eos

EOS is a ceramide found in the outer layer of the epidermis in mammals. It is comprised of an ω-hydroxy very long-chain ceramide (C28-36) esterified to the essential fatty acid linoleic acid . The consecutive regio- and stereospecific oxygenation of the linoleate portion of EOS by 12(R)-lipoxygenase (12(R)-LO) and eLOX3 is essential for the maintenance of the epidermal barrier to prevent water loss. Following oxygenation, the oxidized linoleate is hydrolyzed, leaving the ω-hydroxy end of the very long-chain fatty acid to covalently bind the protein layer, forming the corneocyte lipid envelope and sealing the gap between the extracellular lipid lamellae and the cornified cell envelope of the corneocyte.

Pesampator (PF-04958242) is a potent, highly selective positive allosteric modulator of the AMPA receptor, also known as an AMPA potentiator, demonstrating an EC50 of 310 nM and a Ki of 170 nM [1].

TP-353 (EOS-61973) is a CDK7 inhibitor.

Belrestotug (EOS-448), an antagonistic anti-TIGIT (VSIG9, VSTM3) antibody of the human immunoglobulin G1 kappa (hIgG1 kappa) class, exhibits antineoplastic activity [1].

Neosalvianen was isolated from Salvia miltiorrhiza.

Oleoside 11-methyl ester (Methyloleoside) is a natural product.

Coreoside B is isolated from coreoside and showed weak antimicrobial activity against S. aureus and B. anthracis.

Volociximab (M200) is an IgG4 monoclonal antibody targeting the α5β1 integrin , with antiangiogenic, antitumor and anticancer activity, inhibits the growth of rabbit VX2 tumors and is used to study solid tumors.

Neostigmine is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.

MeOSuc-AAPF-CMK (MeOSuc-Ala-Ala-Pro-Phe-CH2Cl) is a potent inhibitor of the enzyme proteinase K [1].

Methyl glucooleoside is a useful organic compound for research related to life sciences. The catalog number is T126324 and the CAS number is 115623-36-4.

Osteostatin, derived from parathyroid hormone-related protein (PTHrP) 107-111, has demonstrated properties conducive to bone repair in animal models presenting with bone defects and exhibits efficacy in mitigating bone erosion associated with inflammatory arthritis. Additionally, it possesses the capacity to inhibit both collagen-induced arthritis and direct osteoclastic bone resorption, marking its potential utility in inflammation and immunology research [1] [2] [3] [4].

Remdesivir nucleoside monophosphate, a metabolite of Remdesivir, is a potent antiviral compound with nucleoside analogue characteristics. It exhibits effective antiviral activity against both SARS-CoV and MERS-CoV.

Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat), also known as Human PTHrP (107-111) amide, is a C-terminal fragment of parathyroid hormone-related protein that inhibits bone resorption [1] [2].

Neostenine shows significant antitussive activity.

Dregeoside Da1 is a natural product from Dregea volubilis.

Araneosol is a natural product of Ehretia, Boraginaceae. The catalog number is TN3437 and the CAS number is 50461-86-4. Araneosol can be used as a reference standard.

Dregeoside Aa1 is a natural product from Dregea volubilis.

Creosol is an agent of Antioxidant and Antibacterial.

Luteoskyrin is a hepatotoxic and hepatocarcinogenic bisdihydroanthraquinone produced by Penicillium islandicum Sopp.

Jaceoside is a useful organic compound for research related to life sciences. The catalog number is T125193 and the CAS number is 25474-11-7.

Geoside is a natural compound isolated from stevia rebaudiana.

Neoschaftoside has antioxidant activity.

Campneoside II, a compound extracted from the wood of Paulownia tomentosa var. tomentosa, demonstrates remarkable anti-complement activity [1].

Purine Nucleoside Phosphorylase, an essential enzyme in purine metabolism, plays a critical role in the purine salvage pathway. Its deficiency impairs T cell function. With inorganic orthophosphate as a co-substrate, this enzyme catalyzes the cleavage of the glycosidic bond linking ribose and deoxyribonucleoside, resulting in the production of a purine base and ribose (deoxyribose)-1-phosphate [1].

ER Proteostasis Regulator-1 (Compound 481) is a potent modulator of endoplasmic reticulum proteostasis with research applications in Alzheimer's disease and diabetes [1].

Dregeoside Ga1 is a natural product for research related to life sciences. The catalog number is TN5293 and the CAS number is 98665-66-8.

Bruceoside A is a bitter wood glycoside that can be isolated from opuntia and has anticancer and tumor activity and can be used with the study of leukemia.

Creoside III is a natural product for research related to life sciences. The catalog number is TN5837 and the CAS number is 1038602-12-8.

Dregeoside A11 is a natural product from Dregea volubilis.

Methyl alpha-eleostearate (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, α-ESA induced apoptosis through up-regulation of GADD45, p53, and PPARγ. In DLD-1 cells supplemented with α-ESA, apoptosis was induced via lipid peroxidation with an EC50 of 20 μM. It also inhibits DNA polymerases and topoisomerases with IC50s ranging from ~5-20 μM for different isoforms of the enzymes. α-ESA methyl ester is a neutral, more lipid soluble form of the free acid.

MeOSuc-AAPA-CMK is a potent inhibitor of human neutrophil elastase (HNE) [1].

Viscumneoside III, a dihydroflavone O-glycoside, is a potent Tyrosinase inhibitor with an IC50 of 0.5 mM. Viscumneoside III has anti-angina pectoris.

Neostigmine methyl sulfate (Syntostigmin) is a reversible inhibitor of acetylcholinesterase, can not cross the blood-brain barrier, used in the treatment of myasthenia gravis.

Spliceostatin A is an anticancer agent and splicing inhibitor that inhibits the splicing mechanism of the spliceosome and inhibits mitotic clonal expansion and adipogenesis.Spliceostatin A induces cell cycle arrest in the G1 and G2/M phases, and induces apoptosis.

Spiraeoside is a natural product

Osteosarcoma-IN-D14 is an inhibitor of migration and invasion of osteosarcoma cells mediated by p53, regulating EMT-related genes.

Neosarranicine is a useful organic compound for research related to life sciences and the catalog number is T125984.

Jaslanceoside B is a natural product for research related to life sciences. The catalog number is TN5558 and the CAS number is 188300-82-5.

Neosartorin is a useful organic compound for research related to life sciences and the catalog number is T130965.

Neoseptin 3 is an agonist of Toll-like receptor 4/myeloid differentiation factor 2 (EC50: 18.5 μM).

Roseoside ((6S,9R)-roseoside), a sesquiterpenoid isolated from Catharanthus roseus, has strong antioxidant and proinsulinic activity, inhibits lipid oxidation, enhances insulin release from the β-cell line INS-1, and can be used in cancer research.

Neostigmine Bromide EP Impurity C-d6 is a deuterated compound of Neostigmine Bromide EP Impurity C. Neostigmine Bromide EP Impurity C has a CAS number of 16088-19-0.

Isoacteoside has the anti-inflammatory effect, mediated by action on caspase-1, mitogen-activated protein kinases (c-Jun N-terminal kinase, p38, extracellular signal-regulated protein kinase) and nuclear factor-kappa B pathways.

2'-Acetylacteoside has antioxidative activity. It can significantly attenuate glutamate-induced neurotoxicity at concentrations ranging from 0.1 to 10 μM. 2'-Acetylacteoside shows antiproliferative effects on aortic smooth muscle, indicates that it may ha

Mumeose K is a natural product for research related to life sciences. The catalog number is TN5846 and the CAS number is 2132384-01-9.

L-Ristosamine nucleoside shows antiviral activity.