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Reverse Transcriptase

A reverse transcriptase (RT) is an enzyme used to generate complementary DNA (cDNA) from an RNA template, a process termed reverse transcription. Reverse transcriptases are used by retroviruses to replicate their genomes, by retrotransposon mobile genetic elements to proliferate within the host genome, by eukaryotic cells to extend the telomeres at the ends of their linear chromosomes, and by some non-retroviruses such as the hepatitis B virus, a member of the Hepadnaviridae, which are dsDNA-RT viruses.
Cat No. product name
T2330 Rilpivirine Rilpivirine is a diarylpyrimidine derivative and reverse transcriptase inhibitor with antiviral activity against HIV-1 that is used in the treatment of HIV infec...
T1416 Zidovudine Zidovudine is a synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zidovudine inhibits DNA polymerase, resulting in the i...
T16098 Islatravir Islatravir is an effective anti-HIV-1 agent. It acting as a nucleoside reverse transcriptase inhibitor (EC50s: 0.068 nM, 3.1 nM, and 0.15 nM for HIV-1 (WT), HIV-...
T6519 Gramine Gramine, a natural indole alkaloid, present in several plant species, acts as an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 μM for A...
T0753 Salicylanilide Salicylanilides are a group of compounds with antiviral potency, antibacterial and antifungal activities.
T2901 Daidzin Daidzin is an isoflavone isolated from soya bean with anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities.
T4326 AG 555 AG 555 is an EGFR tyrosine kinase inhibitor.
T7447 Adefovir Adefovir is an acyclic nucleoside phosphonate that acts as a reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection...
T2393 Efavirenz Efavirenz is a Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor. The mechanism of action of efavirenz is as a Non-Nucleoside ...
T0220 Foscarnet sodium Foscarnet sodium is an antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.
T3632 Doravirine Doravirine is a non-nucleoside reverse transcriptase inhibitor, used in the treatment of HIV/AIDS.
T7700 Lersivirine Lersivirine(UK 453061) is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) under development for HIV infection therapy.
T7282 Tenofovir alafenamide hemifumarate Tenofovir alafenamide fumarate (TAF) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV)
T3273 Bifendate Bifendatatum is commonly used to treat the transaminase elevation that caused by viral hepatitis and drug-induced liver injury.
T0682 Lamivudine Lamivudine is a reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat HIV...
T2409 Tenofovir alafenamide Tenofovir Alafenamide (GS-7340) is a nucleotide reverse transcriptase inhibitor (NRTI) and a novel ester prodrug of the antiretroviral tenofovir.
T1675 Adefovir dipivoxil Adefovir Dipivoxil is a dipivoxil formulation of adefovir, a nucleoside reverse transcriptase inhibitor analog of adenosine with activity against hepatitis B vir...
T7212 Delavirdine mesylate Delavirdine (mesylate) is a non-nucleoside reverse transcriptase inhibitor (NNRTI).
T2160 Suramin Sodium Salt Suramin Sodium is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various gro...
T1649 Tenofovir Tenofovir is an adenine analog REVERSE TRANSCRIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B. It is used to treat HIV INFECTIONS and CHRO...
T6367 Abacavir sulfate Abacavir, a nucleoside analogue, effectively utilize its antiviral activity
T6214 Emtricitabine Emtricitabine (FTC), a nucleoside reverse transcriptase inhibitor, exhibits inhibition activity against human immunodeficiency virus (HIV) and hepatitis B virus....
T27154 Dexelvucitabine Dexelvucitabine, a nucleoside reverse transcriptase inhibitor, is used potentially for the treatment of HIV infection.
T3730 Methyl gallate Methyl gallate is a reverse transcriptase inhibitor with antioxidant, anti-HIV-1 and HIV-1 enzyme inhibition activities.
T7111 Tenofovir Disoproxil Tenofovir Disoproxil is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B.
T0153 Oltipraz Oltipraz is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as g...
T0110 Zalcitabine Zalcitabine(Dideoxycytidine;ddC; 2', 3'-Dideoxycytidine) is a nucleoside analog reverse transcriptase inhibitor (NRTI); At low concentrations, It can potently in...
T2409L Tenofovir Disoproxil Fumarate Tenofovir Disoproxil Fumarate is a pro-drug, fumaric acid salt form of tenofovir, a nucleoside reverse transcriptase inhibitor analog of adenosine. Tenofovir dis...
