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Liver X Receptor

The liver X receptor (LXR) is a member of the nuclear receptor family of transcription factors and is closely related to nuclear receptors such as the PPARs, FXR and RXR. Liver X receptors (LXRs) are important regulators of cholesterol, fatty acid, and glucose homeostasis. LXRs were earlier classified as orphan nuclear receptors, however, upon discovery of endogenous oxysterols as ligands, they were subsequently deorphanized.Two isoforms of LXR have been identified and are referred to as LXRα and LXRβ.
Cat No. product name
T27478 GSK3987 GSK3987 is a potent and specific agonist of LXRalpha and LXRbeta.
T2810 (20S)-Protopanaxatriol (20S)-Protopanaxatriol(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid receptor.
T6690 T0901317 T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).
T2768 Saikosaponin A Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-b...
T1783 LXR-623 WAY-252623 (LXR-623) is an orally bioavailable and highly specifical synthetic modulator of LXR.
T1801 SR9243 SR9243, an LXR inverse agonist, can induce LXR-corepressor interaction; shows anticancer activity and selectively targets the lipogenesis and Warburg effect.
T7768 RGX-104 RGX-104 free Acid is an agonist of potent liver-X nuclear hormone receptor (LXR)
TN1055 Licochalcone E Licochalcone E is a potential LXRβ agonist.
TN1719 Gymnestrogenin Gymnestrogenin has a dual LXRα±/α² antagonistic profile.
TN4016 Ethyl 2,4,6-trihydroxybenzoate Ethyl 2,4,6-trihydroxybenzoate is a dual-LXR modulator that regulates the expression of key genes in cholesterol homeostasis in multiple cells without inducing l...
TQ0274 27-Hydroxycholesterol 27-Hydroxycholesterol is a selective modulator of estrogen receptor and an agonist of the liver X receptor.
T3970 BMS-779788 BMS-779788 is an LXRα/β partial agonist (IC50: 68/14 nM).
T5178 AZ876 AZ876 is a potent, highly selective LXR agonist with Ki/EC50 of 7/6 nM and 11/73 nM for hLXRα and hLXRβ respectively.
T5128 RGX-104 hydrochloride RGX-104 is a liver X receptor (LXR) agonist with potential immunomodulating and antineoplastic activities. It modulates innate immunity via transcriptional activ...
T5743 Gymnemagenin Gymnemagenin is a potent and selective antagonist for the β isoform of LXR, it has antihyperglycemic activity.
T6310 GW3965 hydrochloride GW3965 HCl is an effective and specific LXR agonist for hLXRα/β (EC50: 190/30 nM).
T16930 SR9238 SR9238 is a synthetic agonist of liver X receptor inverse (IC50s: 214 nM and 43 nM for LXRα and LXRβ, respectively).
T16792 Rovazolac Rovazolac is a liver x receptor modulator.
T15427 GSK2033 GSK2033 is an antagonist of LXR (pIC50s: 7 and 7.4 for LXRα or LXRβ, respectively).
T14679 XL041 XL041 (BMS-852927) is an agonist of LXRβ-selective.
GSK3987
T27478
GSK3987 is a potent and specific agonist of LXRalpha and LXRbeta.
(20S)-Protopanaxatriol
T2810
(20S)-Protopanaxatriol(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid receptor.
T0901317
T6690
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).
Saikosaponin A
T2768
Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-b...
LXR-623
T1783
WAY-252623 (LXR-623) is an orally bioavailable and highly specifical synthetic modulator of LXR.
SR9243
T1801
SR9243, an LXR inverse agonist, can induce LXR-corepressor interaction; shows anticancer activity and selectively targets the lipogenesis and Warburg effect.
RGX-104
T7768
RGX-104 free Acid is an agonist of potent liver-X nuclear hormone receptor (LXR)
Licochalcone E
TN1055
Licochalcone E is a potential LXRβ agonist.
Gymnestrogenin
TN1719
Gymnestrogenin has a dual LXRα±/α² antagonistic profile.
Ethyl 2,4,6-trihydroxybenzoate
TN4016
Ethyl 2,4,6-trihydroxybenzoate is a dual-LXR modulator that regulates the expression of key genes in cholesterol homeostasis in multiple cells without inducing l...
27-Hydroxycholesterol
TQ0274
27-Hydroxycholesterol is a selective modulator of estrogen receptor and an agonist of the liver X receptor.
BMS-779788
T3970
BMS-779788 is an LXRα/β partial agonist (IC50: 68/14 nM).
AZ876
T5178
AZ876 is a potent, highly selective LXR agonist with Ki/EC50 of 7/6 nM and 11/73 nM for hLXRα and hLXRβ respectively.
RGX-104 hydrochloride
T5128
RGX-104 is a liver X receptor (LXR) agonist with potential immunomodulating and antineoplastic activities. It modulates innate immunity via transcriptional activ...
Gymnemagenin
T5743
Gymnemagenin is a potent and selective antagonist for the β isoform of LXR, it has antihyperglycemic activity.
GW3965 hydrochloride
T6310
GW3965 HCl is an effective and specific LXR agonist for hLXRα/β (EC50: 190/30 nM).
SR9238
T16930
SR9238 is a synthetic agonist of liver X receptor inverse (IC50s: 214 nM and 43 nM for LXRα and LXRβ, respectively).
Rovazolac
T16792
Rovazolac is a liver x receptor modulator.
GSK2033
T15427
GSK2033 is an antagonist of LXR (pIC50s: 7 and 7.4 for LXRα or LXRβ, respectively).
XL041
T14679
XL041 (BMS-852927) is an agonist of LXRβ-selective.