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Cat No. | Product Name | Synonyms | Targets |
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T10894 | CSF1R-IN-1 | c-Fms | |
CSF1R-IN-1 is a CSF1R inhibitor with IC50 of 0.5 nM. | |||
T13194 | CSF1R-IN-2 | c-Fms , c-Met/HGFR , Src | |
CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively). | |||
T64066 | CSF1R-IN-3 | c-Fms , CSF-1R | |
CSF1R-IN-3 is an orally effective CSF-1R inhibitor with an IC50 value of 2.1 nM. CSF1R-IN-3 has anti-proliferative activity against colorectal cancer cells. CSF1R-IN-3 exhibits anti-tumour effects and immune enhancing ef... | |||
T62557 | CSF1R-IN-14 | ||
CSF1R-IN-14, an isoindolinone derivative compound, is a potent inhibitor of CSF1R. CSF1R-IN-14 has potential for cancer disease research. | |||
T79472 | CSF1R-IN-17 | c-Fms | |
CSF1R-IN-17 (compound 9) is a potent, selective antagonist of CSF1R, exhibiting an inhibition concentration half-maximum (IC50) of 0.2 nM. It is capable of inhibiting osteoclast differentiation [1]. | |||
T62342 | CSF1R-IN-4 | ||
CSF1R-IN-4 is a potent inhibitor of CSF-1R. CSF1R-IN-4 can affect the exchange of inflammatory factors between TAM and glioma cells. CSF1R-IN-4 has potential for the study of cancer diseases. EGFR-IN-40. | |||
T62187 | CSF1R-IN-6 | ||
CSF1R-IN-6 is a potent inhibitor of CSF1R. CSF1R-IN-6 is a potent inhibitor of CSF1R, which is expressed in macrophages and is dependent on the CSF-1/CSF-1R signalling pathway for survival and differentiation of macropha... | |||
T62364 | CSF1R-IN-5 | ||
CSF1R-IN-5 is a potent inhibitor of CSF1R. CSF1R-IN-5 can affect the exchange of inflammatory factors between TAM and glioma cells. CSF1R-IN-5 has the potential to be used in the study of cancer diseases. | |||
T62190 | CSF1R-IN-7 | ||
CSF1R-IN-7 (Formula I) is a CSF-1R inhibitor that can be used to study Alzheimer's disease. | |||
T61893 | CSF1R-IN-12 | ||
CSF1R-IN-12 is an effective CSF1R inhibitor. CSF1R-IN-12 has research potential in cancer diseases. | |||
T61554 | CSF1R-IN-13 | ||
CSF1R-IN-13 is a powerful CSF1R inhibitor with potential applications in researching cancer diseases [1]. CSF1R, also known as colony stimulating factor 1 receptor, is a critical growth factor that regulates various cell... | |||
T62318 | CSF1R-IN-9 | ||
CSF1R-IN-9 (Compound 46) is a CSF-1R inhibitor (IC50: 0.028 μM). | |||
T62313 | CSF1R-IN-10 | ||
CSF1R-IN-10 (Compound 48) is a CSF-1R inhibitor (IC50: 0.005 μM). | |||
T62390 | CSF1R-IN-8 | ||
CSF1R-IN-8 (Compound 22) is a CSF-1R inhibitor (IC50: 0.012 μM). | |||
T72574 | Axl/Mer/CSF1R-IN-1 | ||
Axl/Mer-IN-1 is a compound that functions as an inhibitor for Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R, exhibiting dissociation constants (Kds) of less than 0.1 μM. | |||
T5586 | CFMS Receptor Inhibitor II | c-Fms | |
cFMS Receptor Inhibitor II is a CSF1R kinase inhibitor | |||
T14380 | AZD7507 | CSF-1R , HER , Sodium Channel | |
AZD7507 is a CSF-1R inhibitor with an IC50 of 32 nM. AZD7507 has antitumor activity. | |||
T6119 | Sotuletinib | BLZ945 | c-Fms , CSF-1R |
Sotuletinib (BLZ945) is an orally active, effective and specific CSF-1R inhibitor (IC50: 1 nM), >1000-fold selective against its closest receptor tyrosine kinase homologs. | |||
T10652 | Vimseltinib | DCC-3014 | c-Fms , CSF-1R , c-Kit |
Vimseltinib (DCC-3014) is a c-FMS (CSF-IR) and c-Kit dual inhibitor (IC50s: <0.01 μM and 0.1-1 μM). | |||
TQ0015 | PRN1371 | c-Fms , FGFR , CSF-1R | |
PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 and CSF1R). | |||
T7100 | PLX5622 | PLX-5622 | c-Fms , CSF-1R |
PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor. | |||
T2115 | Pexidartinib | PLX-3397 | Apoptosis , c-Fms , FLT , CSF-1R , c-Kit |
Pexidartinib (PLX-3397) is a capsule formulation containing a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity. | |||
T2659 | GW2580 | GW 2580,SC-203877 | c-Fms |
GW2580 (SC-203877) is a specific, oral-bioavailable CSF-1R inhibitor for c-FMS. | |||
T15199 | Edicotinib | JNJ-527,JNJ-40346527 | c-Fms , FLT , CSF-1R , c-Kit |
Edicotinib (JNJ-527) is a brain penetrant and orally active inhibitor of the colony-stimulating factor-1 receptor (IC50: 3.2 nM). It shows less inhibitory effects on KIT and FLT3 (IC50: 20 nM and 190 nM). It has the pote... | |||
T2624 | OSI-930 | OSI 930 | Apoptosis , c-Fms , Raf , VEGFR , FLT , CSF-1R , Src , c-Kit |
OSI-930, an orally active inhibitor of c-Kit and the vascular endothelial growth factor receptor-2 (VEGFR-2), targets cancer cell proliferation and blood vessel growth (angiogenesis) in tumors. | |||
T35570 | Chiauranib | CS2164 | c-Fms , VEGFR , FLT , PDGFR , c-Kit , Aurora Kinase |
Chiauranib is a multi-target inhibitor against tumor angiogenesis and exhibits potent anticancer effects. Chiauranib potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRα and c-Kit), mitosis-... | |||
T4315 | Ki20227 | c-Fms , VEGFR , CSF-1R , PDGFR , c-Kit | |
Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM). It also has certain inhibitory against VEGFR2(IC50: 12 nM) and c-Kit/PDGFRβ(IC50: 451/217 nM), respectively. | |||
T6930 | Pazopanib Hydrochloride | GW786034,Pazopanib HCl,GW786034 HCl,Votrient HCl,Armala | c-Fms , VEGFR , FGFR , PDGFR , c-Kit , Autophagy |
Pazopanib Hydrochloride (Votrient HCl) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, resp... | |||
T2514 | Linifanib | ABT-869,RG3635,AL-39324 | Apoptosis , c-Fms , VEGFR , FLT , CSF-1R , PDGFR , c-Kit , Autophagy |
Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) and PDGFRβ (IC50: 66 nM). Linifanib may exhibit potent antiprolife... | |||
T6289 | Dovitinib | TKI258,CHIR-258 | VEGFR , FGFR , FLT , PDGFR , c-Kit |
Dovitinib (CHIR-258) (TKI258, CHIR258) is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit, IC50: 1/2 nM), also effective to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs (IC50: 8-13 nM), less potent to E... | |||
T6028 | PF 477736 | PF 00477736,PF-477736,PF-736,PF-00477736,PF477736 | c-Fms , VEGFR , FGFR , FLT , c-RET , Chk , CDK , Src , Aurora Kinase |
PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CSF1R), Ret and Yes. | |||
T1925 | PLX647 | c-Fms , c-Kit | |
PLX647 is a highly selective dual FMS/KIT kinase inhibitor (IC50: 28/16 nM). | |||
TQ0235 | AC710 | FLT , PDGFR , c-Kit | |
AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ). | |||
T79157 | Pimicotinib | ABSK021,ABSK-021 | c-Fms , Others |
Pimicotinib (ABSK021) is a potent CSF1R inhibitor with antitumor activity and can be used to study advanced solid tumors. | |||
T4075 | Sulfatinib | KDR-IN-1 | VEGFR , FGFR , HER |
Sulfatinib (KDR-IN-1) (HMPL-012) is a potent and highly selective tyrosine kinase inhibitor against VEGFR1/2/3, FGFR1 and CSF1R with IC 50 s ranging from 1 to 24 nM. | |||
T76776 | Emactuzumab | RO 5509554,RG 7155 | c-Fms , TAM Receptor |
