Thrombin

Thrombin ( fibrinogenase, thrombase, thrombofort, topical, thrombin-C, tropostasin, activated blood-coagulation factor II, blood-coagulation factor IIa, factor IIa, E thrombin, beta-thrombin, gamma-thrombin) is a serine protease, an enzyme that, in humans, is encoded by the F2 gene. Prothrombin (coagulation factor II) is proteolytically cleaved to form thrombin in the clotting process. Thrombin in turn acts as a serine protease that converts soluble fibrinogen into insoluble strands of fibrin, as well as catalyzing many other coagulation-related reactions.

Cat. No.	Product name	CAS No.	Purity
T67959	Pirodomast	108310-20-9	98%
T67959	Pirodomast is a thromboxane A (TXA2) synthase inhibitor. Pirodomast inhibits leukotriene (LT) D4, C4, E4 formation and thromboxane B2 (TXB2) activity, but is wea...
T68002	Naroparcil	120819-70-7	98%
T68002	Naroparcil, an orally available thioglycoside analog of 4-methylumbelliferyl β-D-xyloside, showed antithrombotic effects in the Wessler sludge model of venous th...
T68086	Imitrodast	114686-12-3	98%
T68086	Imitrodast is a small molecule thromboxane A2 synthase (TXA2 synthase) inhibitor for the treatment of immune system disorders, respiratory disorders, and cardiov...
T11994	Melagatran	159776-70-2	98%
T11994	Melagatran, a direct and orally active thrombin inhibitor, specifically inhibits thrombin without affecting other enzymes in the coagulation cascade or fibrinoly...
T15046	Dabigatran ethyl ester	429658-95-7	98%
T15046	Dabigatran ethyl ester is an emerging oral anticoagulant and it also is a direct inhibitor of thrombin activity.
T16292	NFPS	405225-21-0	98%
T16292	NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion. NFPS is a selective and non-competiti...
T16377	Odiparcil	137215-12-4	98%
T16377	Odiparcil is an orally active beta-d-thioxyloside analog. Odiparcil is an indirect thrombin inhibitor that exerts its anticoagulant effect through activation of ...
T12301	OM-189	55381-18-5	98%
T12301	OM-189 is a selective inhibitor of synthetic thrombin.
T19580	Thrombin (MW 37kDa)	9002-04-4	98%
T19580	Thrombin is a trypsin-like allosteric serine protease.
T12782	RWJ-445167	226566-43-4	98%
T12782	RWJ-445167 is a thrombin and factor Xa dual inhibitor(Ki of 4.0 nM and 230 nM, respectively), with potent antithrombotic activity.
T10081	Thrombin inhibitor 1	855998-46-8	98%
T10081	Thrombin inhibitor 1 is a potent inhibitor of thrombin (Ki: 0.66 nM, 2xaPTT=0.43 μM).
T5133	Dabigatran Etexilate Mesylate	872728-81-9	98%
T5133	Dabigatran etexilate mesylate is the orally active prodrug of dabigatran. Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI, Ki: 4.5 nM).
T6825	Eltrombopag Olamine	496775-62-3	98%
T6825	Eltrombopag Olamine is the orally active ethanolamine salt of eltrombopag, a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-sti...
T3757	NQ301	130089-98-4	98%
T3757	NQ301, an antithrombotic agent, inhibits collagen-challenged rabbit platelet aggregation (IC50: 10 mg/mL).
T0155	Argatroban	74863-84-6	98%
T0155	Argatroban, a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.
TQ0223	Lusutrombopag	1110766-97-6	98%
TQ0223	Lusutrombopag is an orally bioavailable, small molecule thrombopoietin (TPO) receptor agonist for chronic liver disease (CLD) patients with thrombocytopenia prio...
T6625	Ozagrel hydrochloride	78712-43-3	98%
T6625	Ozagrel HCl is a selective thromboxane A(2) synthetase inhibitor used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ...
T7053	P-Hydroxycinnamic acid	7400-08-0	98%
T7053	p-Hydroxycinnamic acid can inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 ...
T0438	Proflavine Hemisulfate	1811-28-5	98%
T0438	Proflavine Hemisulfate is the hemisulfate salt form of proflavine, an acridine-derived fluorescent contrast and disinfectant agent that can potentially be used f...
T0389	Dabigatran etexilate	211915-06-9	98%
T0389	Dabigatran is a thrombin inhibitor, which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation.