pro-apoptotic

The compound, tumor-targeted pro-apoptotic peptide (CNGRC-GG-D(KLAKLAK)2), functions as an anti-tumor agent by disrupting mitochondrial membranes to induce apoptosis, demonstrating anticancer efficacy in mice [1].

r8 Bid BH3, a biologically active peptide, is a pro-apoptotic member of the BH3-only subset within the BCL-2 family proteins, pivotal in regulating apoptosis. This compound exhibits lethality towards Bcl-2-expressing human leukemia cell lines, indicating its promise as a potential cancer therapeutic. The peptide is conjugated with poly-D-arginine (denoted by rrrrrrrr), enhancing cellular uptake.

Bid BH3 (80-99) is a biologically active peptide and a pro-apoptotic member of the 'BH3-only' (BOPS) subset within the BCL-2 protein family, crucial in apoptosis regulation. It interacts with Bcl-2, Bax, and Bak to initiate their activation or inactivation, inducing cell death. Bid translocates from the cytosol to the mitochondrial membrane as part of its mechanism. Pyroglutamyl (pGlu) peptides, which can arise from Glutamine (Q) or Glutamic acid (E) at the N-terminus, have a hydrophobic γ-lactam ring that enhances stability and provides resistance to gastrointestinal proteases. These peptides are recognized variants in peptide analyses, including HPLC purity assessments.

Cell-permeable peptide cleaved from protease-activated receptor 1 (PAR1) upon receptor activation. Attenuates endothelial cell migration and proliferation (IC50 ~ 20 μM), and induces cell cycle arrest. Promotes activation of caspase-3 and exhibits pro-apo

Cell-permeable peptide cleaved from protease-activated receptor 1 (PAR1) upon receptor activation. Attenuates endothelial cell migration and proliferation (IC50 ~ 3 μM), and induces cell cycle arrest. Promotes activation of caspase-3 and exhibits pro-apop

Bim BH3, Peptide IV TFA is a 26-site residue of BH3 protein Bim, belonging to the pro-apoptotic group of bcl-2 protein family.

Bim BH3 is a bioactive peptide that belongs to the pro-apoptotic Bcl-2 family of proteins.

Bim BH3, Peptide IV TFA, is a 26-residue peptide derived from the BH3-only protein Bim, a member of the pro-apoptotic Bcl-2 protein family [1] [2].

This Bim peptide belongs to the pro-apoptotic group of the Bcl-2 family of proteins.

PUMA BH3, a peptide that includes the BH3 domain from the p53-upregulated modulator of apoptosis (PUMA) and activates the pro-apoptotic protein Bak, demonstrates binding affinity to Bak with dissociation constants (Kds) of 290 nM in HEPES buffer and 26 nM in CHAPS buffer. This interaction with Bak induces its homo-oligomerization and facilitates Bak-mediated membrane permeabilization.

HKPao (Hunter-killer peptide ao) is a biologically active peptide with dual functionality, exhibiting anti-obesity and anti-tumor pro-apoptotic activities by inducing cytochrome c release from vesicles, thus significantly contributing to cellular apoptosis [1].

BH3 hydrochloride, a peptide that crosses the blood-brain barrier, induces apoptosis either through direct activation of the pro-apoptotic proteins Bax/Bak or by inhibiting anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-XL, Bcl-w, Mcl-1, and A-1) through their BH3 domain [1][2].