
Cobimetinib racemate
|
934662-91-6
|
98%
|
|
GDC-0973 is a selective inhibitor of MEK. GDC-0973 is also known as a mitogen-activated protein kinase, is a key component of the RAS/RAF/MEK/ERK pathway.
|
T21332 |
U0126
|
109511-58-2
|
98%
|
|
U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 μM respectively. U0126 inhi...
|
TN1462 |
Cajanin
|
32884-36-9
|
98%
|
|
Cajanin has potential hypolipidemic effects,possibly via up-regulating the ABCA1 protein expression,subsequently resulting in increased macrophage cholesterol ef...
|
T6189 |
Mirdametinib
|
391210-10-9
|
99.91%
|
|
PD0325901 is a specific and non-ATP-competitive MEK inhibitor (IC50: 0.33 nM).
|
T2327 |
Pelitinib
|
257933-82-7
|
99.86%
|
|
Pelitinib (EKB-569) is an effective irreversible EGFR inhibitor (IC50: 38.5 nM).
|
T2416 |
BIX02189
|
1094614-85-3
|
99.86%
|
|
BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.
|
T6152 |
PD318088
|
391210-00-7
|
99.81%
|
|
PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binding simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-bi...
|