Pim

Proto-oncogene serine/threonine-protein kinase Pim-1 is an enzyme that in humans is encoded by the PIM1 gene. Pim-1 is a proto-oncogene which encodes for the serine/threonine kinase of the same name. The pim-1 oncogene was first described in relation to murine T-cell lymphomas, as it was the locus most frequently activated by the Moloney murine leukemia virus.

Cat. No.	Product name	CAS No.	Purity
T15406	GNE-955	1527523-39-2	98%
T15406	GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).
T19611	(2R)-Octyl-α-hydroxyglutarate	1391194-67-4	98%
T19611	(2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) is a D-isomer 2-Hydroxyglutarate modified form.
T12474	PIM1-IN-1	1417630-95-5	98%
T12474	PIM1-IN-1 is a potent and highly selective inhibitor of PIM1/3(IC50s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively),with Antiproliferative and anti...
T71339	BMS-863233 HCl	1169562-71-3	98%
T71339	BMS-863233 HCl is an ATP-competitive Cdc7 inhibitor (IC50: 3.4 nM) that is potent and selective.BMS-863233 HCl inhibited CK2 and PIM1 with IC50 values of 215 and...
T24152	HTH-01-091	2000209-42-5	98%
T24152	HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM).HTH-01-091 inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK...
T1834	CX-6258	1202916-90-2	98%
T1834	CX-6258 is an orally valid Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor. It has good biological activity and kinase specificity.
T3989	SMI-16a	587852-28-6	98%
T3989	PIM1/2 Kinase Inhibitor VI, a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (IC50: 150/20 nM...
T5093	Pim1/AKK1-IN-1	1093222-27-5	98%
T5093	Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TN...
T27704	K00135	869650-21-5	98%
T27704	K00135 is a selective inhibitor of Pim kinases and can be used in studies about gastric cancer and antileukemic therapeutics.
T6148	CX-6258 hydrochloride	1353859-00-3	98%
T6148	CX-6258 HCl is an effective, orally efficacious Pim1/2/3 kinase inhibitor (IC50: 5/25/16 nM).
T15830	M-110	1395048-49-3	98%
T15830	M-110 is a highly selective, ATP-competitive inhibitor of PIM kinases with a preference for PIM-3 (IC50=47 nM). M-110 inhibits PIM-1 and PIM-2 with similar IC50s...
TQ0201	Hispidulin	1447-88-7	98%
TQ0201	Hispidulin, a natural flavone with a broad spectrum of biological activities, is a Pim-1 inhibitor (IC50: 2.71 μM).
T10827	CK2/ERK8-IN-1	1085822-09-8	98%
T10827	CK2/ERK8-IN-1 is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds to PIM1,...
T14779	BRD7389	376382-11-5	98%
T14779	BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.
T2300	AZD1208	1204144-28-4	98%
T2300	AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.
T3058	(Z)-SMI-4a	438190-29-5	98%
T3058	(Z)-SMI-4a is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM.
T9583	1-phenoxazin-10-ylethanone	6192-43-4	98%
T9583	1-phenoxazin-10-ylethanone is a Pim-2 inhibitor. 1-phenoxazin-10-ylethanone induces apoptosis and autophagic cell death in triple-negative human breast cancer.
T2253	TCS PIM-1 1	491871-58-0	98%
T2253	TCS PIM-1 1(sc-204330) is a effective and specific ATP-competitive Pim-1 kianse inhibitor (IC50: 50 nM) , exhibits good specific over MEK1/MEK2 and Pim-2(IC50s >...
T12477	Uzansertib phosphate	2088852-47-3	98%
T12477	INCB053914 phosphate is an orally active, ATP-competitive inhibitor of pan-PIM kinase(PIM1, PIM2, PIM3 with IC50s of 0.24 nM, 30 nM, 0.12 nM , respectively).
T8114	Quercetagetin	90-18-6	98%
T8114	Quercetagetin (6-Hydroxyquercetin) is the major flavonoid isolated from Citrus unshiu. It is a moderately potent and selective, cell-permeable pim-1 kinase inhib...