YAP

YAP (Yes-associated protein) is a transcription co-activator in the Hippo tumor suppressor pathway and controls cell growth, tissue homeostasis and organ size. YAP is inhibited by the kinase Lats, which phosphorylates YAP to induce its cytoplasmic localization and proteasomal degradation. YAP induces gene expression by binding to the TEAD family transcription factors. The function of YAP in human cancer is complex and could be cell-type-dependent. For instance, YAP could function as a tumor suppressor in some cell types, such as hematological cancers, by inducing apoptosis in response to DNA damage.

Cat. No.	Product name	CAS No.	Purity
T77580	IK-930	2563892-44-2	98%
T77580	IK-930 is an orally active TEAD inhibitor (EC50 < 0.1 µM) with potent potency.
T60148	MSC-4106	2738542-58-8	98%
T60148	MSC-4106 is an orally active and potent inhibitor of YAP/TAZ-TEAD. MSC-4106 inhibits TEAD1 or TEAD3 auto-palmitoylation and exhibits inhibitory effect on NCI-H22...
TP2160L1	YAP-TEAD-IN-1 acetate	TP2160L1	98%
TP2160L1	YAP-TEAD-IN-1 acetate is an effective and competitive inhibitor of YAP–TEAD interaction with an IC50 of 25 nM.
T64342	DC-TEADin02	2380228-45-3	98%
T64342	DC-TEADin02 is an inhibitor of TEAD auto palmitoylation (IC50 = 197 nM). DC-TEADin02 can be in studies about development, regeneration, and tissue homeostasis.
T60218	YAP/TAZ inhibitor-2	2762617-31-0	98%
T60218	YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC 50 value of 3 nM. YAP/TAZ inhibitor-2 shows anti-proliferative and antitumor ...
T9566	PY-60	2765218-56-0	98%
T9566	PY-60 potently activates YAP transcriptional activities targeting annexin A2 (Kd = 1.4 µM). PY-60 activates a proproliferative, YAP-dependent transcriptional pro...
T22372	MYF-01-37	2416417-65-5	98%
T22372	MYF-01-37 is a novel covalent TEAD inhibitor.
T67872	VT104	2417718-25-1	98%
T67872	VT104 is a potent YAP/TAZ inhibitor with oral activity that can be used in cancer research. VT104 prevents palmitylation of endogenous TEAD1 and TEAD3 proteins.
T3050	ML-7 hydrochloride	110448-33-4	98%
T3050	ML-7 Hcl is a cell-permeable, reversible, effective, ATP-competitive, and specific inhibitor of myosin light chain kinase (Ki: 300 nM); also inhibits smooth-musc...
T1477	AICAR	2627-69-2	98%
T1477	Acadesine is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating othe...
T35545	VT107	2417718-63-7	98%
T35545	VT107 is a potent pan-TEAD auto-palmitoylation inhibitor. VT-107 can be used for the research of cancer[1].
T9053	Lats-IN-1	1424635-83-5	98%
T9053	Lats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.
T3112	Verteporfin	129497-78-5	98%
T3112	Verteporfin, a benzoporphyrin derivative monoacid ring A, can inhibit the activity of YAP.
T8421	TED-347	2378626-29-8	98%
T8421	TED-347 is an irreversible and covalent inhibitor of TEAD4-Yap1 protein-protein interaction(EC50 of 5.9 μM), and inhibits glioblastoma cell viability.
T69760	TT-10	2230640-94-3	98%
T69760	TT-10 (TAZ-K) is an activator of YES-associated protein (YAP)-transcriptional enhancer factor domain (TEAD) activity. TT-10 can be used for the research of heart...