MEK

MEK is a member of the MAPK signaling cascade that is activated in melanoma. When MEK is inhibited, cell proliferation is blocked and apoptosis (controlled cell death) is induced.

Cat. No.	Product name	CAS No.	Purity
T2610	BMS-599626	714971-09-2	98.73%
BMS-599626 has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.
T11993	MEK inhibitor	334951-92-7	98%
MEK inhibitor is a potent MEK inhibitor with antitumor potency.
T10675	MEK-IN-1	870600-45-6	98%
MEK-IN-1 is a MEK inhibitor from patent WO2008076415A1.
TN1953	Morusinol	62949-93-3	98%
Morusinol is a flavonoid extracted from the root bark of Morus alba. Morusinol has antiplatelet and anticancer activities, inhibits arterial thrombosis in vivo, ...
TN3525	Boehmenan	57296-22-7	98%
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
T15193	EBI-1051	1801896-05-8	98%
EBI-1051 is a highly potent and orally efficacious inhibitor of MEK (IC50: 3.9 nM).
TN4166	Griffipavixanthone	219649-95-3	98%
Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mito...
TN5201	Uncarinic acid E	277751-61-8	98%
Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resul...
TN3711	Corylifol C	775351-91-2	98%
Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration 50% values for epidermal growth factor receptor...
TN3397	Alpinumisoflavone	34086-50-5	98%
Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is e...
T13782	MS432	T13782	98%
MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.
T14055	5Z-7-Oxozeaenol	253863-19-3	98%
5Z-7-Oxozeaenol, a natural anti-protozoan compound from fungal origin, acting as a potent irreversible and selective inhibitor of TAK1 and VEGF-R2, with IC50s of...
T16114	Pavinetant	941690-55-7	98%
Pavinetant is a small molecule orally active and selective neurokinin-3 (NK3) receptor antagonist for the treatment of hot flashes and polycystic ovarian syndrom...
T22677	Cobimetinib racemate	934662-91-6	98%
GDC-0973 is a selective inhibitor of MEK. GDC-0973 is also known as a mitogen-activated protein kinase, is a key component of the RAS/RAF/MEK/ERK pathway.
T21332	U0126	109511-58-2	98%
U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 μM respectively. U0126 inhi...
TN1462	Cajanin	32884-36-9	98%
Cajanin has potential hypolipidemic effects,possibly via up-regulating the ABCA1 protein expression,subsequently resulting in increased macrophage cholesterol ef...
T6189	Mirdametinib	391210-10-9	99.91%
PD0325901 is a specific and non-ATP-competitive MEK inhibitor (IC50: 0.33 nM).
T2327	Pelitinib	257933-82-7	99.86%
Pelitinib (EKB-569) is an effective irreversible EGFR inhibitor (IC50: 38.5 nM).
T2416	BIX02189	1094614-85-3	99.86%
BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.
T6152	PD318088	391210-00-7	99.81%
PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binding simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-bi...

Cat. No.

Product name

CAS No.

Purity

Chemical Structure

T2610

BMS-599626

714971-09-2

98.73%

BMS-599626 has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.

T11993

MEK inhibitor

334951-92-7

98%

MEK inhibitor is a potent MEK inhibitor with antitumor potency.

T10675

MEK-IN-1

870600-45-6

98%

MEK-IN-1 is a MEK inhibitor from patent WO2008076415A1.

TN1953

Morusinol

62949-93-3

98%

Morusinol is a flavonoid extracted from the root bark of Morus alba. Morusinol has antiplatelet and anticancer activities, inhibits arterial thrombosis in vivo, ...

TN3525

Boehmenan

57296-22-7

98%

(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...

T15193

EBI-1051

1801896-05-8

98%

EBI-1051 is a highly potent and orally efficacious inhibitor of MEK (IC50: 3.9 nM).

TN4166

Griffipavixanthone

219649-95-3

98%

Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mito...

TN5201

Uncarinic acid E

277751-61-8

98%

Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resul...

TN3711

Corylifol C

775351-91-2

98%

Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration 50% values for epidermal growth factor receptor...

TN3397

Alpinumisoflavone

34086-50-5

98%

Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is e...

T13782

MS432

T13782

98%

MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.

T14055

5Z-7-Oxozeaenol

253863-19-3

98%

5Z-7-Oxozeaenol, a natural anti-protozoan compound from fungal origin, acting as a potent irreversible and selective inhibitor of TAK1 and VEGF-R2, with IC50s of...

T16114

Pavinetant

941690-55-7

98%

Pavinetant is a small molecule orally active and selective neurokinin-3 (NK3) receptor antagonist for the treatment of hot flashes and polycystic ovarian syndrom...

T22677

Cobimetinib racemate

934662-91-6

98%

GDC-0973 is a selective inhibitor of MEK. GDC-0973 is also known as a mitogen-activated protein kinase, is a key component of the RAS/RAF/MEK/ERK pathway.

T21332

U0126

109511-58-2

98%

U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 μM respectively. U0126 inhi...

TN1462

Cajanin

32884-36-9

98%

Cajanin has potential hypolipidemic effects,possibly via up-regulating the ABCA1 protein expression,subsequently resulting in increased macrophage cholesterol ef...

T6189

Mirdametinib

391210-10-9

99.91%

PD0325901 is a specific and non-ATP-competitive MEK inhibitor (IC50: 0.33 nM).

T2327

Pelitinib

257933-82-7

99.86%

Pelitinib (EKB-569) is an effective irreversible EGFR inhibitor (IC50: 38.5 nM).

T2416

BIX02189

1094614-85-3

99.86%

BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.

T6152

PD318088

391210-00-7

99.81%

PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binding simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-bi...