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Search Results for " pro-apoptotic "

Targets

52

Compounds

12

Natural Products

34

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T21919 UCF 101 Apoptosis
UCF 101 is a specific inhibitor of HtrA2 and reduces apoptosis in PC12 cells.
T76371 Tumor targeted pro-apoptotic peptide
Tumor targeted pro-apoptotic peptide (CNGRC-GG-D(KLAKLAK)2) is an anti-tumor peptide. Tumor targeted pro-apoptotic peptide disrupts mitochondrial membranes and promotes apoptosis , showing anticancer activity in mice [1]...
T23861 CAY10526 CAY-10526,BTH,CAY 10526 Prostaglandin Receptor
CAY10526 (BTH) is a selective mPGES-1 inhibitor that acts as an inhibitor of the NF-κB signaling pathway.
T12870 SCH79797 dihydrochloride Apoptosis , Others , Protease-activated Receptor
SCH79797 dihydrochloride is an effective and selective antagonist of protease activated receptor 1 (PAR1) with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects.
T77662 DJ4 Apoptosis
DJ4 induces a dose-dependent pro-apoptotic effect in the micromolar range.
T13689 Ethylene dimethanesulfonate Apoptosis
Ethylene dimethanesulfonate has selective pro-apoptotic effects on LCs. Ethylene dimethanesulfonate is a mild alkylating, non-volatile methanesulfonic diester of ethylene glycol. 
T4212 XMU-MP-1 Hippo pathway
XMU-MP-1 is an inhibitor of the pro-apoptotic, sterile 20-like kinases MST1 and 2.
T12644L (S)-Thalidomide (S)-(-)-Thalidomide Apoptosis
(S)-Thalidomide ((S)-(-)-Thalidomide) is the S-isomer of Thalidomide with immunomodulatory, anti-inflammatory, anticancer, anti-angiogenic and pro-apoptotic activities, and is used in the study of leprosy erythema nodosu...
T77571 Bcl-B inhibitor 1 Apoptosis , BCL
Bcl-B inhibitor 1 is a Bcl-B inhibitor with antitumor activity that binds to and inactivates pro-apoptotic proteins in the BH3 structural domain.
T9726 2’-OMe-Guanosine Apoptosis , Nucleoside Antimetabolite/Analog
2'-OMe-Guanosine is a modified nucleoside produced by the action of tRNA guanosine-2'-o-methyltransferase. 2'-OMe-Guanosine has a certain pro-apoptotic effect.
T77332 TV 3279 BCL , PKC
TV 3279 is a novel ChE-MAI inhibitor , and the neuroprotective properties depend on their ability to induce the anti-apoptotic proteins PKC, Bcl-2, Bcl-x, and SOD, and to block the nuclear translocation of the pro-apopto...
T70388 (S)-Enitociclib VIP152 CDK
(S)-Enitociclib (VIP152) is a selective CDK9 inhibitor that induces complete regression of MYC+ lymphomas by inhibiting RNA polymerase II-mediated transcription of anti-apoptotic and pro-survival proteins.
T10827 CK2/ERK8-IN-1 TMCB Apoptosis , ERK , Casein Kinase , Pim , DYRK
CK2/ERK8-IN-1 (TMCB) is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds to PIM1, DYRK1A, and HIPK2 (Kis: 8.65 µM, 11.9 µM, and 15.25...
T31020 CP 461 OSI 461,UNII-68OJX9I7DT,CP-461,CP461 Apoptosis , PDE
CP 461 (UNII-68OJX9I7DT), a specific PDE2A inhibitor, is a novel pro-apoptotic compound that inhibits cyclic GMP phosphodiesterase but not cyclooxygenase-1 or -2. CP 461 inhibits the growth of a variety of human tumor ce...
T10706 CCI-006 Mitochondrial Metabolism
CCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells. It inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein r...
T2129 Zaprinast PDE
Zaprinast is a cGMP-selective phosphodiesterase (PDE) inhibitor and a GPR35 agonist. It has a strong activating effect on rat GPR35 and a certain activating effect on human GPR35. It reduces vascular remodeling through a...
