T0314 |
Hexylresorcinol |
Hexylresorcinol is a substituted dihydroxybenzene used topically as an antiseptic for the treatment of minor skin infections. |
T0473 |
Arbutin |
Arbutin(β-Arbutin) is a glycosylated hydroquinone extracted from the bearberry plant in the genus Arctostaphylos and can inhibit tyrosinase and thus prevent th...
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T0759 |
Monobenzone |
Monobenzone is a Depigmenting Agent. The mechanism of action of monobenzone is as a Melanin Synthesis Inhibitor. The physiologic effect of monobenzone is by mea...
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T1188 |
Mizoribine |
Mizoribine belongs to the family of 1-Ribosyl-imidazolecarboxamides. Mizoribine has been investigated for the treatment of Rheumatoid Arthritis. |
T1210 |
Sodium etidronate |
Etidronate Disodium is a synthetic therapeutic diphosphonate analog of endogenous pyrophosphate. As a member of the family of drugs known as bisphosphonates, et...
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T1738 |
Taxifolin |
Taxifolin is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on. |
T3403 |
Glabridin |
Glabridin may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-glu...
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T3737 |
Hydroumbellic acid |
Hydroumbellic acid is a predicted metabolite generated by BioTransformer¹ that is produced by the metabolism of 3-(2, 4-dihydroxyphenyl)prop-2-enoic acid. It i...
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T3827 |
Rhein-8-glucoside calcium salt |
Rhein-8-O-beta-D-glucopyranoside(Rhein-8-glucoside calcium salt) shows moderate bioactivity against human Protein Tyrosine Phosphatase 1B (hPTP1B) in vitro. |
T3923 |
Calycosin |
Calycosin acts as a selective estrogen receptor modulator. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 fami...
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T4185 |
lavendustin C |
Lavendustin C is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase. |
T6463 |
Deoxyarbutin |
DeoxyArbutin(IC50=50 nM) inhibits tyrosinase activity reversibly. |
T4182 |
lavendustin B |
Lavendustin B is a Tyrosine Kinase Inhibitor and an inhibitor of HIV-1 integrase (IN) interaction with its cognate cellular cofactor, lens epithelium-derived gr...
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T4291 |
(+)-Isocorydine hydrochloride |
(+)-Isocorydine is a eukaryote protein kinases Inhibitor. |
T2P2923 |
Stearic acid |
1. Stearic Acid can reduce metastatic tumor burden. 2. Stearic Acid leads to dramatically reduced visceral fat likely by causing the apoptosis of preadipocytes....
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T3S1068 |
Oxyresveratrol |
1. Oxyresveratro can inhibit tyrosinase activity. 2. Oxyresveratro is useful to trauma models, as toxicity to glia could be beneficial by inhibiting reactive gl...
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T3S1612 |
kuwanon G |
1. Kuwanon G as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment fo...
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TCS2170 |
2-5-dihydroxyacetophenone |
1. 2, 5-Dihydroxyacetophenone possess anti-anxiety, and neuroprotective qualities. 2. 2, 5-Dihydroxyacetophenone treatment can induce a sustained activation of ...
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T7052 |
Gnetol |
Gnetol competitivity inhibits butyrylcholinesterase (IC50: 1.3 uM). Gnetol has a strong inhibitory effect on murine tyrosinase activity. Gnetol significantly su...
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T5552 |
Methyl cinnamate |
Methyl cinnamate, a tyrosinase inhibitor and a flavoring compound, has antimicrobial, antiadipogenic, vasorelaxant, and anti-inflammatory effects. |
T5755 |
Aloesin |
Aloesin is a C-glycosylated chromone compound found in aloe (Liliaceae) that inhibits tyrosinase (IC50 = 0.9 mM), an enzyme responsible for catalyzing the first...
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T7125 |
4-Butylresorcinol |
4-Butylresorcinol is a potent inhibitor of tyrosinase(IC50 : 11.27 μM), and is used in cosmetics as a depigmenting agent. |
T5985 |
Glycolic acid |
Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation,and used in skincare products |
T7438 |
3,5-Dimethoxyphenol |
3,5-Dimethoxyphenol as a marker of Taxus poisoning, being present in all species of Taxus. It has potent tyrosinase-inhibiting activity. |
T7714 |
Temocapil |
Temocapril is an inhibitor of tyrosine kinase. |
T4183 |
lavendustin A |
lavendustin A is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase. |
T6S1597 |
Mulberroside A |
1. Mulberroside has nephroprotective, hypoglycemic, and antidiabetic effects. 2. Mulberroside A is a glycosylated stilbene of oxyresveratrol; thus, the deglycos...
