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PAI-1

Plasminogen activator inhibitor-1 (PAI-1) also known as endothelial plasminogen activator inhibitor or serpin E1 is a protein that in humans is encoded by the SERPINE1 gene. Elevated PAI-1 is a risk factor for thrombosis and atherosclerosis,PAI-1 is a serine protease inhibitor (serpin) that functions as the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), the activators of plasminogen and hence fibrinolysis (the physiological breakdown of blood clots). It is a serine protease inhibitor (serpin) protein (SERPINE1).The other PAI, plasminogen activator inhibitor-2 (PAI-2) is secreted by the placenta and only present in significant amounts during pregnancy. In addition, protease nexin acts as an inhibitor of tPA and urokinase. PAI-1, however, is the main inhibitor of the plasminogen activators.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T3876 Loureirin B 119425-90-0 99.91%
Loureirin B
Loureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppress...
T4255 TM5275 sodium 1103926-82-4 99.55%
TM5275 sodium
TM5275 sodium (TM5275 sodium salt) is an inhibitor of plasminogen activator inhibitor 1 (PAI-1).
T26629 Angstrom6 220334-14-5 99.36%
Angstrom6
Angstrom6 (A-6 peptide) is an 8 amino acid peptide derived from single chain urokinase fibrinogen activator (scuPA) that interferes with the uPA/uPAR cascade and...
T9947 GW-6604 452342-37-9 99.26%
GW-6604
GW-6604 is an ALK5 inhibitor and shows clear antifibrotic effects resulting in liver function improvement.
T4S0592 Toddalolactone 483-90-9 99.06%
Toddalolactone
Toddalolactone ((+)-Toddalolactone) is an anti-inflammatory and analgesic.
T4254 TM5441 1190221-43-2 98.87%
TM5441
TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor 1 (PAI-1).
T23764 AZ3976 1418747-15-5 98.01%
AZ3976
AZ3976 is an inhibitor of PAI-1 with an IC50 of 16 μM in a plasma clot lysis assay. AZ3976 displays profibrinolytic activities.
T29856 Aleplasinin 481629-87-2 97.51%
Aleplasinin
Aleplasinin (PAZ 417) is a selective and orally active inhibitor of Plasminogen activator inhibitor-1(PAI-1) and a key negative regulator of the fibrinolytic sys...
T8962 TM5007 342595-05-5 96.91%
TM5007
TM5007 is a poent inhibitor of plasminogen activator inhibitor-1 (PAI-1; IC50 of 29 uM).
T3442 UK-371804 256477-09-5 95.81%
UK-371804
UK-371804 is an effective and specific uPA inhibitor. It was selected as a candidate for further preClinicalal evaluation for the treatment of chronic dermal ulc...
T13257 Upamostat 590368-25-5 98%
Upamostat
Upamostat is an inhibitor of a serine protease and is a urokinase plasminogen activator (uPA) inhibitor.
T2030 Tiplaxtinin 393105-53-8 98%
Tiplaxtinin
Tiplaxtinin (Tiplasinin)(PAI-039) is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 uM.
Loureirin B
T3876
Loureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppress...
TM5275 sodium
T4255
TM5275 sodium (TM5275 sodium salt) is an inhibitor of plasminogen activator inhibitor 1 (PAI-1).
Angstrom6
T26629
Angstrom6 (A-6 peptide) is an 8 amino acid peptide derived from single chain urokinase fibrinogen activator (scuPA) that interferes with the uPA/uPAR cascade and...
GW-6604
T9947
GW-6604 is an ALK5 inhibitor and shows clear antifibrotic effects resulting in liver function improvement.
Toddalolactone
T4S0592
Toddalolactone ((+)-Toddalolactone) is an anti-inflammatory and analgesic.
TM5441
T4254
TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor 1 (PAI-1).
AZ3976
T23764
AZ3976 is an inhibitor of PAI-1 with an IC50 of 16 μM in a plasma clot lysis assay. AZ3976 displays profibrinolytic activities.
Aleplasinin
T29856
Aleplasinin (PAZ 417) is a selective and orally active inhibitor of Plasminogen activator inhibitor-1(PAI-1) and a key negative regulator of the fibrinolytic sys...
TM5007
T8962
TM5007 is a poent inhibitor of plasminogen activator inhibitor-1 (PAI-1; IC50 of 29 uM).
UK-371804
T3442
UK-371804 is an effective and specific uPA inhibitor. It was selected as a candidate for further preClinicalal evaluation for the treatment of chronic dermal ulc...
Upamostat
T13257
Upamostat is an inhibitor of a serine protease and is a urokinase plasminogen activator (uPA) inhibitor.
Tiplaxtinin
T2030
Tiplaxtinin (Tiplasinin)(PAI-039) is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 uM.
TargetMol