T21911 Rilmenidine hemifumarate Rilmenidine (hemifumarate),S-3341 hemifumarate Apoptosis , Imidazoline Receptor
Rilmenidine hemifumarate (S-3341 hemifumarate) is a novel, orally active and selective I1 imidazoline receptor and α2-adrenoceptor agonist that induces autophagy, regulates the proliferation of leukaemia cells, stimulate...
T60202 MMRi62 7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol Ferroptosis
MMRi62 (7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol), a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity aga...
T36013 Lysophosphatidylcholines ​Lyso-Lecithins (egg)
Lysophosphatidylcholines are produced by hydrolysis of the fatty acid of phosphatidylcholine at either the sn-1 or sn-2 position by phospholipase A2 (PLA2) or by lecithin-cholesterol acyltranferase (LCAT), which transfer...
T34335 RM-133 RM133
RM-133 is a promising pro-apoptotic agent which shows activity on various cancer cell lines.
TP1611 Bim BH3, Peptide IV
This Bim peptide belongs to the pro-apoptotic group of the Bcl-2 family of proteins.
T36901 Pelcitoclax
Pelcitoclax (APG-1252) is a powerful inhibitor of the Bcl-2 and Bcl-xl proteins, displaying significant antineoplastic and pro-apoptotic properties[1].
T26789 BH3I-2' BH3I2',BH3I 2'
BH3I-2' is a cell-permeable BH3 mimetic. BH3I-2' induces apoptosis by specifically preventing BH3 domain-mediated interactions between pro-apoptotic and anti-apoptotic members of the Bcl-2 family, thereby blocking the in...
T72906 [D-Leu-4]-OB3
-OB3 inhibits expressions of pro-inflammatory, proliferative and metastatic genes and PD-L1 expression. -OB3 stimulates expression of pro-apoptotic genes .
T29060 UNBS-1450 UNBS 1450,UBS1450,UBS-1450,UBS 1450
UNBS-1450 is a sodium channel antagonist. UNBS-1450 is a hemi-synthetic cardenolide derived from 2″-oxovorusharin, it is effective against various cancer cell types with an excellent differential toxicity. At low nanomol...
T80038 Bim BH3
Bim BH3 is a bioactive peptide that belongs to the pro-apoptotic Bcl-2 family of proteins.
TP1718 Bim BH3, Peptide IV TFA (721885-31-0 free base) Bim BH3, Peptide IV TFA
Bim BH3, Peptide IV TFA is a 26-site residue of BH3 protein Bim, belonging to the pro-apoptotic group of bcl-2 protein family.
T68027 (Z/E)-cp-461 free base
CP-461 is an orally bioavailable second-generation selective apoptotic antineoplastic drug (SAAND) and analog of the nonsteroidal anti-inflammatory drug (NSAID) sulindac, with potential pro-apoptotic and antineoplastic a...
T35270 YO-Pro 1 YO-Pro1,YO-Pro-1
YO-Pro 1, a cyanine dye consisting of benzoxazole and quinoline rings connected by a linker, is almost nonfluorescent in water, but its fluorescence is greatly enhanced after intercalation in double-stranded DNA, forming...
T11534L Haemanthamine hydrochloride (466-75-1 free base) Haemanthamine hydrochloride Others
Haemanthamine hydrochloride is an alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. It inhibits protein biosynthesis during the elongation stage of translation. It has antimalarial, pro-ap...
T76073 BH3 hydrochloride
BH3 hydrochloride, a BBB penetrated peptide, provoke apoptosis either by direct activation of pro-apoptotic Bax/Bak or by neutralizing anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-XL , Bcl-w , Mcl-1 and A-1) via their BH3 d...
T69296 PHA-680626
PHA-680626 is a potent and selective PLK inhibitor. PHA-680626 exhibits anti-proliferative and pro-apoptotic activity on Imatinib-resistant chronic myeloid leukemia cell lines and primary CD34+ cells by inhibition of bot...
T76030 Bim BH3, Peptide IV TFA
Bim BH3, Peptide IV TFA is a 26-residue peptide from BH3-only protein Bim , which belongs to the pro-apoptotic group of the Bcl-2 family of proteins [1] [2] .
