T34541 |
SB-209670
|
157659-79-5
|
98%
|
|
SB-209670 is a selective endothelin receptor antagonist that inhibits the activity of ET(B) receptors in rat vascular endothelium and vascular smooth muscle.
|
TP2262L |
IRL-1038 acetate
|
TP2262L
|
98%
|
|
IRL-1038 acetate is a potent ETB endothelin receptor antagonist.
|
TN4606 |
Myriceric acid C
|
162059-94-1
|
98%
|
|
Myriceric acid C has cytotoxic activity against human lung carcinoma and breast carcinoma.
|
T6258 |
Zibotentan
|
186497-07-4
|
98%
|
|
Zibotentan (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.
|
T7817 |
Aprocitentan
|
1103522-45-7
|
98%
|
|
Aprocitentan is ETA and ETB antagonist .
|
TQ0282 |
Avosentan
|
290815-26-8
|
98%
|
|
Avosentan (Ro 67-0565) is an effective and selective antagonist of the endothelin receptor (ETA receptor).
|
T5355 |
Sparsentan
|
254740-64-2
|
98%
|
|
Sparsentan is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM, respectively)
|
TQ0270 |
Atrasentan hydrochloride
|
195733-43-8
|
98%
|
|
Atrasentan hydrochloride (ABT-627 hydrochloride) is an endothelin receptor antagonist (IC50: 0.0551 nM for ETA).
|
T3474 |
RO 46-8443
|
175556-12-4
|
98%
|
|
RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms...
|
T15596 |
IRL 2500
|
169545-27-1
|
98%
|
|
IRL 2500 is an antagonist of Endothelin receptor with IC50s of 1.3 and 94 nM for Endothelin A receptor and Endothelin B receptor.
|
T6672 |
Sitaxsentan sodium
|
210421-74-2
|
98%
|
|
Sitaxsentan (sodium) is a highly selective antagonist of endothelin A receptors.
|
T6792 |
BQ-123
|
136553-81-6
|
98%
|
|
BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.
|
T12924 |
Sitaxsentan
|
184036-34-8
|
98%
|
|
Sitaxsentan is A selective endothelin A (ETA) receptor antagonist. Endothelin is an effective vasoconstrictor. Sitaxsentan blocks the binding of endothelin to it...
|
T5458 |
Darusentan
|
171714-84-4
|
98%
|
|
Darusentan is a potent inhibitor of endothelin signaling and function in both large and small arteries
|
T15595L |
IRL-1620 acetate
|
T15595L
|
98%
|
|
IRL-1620 acetate is an effective and selective agonist of Endothelin B receptor (ETB) with a Ki of 16 pM which is more selective than ETA with a Ki of 19 μM.
|
T19309L1 |
Endothelin 1 (swine, human) acetate
|
T19309L1
|
98%
|
|
Endothelin 1 (swine, human) acetate is a synthetic peptide with the sequence of human and swine Endothelin 1. Endothelin 1 is a potent endogenous vasoconstrictor...
|
T21790 |
BMS 182874 hydrochloride
|
1215703-04-0
|
98%
|
|
BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist.
|
T1655 |
Ambrisentan
|
177036-94-1
|
98%
|
|
Ambrisentan is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Ambrisentan has been associated with a low rate of...
|
T2561 |
Macitentan
|
441798-33-0
|
98%
|
|
Macitentan is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH).
|
T6265 |
Bosentan (hydrate)
|
157212-55-0
|
98%
|
|
Bosentan is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.
|