PERK

protein kinase R-like endoplasmic reticulum kinase (PERK), inositol-requiring kinase 1 (IRE1) and activating transcription factor 6 (ATF6). Consequently, the harmful stimuli from the ER stress transducers induce apoptosis and autophagy, which share several crosstalks and eventually decide the cell fate.

Cat. No.	Product name	CAS No.	Purity
T41231	GP 1a	511532-96-0	98%
T41231	GP 1a is a potent agonist of cannabinoid receptor 2 (CB2) (EC50=7.1), as shown in cAMP, GTPγS and β-arrestin recruitment assays. GP 1a is approximately 30-fold m...
T77499	MSU-42011	2456434-36-7	98%
T77499	MSU-42011 is an orally active retinoid X receptor-like (RXR) agonist.MSU-42011 potently inhibits the expression of iNOS, low SREBP-induced and activated RXR, and...
T14902	CCT020312	324759-76-4	98%
T14902	CCT020312 is a selective activator of EIF2AK3 and PERK. CCT020312 durably inhibits cell proliferation and elicits the phosphorylation of EIF2A.
T29955	AMC-01	1047978-71-1	98%
T29955	AMC-01 has potential antiviral activity and induces dose- and time-dependent inactivation of eIF2-α via phosphorylation of serine residue 51. AMC-01 can be used ...
TQ0131	Rocaglamide	84573-16-0	98%
TQ0131	Rocaglamide, isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB act...
T11374	GCN2-IN-6	2183470-09-7	98%
T11374	GCN2-IN-6 is also a eIF2α kinase PERK inhibitor with an IC50 of 0.26 nM (in enzymatic assay) and 230 nM (in cells). GCN2-IN-6 is a potent, and orally available ...
T3881	Vaccarin	53452-16-7	98%
T3881	Vaccarin is a major flavonoid glycoside in Vaccariae semen, its biotransformation pathways involves methylation, hydroxylation, glycosylation and deglycosylation...
T3045	Salubrinal	405060-95-9	98%
T3045	Salubrinal, a phosphatases (PP1) inhibitor(IC50=1.7 μM), exhibits function on the eukaryotic translation initiation factor 2 subunit (eIF2α).
T2027	ISRIB	548470-11-7	98%
T2027	ISRIB is a potent and selective PERK inhibitor.
T2654	GSK2656157	1337532-29-2	98%
T2654	GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay. The selectivty is 500-fold higher against a panel of 300 ...
T5173	SBI-0640756	1821280-29-8	98%
T5173	SBI-0640756 (SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex.
T4304	Azoramide	932986-18-0	98%
T4304	Azoramide, a small-molecule modulator, has the antidiabetic activity of unfolded protein response.
T1742	4E1rcat	328998-25-0	98%
T1742	4E1RCat is a dual inhibitor of eIF4E:eIF4 g and eIF4E:4E-BP1 interaction. And it inhibits the binding of eIF4 g to eIF4E with IC50 of 3.2 μM.
T2665	4EGI-1	315706-13-9	98%
T2665	4EGI-1, a competitive eIF4E/eIF4 g interaction inhibitor, binds to eIF4E(KD=25 μM).
T3207	Briciclib	865783-99-9	98%
T3207	Briciclib is a small molecule that suppresses cyclin D1 accumulation in Y cells.
T6183	ISRIB (trans-isomer)	1597403-47-8	98%
T6183	ISRIB (trans-isomer), the trans-isomer of ISRIB, is a effective and specific PERK inhibitor (IC50: 5 nM).
T72053	PERK-IN-6	1337532-14-5	98%
T72053	PERK-IN-6 is a novel and highly potent PERK inhibitor (IC50:2.5 nM).
T3564	SHP099	1801747-42-1	98%
T3564	SHP099 free base is an effective, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM). S...
T7150	BTdCPU	1257423-87-2	98%
T7150	BTdCPU is a potent activator of heme-regulated eIF2α kinase (HRI) . BTdCPU promotes eIF2α phosphorylation and induced apoptosis in resistant cell.
T2417	Sal003	1164470-53-4	98%
T2417	Sal003, an effective cell-permeable analog, inhibitis the eIF2α phosphatase.