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IκB/IKK

The IκB kinase (IKK) is an enzyme complex that is involved in propagating the cellular response to inflammation.The IκB kinase enzyme complex is part of the upstream NF-κB signal transduction cascade. The IκBα (inhibitor of nuclear factor kappa B) protein inactivates the NF-κB transcription factor by masking the nuclear localization signals (NLS) of NF-κB proteins and keeping them sequestered in an inactive state in the cytoplasm. Specifically, IKK phosphorylates the inhibitory IκBα protein. This phosphorylation results in the dissociation of IκBα from NF-κB. NF-κB, which is now free, migrates into the nucleus and activates the expression of at least 150 genes; some of which are anti-apoptotic.
Cat No. product name
T7081 CCCP CCCP inhibits activation of STING and its downstream signalling molecules, TBK1 and IRF3. CCCP inhibits STING-mediated IFN-β production via disrupting mitochondr...
T9105 NF-κB-IN-1 NF-κB-IN-1 is a potent NF-κB signaling pathway inhibitor. It is a 4-arylidene crucumin analogue. NF-κB-IN-1 directly inhibits IKK to block NF-κB activation. NF-κ...
T2081 LY2409881 trihydrochloride LY2409881 trihydrochloride is a novel specific inhibitor of IKK2 (IC50: 30 nM); IC50 for IKK1 and other common kinases is at least one log higher.
T0167 Vinpocetine Vinpocetine is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).
T1830 BX795 BX795 is an effective and selective PDK1 inhibitor (IC50: 6 nM), and its selectivity is 140- and 1600-fold for PDK1 over PKA and PKC in cell-free assays, respect...
T3049 TPCA-1 TPCA-1 is an effective and specific IKK-2 inhibitor (IC50: 17.9 nM); shows >22-fold selectivity over IKK-1 and >550-fold selectivity over others kinases and enzy...
T1639 Amlexanox Amlexanox is an anti-aphthous ulcer drug. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, from mast...
T6165 Bardoxolone Methyl Bardoxolone Methyl, an IKK inhibitor, exhibits effective proapoptotic and anti-inflammatory activities.
T20770 BAY32-5915 BAY32-5915 is an inhibitor of IKKalpha.
TJS1779 Protosappanin A Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB inflammat...
T3775 Armepavine Armepavine exerted both in vitro and in vivo antifibrotic effects in rats, with inhibition of NF-κB, JunD and C/EBP pathways. It improves experimental autoimmun...
TD0099 Malachite green oxalate Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions.
T25465 GS143 GS143 is a selec­tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup­presses NF-κB acti­va­tion and t...
T1934 Bay 11-7085 BAY 11-7085 can irreversibly inhibit the IκBα phosphorylation induced by TNFα (IC50: 10 μM).
T3094 PS-1145 PS-1145 is a specific IKK inhibitor with IC50 of 88 nM.
T1902 BAY 11-7082 BAY 11-7082, a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21.
T3736 Olivetol Olivetol (5-pentylresorcinol, 5-pentyl-1,3-benzenediol) is an organic compound found in certain species of lichen; it is also a precursor in various syntheses of...
T6186 TRAM-34 TRAM-34(Kd=20 nM), an effective and specific inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1), does not block cytochrome P450....
T8910 2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC 2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC is Inhibitior of IKKβ.
T2765 Rosmarinic acid Rosmarinic acid has shown to contain antioxidant, anti-inflammatory and antimicrobial activities. Possesses promising physiological actions related to cognitive ...
T1558 Resveratrol Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.
T0097 MRT67307 Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy. MRT67307 prevents the phosphorylation of IRF3 and the production of IFN-β and increases toll-lik...
T2S0606 Bakkenolide A Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sign...
T2118 SC-514 SC-514 is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.
T2106 WS6 WS6, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.
T2055 WS3 WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.
T2833 Dehydrocostus Lactone Dehydrocostus shows anti-inflammatory, anti-ulcer, immunomodulatory and anti-tumor properties.
TN2534 1-Hydroxy-2,3,5-trimethoxyxanthone 1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independ...
