neuraminidase

Neuraminidase, Microorganism (Exo-α-sialidase) is a sialidase that catalyzes the hydrolysis of sialic acid, has antigenic properties, and assists in the separation of mature influenza viruses from the host cell to infect new cells.Sodium caseinates is used as a thickening and emulsifying agent in the food industry.

Neuraminidase-IN-5 (Compound 5b), a dihydrofurocoumarin derivative, acts as a potent neuraminidase (NA) inhibitor, exhibiting significant inhibition with an IC 50 of 0.02 μM. Given NA's role in influenza pathogenesis, this compound emerges as a promising candidate for anti-influenza drug development [1].

Neuraminidase-IN-11 (15e) is a selective and potent neuraminidase (NA) inhibitor that acts on the neuraminidase of H1N1 virus (IC50: 4.7 nM), H5N1 virus (IC50: 8.46 nM) and H5N8 virus (IC50: 1.5 nM).

Neuraminidase-IN-4 (Compound 4b) is a potent inhibitor of neuraminidase (EC50: 1.59 μM). Neuraminidase-IN-4 exhibited significant antiviral activity against A/chicken/Hubei/327/2004 (H5N1-DW).

Neuraminidase-IN-10 is a neuraminidase inhibitor that exhibits anti-influenza effects and is able to act on H1N1 (IC50: 2.6 nM), H5N1 (IC50: 5.1 nM) and H5N8 (IC50: 1.65 nM).

Neuraminidase-IN-6 (Compound 5c) is a derivative of 1,3,4-triazole-3-acetamide. Neuraminidase-IN-6 is a potent neuraminidase inhibitor with an IC50 value of 0.11 μM. Neuraminidase (NA) is an ideal target for the anti-influenza drugs development [1].

Neuraminidase-IN-3 (compound 23d) is a potent inhibitor of influenza neuraminidase (NA) and acts on H1N1 (IC50: 0.73 nM), H5N1 (IC50: 0.26 nM) and H5N8 NAs (IC50: 0.63 nM).

Neuraminidase-IN-9 (Compound 6l) is a potent inhibitor of influenza virus neuraminidase, acting on H5N1 (IC50: 0.12 μM), H5N2 (IC50: 0.049 μM) and H5N6 (IC50: 0.16 μM). The H5N6 and H5N5N5 are the most important drugs in the world.

Neuraminidase-IN-1 (Compound Y-1) is a novel neuraminidase inhibitor.

Neuraminidase-IN-13 (Compound 10), a neuraminidase inhibitor exhibiting antiviral activity, demonstrates significant inhibition of NDV infection in Vero cells with minimal cytotoxicity by impeding the release of viral particles from infected cells [1].

NDV-IN-1 is an antiviral agent with high neuraminidase inhibitory activity. NDV-IN-1 exhibits in vitro inhibitory activity against Newcastle disease virus ( NDV ). NDV-IN-1 significantly inhibits NDV infection of Vero cells by preventing the release of virus particles from infected cells [1] .

Neuraminidase-IN-16 (Compound 43b) serves as a potent inhibitor of neuraminidase, demonstrating IC50 values of 0.031, 0.15, 0.25, 0.60, 0.63, and 10.08 μM against the neuraminidase from H5N1, H5N8, H1N1, H3N2, H5N1–H274Y, and H1N1–H274Y strains, respectively [1].

Neuraminidase-IN-8 (Compound 6d) is a powerful inhibitor of neuraminidase, exhibiting a low half-maximal inhibitory concentration (IC50) of 0.027 μM and demonstrating significant anti-influenza activities [1].

Neuraminidase-IN-7 (compound 4b), a thiophene derivative, is a potent inhibitor of neuraminidase (IC50: 0.03 μM). -Neuraminidase-IN-7 has potential for influenza studies.

Oseltamivir (GS 4104) is an orally active and highly potent viral neuraminidase (NA) with antiviral activity, inhibits A/H3N2, A/H1N2, A/H1N1 and influenza B viruses, and can be used in studies of influenza and pneumonia.

Peramivir (BCX1812) is a highly selective influenza A and B neuraminidase inhibitor with antiviral activity and anti-cytokine effects, which can be used in the study of novel coronavirus and influenza virus infections.

X-NeuNAc (5-Bromo-4-chloro-3-indolyl-alpha-D-N-acetylneuraminic acid sodium salt) is a new chromogenic assay substrate of neuraminidase activity in bacterial expression systems.

Zanamivir (GG167) is a guanido-neuraminic acid that is used to inhibit NEURAMINIDASE.

