Endothelin Receptor

There are at least four known endothelin receptors, ETA, ETB1, ETB2 and ETC, all of which are G protein-coupled receptors whose activation result in elevation of intracellular-free calcium, which constricts the smooth muscles of the blood vessels, raising blood pressure, or relaxes the smooth muscles of the blood vessels, lowering blood pressure, among other functions.

Cat. No.	Product name	CAS No.	Purity
T34541	SB-209670	157659-79-5	98%
T34541	SB-209670 is a selective endothelin receptor antagonist that inhibits the activity of ET(B) receptors in rat vascular endothelium and vascular smooth muscle.
TP2262L	IRL-1038 acetate	TP2262L	98%
TP2262L	IRL-1038 acetate is a potent ETB endothelin receptor antagonist.
TN4606	Myriceric acid C	162059-94-1	98%
TN4606	Myriceric acid C has cytotoxic activity against human lung carcinoma and breast carcinoma.
T6258	Zibotentan	186497-07-4	98%
T6258	Zibotentan (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.
T7817	Aprocitentan	1103522-45-7	98%
T7817	Aprocitentan is ETA and ETB antagonist .
TQ0282	Avosentan	290815-26-8	98%
TQ0282	Avosentan (Ro 67-0565) is an effective and selective antagonist of the endothelin receptor (ETA receptor).
T5355	Sparsentan	254740-64-2	98%
T5355	Sparsentan is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM, respectively)
TQ0270	Atrasentan hydrochloride	195733-43-8	98%
TQ0270	Atrasentan hydrochloride (ABT-627 hydrochloride) is an endothelin receptor antagonist (IC50: 0.0551 nM for ETA).
T3474	RO 46-8443	175556-12-4	98%
T3474	RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms...
T15596	IRL 2500	169545-27-1	98%
T15596	IRL 2500 is an antagonist of Endothelin receptor with IC50s of 1.3 and 94 nM for Endothelin A receptor and Endothelin B receptor.
T6672	Sitaxsentan sodium	210421-74-2	98%
T6672	Sitaxsentan (sodium) is a highly selective antagonist of endothelin A receptors.
T6792	BQ-123	136553-81-6	98%
T6792	BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.
T12924	Sitaxsentan	184036-34-8	98%
T12924	Sitaxsentan is A selective endothelin A (ETA) receptor antagonist. Endothelin is an effective vasoconstrictor. Sitaxsentan blocks the binding of endothelin to it...
T5458	Darusentan	171714-84-4	98%
T5458	Darusentan is a potent inhibitor of endothelin signaling and function in both large and small arteries
T15595L	IRL-1620 acetate	T15595L	98%
T15595L	IRL-1620 acetate is an effective and selective agonist of Endothelin B receptor (ETB) with a Ki of 16 pM which is more selective than ETA with a Ki of 19 μM.
T19309L1	Endothelin 1 (swine, human) acetate	T19309L1	98%
T19309L1	Endothelin 1 (swine, human) acetate is a synthetic peptide with the sequence of human and swine Endothelin 1. Endothelin 1 is a potent endogenous vasoconstrictor...
T21790	BMS 182874 hydrochloride	1215703-04-0	98%
T21790	BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist.
T1655	Ambrisentan	177036-94-1	98%
T1655	Ambrisentan is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Ambrisentan has been associated with a low rate of...
T2561	Macitentan	441798-33-0	98%
T2561	Macitentan is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH).
T6265	Bosentan (hydrate)	157212-55-0	98%
T6265	Bosentan is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.