MEG hemisulfate (Mercaptoethylguanidine hemisulfate) acts as a highly potent and selective suppressor of inducible NO synthase (iNOS), demonstrating EC50 values of 11.5 μM for iNOS, 110 μM for ecNOS, and 60 μM for bNOS in tissue homogenates. It is notably effective as a peroxynitrite scavenger and blocks peroxynitrite-triggered oxidative mechanisms. Furthermore, this compound offers protective benefits across various experimental inflammation prototypes, such as ischemia/reperfusion injury, hemorrhagic shock, periodontitis, inflammatory bowel disease, and both endotoxic and septic shock.

Mercaptoethylguanidine (MEG) dihydrobromide is a selective inducible nitric oxide synthase inhibitor and peroxynitrite scavenger with potential for inflammatory bowel diseases research.

Imeglimin hydrochloride (EMD 387008 hydrochloride) prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration.

Rimegepant (BMS 927711) is a highly potent, oral calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki value of 0.027 nM.

Diatrizoate meglumine (Renocal) is the meglumine salt of diatrizoate, it is an organic, iodinated, radiopaque X-ray contrast medium used in diagnostic radiography.

Dazmegrel (UK 38,485) is a potent and specific thromboxane A2 (TXA2) synthase inhibitor for the prevention of increased whole platelet aggregation in normal pregnancy.

Cameglipti, a dipeptidyl peptidase IV (DPP-4) inhibitor, is used potentially for the treatment of type 2 diabetes.

Dazmegrel HCl is a platelet thromboxane inhibitor used in the study of myocardial infarction and arrhythmias.

Flunixin meglumine (Banamine) is an effective inhibitor of the enzyme cyclooxygenase with anti-inflammatory and antipyretic activity.

Omega-3 Arachidonic Acid ethyl ester, a rare polyunsaturated fatty acid with limited presence in dietary sources, is crucial for infant growth and development and offers protection against heart disease, blood clots, high blood pressure, and inflammatory and autoimmune disorders. In human platelet membranes, it impedes arachidonyl-CoA synthetase, exhibiting a Ki of 14 μM, and shows similar inhibitory effects on arachidonoyl-CoA synthetase in calf brain extract with an IC50 of roughly 5 μM. The ethyl arachidonate derivative offers enhanced lipophilicity compared to its free acid counterpart.

Hymeglusin, A selective 3-hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) synthase 1 inhibitor, is also an antibiotic that reduces the expression level of BCL2 in HL-60 and KG-1 cells and can be used to study leukemia.

Emeguisin A is a depsidone fungal metabolite originally isolated fromE. unguis.1It is active against the bacteriaS. aureusand methicillin-resistantS. aureus(MRSA; MIC = 0.5 μg/ml for both), the fungusC. neoformans(MIC = 0.5 μg/ml), and the protozoanP. falciparum(IC50= 2.2 μM).2 1.Kawahara, N., Nozawa, K., Nakajima, S., et al.Isolation and structures of novel fungal depsidones, emeguisins A, B, and C, from Emericella unguisJ. Chem. Soc., Perkin Trans. 12611-2614(1988) 2.Klaiklay, S., Rukachaisirikul, V., Aungphao, W., et al.Depsidone and phthalide derivatives from the soil-derived fungus Aspergillus unguis PSU-RSPG199Tetrahedron Lett.57(39)4348-4351(2016)

Gadopentetate dimeglumine is used in magnetic resonance imaging (MRI) to allow blood vessels, organs and other non-bone tissues to be visualized more clearly.Gadopentetate dimeglumine induces atrophy of spermatogonia.

Megastigm-7-ene-3,5,6,9-tetraol is a natural product for research related to life sciences. The catalog number is TN5337 and the CAS number is 276870-26-9.

6,9,10-Trihydroxy-7-megastigmen-3-one is a natural product for research related to life sciences. The catalog number is TN5338 and the CAS number is 476682-97-0.

Megestrol acetate (BDH1298) is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties. It is given by mouth in the palliative treatment or as an adjunct to other therapy in endometrial carcinoma and in breast cancer. Megestrol acetate has been approved to treat anorexia and cachexia.

Fosaprepitant dimeglumine (MK-0517) is the dimeglumine salt form of fosaprepitant, the water-soluble, N-phosphorylated prodrug of aprepitant, with antiemetic activity. Upon intravenous administration and rapid conversion to aprepitant, this agent binds selectively to the human substance P/neurokinin 1 (NK1) receptors in the central nervous system (CNS). This inhibits receptor binding of the endogenous substance P and prevents substance P-induced emesis.

MEGA-9 (Nonanoyl-N-Methylglucamide) solubilizes membrane protein and can be used as a nonionic detergent.

Bio-reagent, fine chemical, carbohydrate; for test strip and diagnostic

Cucumegastigmane I is a natural product of Trichosanthes, Cucurbitaceae. The catalog number is TN5332 and the CAS number is 929881-46-9. Cucumegastigmane I can be used as a reference standard.

Meglutol (3-Hydroxy-3-methylglutaric acid) is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethyl glutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate-limiting enzyme in the biosynthesis of cholesterol.

