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Proton pump

A proton pump is an integral membrane protein pump that builds up a proton gradient across a biological membrane.During evolution, proton pumps have arisen independently on multiple occasions. Thus, not only throughout nature but also within single cells, different proton pumps that are evolutionarily unrelated can be found. Proton pumps are divided into different major classes of pumps that use different sources of energy, have different polypeptide compositions and evolutionary origins.
Cat No. product name
T40437L Caloxin 2A1 acetate Caloxin 2A1 acetate 是细胞外质膜 Ca2+-ATPase (PMCA) 肽的抑制剂。 Caloxin 2A1 acetate 抑制 140-kDa 酸稳定酰基磷酸盐的 Ca2+ 依赖性形成。
TN1103 Diphyllin Diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt/β-catenin signaling.
T21254 Vonoprazan Fumarate Vonoprazan Fumurate, a novel potassium-competitive acid blocker, inhibits gastric acid secretion by competitively inhibiting K+ binding sites on H+, K+ - ATPase
T6368 Abscisic Acid Abscisic Acid is a plant hormone, which is involved in many plant developmental processes, modulates ion homeostasis and metabolism, and inhibits germination and...
T6928 Pantoprazole Pantoprazole is a proton pump inhibitor used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.
T1651 Rabeprazole sodium Rabeprazole sodium is a 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of stomach ulcers and Zollinger-Ellison synd...
T20626 Esomeprazole Esomeprazole is the S-isomer of omeprazole, it is used in Gastro-oesophageal reflux disease (GORD).
T0757 Omeprazole Omeprazole is a proton pump inhibitor (PPI), Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).
T1734 Rabeprazole Sulfide Rabeprazole is an antiulcer drug in the class of proton pump inhibitors.
T2686L Esomeprazole Sodium Esomeprazole Sodium is the S-isomer of omeprazole with selective and irreversible proton pump inhibitor activity.Esomeprazole acts as an exosome inhibitor by blo...
T2686 Esomeprazole Magnesium Esomeprazole Magnesium is the S-isomer of omeprazole, can reduce gastric acid secretion with selective and irreversible proton pump inhibitor activity.Esomepraz...
T0674 Lansoprazole Lansoprazole is a 2, 2, 2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug...
T0502 Zinc pyrithione Zinc pyrithione, an antibacterial and antifungal agent can disrupt membrane transport by blocking the proton pump.
T2188 Thonzonium Bromide Thonzonium bromide is a cationic surface-active compound.
T17030 Tegoprazan Tegoprazan is a potassium-competitive acid blocker and is a potent, oral active, and highly selective inhibitor of gastric H+/K+-ATPase. That could control gastr...
T2687 Omeprazole sulfide Omeprazole sulfide is a metabolite of Omeprazole, which is a proton pump inhibitor.
TQ0184 Chebulinic acid Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.
T0161 Pantoprazole Sodium Hydrate Pantoprazole is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease....
T6929 Pantoprazole sodium Pantoprazole Sodium is the sodium salt form of a substituted benzimidazole with proton pump inhibitor activity. Pantoprazole is a lipophilic, weak base that cros...
T1756 Ilaprazole sodium Ilaprazole, a substituted benzimidazole prodrug, is a selective and irreversible proton pump inhibitor. A weak base, Ilaprazole accumulates in the acidic environ...
T11191 EN6 EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activati...
T6740 Bafilomycin A1 Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways. Bafilomycin A1 is a vacuola...
T21651 Lansoprazole sodium Lansoprazole sodium is a proton pump inhibitor (PPI) and a potent inhibitor of gastric acidity which is widely used in the therapy of gastroesophageal reflux and...
T20714 Levolansoprazole Levolansoprazole, a proton pump inhibitor, irreversibly inhibits H+/K+-stimulated ATPase pumps in parietal cells (IC50: 5.2 µM). It also inhibits acid formation ...
T8386 Esomeprazole Magnesium trihydrate Esomeprazole Magnesium trihydrate is a proton pump inhibitor indicated for the short-term treatment of gastroesophageal reflux disease in patients with a history...
T8388 Vonoprazan Vonoprazan is an orally active potassium-competitive acid blocker.Vonoprazan can be used for the treatment of gastroduodenal ulcer and reflux esophagitis
T11817 Lansoprazole Sulfide D4 Lansoprazole Sulfide D4 is a deuterium labeled Lansoprazole Sulfide. Lansoprazole Sulfide is an orally active anti-TB (Mycobacterium tuberculosis) agent with IC5...
T11816 Lansoprazole-d4 Lansoprazole D4 (AG-1749 D4) is a deuterium labeled Lansoprazole. Lansoprazole is an inhibitor of proton pump which prevents the stomach from producing acid.
T1021 (R)-Lansoprazole Dexlansoprazole is the R-isomer of lansoprazole and a substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor activity.Lansoprazo...
T5449 Bamaquimast Bamaquimast is an inhibitor of proton pump
T6700 Tenatoprazole Tenatoprazole, a prodrug of the proton pump inhibitor (PPI) class, can inhibit proton transport (IC50: 3.2 μM).
T14051 5-Hydroxylansoprazole 5-Hydroxylansoprazole (AG1908) is an active metabolite of Lansoprazole in plasma. Lansoprazole is a gastric proton-pump inhibitor and is effective in the treatme...