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T3382 |
Wilforlide A |
Wilforlide A is a natural product, separated from the ethanolic extract of tripterygium wilfordii. High-dose wilforlide A has obvious anti-inflammatory effect, ...
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T0666 |
4-Chlorosalicylic acid |
4-Chlorosalicylic acid is antimicrobial compositions comprising a metal salt and a benzoic acid analog. |
T8087 |
Tropolone |
Tropolone, a metal chelator, possesses weak antioxidative and radical-scavenging properties and shows a strong affinity for ferric ion |
TN1314 |
6-Hydroxykaempferol |
6-Hydroxykaempferol is a competitive inhibitor of tyrosinase compared to L-DOPA, it shows also high antioxidant activities. |
TN1325 |
6-Prenylnaringenin |
6-Prenylnaringenin is an isomer of the potent phytoestrogen, 8-prenylnaringenin. |
TN1690 |
Glabrene |
Glabrene, Liquiritin apioside, neolicuroside, and 18α²-glycyrrhetic acid are the predominant phenolic derivatives partitioning at the interface and most likel...
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TN1928 |
Methyl rosmarinate |
Methyl rosmarinate is a noncompetitive tyrosinase inhibitor which is isolated from Rabdosia serra, with an IC50 of 0.28 mM for mushroom tyrosinase.Methyl rosmar...
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TN1958 |
Mulberroside F |
Mulberroside F shows inhibitory effects on tyrosinase activity and on the melanin formation of melan-a cells, it also exhibits superoxide scavenging activity th...
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TN2026 |
Oxyresveratrol 3'-O-beta-D-glucopyranoside |
Oxyresveratrol-3'-O-beta-D-glucopyranoside shows tyrosinase inhibitory activity, it may be a potential candidate as skin-whitening agents without posing any ser...
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TN2078 |
Pinocembrin chalcone |
Pinocembrin chalcone has tyrosinase inhibitory activity.It also shows antimutagenic effect, which is mainly due to the inhibition of the first step of enzymatic...
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TN2148 |
Retusin |
Retusin behaves as pre- and postemergent herbicides. Retusin is a weak inhibitor of ATP synthesis; it exhibits potent free-radical-scavenging capacities as well...
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TN2280 |
Trametenolic acid |
Trametenolic acid is a cytotoxic agent.It exhibits a mode of mixed inhibition with a K I of 0.9μM, K IS of 0.5μM, and an IC50 of 7.25μM.Trametenolic acid and...
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TN2288 |
Uralenol |
Uralenol significantly shows the inhibitory activities against the PTP1B enzyme; it also shows inhibitory activities on mushroom tyrosinase using l-tyrosine as ...
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TN2303 |
Viscumneoside III |
Viscumneoside III demonstrates high tyrosinase inhibition, it can be utilized in skin whitening cosmetics. |
TN1772 |
Isoastilbin |
Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) w...
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TN2025 |
Oxyresveratrol 2-O-beta-D-glucopyranoside |
Oxyresveratrol-2-O-beta-D-glucopyranoside shows better tyrosinase inhibitory activities than kojic acid. |
TN1705 |
Glycyrrhisoflavone |
Glycyrrhisoflavone is a tyrosinase inhibitor, it also shows inhibitory effects on monoamine oxidase. |
TN1804 |
Isosilybin A |
Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (...
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TN1832 |
Kanzonol C |
Kanzonol C has antimicrobial activity, it also shows potent PTP1B inhibitory activity (IC50 value of 0.31-0.97uM). Kanzonol C has chemopreventive activity,it sh...
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TN1840 |
Kurarinol |
Kurarinol is a potent inhibitor of sortase A, with an IC50 value of 107.7 ± 6.6 μM. Kurarinol has extremely strong tyrosinase inhibitory activity, exerts vary...
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T4S1658 |
Benzoyloxypeoniflorin |
Benzoyloxypeoniflorin is a natural product,contributes to improving blood circulation through their inhibitory effects on both platelet aggregation and blood co...