T5981 2,2'-Anhydrouridine 2,2'-Cyclouridine is a research tool for antiviral and anticancer studies.
T1513 Telbivudine Telbivudine is a Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor. The mechanism of action of telbivudine is as a Nucleoside Reverse Transcrip...
T1595 Nevirapine Nevirapine is a benzodiazepine non-nucleoside reverse transcriptase inhibitor. In combination with other antiretroviral drugs, nevirapine reduces HIV viral loads...
T1404 Stavudine Stavudine, a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV.
T12609 R-10015 R-10015 is a potent and selective inhibitor of LIM domain kinase (LIMK) and binds to the ATP-binding pocket(IC50 of 38 nM for human LIMK1),and a broad-spectrum a...
T3795 Corilagin Corilagin has anti-inflammatory activity. Corilagin has a significant antitumour potential and lower toxicity in normal cells in vitro.Corilagin can enhance the ...
T1815 Dapivirine Dapivirine is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor.
T2578 Didanosine Didanosine is a nucleoside reverse transcriptase inhibitor analog of adenosine (IC50: 0.49 μM).
T14489 Azvudine Azvudine is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine inhibits NRTI-resistant viral strai...
T2551 Etravirine Etravirine is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor. Etravirine is designed to be active against HIV isolates with mutations that con...
T1267 Abacavir Abacavir is a nucleoside reverse transcriptase inhibitor analog of guanosine. This agent decreases HIV viral loads, retards or prevents the damage to the immune ...
T3578 Pyridoxal phosphate Pyridoxal Phosphate is the active form of vitamin B6 and a coenzyme for many pyridoxal phosphate (PLP)-dependent enzymes. PLP is involved in numerous enzymatic t...
T9223 RO-0335 RO-0335 is a potent diphenylether nonnucleoside reverse transcriptase inhibitor. RO-0335 inhibits Wt HIV-1 (IC50 = 1.1 nM) and retained activity (IC50< 100 nM) a...
T11189 Emtricitabine S-oxide Emtricitabine is a potent nucleoside reverse transcriptase inhibitor used for the treatment of HIV infection.Emtricitabine S-oxide (Emtricitabine sulfoxide) is a...
T19963 Alizarin Complexone Alizarin Complexone 是 Rous 相关病毒 2 逆转录酶的抑制剂。 Alizarin Complexone 可用作生物研究的钙示踪剂和螯合剂。
Rilpivirine
T2330
Rilpivirine is a diarylpyrimidine derivative and reverse transcriptase inhibitor with antiviral activity against HIV-1 that is used in the treatment of HIV infec...
Zidovudine
T1416
Zidovudine is a synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zidovudine inhibits DNA polymerase, resulting in the i...
Islatravir
T16098
Islatravir is an effective anti-HIV-1 agent. It acting as a nucleoside reverse transcriptase inhibitor (EC50s: 0.068 nM, 3.1 nM, and 0.15 nM for HIV-1 (WT), HIV-...
Gramine
T6519
Gramine, a natural indole alkaloid, present in several plant species, acts as an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 μM for ...
Salicylanilide
T0753
Salicylanilides are a group of compounds with antiviral potency, antibacterial and antifungal activities.
Daidzin
T2901
Daidzin is an isoflavone isolated from soya bean with anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities.
AG 555
T4326
AG 555 is an EGFR tyrosine kinase inhibitor.
Adefovir
T7447
Adefovir is an acyclic nucleoside phosphonate that acts as a reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection...
Efavirenz
T2393
Efavirenz is a Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor. The mechanism of action of efavirenz is as a Non-Nucleoside ...
Foscarnet sodium
T0220
Foscarnet sodium is an antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.
Doravirine
T3632
Doravirine is a non-nucleoside reverse transcriptase inhibitor, used in the treatment of HIV/AIDS.
Lersivirine
T7700
Lersivirine(UK 453061) is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) under development for HIV infection therapy.
Tenofovir alafenamide hemifumarate
T7282
Tenofovir alafenamide fumarate (TAF) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV)
Bifendate
T3273
Bifendatatum is commonly used to treat the transaminase elevation that caused by viral hepatitis and drug-induced liver injury.
Lamivudine
T0682
Lamivudine is a reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat HIV...
Tenofovir alafenamide
T2409
Tenofovir Alafenamide (GS-7340) is a nucleotide reverse transcriptase inhibitor (NRTI) and a novel ester prodrug of the antiretroviral tenofovir.