Emactuzumab(RG 7155) is a monoclonal antibody against colony-stimulating factor-1 receptor targeting tumor-associated macrophages (TAMs) Emactuzumab has antitumor activity and inhibits activation of colony-stimulating fa... | |||
T5172 | AZ304 | c-Fms , Raf , p38 MAPK , Autophagy | |
AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM). | |||
T35333 | ARRY-382 | CSF-1R | |
ARRY-382 is a highly selective oral inhibitor of CSF-1R with an IC50 of 9 nM. | |||
T4376 | Nampt-IN-1 | LSN3154567 | c-Fms , NAMPT , CSF-1R |
Nampt-IN-1 (LSN3154567) (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM. | |||
T11729 | JTE-952 | Histamine Receptor | |
JTE-952 is a oral, potent active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , resp... | |||
T10228 | AC710 Mesylate | PDGFR | |
AC710 Mesylate is a potent PDGFR inhibitor (Kds: 0.6, 1.57, 1, 1.3, 1.0 nM for FLT3, CSF1R, KIT, PDGFRα and PDGFRβ). | |||
T40164 | BPR1R024 | BPR1R024 | |
BPR1R024 is an orally active and selective CSF1R inhibitor ( IC 50 = 0.53 nM). | |||
T29542 | AC708 | AC 708,AC-708 | |
AC708 is a small molecule CSF1R inhibitor that effectively inhibits CSF1R phosphorylation mediated by CSF-1 (IC50 = 26 nM) and IL-34 (IC50 = 33 nM). It also inhibited the activity of growth factor-dependent cells culture... | |||
T69759 | IACS-9439 | c-Fms | |
IACS-9439 is a potent, selective, and orally active inhibitor of CSF1R, exhibiting a K(i) of 1 nM. It is applicable in the research of advanced solid tumors [1]. | |||
T21330 | JNJ-28312141 | JNJ 28312141,JNJ28312141 | |
JNJ-28312141 is an orally active CSF1R inhibitor and a FLT3 inhibitor. JNJ-28312141 is a new agent with potential therapeutic activity in acute myeloid leukemia and in settings where CSF-1-dependent macrophages and osteo... | |||
T62788 | Pexidartinib hydrochloride | ||
Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, selective, orally active, ATP-competitive inhibitor of colony-stimulating factor 1 (CSF1R or M-CSFR) (IC50: 20 nM) and c-Kit (IC50: 10 nM). Pexidartinib hy... | |||
T12505 | PLX5622 hemifumarate | c-Fms | |
PLX5622 hemifumarate is a highly selective brain penetrant and orally active CSF1R inhibitor with an IC 50 of 0.016 μM and Ki of 5.9 nM. PLX5622 hemifumarate allows for extended and specific microglial elimination, prece... | |||
T76786 | Cabiralizumab | ||
Cabiralizumab (FPA 008), an anti-CSF1R monoclonal antibody (MAb), promotes T cell infiltration and boosts antitumor immune responses. It also prevents osteoclast activation, thereby inhibiting bone destruction, and is ut... | |||
T70444 | Edicotinib HCl | ||
Edicotinib, also known as JNJ-40346527, is a small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; FMS) with potential antineoplastic activity. FMS tyrosine kinase inhibitor JNJ-40... | |||
T71400 | Quizartinib HCl | ||
Quizartinib, also know as AC220 and AC010220, is an orally available FLT3 / STK1 inhibitor with potential antineoplastic activity. Class III receptor tyrosine kinase inhibitor AC220 selectively inhibits class III recept... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01037 | CSF1R Protein (Met1-Glu512), Human, Recombinant (His) | Human | HEK293 |
M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein... | |||
TMPJ-01418 | CSF1R Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | Human Cells |
Macrophage colony-stimulating factor 1 receptor (CSF1R) is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-l... | |||
TMPJ-01419 | CSF1R Protein, Cynomolgus, Recombinant (His) | Cynomolgus | Human Cells |
Macrophage colony-stimulating factor 1 receptor (CSF1R) is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-l... | |||
TMPH-00354 | CSF1R Protein, Feline, Recombinant (His & SUMO) | Feline | E. coli |
Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially monon... | |||
TMPK-00656 | M-CSFR/CSF1R/CD115 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
CSF1R also known as M-CSF receptor, the product of the c-fms proto-oncogene, is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain ... | |||
TMPK-00414 | M-CSFR/CSF1R/CD115 Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
CSF1R also known as M-CSF receptor, the product of the c-fms proto-oncogene, is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain ... | |||
TMPK-00415 | M-CSFR/CSF1R/CD115 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
CSF1R also known as M-CSF receptor, the product of the c-fms proto-oncogene, is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain ... | |||
TMPY-00881 | CSF1R Protein, Human, Recombinant | Human | HEK293 |
M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein... | |||
TMPY-03920 | CSF1R Protein, Rat, Recombinant (hFc) | Rat | HEK293 |
M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein... | |||
TMPY-03734 | CSF1R Protein, Rat, Recombinant (His) | Rat | HEK293 |
M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein... | |||
TMPY-05043 | CSF1R Protein, Rhesus, Recombinant (hFc) | Rhesus | HEK293 |
M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein... | |||
TMPY-05264 | CSF1R Protein, Human, Recombinant (mFc) | Human | HEK293 |
M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein... | |||
TMPY-05436 | CSF1R Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein... | |||
TMPY-01833 | CSF1R Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein... | |||
TMPY-05040 | CSF1R Protein, Rhesus, Recombinant (His) | Rhesus | HEK293 |
M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein... | |||
TMPY-05429 | CSF1R Protein, Human, Recombinant (hFc) | Human | HEK293 |
M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein... | |||
TMPY-04358 | CSF1R Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein... | |||
TMPY-04938 | CSF1R Protein, Mouse, Recombinant (His), Biotinylated | Mouse | HEK293 |
M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein... | |||
TMPY-06384 | CSF1R Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein... | |||
TMPY-05513 | CSF1R Protein (Ala299-Glu512), Human, Recombinant (His) | Human | HEK293 |
M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein... | |||
TMPY-06389 | CSF1R Protein, Human, Recombinant (hFc & Avi), Biotinylated | Human | HEK293 |
M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein... | |||
TMPY-05045 | CSF1R Protein, Human, Recombinant (Domain I&II&III, His) | Human | HEK293 |
M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein... | |||
TMPY-05296 | IL-34 Protein, Human, Recombinant (His) | Human | CHO |
IL34 (Interleukin 34) is a Protein Coding gene. IL-34, also known as uncharacterized protein C16 or f77 homolog, belongs to the IL-34 family. IL-34 is a cytokine that promotes the differentiation and viability of monocyt... | |||
TMPY-00986 | IL-34 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
IL34 (Interleukin 34) is a Protein Coding gene. IL-34, also known as uncharacterized protein C16 or f77 homolog, belongs to the IL-34 family. IL-34 is a cytokine that promotes the differentiation and viability of monocyt... |