T71301 Opaganib HCl
ABC294640, also known as Opaganib, is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon administration, ABC294640 competitivel...
T76315 HKPao
HKPao (Hunter-killer peptide ao) is a biologically active peptide . HKPao (Hunter-killer peptide ao) has anti-obesity and anti-tumor pro-apoptotic activity to cause release of cytochrome c from vesicles [1] .
T70008 Bomedemstat ditosylate
Bomedemstat, also known as IMG-7289, is a lysine-specific histone demethylase 1 (LSD1) inhibitor with antineoplastic activity. Bomedemstat may be useful in the treatment of acute myeloid leukaemia, myelodysplastic syndro...
T63757 Bcl-2-IN-9
Bcl-2-IN-9 is a novel, pro-apoptotic, low cytotoxic Bcl-2 inhibitor (IC50: 2.9 μM). Bcl-2-IN-9 downregulates Bcl-2 expression, induces apoptosis in cancer cells, and exhibits high selectivity for leukemia cells.
TP1965 Parstatin(human) Parstatin (human)
Cell-permeable peptide cleaved from protease-activated receptor 1 (PAR1) upon receptor activation. Attenuates endothelial cell migration and proliferation (IC50 ~ 3 μM), and induces cell cycle arrest. Promotes activation...
TP1966 Parstatin(mouse) Parstatin (mouse)
Cell-permeable peptide cleaved from protease-activated receptor 1 (PAR1) upon receptor activation. Attenuates endothelial cell migration and proliferation (IC50 ~ 20 μM), and induces cell cycle arrest. Promotes activatio...
T28874 SU11652 SU-11652,SU 11652
SU11652 is a potent cell-permeable pyrrole-indolinone compound. SU11652 acts as an ATP-competitive tyrosine kinase receptor and angiogenic inhibitor with greater selectivity for PDGFR-β (PDGFRβ, IC50 = 3 nM), Flk-1 (VEGF...
T38042 Resolvin D4 Resolvin D4,RvD4
Resolvin D4 (RvD4) is a specialized pro-resolving mediator derived from docosahexaenoic acid . [1] It has been detected in human milk, in the dorsal pouch of mice before and after infection with S. aureus, and in untreat...
T72570 Antitumor agent-83
Antitumor agent-83 is an activator of pro-apoptotic protein BAX and has significant anti-proliferation effect on tumor cells. Antiumor agent-83 mediates cell Apoptosis by inducing the conformational activation of BAX and...
T37166 RCTR1
Resolvin conjugate in tissue regeneration 1 (RCTR1) is a specialized pro-resolving mediator (SPM) biosynthesized from docosahexaenoic acid by isolated human macrophages and apoptotic polymorphonuclear (PMN) neutrophils.1...
T37379 Protectin D1
Protectin D1 is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid . DHA is oxidized to 16S,17S-epoxy-protectin, which is converted to protectin D1 enzymatically. Protectin D1 increases phag...
T68656 Brivudine monophosphate
Brivudine monophosphate is a phosphate ester of Brivudine. Brivudine, also known as bromovinyl-deoxyuridine, is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. In vitro, bro...
T83751 PUMA BH3 (human) TFA
PUMA BH3, a peptide that includes the BH3 domain from the p53-upregulated modulator of apoptosis (PUMA) and activates the pro-apoptotic protein Bak, demonstrates binding affinity to Bak with dissociation constants (Kds) ...
T38043 Resolvin E4
Resolvin E4 (RvE4) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acid by 15-lipoxygenase (15-LO)via15(S)-HpEPE and 15S-hydroxy, 5S-HpEPE inte...
T79919 S-Adenosyl-L-methionine (1,4-butanedisulfonate) Ademetionine (1,4-butanedisulfonate),S-Adenosyl methionine (1,4-butanedisulfonate),AdoMet (1,4-butanedisulfonate) Endogenous Metabolite
S-Adenosyl-L-methionine (SAMe) 1,4-butanedisulfonate functions as an orally active methyl group donor and serves as a dietary supplement known for its significant antidepressant properties. Additionally, it plays anti-pr...
