T41003 |
KG5
|
|
FLT
,
Raf
,
c-Kit
,
PDGFR
|
|
KG5 is a dual allosteric inhibitor of PDGFRβ and B-Raf with a Kd of 520 nM and 300 nM for PDGFRβ and PDGFRα. KG5 inhibit... |
T5164 |
Cabozantinib hydrochloride
|
Cabozantinib hydrochloride (849217-68-1(free base)) , BMS-907351 , XL184 |
c-Met/HGFR
,
FLT
,
VEGFR
,
TAM Receptor
,
ROR
,
c-Kit
|
|
Cabozantinib (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: ... |
T4315 |
Ki20227
|
|
CSF-1R
,
VEGFR
,
c-Fms
,
c-Kit
,
PDGFR
|
|
Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM). It also has certain inhibitory against VEGFR... |
T5398 |
BMS 599626 2HCl (873837-23-1(HCl))
|
AC480 dihydrochloride |
HER
|
|
BMS-599626 (AC480) is a selective inhibitor of HER1 and HER2 (IC50s: 20 nM and 30 nM), ~8-fold less potent to HER4, >100... |
T0520 |
Lenvatinib
|
E7080 |
VEGFR
,
FGFR
,
c-RET
,
PDGFR
,
c-Kit
|
|
Lenvatinib is a Kinase Inhibitor. The mechanism of action of lenvatinib is as a Receptor Tyrosine Kinase Inhibitor. |
T19222 |
c-Kit-IN-3 maleate
|
|
Others
|
|
c-Kit-IN-3 maleate is a potent and selective c-KIT kinase inhibitor (IC50s: 4 nM, 8 nM for c-KIT wt, and c-KIT T670I). |
T19223 |
c-Kit-IN-3 tartrate
|
|
Others
|
|
c-Kit-IN-3 tartrate is a potent and selective c-KIT kinase inhibitor (IC50s: 4 nM, 8 nM for c-KIT wt, and c-KIT T670I). |
T19220 |
c-Kit-IN-3 hydrochloride
|
|
Others
|
|
c-Kit-IN-3 hydrochloride is a potent and selective c-KIT kinase inhibitor (IC50s: 4 nM, 8 nM for c-KIT wt, and c-KIT T67... |
T19221 |
c-Kit-IN-3 L-tartrate
|
|
Others
|
|
c-Kit-IN-3 L-tartrate is a potent and selective c-KIT kinase inhibitor (IC50s: 4 nM, 8 nM for c-KIT wt, and c-KIT T670I)... |
T19219 |
c-Kit-IN-3 D-tartrate
|
|
Others
|
|
c-Kit-IN-3 D-tartrate is a potent and selective c-KIT kinase inhibitor (IC50s: 4 nM, 8 nM for c-KIT wt, and c-KIT T670I)... |
T23418 |
Tandutinib (MLN518) HCl
|
|
Others
|
|
Tandutinib is an effective antagonist for FLT3, platelet-derived growth factor receptor (PDGFR), and c-Kit. Tandutinib p... |
T40504 |
N-Desmethyl imatinib mesylate
|
Norimatinib mesylate , ImatinibmetaboliteN-Desmethylimatinibmesylate |
|
|
N-Desmethyl imatinib mesylate (Norimatinib mesylate) is a metabolite of Imatinib (HY-15463). Imatinib is a multi-target ... |
T18477 |
NAMPT inhibitor-linker 1
|
|
Others
|
|
NAMPT inhibitor-linker 1 is a drug-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker.... |
T34090 |
PLX9486
|
PLX 9486 , PLX-9486 |
|
|
PLX9486 is an orally bioavailable protein tyrosine kinase inhibitor of mutated forms of the tumor-associated antigen mas... |
T18478 |
NAMPT inhibitor-linker 2
|
|
Others
|
|
NAMPT inhibitor-linker 2 is a drug-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker.... |
T35331 |
Dovitinib (TKI258) Lactate
|
CHIR258 |
FGFR
,
VEGFR
,
PDGFR
,
c-Kit
|
|
|
T11640 |
Imatinib-d8
|
STI571 D8 , CGP-57148B D8 |
Others
|
|
Imatinib D8 is a deuterium-labeled Imatinib. Imatinib is an orally bioavailable tyrosine kinases inhibitor that inhibit... |
T11639 |
Imatinib D4
|
STI571 D4 , CGP-57148B D4 |
Others
|
|
Imatinib D4 is a deuterium-labeled Imatinib. Imatinib is an orally bioavailable tyrosine kinases inhibitor that selecti... |
T61313 |
Antitumor agent-70
|
|
|
|
Antitumor agent-70 (compound 8b) has anti-tumor activity and can induce cell apoptosis. Antitumor agent-70 inhibits mult... |
T9665 |
Esuberaprost Sodium
|
|
|
|
Famitinib (SHR1020), an orally active multi-targeted kinase inhibitor, inhibits the activity of c-kit, VEGFR-2 and PDGFR... |