PERK|Targetmol

PERK

protein kinase R-like endoplasmic reticulum kinase (PERK), inositol-requiring kinase 1 (IRE1) and activating transcription factor 6 (ATF6). Consequently, the harmful stimuli from the ER stress transducers induce apoptosis and autophagy, which share several crosstalks and eventually decide the cell fate.

Cat No.	product name
T1742	4E1rcat	4E1RCat is a dual inhibitor of eIF4E:eIF4 g and eIF4E:4E-BP1 interaction. And it inhibits the binding of eIF4 g to eIF4E with IC50 of 3.2 μM.
T2417	Sal003	Sal003, an effective cell-permeable analog, inhibitis the eIF2α phosphatase.
T2614	GSK2606414	GSK2606414 is an oral-available and specific PERK inhibitor (IC50=0.4 nM).
T2665	4EGI1	4EGI-1, a competitive eIF4E/eIF4 g interaction inhibitor, binds to eIF4E(KD=25 μM).
T3045	Salubrinal	Salubrinal, a phosphatases (PP1) inhibitor(IC50=1.7 μM), exhibits function on the eukaryotic translation initiation factor 2 subunit (eIF2α).
T7150	BTdCPU	BTdCPU is a potent heme-regulated eIF2α kinase (HRI) activator. BTdCPU promotes eIF2α phosphorylation and induced apoptosis in resistant cell.
T2654	GSK2656157	GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay. The selectivty is 500-fold higher against a panel of 300...
T6183	ISRIB (trans-isomer)	ISRIB (trans-isomer), the trans-isomer of ISRIB, is a effective and specific PERK inhibitor (IC50: 5 nM).
T4304	Azoramide	Azoramide, a small-molecule modulator, has the antidiabetic activity of unfolded protein response.

Cat No.

product name

T1742

4E1rcat

4E1RCat is a dual inhibitor of eIF4E:eIF4 g and eIF4E:4E-BP1 interaction. And it inhibits the binding of eIF4 g to eIF4E with IC50 of 3.2 μM.

T2417

Sal003

Sal003, an effective cell-permeable analog, inhibitis the eIF2α phosphatase.

T2614

GSK2606414

GSK2606414 is an oral-available and specific PERK inhibitor (IC50=0.4 nM).

T2665

4EGI1

4EGI-1, a competitive eIF4E/eIF4 g interaction inhibitor, binds to eIF4E(KD=25 μM).

T3045

Salubrinal

Salubrinal, a phosphatases (PP1) inhibitor(IC50=1.7 μM), exhibits function on the eukaryotic translation initiation factor 2 subunit (eIF2α).

T7150

BTdCPU

BTdCPU is a potent heme-regulated eIF2α kinase (HRI) activator. BTdCPU promotes eIF2α phosphorylation and induced apoptosis in resistant cell.

T2654

GSK2656157

GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay. The selectivty is 500-fold higher against a panel of 300...

T6183

ISRIB (trans-isomer)

ISRIB (trans-isomer), the trans-isomer of ISRIB, is a effective and specific PERK inhibitor (IC50: 5 nM).

T4304

Azoramide

Azoramide, a small-molecule modulator, has the antidiabetic activity of unfolded protein response.

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