Endothelin Receptor

There are at least four known endothelin receptors, ETA, ETB1, ETB2 and ETC, all of which are G protein-coupled receptors whose activation result in elevation of intracellular-free calcium, which constricts the smooth muscles of the blood vessels, raising blood pressure, or relaxes the smooth muscles of the blood vessels, lowering blood pressure, among other functions.

Cat. No.	Product name	CAS No.	Purity
TN4606	Myriceric acid C	162059-94-1	98%
TN4606	Myriceric acid C has cytotoxic activity against human lung carcinoma and breast carcinoma.
TQ0282	Avosentan	290815-26-8	98%
TQ0282	Avosentan (Ro 67-0565) is an effective and selective antagonist of the endothelin receptor (ETA receptor).
TP1220L	Carperitide acetate	1366000-58-9	98%
TP1220L	Carperitide acetateis a 28-amino acid hormone. Carperitide acetate is normally produced and secreted by the human heart in response to cardiac injury and mechani...
T19309L1	Endothelin 1 (swine, human) acetate	T19309L1
T19309L1	Endothelin 1 (swine, human) acetate is a synthetic peptide with the sequence of human and swine Endothelin 1. Endothelin 1 is a potent endogenous vasoconstrictor...
T21790	BMS 182874 hydrochloride	1215703-04-0
T21790	BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist.
T6264	Bosentan	147536-97-8	100%
T6264	Bosentan is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than end...
T15595L	IRL-1620 acetate	T15595L	96.64%
T15595L	IRL-1620 acetate is an effective and selective agonist of Endothelin B receptor (ETB) with a Ki of 16 pM which is more selective than ETA with a Ki of 19 μM.
T5458	Darusentan	171714-84-4	97.26%
T5458	Darusentan is a potent inhibitor of endothelin signaling and function in both large and small arteries
T6792	BQ-123	136553-81-6	98%
T6792	BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.
T15596	IRL 2500	169545-27-1	98.29%
T15596	IRL 2500 is an antagonist of Endothelin receptor with IC50s of 1.3 and 94 nM for Endothelin A receptor and Endothelin B receptor.
TQ0270	Atrasentan hydrochloride	195733-43-8	98.64%
TQ0270	Atrasentan hydrochloride (ABT-627 hydrochloride) is an endothelin receptor antagonist (IC50: 0.0551 nM for ETA).
T3194	Ro 46-2005	150725-87-4	98.8%
T3194	Ro 46-2005 is a synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA recep...
T5355	Sparsentan	254740-64-2	98.81%
T5355	Sparsentan is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM, respectively)
T6672	Sitaxsentan sodium	210421-74-2	99%
T6672	Sitaxsentan (sodium) is a highly selective antagonist of endothelin A receptors.
TQ0259	Atrasentan	173937-91-2	99.08%
TQ0259	Atrasentan (ABT-627) is an endothelin receptor antagonist (IC50: 0.0551 nM for ETA).
T7817	Aprocitentan	1103522-45-7	99.17%
T7817	Aprocitentan is ETA and ETB antagonist .
T2561	Macitentan	441798-33-0	99.52%
T2561	Macitentan is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH).
T6265	Bosentan (hydrate)	157212-55-0	99.75%
T6265	Bosentan is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.
T3474	RO 46-8443	175556-12-4	99.77%
T3474	RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms...
T1655	Ambrisentan	177036-94-1	99.85%
T1655	Ambrisentan is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Ambrisentan has been associated with a low rate of...