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Endothelin Receptor

There are at least four known endothelin receptors, ETA, ETB1, ETB2 and ETC, all of which are G protein-coupled receptors whose activation result in elevation of intracellular-free calcium, which constricts the smooth muscles of the blood vessels, raising blood pressure, or relaxes the smooth muscles of the blood vessels, lowering blood pressure, among other functions.
Cat No. product name
T15595L IRL-1620 acetate IRL-1620 acetate 是一种有效的特异性内啡肽 B 受体 (ETB) 激动剂,Ki 为 16 pM,相比于ETA,其Ki 为 19 μM。
T0750 Sulfisoxazole Sulfisoxazole is a short-acting sulfonamide antibacterial with activity against a wide range of gram-negative and gram-positive organisms.Sulfisoxazole inhibits ...
T6258 Zibotentan Zibotentan (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.
T2561 Macitentan Macitentan is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH).
T19309L1 Endothelin 1 (swine, human) acetate Endothelin 1 (swine, human) acetate is a synthetic peptide with the sequence of human and swine Endothelin 1. Endothelin 1 is a potent endogenous vasoconstrictor...
T21790 BMS 182874 hydrochloride BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist.
T7817 Aprocitentan Aprocitentan is ETA and ETB antagonist .
TN4606 Myriceric acid C Myriceric acid C has cytotoxic activity against human lung carcinoma and breast carcinoma.
TQ0282 Avosentan Avosentan (Ro 67-0565) is an effective and selective antagonist of the endothelin receptor (ETA receptor).
TQ0270 Atrasentan hydrochloride Atrasentan hydrochloride (ABT-627 hydrochloride) is an endothelin receptor antagonist (IC50: 0.0551 nM for ETA).
TQ0259 Atrasentan Atrasentan (ABT-627) is an endothelin receptor antagonist (IC50: 0.0551 nM for ETA).
T3474 RO 46-8443 RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms...
T3194 Ro 46-2005 Ro 46-2005 is a synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA recep...
T5355 Sparsentan Sparsentan is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM, respectively)
T5458 Darusentan Darusentan is a potent inhibitor of endothelin signaling and function in both large and small arteries
T6265 Bosentan (hydrate) Bosentan is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.
T6264 Bosentan Bosentan is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than end...
T6672 Sitaxsentan sodium Sitaxsentan (sodium) is a highly selective antagonist of endothelin A receptors.
T6792 BQ-123 BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.
T1655 Ambrisentan Ambrisentan is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Ambrisentan has been associated with a low rate of...
IRL-1620 acetate
T15595L
IRL-1620 acetate 是一种有效的特异性内啡肽 B 受体 (ETB) 激动剂,Ki 为 16 pM,相比于ETA,其Ki 为 19 μM。
Sulfisoxazole
T0750
Sulfisoxazole is a short-acting sulfonamide antibacterial with activity against a wide range of gram-negative and gram-positive organisms.Sulfisoxazole inhibits ...
Zibotentan
T6258
Zibotentan (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.
Macitentan
T2561
Macitentan is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH).
Endothelin 1 (swine, human) acetate
T19309L1
Endothelin 1 (swine, human) acetate is a synthetic peptide with the sequence of human and swine Endothelin 1. Endothelin 1 is a potent endogenous vasoconstrictor...
BMS 182874 hydrochloride
T21790
BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist.
Aprocitentan
T7817
Aprocitentan is ETA and ETB antagonist .
Myriceric acid C
TN4606
Myriceric acid C has cytotoxic activity against human lung carcinoma and breast carcinoma.
Avosentan
TQ0282
Avosentan (Ro 67-0565) is an effective and selective antagonist of the endothelin receptor (ETA receptor).
Atrasentan hydrochloride
TQ0270
Atrasentan hydrochloride (ABT-627 hydrochloride) is an endothelin receptor antagonist (IC50: 0.0551 nM for ETA).
Atrasentan
TQ0259
Atrasentan (ABT-627) is an endothelin receptor antagonist (IC50: 0.0551 nM for ETA).
RO 46-8443
T3474
RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms...
Ro 46-2005
T3194
Ro 46-2005 is a synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA recep...
Sparsentan
T5355
Sparsentan is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM, respectively)
Darusentan
T5458
Darusentan is a potent inhibitor of endothelin signaling and function in both large and small arteries
Bosentan (hydrate)
T6265
Bosentan is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.
Bosentan
T6264
Bosentan is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than end...
Sitaxsentan sodium
T6672
Sitaxsentan (sodium) is a highly selective antagonist of endothelin A receptors.
BQ-123
T6792
BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.
Ambrisentan
T1655
Ambrisentan is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Ambrisentan has been associated with a low rate of...