T80226 R8 Bid BH3
r8 Bid BH3, a biologically active peptide, is a pro-apoptotic member of the "BH3-only" subset within the BCL-2 family proteins, pivotal in regulating apoptosis. This compound exhibits lethality towards Bcl-2-expressing h...
T64158 Nenocorilant
Nenocorilant (Relacorilant) is an orally active glucocorticoid receptor (GR) antagonist (Ki: 0.15 nM). Nenocorilant can be used to study tumours.

Compounds

UCF 101
T21919
Synonym:
Target: Apoptosis
Tumor targeted pro-apoptotic peptide
T76371
Synonym:
Target:
CAY10526
T23861
Synonym: CAY-10526,BTH,CAY 10526
Target: Prostaglandin Receptor
SCH79797 dihydrochloride
T12870
Synonym:
Target: Apoptosis, Others, Protease-activated Receptor
DJ4
T77662
Synonym:
Target: Apoptosis
Ethylene dimethanesulfonate
T13689
Synonym:
Target: Apoptosis
XMU-MP-1
T4212
Synonym:
Target: Hippo pathway
(S)-Thalidomide
T12644L
Synonym: (S)-(-)-Thalidomide
Target: Apoptosis
Bcl-B inhibitor 1
T77571
Synonym:
Target: Apoptosis, BCL
2’-OMe-Guanosine
T9726
Synonym:
Target: Apoptosis, Nucleoside Antimetabolite/Analog
TV 3279
T77332
Synonym:
Target: BCL, PKC
(S)-Enitociclib
T70388
Synonym: VIP152
Target: CDK
CK2/ERK8-IN-1
T10827
Synonym: TMCB
Target: Apoptosis, ERK, Casein Kinase, Pim, DYRK
CP 461
T31020
Synonym: OSI 461,UNII-68OJX9I7DT,CP-461,CP461
Target: Apoptosis, PDE
CCI-006
T10706
Synonym:
Target: Mitochondrial Metabolism
Zaprinast
T2129
Synonym:
Target: PDE
Rilmenidine hemifumarate
T21911
Synonym: Rilmenidine (hemifumarate),S-3341 hemifumarate
Target: Apoptosis, Imidazoline Receptor
MMRi62
T60202
Synonym: 7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol
Target: Ferroptosis
Lysophosphatidylcholines
T36013
Synonym: ​Lyso-Lecithins (egg)
Target:
RM-133
T34335
Synonym: RM133
Target:
Bim BH3, Peptide IV
TP1611
Synonym:
Target:
Pelcitoclax
T36901
Synonym:
Target:
BH3I-2'
T26789
Synonym: BH3I2',BH3I 2'
Target:
[D-Leu-4]-OB3
T72906
Synonym:
Target:
UNBS-1450
T29060
Synonym: UNBS 1450,UBS1450,UBS-1450,UBS 1450
Target:
Bim BH3
T80038
Synonym:
Target:
Bim BH3, Peptide IV TFA (721885-31-0 free base)
TP1718
Synonym: Bim BH3, Peptide IV TFA
Target:
(Z/E)-cp-461 free base
T68027
Synonym:
Target:
YO-Pro 1
T35270
Synonym: YO-Pro1,YO-Pro-1
Target:
Haemanthamine hydrochloride (466-75-1 free base)
T11534L
Synonym: Haemanthamine hydrochloride
Target: Others
BH3 hydrochloride
T76073
Synonym:
Target:
PHA-680626
T69296
Synonym:
Target:
Bim BH3, Peptide IV TFA
T76030
Synonym:
Target:
Opaganib HCl
T71301
Synonym:
Target:
HKPao
T76315
Synonym:
Target:
Bomedemstat ditosylate
T70008
Synonym:
Target:
Bcl-2-IN-9
T63757
Synonym:
Target:
Parstatin(human)
TP1965
Synonym: Parstatin (human)
Target:
Parstatin(mouse)
TP1966
Synonym: Parstatin (mouse)
Target:
SU11652
T28874
Synonym: SU-11652,SU 11652
Target:
Resolvin D4
T38042
Synonym: Resolvin D4,RvD4
Target:
Antitumor agent-83
T72570
Synonym:
Target:
RCTR1
T37166
Synonym:
Target:
Protectin D1
T37379
Synonym:
Target:
Brivudine monophosphate
T68656
Synonym:
Target:
PUMA BH3 (human) TFA
T83751
Synonym:
Target:
Resolvin E4
T38043
Synonym:
Target:
S-Adenosyl-L-methionine (1,4-butanedisulfonate)
T79919
Synonym: Ademetionine (1,4-butanedisulfonate),S-Adenosyl methionine (1,4-butanedisulfonate),AdoMet (1,4-butanedisulfonate)
Target: Endogenous Metabolite
r8 Bid BH3
T80226
Synonym:
Target:
Nenocorilant
T64158
Synonym:
Target:
1 2
Cat No. Product Name Synonyms Targets
T8193 α-Thujone Thujone,ALPHA-(-)-THUJONE Apoptosis , Reactive Oxygen Species , GABA Receptor , AChR , Parasite , Autophagy
α-Thujone is an inhibitor of ACh with an IC50 value of 24.7μM.
