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Apoptosis PERK

PERK

protein kinase R-like endoplasmic reticulum kinase (PERK), inositol-requiring kinase 1 (IRE1) and activating transcription factor 6 (ATF6). Consequently, the harmful stimuli from the ER stress transducers induce apoptosis and autophagy, which share several crosstalks and eventually decide the cell fate.
Cat No. product name
T1742 4E1rcat 4E1RCat is a dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction. And it inhibits the binding of eIF4G to eIF4E with IC50 of 3.2 μM.
T2417 Sal003 Sal003, an effective cell-permeable analog,inhibitis the eIF2α phosphatase.
T2614 GSK2606414 GSK2606414 is an oral-available and specific PERK inhibitor (IC50=0.4 nM).
T2665 4EGI-1 4EGI-1, a competitive eIF4E/eIF4G interaction inhibitor, binds to eIF4E(KD=25 μM).
T3045 Salubrinal Salubrinal, a phosphatases (PP1) inhibitor(IC50=1.7 µM), exhibits function on the eukaryotic translation initiation factor 2 subunit (eIF2α).
T7150 BTdCPU BTdCPU is a potent heme-regulated eIF2α kinase (HRI) activator. BTdCPU promotes eIF2α phosphorylation and induced apoptosis in resistant cell.
T2654 GSK2656157 GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay. The selectivty is 500-fold higher against a panel of 300...
T6183 ISRIB (trans-isomer) ISRIB (trans-isomer), the trans-isomer of ISRIB, is a effective and specific PERK inhibitor (IC50: 5 nM).
4E1rcat
T1742CAS 328998-25-0
4E1RCat is a dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction. And it inhibits the binding of eIF4G to eIF4E with IC50 of 3.2 μM.
Sal003
T2417CAS 1164470-53-4
Sal003, an effective cell-permeable analog,inhibitis the eIF2α phosphatase.
GSK2606414
T2614CAS 1337531-36-8
GSK2606414 is an oral-available and specific PERK inhibitor (IC50=0.4 nM).
4EGI-1
T2665CAS 315706-13-9
4EGI-1, a competitive eIF4E/eIF4G interaction inhibitor, binds to eIF4E(KD=25 μM).
Salubrinal
T3045CAS 405060-95-9
Salubrinal, a phosphatases (PP1) inhibitor(IC50=1.7 µM), exhibits function on the eukaryotic translation initiation factor 2 subunit (eIF2α).
BTdCPU
T7150CAS 1257423-87-2
BTdCPU is a potent heme-regulated eIF2α kinase (HRI) activator. BTdCPU promotes eIF2α phosphorylation and induced apoptosis in resistant cell.
GSK2656157
T2654CAS 1337532-29-2
GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay. The selectivty is 500-fold higher against a panel of 300...
ISRIB (trans-isomer)
T6183CAS 1597403-47-8
ISRIB (trans-isomer), the trans-isomer of ISRIB, is a effective and specific PERK inhibitor (IC50: 5 nM).