Trk receptor

Trk receptors are a family of tyrosine kinases that regulates synaptic strength and plasticity in the mammalian nervous system. Trk receptors affect neuronal survival and differentiation through several signaling cascades.The common ligands of trk receptors are neurotrophins, a family of growth factors critical to the functioning of the nervous system. The binding of these molecules is highly specific. Each type of neurotrophin has different binding affinity toward its corresponding Trk receptor. The activation of Trk receptors by neurotrophin binding may lead to activation of signal cascades resulting in promoting survival and other functional regulation of cells.

Cat. No.	Product name	CAS No.	Purity
T78968	TRK-IN-23	2924344-29-4	98%
T78968	TRK-IN-23 (compound 24b) is a potent, orally active inhibitor of TRK with IC50s of 0.5 nM for TRKA, 9 nM for TRKC, 14 nM for TRKA G595R, 4.4 nM for TRKA F589L, a...
T79011	TrkB-IN-1	1609067-49-3	98%
T79011	TrkB-IN-1 is a potent, orally active agonist of the TrkB receptor, with favorable pharmacokinetic (PK) properties. It has been shown to reverse cognitive deficit...
T79125	Protein kinase inhibitor 5	2278204-94-5	98%
T79125	Protein kinase inhibitor 5 is a potent inhibitor of TRK-A, demonstrating an IC50 of 1.8 nM, and effectively suppresses cell viability [1].
T79126	Protein kinase inhibitor 5 sulfate hydrate		98%
T79126	Protein kinase inhibitor 5 sulfate hydrate, a potent TRK-A inhibitor, exhibits an IC50 of 1.8 nM and impairs cell viability [1].
T79706	TRK-IN-24	2937544-01-7	98%
T79706	TRK-IN-24 (compound 10g) is a selective inhibitor of Trk receptors, effectively targeting TRKA, TRKC, and mutant forms TRKA G595R, TRKA G667C, and TRKA F589L, wi...
T81740	Multi-kinase-IN-6		98%
T81740	Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that effectively impedes the activity of TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2. It exhi...
T13208	TrkA-IN-1	1680179-43-4	98%
T13208	TrkA-IN-1 is a potent and selective inhibitor of Tropomyosin-related kinase A (TrkA) (IC50: 99 nM in a cell-based assay) with analgesic activity.
T6936	PF-03814735	942487-16-3	98%
T6936	PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and...
T13207	PF-06733804	1873373-33-1	98%
T13207	PF-06733804 is a potent inhibitor of pan-Trk in cell-based assays (IC50s: 8.4 nM, 6.2 nM, and 2.2 nM for TrkA, TrkB, and TrkC) with anti-hyperalgesic effect.
TN2890	3,5,7,15-Tetraacetoxy-9-nicotinoyloxy-6(17),11-jatrophadien-14-one	244277-75-6	98%
TN2890	3,5,7,15-Tetraacetoxy-9-nicotinoyloxy-6(17),11-jatrophadien-14-one is a natural product of Euphorbia, Euphorbiaceae. The catalog number is TN2890 and the CAS num...
T17000	Tavilermide	263251-78-1	98%
T17000	Tavilermide is a selective and partial agonist of TrkA or a nerve growth factor mimetic.
T72289	Type II TRK inhibitor 1	2937543-72-9	98%
T72289	Type II TRK Inhibitor 1 is a potent inhibitor targeting multiple tropomyosin receptor kinase (TRK) fusion protein variants as well as the wild type. It demonstra...
T73033	TRK II-IN-1	2904690-41-9	98%
T73033	TRK II-IN-1 is a potent type II inhibitor of tropomyosin receptor kinases (TRK), demonstrating inhibitory half-maximal inhibitory concentrations (IC50s) of 3.3, ...
T17170	PF-06737007	1863905-38-7	98%
T17170	PF-06737007 is an effective inhibitor of pan-Trk in cell-based assays (IC50s: 7.7 nM, 15 nM, and 3.9 nM for TrkA, TrkB, and TrkC, respectively).
T17169	Trk-IN-4	1799788-94-5	98%
T17169	Trk-IN-4 is an effective pan-Trk inhibitor in cell-based assays (IC50s: 1.9 nM, 2.6 nM, and 1.1 nM for TrkA, TrkB, and TrkC, respectively).
T22318	Taletrectinib	1505515-69-4	99.96%
T22318	Taletrectinib (AB-106) is a new-generation selective inhibitor of ROS1/NTRK including ROS1,NTRK1,NTRK2 and NTRK3 with IC50 of 0.207 nM,0.622 nM,2.28 nM and 0.980...
T2359	ANA-12	219766-25-3	99.87%
T2359	ANA-12 is a potent and selective TrkB antagonist with anxiolytic and antidepressant activity in mice.
T4071	Repotrectinib	1802220-02-5	99.86%
T4071	Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respec...
T6081	Milciclib	802539-81-7	99.73%
T6081	Milciclib (PHA-848125) (PHA-848125) is a potent, ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM. It is >3-fold more selective for CDK2 than CDK1, 2, 4...
T3678	Entrectinib	1108743-60-7	99.61%
T3678	Entrectinib (RXDX-101) is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1....