T11900 |
LY-2584702 hydrochloride
|
1082948-81-9
|
98%
|
|
Ly-2584702 hydrochloride is a p70S6K selective ATP competitive inhibitor with IC50 of 4 nM.In the S6K1 enzyme assay, the IC50 of LY-2584702 was 2 nM.
|
T7790 |
Bisindolylmaleimide V
|
113963-68-1
|
98%
|
|
Bisindolylmaleimide V (BIM V) is a weak protein kinase C (PKC)inhibitor( IC50 >100 µM)
|
T19913 |
CKI-7
|
1177141-67-1
|
98%
|
|
CKI-7 2HCl is an inhibitor of casein kinase 1 (CK1).
|
T6458 |
CYC-116
|
693228-63-6
|
98%
|
|
CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active a...
|
T3074 |
CHIR 98024
|
556813-39-9
|
98%
|
|
CHIR 98024 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 ...
|
T5428 |
BIX 02565
|
1311367-27-7
|
98%
|
|
BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).
|
T14072 |
A-443654
|
552325-16-3
|
98%
|
|
A-443654 is a pan-Akt inhibitor. It has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
|
T1961 |
Vistusertib
|
1009298-59-2
|
98%
|
|
AZD2014 is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.
|
T6250 |
H-89 dihydrochloride
|
130964-39-5
|
98%
|
|
H 89 is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 µM, Ki: 48 nM).
|
T1746 |
LY-2584702 tosylate salt
|
1082949-68-5
|
98%
|
|
LY2584702 Tosylate is a selective, ATP-competitive p70S6K inhibitor, used in trials studying the treatment of cancer.
|
T6159 |
LY-2584702 free base
|
1082949-67-4
|
98%
|
|
LY2584702 is a selective, ATP-competitive p70S6K inhibitor(IC50: 4 nM).
|
T11961 |
MBM-55S
|
2083624-07-9
|
98%
|
|
MBM-55S is an effective inhibitor of Nek2 with an IC50 of 1 nM. MBM-55S indecus cell cycle arrest and apoptosis thereby inhibiting the proliferation of cancer ce...
|
T6948 |
Pluripotin
|
839707-37-8
|
98%
|
|
Pluripotin (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP.
|
T2871 |
Quercitrin
|
522-12-3
|
98%
|
|
Quercitrin is a plant-derived flavonoid compound, displays antioxidant and anti-inflammatory activities. Quercitrin can be found in a number of food items such a...
|
TQ0310 |
FMK
|
821794-92-7
|
98%
|
|
FMK is an irreversible inhibitor of RSK2 kinase.
|
TN1712 |
Gossypin
|
652-78-8
|
98%
|
|
Gossypin has antidiabetic, antioxdiant, anticonvulsant, anti-allergic, antiinflammatory, antinociceptive, cytotoxic and antibacterial activities; it inhibits the...
|
T2482 |
AT13148
|
1056901-62-2
|
98%
|
|
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
|
T6S1302 |
Carnosol
|
5957-80-2
|
98%
|
|
Carnosol has anti-oxidative, anti-inflammatory, antiproliferative and apoptosis inducing properties. Carnosol enhances the sensitivity of chemoresistant cancer c...
|
T4488 |
GSK-25
|
874119-56-9
|
98%
|
|
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically impr...
|
T14779 |
BRD7389
|
376382-11-5
|
98%
|
|
BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.
|