T8542 BMS-345541 hydrochloride BMS-345541 hydrochloride is a selective IKK inhibitor (IKK2 and IKK1 with IC50 of 0.3 μM and 4 μM,respectively).
T8705 BOT-64 BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathiole comp...
T8951 JTP 0819958 - HOIPIN-1 JTP-0819958 is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 of 2.8 μM[1]. JTP-0819958 suppress LUBAC-mediated NF-kB activat...
T7951 TBK1/IKKε-IN-5 TBK1/IKKε-IN-5 is a dual TBK1 and IKKε inhibitor(IC50 of 1 nM and 5.6 nM, respectively).
T10472L Bay 65-1942 free base Bay 65-1942 free base is an inhibitor of ATP-competitive and selective IKKβ.
T10477 BAY-985 BAY-985 is a potent, selective, and orally active ATP-competitive dual inhibitor of TBK1 and IKKε (IC50s: 2/30 and 2 nM for TBK1 (low/high ATP) and IKKε) with an...
T10237 ACHP Hydrochloride ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor (IC50: 8.5 nM).
T12659 (Rac)-BAY-985 (Rac)-BAY-985 is a potent, ATP-competitive and selective inhibitor of TBK1(IC50 of 1.5 nM),with antitumor efficacy.
T13097 TBK1/IKKε-IN-1 TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).
T11633 IKK-IN-1 IKK-IN-1 is an inhibitor of IKK.
TN3219 7,8-Didehydrocimigenol 7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of ...
TN2775 2-Methoxystypandrone 2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflamm...
TN3635 Chlojaponilactone B Chlojaponilactone B has anti-inflammatory activity, it exhibits pronounced inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264...
TN3726 Cudraflavone B Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mo...
TN3539 Broussonin A Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, tra...
TN3614 Cearoin Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the...
TN3486 Bakkenolide IIIa Bakkenolide IIIa has antioxidant, and neuroprotective effects, it protects against cerebral damage by inhibiting AKT and ERK1/2 activation and inactivated NF-κB...
TN3517 Bisacurone Bisacurone has anti-oxidant, anti-inflammatory, and anti-metastatic activities, it may have a protective effect against ethanol-induced liver injury by suppressi...
TN4162 Goshonoside F5 Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.
TN3806 Dehydroglyasperin C Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemop...
TN4318 Isophysalin A Isophysalin A exhibits anti-inflammatory activitiy, it exhibits conjugating abilities with glutathione and also shows significant nitric oxide (NO) production in...
TN4383 Kazinol U Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduces ce...
CCCP
T7081
CCCP inhibits activation of STING and its downstream signalling molecules, TBK1 and IRF3. CCCP inhibits STING-mediated IFN-β production via disrupting mitochond...
NF-κB-IN-1
T9105
NF-κB-IN-1 is a potent NF-κB signaling pathway inhibitor. It is a 4-arylidene crucumin analogue. NF-κB-IN-1 directly inhibits IKK to block NF-κB activation. ...
LY2409881 trihydrochloride
T2081
LY2409881 trihydrochloride is a novel specific inhibitor of IKK2 (IC50: 30 nM); IC50 for IKK1 and other common kinases is at least one log higher.
Vinpocetine
T0167
Vinpocetine is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).
BX795
T1830
BX795 is an effective and selective PDK1 inhibitor (IC50: 6 nM), and its selectivity is 140- and 1600-fold for PDK1 over PKA and PKC in cell-free assays, respect...
TPCA-1
T3049
TPCA-1 is an effective and specific IKK-2 inhibitor (IC50: 17.9 nM); shows >22-fold selectivity over IKK-1 and >550-fold selectivity over others kinases and enzy...
Amlexanox
T1639
Amlexanox is an anti-aphthous ulcer drug. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, from mast...
Bardoxolone Methyl
T6165
Bardoxolone Methyl, an IKK inhibitor, exhibits effective proapoptotic and anti-inflammatory activities.
BAY32-5915
T20770
BAY32-5915 is an inhibitor of IKKalpha.
Protosappanin A
TJS1779
Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB infla...
