4E1RCat is a dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction. And it inhibits the binding of eIF4G to eIF4E with IC50 of 3.2 μM. |
Sal003, an effective cell-permeable analog,inhibitis the eIF2α phosphatase. |
GSK2606414 is an oral-available and specific PERK inhibitor (IC50=0.4 nM). |
4EGI-1, a competitive eIF4E/eIF4G interaction inhibitor, binds to eIF4E(KD=25 μM). |
Salubrinal, a phosphatases (PP1) inhibitor(IC50=1.7 µM), exhibits function on the eukaryotic translation initiation factor 2 subunit (eIF2α). |
BTdCPU is a potent heme-regulated eIF2α kinase (HRI) activator. BTdCPU promotes eIF2α phosphorylation and induced apoptosis in resistant cell. |
GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay. The selectivty is 500-fold higher against a panel of 300...
ISRIB (trans-isomer), the trans-isomer of ISRIB, is a effective and specific PERK inhibitor (IC50: 5 nM). |