T1756L Ilaprazole Ilaprazole is a proton pump inhibitor used in the treatment of dyspepsia gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. Studies also showed that...
T16682 Pumaprazole Pumaprazole is an antagonist of a reversible proton pump.
Caloxin 2A1 acetate
T40437L
Diphyllin
TN1103
Diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt/β-catenin signaling.
Vonoprazan Fumarate
T21254
Vonoprazan Fumurate, a novel potassium-competitive acid blocker, inhibits gastric acid secretion by competitively inhibiting K+ binding sites on H+, K+ - ATPase
Abscisic Acid
T6368
Abscisic Acid is a plant hormone, which is involved in many plant developmental processes, modulates ion homeostasis and metabolism, and inhibits germination and...
Pantoprazole
T6928
Pantoprazole is a proton pump inhibitor used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.
Rabeprazole sodium
T1651
Rabeprazole sodium is a 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of stomach ulcers and Zollinger-Ellison synd...
Esomeprazole
T20626
Esomeprazole is the S-isomer of omeprazole, it is used in Gastro-oesophageal reflux disease (GORD).
Omeprazole
T0757
Omeprazole is a proton pump inhibitor (PPI), Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).
Rabeprazole Sulfide
T1734
Rabeprazole is an antiulcer drug in the class of proton pump inhibitors.
Esomeprazole Sodium
T2686L
Esomeprazole Sodium is the S-isomer of omeprazole with selective and irreversible proton pump inhibitor activity.Esomeprazole acts as an exosome inhibitor by blo...
Esomeprazole Magnesium
T2686
Esomeprazole Magnesium is the S-isomer of omeprazole, can reduce gastric acid secretion with selective and irreversible proton pump inhibitor activity.Esomepraz...
Lansoprazole
T0674
Lansoprazole is a 2, 2, 2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug...
Zinc pyrithione
T0502
Zinc pyrithione, an antibacterial and antifungal agent can disrupt membrane transport by blocking the proton pump.
Thonzonium Bromide
T2188
Thonzonium bromide is a cationic surface-active compound.
Tegoprazan
T17030
Tegoprazan is a potassium-competitive acid blocker and is a potent, oral active, and highly selective inhibitor of gastric H+/K+-ATPase. That could control gastr...
Omeprazole sulfide
T2687
Omeprazole sulfide is a metabolite of Omeprazole, which is a proton pump inhibitor.
Chebulinic acid
TQ0184
Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.
Pantoprazole Sodium Hydrate
T0161
Pantoprazole is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease....
Pantoprazole sodium
T6929
Pantoprazole Sodium is the sodium salt form of a substituted benzimidazole with proton pump inhibitor activity. Pantoprazole is a lipophilic, weak base that cros...
Ilaprazole sodium
T1756
Ilaprazole, a substituted benzimidazole prodrug, is a selective and irreversible proton pump inhibitor. A weak base, Ilaprazole accumulates in the acidic environ...
EN6
T11191
EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activati...
Bafilomycin A1
T6740
Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways. Bafilomycin A1 is a vacuola...
Lansoprazole sodium
T21651
Lansoprazole sodium is a proton pump inhibitor (PPI) and a potent inhibitor of gastric acidity which is widely used in the therapy of gastroesophageal reflux and...
Levolansoprazole
T20714
Levolansoprazole, a proton pump inhibitor, irreversibly inhibits H+/K+-stimulated ATPase pumps in parietal cells (IC50: 5.2 µM). It also inhibits acid formation...
Esomeprazole Magnesium trihydrate
T8386
Esomeprazole Magnesium trihydrate is a proton pump inhibitor indicated for the short-term treatment of gastroesophageal reflux disease in patients with a history...
Vonoprazan
T8388
Vonoprazan is an orally active potassium-competitive acid blocker.Vonoprazan can be used for the treatment of gastroduodenal ulcer and reflux esophagitis
Lansoprazole Sulfide D4
T11817
Lansoprazole Sulfide D4 is a deuterium labeled Lansoprazole Sulfide. Lansoprazole Sulfide is an orally active anti-TB (Mycobacterium tuberculosis) agent with IC5...
Lansoprazole-d4
T11816
Lansoprazole D4 (AG-1749 D4) is a deuterium labeled Lansoprazole. Lansoprazole is an inhibitor of proton pump which prevents the stomach from producing acid.
(R)-Lansoprazole
T1021
Dexlansoprazole is the R-isomer of lansoprazole and a substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor activity.Lansoprazo...
Bamaquimast
T5449
Bamaquimast is an inhibitor of proton pump
Tenatoprazole
T6700
Tenatoprazole, a prodrug of the proton pump inhibitor (PPI) class, can inhibit proton transport (IC50: 3.2 μM).
5-Hydroxylansoprazole
T14051
5-Hydroxylansoprazole (AG1908) is an active metabolite of Lansoprazole in plasma. Lansoprazole is a gastric proton-pump inhibitor and is effective in the treatme...
Ilaprazole
T1756L
Ilaprazole is a proton pump inhibitor used in the treatment of dyspepsia gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. Studies also showed that...
Pumaprazole
T16682
Pumaprazole is an antagonist of a reversible proton pump.