PERK

protein kinase R-like endoplasmic reticulum kinase (PERK), inositol-requiring kinase 1 (IRE1) and activating transcription factor 6 (ATF6). Consequently, the harmful stimuli from the ER stress transducers induce apoptosis and autophagy, which share several crosstalks and eventually decide the cell fate.

Cat No.	product name
T7150	BTdCPU	BTdCPU is a potent heme-regulated eIF2α kinase (HRI) activator. BTdCPU promotes eIF2α phosphorylation and induced apoptosis in resistant cell.
T3564	SHP099	SHP099 free base is an effective, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM). S...
T5173	SBI-0640756	SBI-0640756 (SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex.
T6183	ISRIB (trans-isomer)	ISRIB (trans-isomer), the trans-isomer of ISRIB, is a effective and specific PERK inhibitor (IC50: 5 nM).
T2654	GSK2656157	GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay. The selectivty is 500-fold higher against a panel of 300 ...
T1742	4E1rcat	4E1RCat is a dual inhibitor of eIF4E:eIF4 g and eIF4E:4E-BP1 interaction. And it inhibits the binding of eIF4 g to eIF4E with IC50 of 3.2 μM.
T2027	ISRIB	ISRIB is a potent and selective PERK inhibitor.
T4304	Azoramide	Azoramide, a small-molecule modulator, has the antidiabetic activity of unfolded protein response.
T2614	GSK2606414	GSK2606414 is an oral-available and specific PERK inhibitor (IC50=0.4 nM).
T3207	Briciclib	Briciclib is a small molecule that suppresses cyclin D1 accumulation in Y cells.
T2665	4EGI-1	4EGI-1, a competitive eIF4E/eIF4 g interaction inhibitor, binds to eIF4E(KD=25 μM).
T3045	Salubrinal	Salubrinal, a phosphatases (PP1) inhibitor(IC50=1.7 μM), exhibits function on the eukaryotic translation initiation factor 2 subunit (eIF2α).
T2417	Sal003	Sal003, an effective cell-permeable analog, inhibitis the eIF2α phosphatase.
T11374	GCN2-IN-6	GCN2-IN-6 is also a eIF2α kinase PERK inhibitor with an IC50 of 0.26 nM (in enzymatic assay) and 230 nM (in cells). GCN2-IN-6 is a potent, and orally available ...
T9149	2BAct	2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress response
T14044	4E2RCat	4E2RCat is an eIF4E-eIF4G interaction inhibitor (IC50: 13.5 μM).
T3881	Vaccarin	Vaccarin is a major flavonoid glycoside in Vaccariae semen, its biotransformation pathways involves methylation, hydroxylation, glycosylation and deglycosylation...
TQ0131	Rocaglamide	Rocaglamide, isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB act...

Cat No.

product name

T7150

BTdCPU

BTdCPU is a potent heme-regulated eIF2α kinase (HRI) activator. BTdCPU promotes eIF2α phosphorylation and induced apoptosis in resistant cell.

T3564

SHP099

SHP099 free base is an effective, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM). S...

T5173

SBI-0640756

SBI-0640756 (SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex.

T6183

ISRIB (trans-isomer)

ISRIB (trans-isomer), the trans-isomer of ISRIB, is a effective and specific PERK inhibitor (IC50: 5 nM).

T2654

GSK2656157

GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay. The selectivty is 500-fold higher against a panel of 300 ...

T1742

4E1rcat

4E1RCat is a dual inhibitor of eIF4E:eIF4 g and eIF4E:4E-BP1 interaction. And it inhibits the binding of eIF4 g to eIF4E with IC50 of 3.2 μM.

T2027

ISRIB

ISRIB is a potent and selective PERK inhibitor.

T4304

Azoramide

Azoramide, a small-molecule modulator, has the antidiabetic activity of unfolded protein response.

T2614

GSK2606414

GSK2606414 is an oral-available and specific PERK inhibitor (IC50=0.4 nM).

T3207

Briciclib

Briciclib is a small molecule that suppresses cyclin D1 accumulation in Y cells.

T2665

4EGI-1

4EGI-1, a competitive eIF4E/eIF4 g interaction inhibitor, binds to eIF4E(KD=25 μM).

T3045

Salubrinal

Salubrinal, a phosphatases (PP1) inhibitor(IC50=1.7 μM), exhibits function on the eukaryotic translation initiation factor 2 subunit (eIF2α).

T2417

Sal003

Sal003, an effective cell-permeable analog, inhibitis the eIF2α phosphatase.

T11374

GCN2-IN-6

GCN2-IN-6 is also a eIF2α kinase PERK inhibitor with an IC50 of 0.26 nM (in enzymatic assay) and 230 nM (in cells). GCN2-IN-6 is a potent, and orally available ...

T9149

2BAct

2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress response

T14044

4E2RCat

4E2RCat is an eIF4E-eIF4G interaction inhibitor (IC50: 13.5 μM).

T3881

Vaccarin

Vaccarin is a major flavonoid glycoside in Vaccariae semen, its biotransformation pathways involves methylation, hydroxylation, glycosylation and deglycosylation...

TQ0131

Rocaglamide

Rocaglamide, isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB act...