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T10664 |
Calcium 2-oxoglutarate |
Calcium 2-oxoglutarate is an intermediate in the production of GTP or ATP in the Krebs cycle. It is a reversible inhibitor of tyrosinase (IC50: 15 mM). |
T2S0799 |
Noroxyhydrastinine |
Noroxyhydrastinine exhibits potent melanogenesis-inhibitory activities, it inhibits melanogenesis, at least in part, by inhibiting the expression of protein lev...
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TC0017 |
Haplopine |
Haplopine shows photo-activated antimicrobial activity against S. aureus. It exhibits potent melanogenesis-inhibitory activities with almost no toxicity to the ...
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TN2672 |
2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran |
2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran shows radical scavenging activities. It also shows mushroom tyrosinase inhibitory activity with an IC50 value of 5.2...
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TN2923 |
3'-Deoxy-4-O-methylsappanol |
3'-Deoxy-4-O-methylsappanol shows moderate cytotoxicities against cultured human melanoma HMV-II cells with the IC50 value of 872.0 uM ± 2.4. |
TMA0593 |
Broussoflavonol F |
Broussoflavonol F has antiplatelet effect, is partially due to an inhibitory effect on cyclooxygenase, can inhibit arachidonic acid (AA)-induced platelet aggreg...
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TN3540 |
Broussonin C |
Broussonin C and broussin are antifungal compounds. Broussonin C exerts simple reversible slow-binding inhibition against diphenolase. |
TN3545 |
Buddlenoid A |
Buddlenoid A shows high inhibition of mushroom tyrosinase. |
TN3644 |
Chlorophorin |
Chlorophorin shows high anti-protozoal activity with an MIC of 0.25 microg/ml. Chlorophorin can strongly inhibit mushroom tyrosinase activity with IC50 values o...
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TN3753 |
Dalbergioidin |
Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyce...
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TN3882 |
Dodoviscin A |
Dodoviscin A may be a new promising pigmentation-altering agent for cosmetic and therapeutic applications, it can inhibit melanin biosynthesis induced by 3-isob...
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TN4117 |
GB 1a |
GB 1a shows potential in vitro antioxidant activities. |
TN4148 |
Glyasperin C |
Glyasperin C acts as a partial estrogen antagonist, it shows tyrosinase inhibitory activity (IC (50) = 0.13 +/- 0.01 microg/mL), it could be a promising candida...
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TN4179 |
Haginin A |
Haginin A is an effective inhibitor of hyperpigmentation caused by UV irradiation or by pigmented skin disorders through downregulation via ERK and Akt/PKB acti...
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TN4279 |
Isoderrone |
Isoderrone shows inhibitory effects on α-glucosidase in vitro; it is a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with IC50 value of 22.7 ± 1.7 uM, su...
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TN4580 |
Morachalcone A |
Morachalcone A displays significant tyrosinase inhibitory activity (IC50, 0.013 uM); it also exerts strong pancreatic lipase inhibition with IC 50 value of 6.2 ...
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TN4642 |
Neorauflavane |
Neorauflavane shows tyrosinase inhibition, it can inhibit tyrosinase monophenolase activity with an IC50 of 30 nM, it also can efficiently reduce melanin conten...
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TMA2563 |
Pedalitin |
Pedalitin is a mixed-type inhibitor of tyrosinase. In the assay of α-glucosidase inhibition, rosmarinic acid is a competitive inhibitor, whereas both methyl ro...
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TN5117 |
Taxiphyllin |
Taxiphyllin can inhibit tyrosinase activity in vitro significantly and is a potent tyrosinase inhibitor. Taxiphyllin displays mild antibacterial activity agains...
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TN5119 |
Taxoquinone |
Taxoquinone has strong antibacterial effect, it could be used as a promising antibacterial agent in food industry to inhibit the growth of certain important foo...
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TN5153 |
Torilin |
Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linoleni...
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TMA0003 |
Trans-caffeic acid |
Trans-caffeic acid stearyl ester is posited to inhibit melanogenesis signaling while suppressing cAMP levels and, subsequently, MC1R, MITF, tyrosinase, TRP-2 an...
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TN1545 |
D-Tyrosine |
D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine inhibits biofilm formati...
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T2A2524 |
4-Methoxysalicylaldehyde |
2-Hydroxy-4-methoxybenzaldehyde, a chemical compound and an isomer of Vanillin, could be used to synthesis Urolithin M7. 2-hydroxy-4-methoxybenzaldehyde is a po...
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TN2246 |
Swertiajaponin |
Swertiajaponin possesses antimicrobial activity.
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