T13903 Stearoylethanolamide N-(2-Hydroxyethyl)octadecanamide Apoptosis
Stearoylethanolamide(N-(2-Hydroxyethyl)octadecanamide) is a cannabinoid compound present in the brains of humans, rats, and mice with pro-apoptotic activity.
T3395 Timosaponin AIII Filiferin B,AneMarsaponin A3,Timosaponin A3 AChE , mTOR
Timosaponin AIII (Timosaponin A3) induces autophagy in HeLa cells followed by apoptotic cell death (IC50: 10 μM). The Timosaponin AIII cellular response is mediated via inhibition of mTORC1 and induction of ER stress (IC...
T5679 (E)-Ferulic acid trans-Ferulic acid,(E)-Coniferic acid BCL , Ferroptosis , Wnt/beta-catenin , Endogenous Metabolite
(E)-Ferulic acid ((E)-Coniferic acid) causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pr...
T36715 Tetrac Tetraiodothyroacetic acid,3,3',5,5'-Tetraiodothyroacetic acid Apoptosis , EGFR
Tetrac (Tetraiodothyroacetic acid) is a derivative of L-thyroxine (T4), a thyroxine integrin receptor antagonist.Tetrac induces antiproliferation by blocking EGFR-mediated cell signaling in colorectal cancer cells.Tetrac...
TCS2170 2,5-Dihydroxyacetophenone Quinacetophenone,2-Acetylhydroquinone,2-5-dihydroxyacetophenone,Acetylhydroquinone,DHAP ERK , NF-κB , Tyrosinase
1. 2,5-Dihydroxyacetophenone (Quinacetophenone) possess anti-anxiety, and neuroprotective qualities. 2. 2,5-Dihydroxyacetophenone (Quinacetophenone) reatment can induce a sustained activation of JNK, ERK1/2, and p38 MAPK...
T13864 Resolvin D1 RvD1 Others
Resolvin D1 is an endogenous pro-resolving mediator of inflammation, blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagoc...
T11534 Haemanthamine Others
Haemanthamine is an alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. It inhibits protein biosynthesis during the elongation stage of translation. It has antimalarial, pro-apoptotic, antiv...
TMA1743 Ergosterol peroxide ERK , VEGFR , p38 MAPK , Wnt/beta-catenin , Akt , JAK , CDK , JNK , STAT , Antifection
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Foxo3a activity by inhibiting pAKT and c-Myc and activating pr...
TN1543 Cynaropicrin IL Receptor , Others , TNF
Cynaropicrin is a potent activator of the AhR-Nrf2-Nqo1 pathway, and could therefore be applied to prevention of UVB-induced photo aging; it may be a potential anticancer agent against some leukocyte cancer cells such as...
T73813 Haemanthamine hydrochloride
Haemanthamine hydrochloride is a crinine-type alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. Haemanthamine hydrochloride targets ribosomal that inhibits protein biosynthesis during the ...
