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Thrombin

Thrombin ( fibrinogenase, thrombase, thrombofort, topical, thrombin-C, tropostasin, activated blood-coagulation factor II, blood-coagulation factor IIa, factor IIa, E thrombin, beta-thrombin, gamma-thrombin) is a serine protease, an enzyme that, in humans, is encoded by the F2 gene. Prothrombin (coagulation factor II) is proteolytically cleaved to form thrombin in the clotting process. Thrombin in turn acts as a serine protease that converts soluble fibrinogen into insoluble strands of fibrin, as well as catalyzing many other coagulation-related reactions.
Cat No. product name
T0155 Argatroban Argatroban, a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.
T0389 Dabigatran etexilate Dabigatran is a thrombin inhibitor, which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation.
T0438 Proflavine Hemisulfate Proflavine Hemisulfate is the hemisulfate salt form of proflavine, an acridine-derived fluorescent contrast and disinfectant agent that can potentially be used ...
T0448 Dexibuprofen Dexibuprofen, S(+)-ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
T0449 Menadione Menadione is a synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after...
T1184 Rivaroxaban Rivaroxaban is an orally bioavailable oxazolidinone derivative and direct inhibitor of the coagulation factor Xa with anticoagulant activity. Upon oral administ...
T2368 Edoxaban Tosylate Monohydrate Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.
T2368L Edoxaban Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.
T2562 Eltrombopag Eltrombopag, an orally active thrombopoietin receptor agonist with megakaryopoiesis stimulating activity, binds to and stimulates the platelet thrombopoietin r...
T6236 Ozagrel Ozagrel is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrov...
T6295 Dabigatran Dabigatran is a THROMBIN inhibitor which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. It is used to reduce the r...
T6531 Heparin sodium Heparin sodium is a sulfated polysaccharide, which belongs to the family of glycosaminoglycans. It is utilized as an anticoagulant and interacted with diverse p...
T6625 Ozagrel hydrochloride Ozagrel HCl is a selective thromboxane A(2) synthetase inhibitor used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral...
T6825 Eltrombopag Olamine Eltrombopag Olamine is the orally active ethanolamine salt of eltrombopag, a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-st...
T7053 p-Hydroxy-cinnamic acid p-Hydroxycinnamic acid can inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin ...
T5133 Dabigatran Etexilate Mesylate Dabigatran etexilate mesylate is the orally active prodrug of dabigatran. Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI, Ki: 4.5 nM).
T5519 Bivalirudin Bivalirudin is a reversible inhibitor of α- and ζ-thrombin (Kis = 2.56 and 1.84 nM, respectively), enzymes that exhibit high fibrinogen-clotting activities.
TQ0223 Lusutrombopag Lusutrombopag is an orally bioavailable agonist of thrombopoietin (TPO) receptor.
T12301 OM-189 OM-189 is a selective inhibitor of synthetic thrombin.
T12782 RWJ-445167 RWJ-445167 is a thrombin and factor Xa dual inhibitor(Ki of 4.0 nM and 230 nM, respectively), with potent antithrombotic activity.
T16292 NFPS NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion. NFPS is a selective and non-competit...
T10081 Thrombin inhibitor 1 Thrombin inhibitor 1 is a potent inhibitor of thrombin (Ki: 0.66 nM, 2xaPTT=0.43 μM).
T16377 Odiparcil Odiparcil is an orally active beta-d-thioxyloside analog. Odiparcil is an indirect thrombin inhibitor that exerts its anticoagulant effect through activation of...
T11994 Melagatran Melagatran does not require endogenous co-factors for its antithrombin effect and may help to alleviate some of the damaging effects of endotoxemia. Melagatran ...
Argatroban
T0155CAS 74863-84-6
Argatroban, a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.
Dabigatran etexilate
T0389CAS 211915-06-9
Dabigatran is a thrombin inhibitor, which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation.
Proflavine Hemisulfate
T0438CAS 1811-28-5
Proflavine Hemisulfate is the hemisulfate salt form of proflavine, an acridine-derived fluorescent contrast and disinfectant agent that can potentially be used ...
Dexibuprofen
T0448CAS 51146-56-6
Dexibuprofen, S(+)-ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
Menadione
T0449CAS 58-27-5
Menadione is a synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after...
Rivaroxaban
T1184CAS 366789-02-8
Rivaroxaban is an orally bioavailable oxazolidinone derivative and direct inhibitor of the coagulation factor Xa with anticoagulant activity. Upon oral administ...
Edoxaban Tosylate Monohydrate
T2368CAS 1229194-11-9
Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.
Edoxaban
T2368LCAS 912273-65-5
Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.
Eltrombopag
T2562CAS 496775-61-2
Eltrombopag, an orally active thrombopoietin receptor agonist with megakaryopoiesis stimulating activity, binds to and stimulates the platelet thrombopoietin r...
Ozagrel
T6236CAS 82571-53-7
Ozagrel is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrov...
Dabigatran
T6295CAS 211914-51-1
Dabigatran is a THROMBIN inhibitor which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. It is used to reduce the r...
Heparin sodium
T6531CAS 9041-08-1
Heparin sodium is a sulfated polysaccharide, which belongs to the family of glycosaminoglycans. It is utilized as an anticoagulant and interacted with diverse p...
Ozagrel hydrochloride
T6625CAS 78712-43-3
Ozagrel HCl is a selective thromboxane A(2) synthetase inhibitor used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral...
Eltrombopag Olamine
T6825CAS 496775-62-3
Eltrombopag Olamine is the orally active ethanolamine salt of eltrombopag, a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-st...
p-Hydroxy-cinnamic acid
T7053CAS 7400-08-0
p-Hydroxycinnamic acid can inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin ...
Dabigatran Etexilate Mesylate
T5133CAS 872728-81-9
Dabigatran etexilate mesylate is the orally active prodrug of dabigatran. Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI, Ki: 4.5 nM).
Bivalirudin
T5519CAS 128270-60-0
Bivalirudin is a reversible inhibitor of α- and ζ-thrombin (Kis = 2.56 and 1.84 nM, respectively), enzymes that exhibit high fibrinogen-clotting activities.
Lusutrombopag
TQ0223CAS 1110766-97-6
Lusutrombopag is an orally bioavailable agonist of thrombopoietin (TPO) receptor.
OM-189
T12301CAS 55381-18-5
OM-189 is a selective inhibitor of synthetic thrombin.
RWJ-445167
T12782CAS 226566-43-4
RWJ-445167 is a thrombin and factor Xa dual inhibitor(Ki of 4.0 nM and 230 nM, respectively), with potent antithrombotic activity.
NFPS
T16292CAS 405225-21-0
NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion. NFPS is a selective and non-competit...
Thrombin inhibitor 1
T10081CAS 855998-46-8
Thrombin inhibitor 1 is a potent inhibitor of thrombin (Ki: 0.66 nM, 2xaPTT=0.43 μM).
Odiparcil
T16377CAS 137215-12-4
Odiparcil is an orally active beta-d-thioxyloside analog. Odiparcil is an indirect thrombin inhibitor that exerts its anticoagulant effect through activation of...
Melagatran
T11994CAS 159776-70-2
Melagatran does not require endogenous co-factors for its antithrombin effect and may help to alleviate some of the damaging effects of endotoxemia. Melagatran ...