Oseltamivir acid (GS4071) is a potent influenza virus neuraminidase inhibitor and the prodrug of GS4071.

Filixic acid ABA exhibits inhibitory effects on neuraminidase of influenza virus H5N1 with IC50 as 29.57 ± 2.48 μM, it may have anti-influenza virus activity.

Tenaxin I, an extract from Radix Scutellariae, exhibits neuraminidase inhibitory activity [1].

Koaburaside exhibits antioxidant activity with an IC50 value of 9.0μM, it shows weak inhibitory activity against influenza A neuraminidase. Koaburaside may have anti-allergic inflammatory activity, it can suppress histamine release from mast cells.

The binding affinities of ganoderic acid DM and ganoderic acid Z (ΔGbind, -16.83 and-10.99 kcal mol-1) are comparable to that of current commercial drug oseltamivir (-23.62 kcal mol-1);Ganoderic acid DM is a potential source of anti-influenza ingredient, with novel binding pattern and advantage over oseltamivir, it has steric hindrance on the 150 cavity of N1 protein, and exerts activities across the H274Y and N294S mutations, is the attractive candidates of novel neuraminidase (NA) inhibitors.Ganoderic acid zeta has cytotoxicity in vitro against Meth-A and LLC cell lines.

Erythrabyssin II actives against several strains of Staphylococcus and Streptococcus with an MIC range of 0.78-1.56 microg/ml. It inhibits bacterial neuraminidase in a dose-dependent manner with significant inhibition (IC(50)=0.09-3.25 μM).

Ganglioside GM1 asialo is a component of cellular lipid rafts and can be formed by the cleavage of the sialic acid residue from ganglioside GM1 by neuraminidase. Ganglioside GM1 asialo is a glycolipid receptor for P. aeruginosa flagellin and stimulates defensive responses in host cells, including extracellular ATP release, calcium mobilization, and ERK1/2 phosphorylation when stimulated by flagellin and an anti-ganglioside GM1 asialo antibody. The percentage of ganglioside GM1 asialo-positive natural killer (NK) and CD8+ T cells in lung is increased in a mouse model of respiratory syncytial virus (RSV) infection compared with healthy animals. Depletion of ganglioside GM1 asialo-positive NK and T cells reduces IFN-γ levels in the lung, reduces weight loss, and increases lung viral load in RSV-infected mice. Ganglioside GM1 asialo mixture contains ganglioside GM1 asialo molecular species with C18:1 and C20:1 sphingoid backbones.

Zanamivir-13C,15N2is intended for use as an internal standard for the quantification of zanamivir by GC- or LC-MS. Zanamivir is a sialic acid analog that inhibits neuraminidase release of newly replicated influenza virus particles.1It has been shown to selectively inhibit the growth of influenza A and B viruses in plaque reduction assays with IC50values ranging from 5 to 14 nM and to directly inhibit influenza A and B virus neuraminidases with IC50values ranging from 0.6 to 7.9 nMin vitro. Intranasal zanamivir administration at 0.4 mg/kg twice daily reduces mortality and viral titers in lung homogenates of mice infected with influenza. 1.Elliott, M.Zanamivir: From drug design to the clinicPhilos. Trans. R. Soc. Lond. B Biol Sci.356(1416)1885-1893(2001)

Massarilactone H, a polyketide, is a neuraminidase inhibitor, with an IC 50 of 8.18 µM .

Influenza virus-IN-3 (compound 9) is a potent inhibitor of selective influenza viruses, acting on H5N1 (IC50: 0.88 μM), H5N2 (IC50: 0.10 μM), H5N6 (IC50: 5.5 μM), H5N8 (IC50: 0.51 μM). Influenza virus-IN-3 has antiviral and NA (neuraminidase) inhibitory effects and low cytotoxicity (CC50>200 μM).

Neuraminin inhibits viral but not bacterial neuraminidase.

Pimodivir, also known as VX-787, JNJ-872, is a novel inhibitor of influenza virus replication that blocks the PB2 cap-snatching activity of the influenza viral polymerase complex. VX-787 binds the cap-binding domain of the PB2 subunit with a KD (dissociation constant) of 24 nM as determined by isothermal titration calorimetry (ITC). The cell-based EC50 (the concentration of compound that ensures 50% cell viability of an uninfected control) for VX-787 is 1.6 nM in a cytopathic effect (CPE) assay, with a similar EC50 in a viral RNA replication assay. VX-787 is active against a diverse panel of influenza A virus strains, including H1N1pdm09 and H5N1 strains, as well as strains with reduced susceptibility to neuraminidase inhibitors (NAIs).