Adefovir dipivoxil
T1675
Adefovir Dipivoxil is a dipivoxil formulation of adefovir, a nucleoside reverse transcriptase inhibitor analog of adenosine with activity against hepatitis B vir...
Delavirdine mesylate
T7212
Delavirdine (mesylate) is a non-nucleoside reverse transcriptase inhibitor (NNRTI).
Suramin Sodium Salt
T2160
Suramin Sodium is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various gro...
Tenofovir
T1649
Tenofovir is an adenine analog REVERSE TRANSCRIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B. It is used to treat HIV INFECTIONS and CHRO...
Abacavir sulfate
T6367
Abacavir, a nucleoside analogue, effectively utilize its antiviral activity
Emtricitabine
T6214
Emtricitabine (FTC), a nucleoside reverse transcriptase inhibitor, exhibits inhibition activity against human immunodeficiency virus (HIV) and hepatitis B virus....
Dexelvucitabine
T27154
Dexelvucitabine, a nucleoside reverse transcriptase inhibitor, is used potentially for the treatment of HIV infection.
Methyl gallate
T3730
Methyl gallate is a reverse transcriptase inhibitor with antioxidant, anti-HIV-1 and HIV-1 enzyme inhibition activities.
Tenofovir Disoproxil
T7111
Tenofovir Disoproxil is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B.
Oltipraz
T0153
Oltipraz is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as g...
Zalcitabine
T0110
Zalcitabine(Dideoxycytidine;ddC; 2', 3'-Dideoxycytidine) is a nucleoside analog reverse transcriptase inhibitor (NRTI); At low concentrations, It can potently in...
Tenofovir Disoproxil Fumarate
T2409L
Tenofovir Disoproxil Fumarate is a pro-drug, fumaric acid salt form of tenofovir, a nucleoside reverse transcriptase inhibitor analog of adenosine. Tenofovir dis...
2,2'-Anhydrouridine
T5981
2,2'-Cyclouridine is a research tool for antiviral and anticancer studies.
Telbivudine
T1513
Telbivudine is a Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor. The mechanism of action of telbivudine is as a Nucleoside Reverse Transcrip...
Nevirapine
T1595
Nevirapine is a benzodiazepine non-nucleoside reverse transcriptase inhibitor. In combination with other antiretroviral drugs, nevirapine reduces HIV viral loads...
Stavudine
T1404
Stavudine, a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV.
R-10015
T12609
R-10015 is a potent and selective inhibitor of LIM domain kinase (LIMK) and binds to the ATP-binding pocket(IC50 of 38 nM for human LIMK1),and a broad-spectrum a...
Corilagin
T3795
Corilagin has anti-inflammatory activity. Corilagin has a significant antitumour potential and lower toxicity in normal cells in vitro.Corilagin can enhance the ...
Dapivirine
T1815
Dapivirine is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor.
Didanosine
T2578
Didanosine is a nucleoside reverse transcriptase inhibitor analog of adenosine (IC50: 0.49 μM).
Azvudine
T14489
Azvudine is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine inhibits NRTI-resistant viral strai...
Etravirine
T2551
Etravirine is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor. Etravirine is designed to be active against HIV isolates with mutations that con...
Abacavir
T1267
Abacavir is a nucleoside reverse transcriptase inhibitor analog of guanosine. This agent decreases HIV viral loads, retards or prevents the damage to the immune ...
Pyridoxal phosphate
T3578
Pyridoxal Phosphate is the active form of vitamin B6 and a coenzyme for many pyridoxal phosphate (PLP)-dependent enzymes. PLP is involved in numerous enzymatic t...
RO-0335
T9223
RO-0335 is a potent diphenylether nonnucleoside reverse transcriptase inhibitor. RO-0335 inhibits Wt HIV-1 (IC50 = 1.1 nM) and retained activity (IC50< 100 nM) a...
Emtricitabine S-oxide
T11189
Emtricitabine is a potent nucleoside reverse transcriptase inhibitor used for the treatment of HIV infection.Emtricitabine S-oxide (Emtricitabine sulfoxide) is a...
Alizarin Complexone
T19963
Alizarin Complexone 是 Rous 相关病毒 2 逆转录酶的抑制剂。 Alizarin Complexone 可用作生物研究的钙示踪剂和螯合剂。