Cysteine Protease

Cysteine proteases, also known as thiol proteases, are enzymes that degrade proteins. These proteases share a common catalytic mechanism that involves a nucleophilic cysteine thiol in a catalytic triad or dyad.

Cat. No.	Product name	CAS No.	Purity
T11554	Cathepsin Inhibitor 2	1017931-53-1	98%
Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor (Ki: <20 nM).
T13439	(RS)-Butyryltimolol	2320274-78-8	98%
(RS)-Butyryltimolol is the racemate of Butyryltimolol. Butyryltimolol is an effective prodrug of Timolol that improves the corneal penetration of Timolol [1]. Bu...
T12819	S130	1160852-22-1	98%
S130 is a high affinity, selectiveATG4B (a major cysteine protease) inhibitor (IC50 of 3.24 µM).It suppresses autophagy flux.
T11846	LHVS	170111-28-1	98%
LHVS effectively blocks T. gondii microneme protein secretion (IC50=10 μM), gliding motility, and cell invasion. LHVS is a potent, non-selective cysteine proteas...
T16106	ML224	1338824-21-7	98%
ML224 is a selective TSHR inverse agonist. ML224 also inhibits TSH-stimulated cAMP production (IC50 = 2.3 μM).
T16394	ONO-5334	868273-90-9	98%
ONO-5334 is an effective and selective cathepsin K inhibitor (Ki: 0.10 nM, 0.049 nM, and 0.85 nM for human, rabbit, and rat cathepsin K, respectively). ONO-5334 ...
T10924	Cysteine protease inhibitor-2	612048-23-4	98%
Cysteine protease inhibitor 2 is a cysteine protease inhibitor extracted from patent US20070032499A1, compound 12. Cysteine protease inhibitor 2 inhibited DCT116...
T16474	Petesicatib	1252637-35-6	98%
Petesicatib is an inhibitor of cathepsin S. Petesicatib used in the research of immune diseases.
T13705	GLPG2451	2055015-61-5	98%
GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. It effectively potentiates low temperature rescued F508del CFTR (EC50: 11.1...
T12051	MIV-247	1352817-76-5	98%
MIV-247 is a selective inhibitor of cathepsin S (human, mouse and cynomolgus monkey cathepsin S with Kis of 2.1, 4.2 and 7.5 nM , respectively).
T11896	LV-320	2449093-46-1	98%
LV-320 is a potent and uncompetitive ATG4B inhibitor with an IC 50 of 24.5 μM and a K d of 16 μM. LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flu...
T37753	Aureusimine B	170713-71-0	98%
Aureusimine B, also known as phevalin, is a natural pyrazinone produced by certain fungi and by Staphylococcus spp., including S. aureus. Its synthesis appears t...
T13288	VBY-825	1310340-58-9	98%
VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.
T19503	Papain	9001-73-4	98%
Papain is a cysteine protease of the peptidase C1 family. Papain is used in food, pharmaceutical, textile, and cosmetic industries.
T2470	MDL-28170	88191-84-8	98%
Calpain Inhibitor III is a Cysteine protease.
T1080	2-Aminoethanethiol	60-23-1	98%
Cysteamine is a Cystine Depleting Agent. The mechanism of action of cysteamine is as a Cystine Disulfide Reduction.
TP2056L	Acetyl-Calpastatin (184-210)(human) acetate		98%
Acetyl-Calpastatin (184-210)(human) acetate is a potent, selective and reversible calpain inhibitor with Ki values of 0.2 nM and 6 μM for µ-calpain and cathepsin...
T7451	2-Cyanopyrimidine	14080-23-0	98%
2-cyano-Pyrimidine is inhibitor of cathepsin K(IC50 : 170 nM)
T3088	N-Ethylmaleimide	128-53-0	98%
N-ethylmaleimide is a sulfhydryl reagent that is widely used in experimental biochemical studies.
T2493	PD 151746	179461-52-0	98%
PD151746 is a calpain inhibitor with a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM). Its IC50 values are 0.26 ± 0...