Laninamivir Octanoate Monohydrate is a neuraminidase inhibitor.

Sanggenol A inhibits influenza A viral and pneumococcal neuraminidase, hence functioning as a dual-acting anti-infective agent.

3,5-O-Dicaffeoylquinic acid (Isochlorogenic Acid A) is an isolated compound from Artemisia argyi; its ester derivatives exert anti-leucyl-tRNA synthetase of Giardia lamblia (GlLeuRS) and potential anti-giardial effects. 3,5-O-Dicaffeoylquinic acid (Isochlorogenic Acid A) as a neuraminidase inhibitory ligand in Flos Lonicerae, it has neuroprotective effects on SH-SY5Y cells and senescence-accelerated-prone mice 8 through the up-regulation of phosphoglycerate kinase-1. 3,5-O-Dicaffeoylquinic acid (Isochlorogenic Acid A) also has antioxidant and anti-complementary activities.

Oseltamivir acid methyl ester is a precursor form of oseltamivir acid, that converts to oseltamivir acid by carboxylesterase 1(CES1). Oseltamivir acid is the neuraminidase inhibitor and antiviral agent [1].

Laninamivir (R 125489) is an effective inhibitor of influenza neuraminidase (NA) (IC50s: 0.90 nM, 1.83 nM, and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively).

Polyaspartic acid, denoted as Asp-Asp-Asp-Asp-Asp-Asp, plays a crucial role in the specificity of catalytic and antigenic sites of influenza virus neuraminidase, which is determined by the presence of specific amino acids.

Asp-Asp-Asp-Asp-Asp-Asp TFA, a polyaspartic acid, influences the specificity of catalytic and antigenic sites in influenza virus neuraminidase through its amino acid composition.

Zanamivir-cholesterol conjugate is an extended-duration neuraminidase inhibitor highly effective against drug-resistant influenza strains.

Laninamivir trifluoroacetate is an antiviral compound that is a drug used for the treatment and prophylaxis of Influenzavirus A and Influenzavirus B. It is a long-acting neuraminidase inhibitor administered by nasal inhalation.

Influenza A virus-IN-4 (compound 23b), a derivative of Oseltamivir, is a highly effective neuraminidase inhibitor. It exerts potent inhibitory effects on influenza viruses [1].

NSC65847 is a novel dual inhibitor of viral and Streptococcus pneumoniae neuraminidase.

Peramivir Trihydrate (RWJ-270201) is a neuraminidase inhibitor (IC50: 0.09 nM) which prevents normal processing of virus particles such that virus particles are not released from infected cells. Peramivir Trihydrate is a cyclopentane derivative with activity against influenza A and B viruses.

Oseltamivir-d3 is a deuterated compound of Oseltamivir. Oseltamivir has a CAS number of 196618-13-0. Oseltamivir (GS 4104) is an orally active and highly potent viral neuraminidase (NA) with antiviral activity, inhibits A/H3N2, A/H1N2, A/H1N1 and influenza B viruses, and can be used in studies of influenza and pneumonia.

Oseltamivir-13C-d3 Acid the 13C and deuterated compound of Oseltamivir Acid. Oseltamivir Acid has a CAS number of 187227-45-8. Oseltamivir acid (GS4071) is a potent influenza virus neuraminidase inhibitor and the prodrug of GS4071.

BCX-1898, a selective cyclopentane-derived, orally active influenza virus neuraminidase inhibitor, exhibits antiviral activity by inhibiting the replication of influenza A (H1N1, H3N2, H5N1) and influenza B viruses in MDCK cells, with EC50 values ranging from <0.01 to 21 μM. It demonstrates protective effects in the mouse influenza model.

Zanamivir hydrate is neuraminidase inhibitors. It is used worldwide for the treatment and prophylaxis of influenza caused by influenza A and B viruses.

Influenza virus-IN-4 (compound 11e) is a potent inhibitor of influenza virus neuraminidase, acting on H5N1 (IC50: 3.4 μM), H5N2 (IC50: 0.094 μM), H5N6 (IC50: 0.79 μM) and H5N8 (IC50: 0.077 μM). Influenza virus-IN-4 inhibits NA (neuraminidase) and has low cytotoxicity (CC50 > 200 μM). influenza virus-IN-4 is not significantly toxic to mice at 1500 mg/kg.

Oseltamivir-acetate, an impurity of Oseltamivir, is a recommended neuraminidase inhibitor for both the treatment and prophylaxis of influenza A and B[1][2].

Laninamivir octanoate (CS-8958) is a long acting influenza neuraminidase (NA) inhibitor which shows superior anti-influenza virus activity.