Adomeglivant, (+)-, is a potent and selective glucagon receptor antagonist. LY2409021 lowers blood glucose in healthy people and in those with type 2 diabetes.

Imeglimin (EMD 387008) is an orally available antidiabetic compound that enhances mitochondrial function, enhances insulin secretion, promotes β-cell proliferation and improves pancreatic β-cell survival in mice.

Pomegralignan is a natural product for research related to life sciences. The catalog number is TN5430 and the CAS number is 1562492-32-3.

Megestrol Acetate-d3 is a deuterated compound of Megestrol Acetate. Megestrol Acetate has a CAS number of 595-33-5. Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties. It is given by mouth in the palliative treatment or as an adjunct to other therapy in endometrial carcinoma and in breast cancer. Megestrol acetate has been approved to treat anorexia and cachexia.

Mega-10 is a useful organic compound for research related to life sciences. The catalog number is TF0074 and the CAS number is 85261-20-7.

Eglumegad (LY354740) hydrochloride is a potent, selective agonist for group II (mGlu2/3) receptors, exhibiting IC50 values of 5 nM for mGlu2 and 24 nM for mGlu3 receptors when transfected into human cells. This compound confers neuroprotection against NMDA-induced toxicity and has demonstrated anxiolytic- and antipsychotic-like properties [1].

Meglumine (Meglumin), a derivative of sorbitol, is used in conjunction with iodinated organic compounds as contrast medium.

Taragarestrant (D-0502) meglumine is a potent, orally active, and selective estrogen receptor degrader (SERD) demonstrating significant efficacy in ER+ breast cancer cell lines and xenograft models [1] [2].

Nomegestrol is a progestin. It is used in the treatment of gynecological disorders, in menopausal hormone therapy for the treatment of menopausal symptoms, and in hormonal contraceptives.

Megastigm-7-ene-3,4,6,9-tetrol is a natural product from Apollonias barbujana.

Adomeglivant (LY2409021) is a potent and selective glucagon receptor antagonist. Which is used in clinical trial for type 2 diabetes mellitus.

Nomegestrol acetate is a widely used progestin-like drug,which is characterized as a full agonist at the progesterone receptor

Megestrol, a progestational hormone, is used most commonly as the acetate ester in the palliative treatment of breast cancer.

Megestrol-d3 is a deuterated compound of Megestrol. Megestrol has a CAS number of 3562-63-8. Megestrol, a progestational hormone, is used most commonly as the acetate ester in the palliative treatment of breast cancer.

Crocetin (Transcrocetin) meglumine, sourced from Crocus sativus L. (saffron), functions as a high-affinity antagonist of the NMDA receptor.

(+/-)- Adomeglivant, also known as LY2409021, is a potent and selective glucagon receptor antagonist. LY2409021 lowers blood glucose in healthy people and in those with type 2 diabetes. Blockade of glucagon signalling in patients with type 2 diabetes is well tolerated and results in substantial reduction of fasting and postprandial glucose with minimal hypoglycaemia, but with reversible increases in aminotransferases. Inhibition of glucagon signalling by LY2409021 is a promising potential treatment for patients with type 2 diabetes and should be evaluated in longer clinical trials to better evaluate benefits and risks.

Timegadine is a competitive inhibitor of COX and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates and in washed rabbit platelets.

(1R,6R,9R)-6,9,11-Trihydroxy-4,7-megastigmadien-3-one 11-O-glucoside is a natural product for research related to life sciences. The catalog number is TN6201 and the CAS number is 289914-68-7.

Delafloxacin meglumine (RX-3341 meglumine) is a broad-spectrum fluoroquinolone antibiotic.

Bemegride (3-Ethyl-3-methylglutarimide), a central nervous system stimulant, serves as an antidote for barbiturate poisoning.

Eglumegad is a highly effective and selective agonist of group II (mGlu2/3) receptor (IC50s: 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively).

Tomeglovir is a potent anti-CMV agent, inhibiting the processing of viral DNA-concatemers (IC50s: 0.34/0.039 μM for HCMV and MCMV).

Demegestone is a progestin, or a synthetic progestogen, and hence is a progesterone receptor agonist, the biological target of progestogens like progesterone. It has no androgenic activity. Previously used to treat luteal insufficiency.

Megestrol-d5 is a deuterated compound of Megestrol. Megestrol has a CAS number of 3562-63-8. Megestrol, a progestational hormone, is used most commonly as the acetate ester in the palliative treatment of breast cancer.

Rimegepant, also known as BMS-927711 and BHV-3000, is a potent, selective, competitive, and orally active calcitonin gene-related peptide (CGRP) antagonist in clinical trials for treating migraines. Rimegepant has shown in vivo efficacy without vasoconstriction effect. BMS-927711 is superior to placebo at several different doses (75 mg, 150 mg, and 300 mg) and has an excellent tolerability profile.

Iodamide Meglumine is a bioactive chemical.

Promegestone is a progestin medication used in menopausal hormone therapy and in the treatment of gynecological disorders.

Pentagastrin meglumine is a synthetic pentapeptide that has effects like gastrin when given parenterally.

Lomeguatrib (PaTrin-2), a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .