Home Tools
Log in
Cart

PERK

protein kinase R-like endoplasmic reticulum kinase (PERK), inositol-requiring kinase 1 (IRE1) and activating transcription factor 6 (ATF6). Consequently, the harmful stimuli from the ER stress transducers induce apoptosis and autophagy, which share several crosstalks and eventually decide the cell fate.
Cat No. product name
T7150 BTdCPU BTdCPU is a potent heme-regulated eIF2α kinase (HRI) activator. BTdCPU promotes eIF2α phosphorylation and induced apoptosis in resistant cell.
T3564 SHP099 SHP099 free base is an effective, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM). S...
T5173 SBI-0640756 SBI-0640756 (SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex.
T6183 ISRIB (trans-isomer) ISRIB (trans-isomer), the trans-isomer of ISRIB, is a effective and specific PERK inhibitor (IC50: 5 nM).
T2654 GSK2656157 GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay. The selectivty is 500-fold higher against a panel of 300 ...
T1742 4E1rcat 4E1RCat is a dual inhibitor of eIF4E:eIF4 g and eIF4E:4E-BP1 interaction. And it inhibits the binding of eIF4 g to eIF4E with IC50 of 3.2 μM.
T2027 ISRIB ISRIB is a potent and selective PERK inhibitor.
T4304 Azoramide Azoramide, a small-molecule modulator, has the antidiabetic activity of unfolded protein response.
T2614 GSK2606414 GSK2606414 is an oral-available and specific PERK inhibitor (IC50=0.4 nM).
T3207 Briciclib Briciclib is a small molecule that suppresses cyclin D1 accumulation in Y cells.
T2665 4EGI-1 4EGI-1, a competitive eIF4E/eIF4 g interaction inhibitor, binds to eIF4E(KD=25 μM).
T3045 Salubrinal Salubrinal, a phosphatases (PP1) inhibitor(IC50=1.7 μM), exhibits function on the eukaryotic translation initiation factor 2 subunit (eIF2α).
T2417 Sal003 Sal003, an effective cell-permeable analog, inhibitis the eIF2α phosphatase.
T11374 GCN2-IN-6 GCN2-IN-6 is also a eIF2α kinase PERK inhibitor with an IC50 of 0.26 nM (in enzymatic assay) and 230 nM (in cells). GCN2-IN-6  is a potent, and orally available ...
T9149 2BAct 2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress response
T14044 4E2RCat 4E2RCat is an eIF4E-eIF4G interaction inhibitor (IC50: 13.5 μM).
T3881 Vaccarin Vaccarin is a major flavonoid glycoside in Vaccariae semen, its biotransformation pathways involves methylation, hydroxylation, glycosylation and deglycosylation...
TQ0131 Rocaglamide Rocaglamide, isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB act...
BTdCPU
T7150
BTdCPU is a potent heme-regulated eIF2α kinase (HRI) activator. BTdCPU promotes eIF2α phosphorylation and induced apoptosis in resistant cell.
SHP099
T3564
SHP099 free base is an effective, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM)....
SBI-0640756
T5173
SBI-0640756 (SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex.
ISRIB (trans-isomer)
T6183
ISRIB (trans-isomer), the trans-isomer of ISRIB, is a effective and specific PERK inhibitor (IC50: 5 nM).
GSK2656157
T2654
GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay. The selectivty is 500-fold higher against a panel of 300 ...
4E1rcat
T1742
4E1RCat is a dual inhibitor of eIF4E:eIF4 g and eIF4E:4E-BP1 interaction. And it inhibits the binding of eIF4 g to eIF4E with IC50 of 3.2 μM.
ISRIB
T2027
ISRIB is a potent and selective PERK inhibitor.
Azoramide
T4304
Azoramide, a small-molecule modulator, has the antidiabetic activity of unfolded protein response.
GSK2606414
T2614
GSK2606414 is an oral-available and specific PERK inhibitor (IC50=0.4 nM).
Briciclib
T3207
Briciclib is a small molecule that suppresses cyclin D1 accumulation in Y cells.
4EGI-1
T2665
4EGI-1, a competitive eIF4E/eIF4 g interaction inhibitor, binds to eIF4E(KD=25 μM).
Salubrinal
T3045
Salubrinal, a phosphatases (PP1) inhibitor(IC50=1.7 μM), exhibits function on the eukaryotic translation initiation factor 2 subunit (eIF2α).
Sal003
T2417
Sal003, an effective cell-permeable analog, inhibitis the eIF2α phosphatase.
GCN2-IN-6
T11374
GCN2-IN-6 is also a eIF2α kinase PERK inhibitor with an IC50 of 0.26 nM (in enzymatic assay) and 230 nM (in cells). GCN2-IN-6  is a potent, and orally availab...
2BAct
T9149
2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress response
4E2RCat
T14044
4E2RCat is an eIF4E-eIF4G interaction inhibitor (IC50: 13.5 μM).
Vaccarin
T3881
Vaccarin is a major flavonoid glycoside in Vaccariae semen, its biotransformation pathways involves methylation, hydroxylation, glycosylation and deglycosylation...
Rocaglamide
TQ0131
Rocaglamide, isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB ac...