T77777 |
HS94
|
1892594-93-2
|
98%
|
|
HS94 (DAPK3 inhibitor HS94) is a selective and potent DAPK3 inhibitor with a Ki value of 126 nM for Pim kinase inhibition and can be used to study hypertension.
|
T78980 |
Pim-1 kinase inhibitor 5
|
2928606-67-9
|
98%
|
|
Pim-1 kinase inhibitor 5 (Compound 4c), with an IC50 of 0.61 μM, exhibits cytotoxicity against various cancer cell lines, including HepG2, MCF-7, PC3, and HCT-11...
|
T79456 |
FD1024
|
1422456-47-0
|
98%
|
|
FD1024 is a potent PIM inhibitor, displaying inhibitory concentrations (IC50s) of 1.96 nM, 38.9 nM, and 4.17 nM for PIM1, PIM2, and PIM3, respectively. It demons...
|
T81460 |
PIM-IN-2
|
1006699-45-1
|
98%
|
|
PIM-IN-2 (Pim-2) is a potent inhibitor of Pim kinases, demonstrating an inhibition concentration half-maximal (IC50) value of 25 nM . It exhibits antiapoptotic p...
|
T12474 |
PIM1-IN-1
|
1417630-95-5
|
98%
|
|
PIM1-IN-1 is a potent and highly selective inhibitor of PIM1/3(IC50s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively),with Antiproliferative and anti...
|
T73247 |
PIM1-IN-4
|
2762767-48-4
|
98%
|
|
PIM1-IN-4 (Compound 8) is a potent PIM1 inhibitor with significant inhibitory activity against five additional enzymes: SGK-1, PKA, CaMK-1, GSK3β, and MSK1, rend...
|
T15376 |
GDC-0339
|
1428569-85-0
|
98%
|
|
GDC-0339 is discovered as a potential treatment of multiple myeloma. GDC-0339 is an orally bioavailable and well-tolerated inhibitor of pan-Pim kinase (Kis: 0.03...
|
TN1985 |
Neoprzewaquinone A
|
630057-39-5
|
98%
|
|
Neoprzewaquinone A (NEO), an active ingredient of S. miltiorrhiza, inhibits breast cancer cell migration and promotes smooth muscle relaxation by targeting PIM1 ...
|
T19611 |
(2R)-Octyl-α-hydroxyglutarate
|
1391194-67-4
|
98%
|
|
(2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) is a D-isomer 2-Hydroxyglutarate modified form.
|
T15406 |
GNE-955
|
1527523-39-2
|
98%
|
|
GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).
|
T4215 |
TCS-PIM-1-4a
|
327033-36-3
|
99.89%
|
|
TCS-PIM-1-4a (SMI-4a), a Pim inhibitor, blocks mTORC1 activity through activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (IC50=0....
|
T9229 |
Pim-1/2 kinase inhibitor 1
|
6320-51-0
|
99.89%
|
|
Pim-1/2 Kinase Inhibitor 1, an orally active inhibitor, impedes the action of Pim kinases by preventing their ability to phosphorylate peptides. It particularly ...
|
T6735 |
XL413 hydrochloride
|
2062200-97-7
|
99.82%
|
|
XL413 hydrochloride (BMS-863233 Hydrochloride) is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC 50 of 3.4 nM. XL413 hydrochloride also ex...
|
T3989 |
SMI-16a
|
587852-28-6
|
99.78%
|
|
SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (IC50...
|
T8114 |
Quercetagetin
|
90-18-6
|
99.76%
|
|
Quercetagetin (6-Hydroxyquercetin) (6-Hydroxyquercetin) is the major flavonoid isolated from Citrus unshiu. It is a moderately potent and selective, cell-permeab...
|
T2253 |
TCS PIM-1 1
|
491871-58-0
|
99.64%
|
|
TCS PIM-1 1 (SC 204330)(sc-204330) is a effective and specific ATP-competitive Pim-1 kianse inhibitor (IC50: 50 nM) , exhibits good specific over MEK1/MEK2 and P...
|
T9583 |
HJ-PI01
|
6192-43-4
|
99.55%
|
|
HJ-PI01 (HJ-PI01) is a Pim-2 inhibitor. HJ-PI01 (HJ-PI01) induces apoptosis and autophagic cell death in triple-negative human breast cancer.
|
T3058 |
(Z)-SMI-4a
|
438190-29-5
|
99.44%
|
|
(Z)-SMI-4a (TCS PIM-1 4a) is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM.
|
T71339 |
BMS-863233 HCl
|
1169562-71-3
|
99.42%
|
|
BMS-863233 HCl is an ATP-competitive Cdc7 inhibitor (IC50: 3.4 nM) that is potent and selective.BMS-863233 HCl inhibited CK2 and PIM1 with IC50 values of 215 and...
|
T14779 |
BRD7389
|
376382-11-5
|
99.17%
|
|
BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.
|