Cat. No.

Product name

CAS No.

Purity

Chemical Structure

T11554

Cathepsin Inhibitor 2

1017931-53-1

98%

Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor (Ki: <20 nM).

T13439

(RS)-Butyryltimolol

2320274-78-8

98%

(RS)-Butyryltimolol is the racemate of Butyryltimolol. Butyryltimolol is an effective prodrug of Timolol that improves the corneal penetration of Timolol [1]. Bu...

T12819

S130

1160852-22-1

98%

S130 is a high affinity, selectiveATG4B (a major cysteine protease) inhibitor (IC50 of 3.24 µM).It suppresses autophagy flux.

T11846

LHVS

170111-28-1

98%

LHVS effectively blocks T. gondii microneme protein secretion (IC50=10 μM), gliding motility, and cell invasion. LHVS is a potent, non-selective cysteine proteas...

T16106

ML224

1338824-21-7

98%

ML224 is a selective TSHR inverse agonist. ML224 also inhibits TSH-stimulated cAMP production (IC50 = 2.3 μM).

T16394

ONO-5334

868273-90-9

98%

ONO-5334 is an effective and selective cathepsin K inhibitor (Ki: 0.10 nM, 0.049 nM, and 0.85 nM for human, rabbit, and rat cathepsin K, respectively). ONO-5334 ...

T10924

Cysteine protease inhibitor-2

612048-23-4

98%

Cysteine protease inhibitor 2 is a cysteine protease inhibitor extracted from patent US20070032499A1, compound 12. Cysteine protease inhibitor 2 inhibited DCT116...

T16474

Petesicatib

1252637-35-6

98%

Petesicatib is an inhibitor of cathepsin S. Petesicatib used in the research of immune diseases.

T13705

GLPG2451

2055015-61-5

98%

GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. It effectively potentiates low temperature rescued F508del CFTR (EC50: 11.1...

T12051

MIV-247

1352817-76-5

98%

MIV-247 is a selective inhibitor of cathepsin S (human, mouse and cynomolgus monkey cathepsin S with Kis of 2.1, 4.2 and 7.5 nM , respectively).

T11896

LV-320

2449093-46-1

98%

LV-320 is a potent and uncompetitive ATG4B inhibitor with an IC 50 of 24.5 μM and a K d of 16 μM. LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flu...

T37753

Aureusimine B

170713-71-0

98%

Aureusimine B, also known as phevalin, is a natural pyrazinone produced by certain fungi and by Staphylococcus spp., including S. aureus. Its synthesis appears t...

T13288

VBY-825

1310340-58-9

98%

VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.

T19503

Papain

9001-73-4

98%

Papain is a cysteine protease of the peptidase C1 family. Papain is used in food, pharmaceutical, textile, and cosmetic industries.

T2470

MDL-28170

88191-84-8

98%

Calpain Inhibitor III is a Cysteine protease.

T1080

2-Aminoethanethiol

60-23-1

98%

Cysteamine is a Cystine Depleting Agent. The mechanism of action of cysteamine is as a Cystine Disulfide Reduction.

TP2056L

Acetyl-Calpastatin (184-210)(human) acetate

98%

Acetyl-Calpastatin (184-210)(human) acetate is a potent, selective and reversible calpain inhibitor with Ki values of 0.2 nM and 6 μM for µ-calpain and cathepsin...

T7451

2-Cyanopyrimidine

14080-23-0

98%

2-cyano-Pyrimidine is inhibitor of cathepsin K(IC50 : 170 nM)

T3088

N-Ethylmaleimide

128-53-0

98%

N-ethylmaleimide is a sulfhydryl reagent that is widely used in experimental biochemical studies.

T2493

PD 151746

179461-52-0

98%

PD151746 is a calpain inhibitor with a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM). Its IC50 values are 0.26 ± 0...