SGK

Serine/threonine-protein kinases SGK represent a kinase subfamily with orthologs found across animal clades and in yeast (compare Treefam family TF320906). In most vertebrates, including humans, there are three isoforms encoded by the genes SGK1, SGK2, and SGK3. The name Serum/glucocorticoid-regulated kinase refers to the first cloning of a SGK family member from a cDNA library screen for genes upregulated by the glucocorticoid dexamethasone in a rat mammary epithelial tumor cell line. The first human family member (human SGK1) was cloned in a screen of hepatocellular genes regulated in response to cellular hydration or swelling.

Cat No.	product name
T6057	URMC-099	URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
T9589	SI-113	SI-113 is a potent and selective inhibitor of SGK1, a serine/threonine protein kinase, that modulates several oncogenic signaling cascades.
T2356	Ro-3306	RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases...
T2622	GSK 650394	GSK650394 is a serum- and glucocorticoid-regulated kinase-1 inhibitor.
T19913	CKI-7	CKI-7 2HCl is an inhibitor of casein kinase 1 (CK1).
T2482	AT13148	AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
T11181	EMD638683 R-Form	EMD638683 is a highly selective SGK1 inhibitor with IC50 of 3 μM. EMD638683 R-Form is the R-form of EMD638683.
T6635	EMD638683	EMD638683,a novel SGK inhibitor with antihypertensive potency(with an IC50 of 3 μM).

Cat No.

product name

T6057

URMC-099

URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...

T9589

SI-113

SI-113 is a potent and selective inhibitor of SGK1, a serine/threonine protein kinase, that modulates several oncogenic signaling cascades.

T2356

Ro-3306

RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases...

T2622

GSK 650394

GSK650394 is a serum- and glucocorticoid-regulated kinase-1 inhibitor.

T19913

CKI-7

CKI-7 2HCl is an inhibitor of casein kinase 1 (CK1).

T2482

AT13148

AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.

T11181

EMD638683 R-Form

EMD638683 is a highly selective SGK1 inhibitor with IC50 of 3 μM. EMD638683 R-Form is the R-form of EMD638683.

T6635

EMD638683

EMD638683,a novel SGK inhibitor with antihypertensive potency(with an IC50 of 3 μM).