TMA0918 Neochamaejasmine A Caspase
Neochamaejasmin A can inhibit cellular (3)H-thymidine incorporation (IC 50 12.5 microg/mL) and subsequent proliferation of human prostate cancer LNCaP cells, it blocks cell cycle progression at the G1 phase by activating...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-02700 BCL2 Protein, Human, Recombinant (His) Human E. coli
BCL2 (B-cell leukemia/lymphoma 2, N-Histidine-tagged), also known as Bcl-2, belongs to the Bcl-2 family. Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein family a...
TMPY-04572 MKK4 Protein, Mouse, Recombinant (His & GST) Mouse Baculovirus-Insect Cells
Dual specificity mitogen-activated protein kinase kinase 4, also known as MAP kinase kinase 4, MAPKK4, JNK-activating kinase 1, MAPK/ERK kinase 4, SAPK/ERK kinase 1, c-Jun N-terminal kinase kinase 1, JNKK, and MAP2K4, is...
TMPY-01356 S100A8 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
S100A8 is a member of the S100 protein family containing 2EF-hand calcium-binding motifs. S100 proteins are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation....
TMPY-00731 Cathepsin B Protein, Human, Recombinant (His) Human HEK293
Cathepsin B is a papain-family cysteine protease that is normally located in lysosomes, where it is involved in the turnover of proteins and plays various roles in maintaining the normal metabolism of cells. This proteas...
TMPY-00834 IGF1R/CD221 Protein, Human, Recombinant (His) Human HEK293
The insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase involved in several biological processes including cell proliferation, differentiation, DNA repair, and cell survival. This a disulfide...
TMPK-00533 TYRO3 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
The TAM receptors (Tyro3, Axl and MerTK) are promising therapeutic targets on tumor-associated macrophages. The TAM receptors are a family of receptor tyrosine kinases with shared ligands Gas6 and Protein S that skew mac...
TMPK-00901 TYRO3 Protein, Mouse, Recombinant (His) Mouse HEK293
The TAM receptors (Tyro3, Axl and MerTK) are promising therapeutic targets on tumor-associated macrophages. The TAM receptors are a family of receptor tyrosine kinases with shared ligands Gas6 and Protein S that skew mac...
TMPY-01561 PIG3 Protein, Human, Recombinant (His) Human E. coli
Nutlin-3 variably induces apoptosis and cell cycle arrest in cancer cells while it shows low/absent cytotoxicity in normal cells, Nutlin-3 is a promising anti-cancer agent, which exhibits activity against a variety of ca...
TMPY-03974 Bim Protein, Human, Recombinant (His) Human E. coli
BCL2L11, also known as Bim, belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. ...
TMPH-00958 AHR Protein, Human, Recombinant (His) Human E. coli
Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood...
TMPH-00495 Lutropin subunit beta Protein, Canine, Recombinant (His) Canine E. coli
Prevents premature death of the host cell during virus production, which would otherwise reduce the amount of progeny virus. Acts as a host B-cell leukemia/lymphoma 2 (Bcl-2) homolog, and interacts with pro-apoptotic pro...
TMPJ-00584 Bc1-w Protein, Human, Recombinant (His) Human E. coli
Bcl-2-like protein 2 (BCL2L2) belongs to the Bcl-2 family. BCL2L2 is highly expressed in thebrain, spinal cord, testis, pancreas, heart, spleen, and mammary glands. BCL2L2 is a peripheral membrane protein containing thre...
TMPY-03434 BMF Protein, Human, Recombinant (His) Human E. coli
BMF(Bcl2 modifying factor) belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BMF...
TMPJ-01066 CYCS Protein, Human, Recombinant (His) Human E. coli
Cytochrome C (CYCS) is a small heme protein that belongs to the cytochrome c family. It is found loosely associated with the inner membrane of the mitochondrion. Cytochrome C is a highly soluble protein that functions as...
TMPY-02578 DKKL1 Protein, Human, Recombinant (hFc) Human HEK293
Dickkopf-like 1 (DKKL1) or soggy 1, is a glycoprotein unique to mammals that is expressed primarily in developing spermatocytes and localized in the acrosome of mature sperm. It is also expressed in the trophectoderm / p...
TMPH-03026 CARDS Protein, Mycoplasma pneumoniae, Recombinant (His & Myc) Mycoplasma pneumoniae E. coli
Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy. Increases cell motility and invasiveness by interacting with non-m...