Armepavine
T3775
Armepavine exerted both in vitro and in vivo antifibrotic effects in rats, with inhibition of NF-κB, JunD and C/EBP pathways. It improves experimental autoimmu...
Malachite green oxalate
TD0099
Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions.
GS143
T25465
Bay 11-7085
T1934
BAY 11-7085 can irreversibly inhibit the IκBα phosphorylation induced by TNFα (IC50: 10 μM).
PS-1145
T3094
PS-1145 is a specific IKK inhibitor with IC50 of 88 nM.
BAY 11-7082
T1902
BAY 11-7082, a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21.
Olivetol
T3736
Olivetol (5-pentylresorcinol, 5-pentyl-1,3-benzenediol) is an organic compound found in certain species of lichen; it is also a precursor in various syntheses of...
TRAM-34
T6186
TRAM-34(Kd=20 nM), an effective and specific inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1), does not block cytochrome P450....
2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC
T8910
2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC is Inhibitior of IKKβ.
Rosmarinic acid
T2765
Rosmarinic acid has shown to contain antioxidant, anti-inflammatory and antimicrobial activities. Possesses promising physiological actions related to cognitive ...
Resveratrol
T1558
Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.
MRT67307
T0097
Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy. MRT67307 prevents the phosphorylation of IRF3 and the production of IFN-β and increases toll-li...
Bakkenolide A
T2S0606
Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sign...
SC-514
T2118
SC-514 is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.
WS6
T2106
WS6, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.
WS3
T2055
WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.
Dehydrocostus Lactone
T2833
Dehydrocostus shows anti-inflammatory, anti-ulcer, immunomodulatory and anti-tumor properties.
1-Hydroxy-2,3,5-trimethoxyxanthone
TN2534
1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independ...
BMS-345541 hydrochloride
T8542
BMS-345541 hydrochloride is a selective IKK inhibitor (IKK2 and IKK1 with IC50 of 0.3 μM and 4 μM,respectively).
BOT-64
T8705
BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathiole comp...
JTP 0819958 - HOIPIN-1
T8951
JTP-0819958 is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 of 2.8 μM[1]. JTP-0819958 suppress LUBAC-mediated NF-kB activa...
TBK1/IKKε-IN-5
T7951
TBK1/IKKε-IN-5 is a dual TBK1 and IKKε inhibitor(IC50 of 1 nM and 5.6 nM, respectively).
Bay 65-1942 free base
T10472L
Bay 65-1942 free base is an inhibitor of ATP-competitive and selective IKKβ.
BAY-985
T10477
BAY-985 is a potent, selective, and orally active ATP-competitive dual inhibitor of TBK1 and IKKε (IC50s: 2/30 and 2 nM for TBK1 (low/high ATP) and IKKε) with ...
ACHP Hydrochloride
T10237
ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor (IC50: 8.5 nM).
(Rac)-BAY-985
T12659
(Rac)-BAY-985 is a potent, ATP-competitive and selective inhibitor of TBK1(IC50 of 1.5 nM),with antitumor efficacy.
TBK1/IKKε-IN-1
T13097
TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).
IKK-IN-1
T11633
IKK-IN-1 is an inhibitor of IKK.
7,8-Didehydrocimigenol
TN3219
7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of...
2-Methoxystypandrone
TN2775
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the infla...
Chlojaponilactone B
TN3635
Chlojaponilactone B has anti-inflammatory activity, it exhibits pronounced inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264...
Cudraflavone B
TN3726
Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mo...
Broussonin A
TN3539
Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, tra...
Cearoin
TN3614
Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the...
Bakkenolide IIIa
TN3486
Bisacurone
TN3517
Bisacurone has anti-oxidant, anti-inflammatory, and anti-metastatic activities, it may have a protective effect against ethanol-induced liver injury by suppressi...
Goshonoside F5
TN4162
Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.
Dehydroglyasperin C
TN3806
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemop...
Isophysalin A
TN4318
Isophysalin A exhibits anti-inflammatory activitiy, it exhibits conjugating abilities with glutathione and also shows significant nitric oxide (NO) production in...
Kazinol U
TN4383
Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduce...
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