TMPY-02065 BID Protein, Mouse, Recombinant (His & GST) Mouse E. coli
The BH3 interacting domain death agonist (BID) is a pro-apoptotic member of the Bcl-2 protein family, which contains only the BH3 domain, and is required for its interaction with the Bcl-2 family proteins and for its pro...
TMPH-00904 Adenylate kinase 7 Protein, Human, Recombinant (His) Human Baculovirus
Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-...
TMPY-02027 BID Protein, Human, Recombinant Human E. coli
The BH3 interacting domain death agonist (BID) is a pro-apoptotic member of the Bcl-2 protein family, which contains only the BH3 domain, and is required for its interaction with the Bcl-2 family proteins and for its pro...
TMPY-04930 Notch 2 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
NOTCH2 (Notch Receptor 2) is a Protein Coding gene. This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics and play a role in a variety of dev...
TMPY-04109 Galectin-7 Protein, Human, Recombinant (His) Human E. coli
LGALS7, also known as Galectin-7, is a member of the galectins family. The galectins are a family of beta-galactoside-binding proteins. There are at least 14 identified members of this family. Galectins share similaritie...
TMPH-01478 HIST1H2AG Protein, Human, Recombinant (His) Human E. coli
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25...
TMPY-02774 Galectin-7 Protein, Human, Recombinant (GST) Human E. coli
LGALS7, also known as Galectin-7, is a member of the galectins family. The galectins are a family of beta-galactoside-binding proteins. There are at least 14 identified members of this family. Galectins share similaritie...
TMPH-01621 BRCC3 Protein, Human, Recombinant (His & SUMO) Human E. coli
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through...
TMPH-02315 XRCC5 Protein, Human, Recombinant (His & Myc) Human E. coli
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negativel...
TMPY-04455 PKC iota Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
Protein kinase C iota type, also known as Atypical protein kinase C-lambda/iota, aPKC-lambda/iota and PRKCI, is a cytoplasm, membrane and nucleus protein which belongs to the protein kinase superfamily, AGC Ser/Thr prote...
TMPY-03556 S100A8 Protein, Mouse, Recombinant (His) Mouse E. coli
S100A8 is a member of the S100 protein family containing 2EF-hand calcium-binding motifs. S100 proteins are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation....
TMPY-04503 Cathepsin B Protein, Rat, Recombinant (His) Rat HEK293
Cathepsin B is a papain-family cysteine protease that is normally located in lysosomes, where it is involved in the turnover of proteins and plays various roles in maintaining the normal metabolism of cells. This proteas...
TMPH-00786 BtuD Protein, Halobacterium salinarum, Recombinant (His) Halobacterium salinarum E. coli
Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad spe...
TMPY-02144 Cathepsin B Protein, Mouse, Recombinant (His) Mouse HEK293
Cathepsin B is a papain-family cysteine protease that is normally located in lysosomes, where it is involved in the turnover of proteins and plays various roles in maintaining the normal metabolism of cells. This proteas...
TMPY-04360 IGF1R/CD221 Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
The insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase involved in several biological processes including cell proliferation, differentiation, DNA repair, and cell survival. This a disulfide...
TMPH-02588 COL12A1 Protein, Mouse, Recombinant (His) Mouse E. coli
Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways. Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold fun...
TMPY-06195 IGF1R/CD221 Protein, Mouse, Recombinant (His) Mouse HEK293
The insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase involved in several biological processes including cell proliferation, differentiation, DNA repair, and cell survival. This a disulfide...
TMPY-06905 IGF1R/CD221 Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293
The insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase involved in several biological processes including cell proliferation, differentiation, DNA repair, and cell survival. This a disulfide...
BCL2 Protein, Human, Recombinant (His)
TMPY-02700
Species: Human
Expression System: E. coli
MKK4 Protein, Mouse, Recombinant (His & GST)
TMPY-04572
Species: Mouse
Expression System: Baculovirus-Insect Cells
S100A8 Protein, Human, Recombinant (His)
TMPY-01356
Species: Human
Expression System: Baculovirus-Insect Cells
Cathepsin B Protein, Human, Recombinant (His)
TMPY-00731
Species: Human
Expression System: HEK293
IGF1R/CD221 Protein, Human, Recombinant (His)
TMPY-00834
Species: Human
Expression System: HEK293
TYRO3 Protein, Cynomolgus, Recombinant (His)
TMPK-00533
Species: Cynomolgus
Expression System: HEK293
TYRO3 Protein, Mouse, Recombinant (His)
TMPK-00901
Species: Mouse
Expression System: HEK293
PIG3 Protein, Human, Recombinant (His)
TMPY-01561
Species: Human
Expression System: E. coli
Bim Protein, Human, Recombinant (His)
TMPY-03974
Species: Human
Expression System: E. coli
AHR Protein, Human, Recombinant (His)
TMPH-00958
Species: Human
Expression System: E. coli
Lutropin subunit beta Protein, Canine, Recombinant (His)
TMPH-00495
Species: Canine
Expression System: E. coli
Bc1-w Protein, Human, Recombinant (His)
TMPJ-00584
Species: Human
Expression System: E. coli
BMF Protein, Human, Recombinant (His)
TMPY-03434
Species: Human
Expression System: E. coli
CYCS Protein, Human, Recombinant (His)
TMPJ-01066
Species: Human
Expression System: E. coli
DKKL1 Protein, Human, Recombinant (hFc)
TMPY-02578
Species: Human
Expression System: HEK293
CARDS Protein, Mycoplasma pneumoniae, Recombinant (His & Myc)
TMPH-03026
Species: Mycoplasma pneumoniae
Expression System: E. coli
BID Protein, Mouse, Recombinant (His & GST)
TMPY-02065
Species: Mouse
Expression System: E. coli
Adenylate kinase 7 Protein, Human, Recombinant (His)
TMPH-00904
Species: Human
Expression System: Baculovirus
BID Protein, Human, Recombinant
TMPY-02027
Species: Human
Expression System: E. coli
Notch 2 Protein, Human, Recombinant (His)
TMPY-04930
Species: Human
Expression System: Baculovirus-Insect Cells
Galectin-7 Protein, Human, Recombinant (His)
TMPY-04109
Species: Human
Expression System: E. coli
HIST1H2AG Protein, Human, Recombinant (His)
TMPH-01478
Species: Human
Expression System: E. coli
Galectin-7 Protein, Human, Recombinant (GST)
TMPY-02774
Species: Human
Expression System: E. coli
BRCC3 Protein, Human, Recombinant (His & SUMO)
TMPH-01621
Species: Human
Expression System: E. coli
XRCC5 Protein, Human, Recombinant (His & Myc)
TMPH-02315
Species: Human
Expression System: E. coli
PKC iota Protein, Human, Recombinant (GST)
TMPY-04455
Species: Human
Expression System: Baculovirus-Insect Cells
S100A8 Protein, Mouse, Recombinant (His)
TMPY-03556
Species: Mouse
Expression System: E. coli
Cathepsin B Protein, Rat, Recombinant (His)
TMPY-04503
Species: Rat
Expression System: HEK293
BtuD Protein, Halobacterium salinarum, Recombinant (His)
TMPH-00786
Species: Halobacterium salinarum
Expression System: E. coli
Cathepsin B Protein, Mouse, Recombinant (His)
TMPY-02144
Species: Mouse
Expression System: HEK293
IGF1R/CD221 Protein, Human, Recombinant (His & GST)
TMPY-04360
Species: Human
Expression System: Baculovirus-Insect Cells
COL12A1 Protein, Mouse, Recombinant (His)
TMPH-02588
Species: Mouse
Expression System: E. coli
IGF1R/CD221 Protein, Mouse, Recombinant (His)
TMPY-06195
Species: Mouse
Expression System: HEK293
IGF1R/CD221 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPY-06905
Species: Human
Expression System: HEK293
Cat No. Product Name
L9000 Apoptosis Compound Library

1796 compounds
A unique collection of 1796 apoptosis-related compounds for apoptosis research, research in tumorigenesis, and anti-cancer drug screening;
TargetMol