Search Result

Search Results for " igf-1r "

Targets

Compounds

Natural Products

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T38502	IGF-1R inhibitor-2
	IGF-1R inhibitor-2 (example 121) is a compound that inhibits the insulin-like growth factor-1 receptor (IGF-1R). By downregulating the IGF-1R, it has the potential to reverse the transformed phenotype of tumor cells and ...
T2085	PQ401	IGF-1R Inhibitor II	Apoptosis , IGF-1R
	PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).		Apoptosis , IGF-1R
T8906	NBI-31772	NBI31772,NBI 31772	IGF-1R
	NBI-31772 (NBI 31772) is the potent inhibitor of insulin-like growth factor-1 binding protein (IGFBP, Ki = 47 nM). NBI-31772 can be used in research on IGF-responsive diseases.		IGF-1R
T2349	BMS-754807		Trk receptor , c-Met/HGFR , IGF-1R
	Dual IGF-1R/InsR Inhibitor BMS-754807 is an oral small molecule inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine kinases with potential antineoplastic activity.		Trk receptor , c-Met/HGFR , IGF-1R
T17267	XL228		IGF-1R , Bcr-Abl , Src , Aurora Kinase
	XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).		IGF-1R , Bcr-Abl , Src , Aurora Kinase
T6003	GSK1904529A	GSK 4529	Apoptosis , Raf , VEGFR , IGF-1R , Syk
	GSK1904529A (GSK 4529) is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .		Apoptosis , Raf , VEGFR , IGF-1R , Syk
T6017	Linsitinib	OSI-906	IGF-1R
	OSI-906 (Linsitinib (OSI-906)) is an orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. Linsitinib selectively inhibits IGF-1R, whic...		IGF-1R
T13564	AZ7550		MLK , FAK , EGFR , FLT , Tyrosine Kinases , PYK2 , MNK , IGF-1R , ACK , BTK , ALK , Drug Metabolite
	AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T3079	GSK1838705A		IGF-1R , JNK , S6 Kinase , ALK
	GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to other protein kinases.		IGF-1R , JNK , S6 Kinase , ALK
T8496	MAZ51		Apoptosis , VEGFR
	MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.		Apoptosis , VEGFR
T6080	NVP-AEW541	AEW541	FLT , Tyrosine Kinases , IGF-1R , Autophagy
	NVP-AEW541 (AEW541), a potent inhibitor of IGF-1R(IC50=150 nM) and InsR(IC50=140 nM), exhibits excellent efficiency and specificity for IGF-1R in a cell-based assay.		FLT , Tyrosine Kinases , IGF-1R , Autophagy
T1791	Ceritinib	LDK378	Serine Protease , IGF-1R , ALK
	Ceritinib (LDK378) is a specific ALK inhibitor (IC50: 0.2 nM).		Serine Protease , IGF-1R , ALK
T1918	NVP-TAE 226	TAE226	Apoptosis , FAK , c-Met/HGFR , PYK2 , IGF-1R
	NVP-TAE 226 (TAE226) is an effective FAK inhibitor (IC50: 5.5 nM) and most effective to Pyk2(IC50: 3.5 nM); 10- to 100-fold less effective against IGF-1R, InsR, c-Met, and ALK.		Apoptosis , FAK , c-Met/HGFR , PYK2 , IGF-1R
T10285	ALK inhibitor 1		FAK , IGF-1R , ALK
	ALK inhibitor 1 is a selective ALK kinase inhibitor.		FAK , IGF-1R , ALK
T1967	AZD-3463	ALK/IGF1R inhibitor	Apoptosis , IGF-1R , ALK , Autophagy
	AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.		Apoptosis , IGF-1R , ALK , Autophagy
T6079	NVP-ADW742	ADW742,ADW,GSK 552602A	Apoptosis , IGF-1R
	NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.		Apoptosis , IGF-1R
T1791L	Ceritinib dihydrochloride	LDK378 dihydrochloride	IGF-1R , ALK
	Ceritinib dihydrochloride (LDK378 dihydrochloride) is a selective, orally bioavailable and ATP-competitive inhibitor of ALK tyrosine kinase(IC50 of 200 pM), and also inhibits IGF-1R, InsR, and STK22D (IC50 values of 8, 7...		IGF-1R , ALK
T13564L	AZ7550 hydrochloride	AZ7550 hydrochloride (1421373-99-0 free base)	EGFR , IGF-1R
	AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).		EGFR , IGF-1R
T6419	BMS-536924	HY-10262,BMS 536924,CS-0117	Apoptosis , FAK , MEK , IGF-1R , Src
	BMS-536924 (BMS 536924) is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2.		Apoptosis , FAK , MEK , IGF-1R , Src
T2693	AG1024	Tyrphostin AG 1024,Tyrphostin,AGS 200	Apoptosis , IGF-1R
	AG1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM), and is less potent for IR(IC50=57 μM).		Apoptosis , IGF-1R
T4324	PQ401 hydrochloride (196868-63-0(free base))		IGF-1R
	PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.		IGF-1R
T77624	WAY-270250		IGF-1R , Src
	WAY-270250 is an IGF-1R/SRC inhibitor.		IGF-1R , Src
T11593	I-OMe-Tyrphostin AG 538	I-OMe-AG 538	IGF-1R , PI3K
	I-OMe-Tyrphostin AG 538 is a specific IGF-1R inhibitor and ATP-competitive inhibitor of PI5P4Kα (IC50: 1 µM).I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and exhibits preferential cytotoxicity to nutrient-d...		IGF-1R , PI3K
T76727	Teprotumumab	R 1507,HZN 001	TSH Receptor , IGF-1R
	Teprotumumab is a human monoclonal antibody that blocks the IGF-1 receptor (IGF-1R). Teprotumumab binds to the extracellular α-subunit domain ligand of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Te...		TSH Receptor , IGF-1R
T68405	KW-2450 free base		IGF-1R
	KW-2450 free base is a multiple inhibitor of IGF-1R/IR and tyrosine kinases with antitumor activity.KW-2450 free base shows modest growth inhibitory activity and inhibits IGF-1-induced signaling in a mouse HT-29/GFP colo...		IGF-1R
T2341	KW-2449	KW2449	Apoptosis , FGFR , FLT , JAK , Bcr-Abl , Src , c-Kit , Aurora Kinase
	KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 (IC50: 6.6 nM), modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.
T5524	Aurora kinase inhibitor-3	Aurora Kinase Inhibitor III	Aurora Kinase
	Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR.		Aurora Kinase
T4605	NT157		IGF-1R , STAT
	NT157 is a small molecule tyrphostin targeting IRS protein and has the potential to inhibit IGF-1R and STAT3 signaling pathways in TME cancer cells and stromal cells, resulting in decreased cancer cell survival.		IGF-1R , STAT
T6184	Orantinib	SU6668,TSU-68,NSC 702827	Apoptosis , VEGFR , FGFR , PDGFR
	Orantinib (NSC 702827) , a excellent effective against PDGFR autophosphorylation with Ki of 8 nM, also highly inhibits Flk-1 and FGFR1 trans-phosphorylation. It shows little effect against IGF-1R, Met, Src, Lck, Zap70, A...		Apoptosis , VEGFR , FGFR , PDGFR
T6289	Dovitinib	TKI258,CHIR-258	VEGFR , FGFR , FLT , PDGFR , c-Kit
	Dovitinib (CHIR-258) (TKI258, CHIR258) is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit, IC50: 1/2 nM), also effective to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs (IC50: 8-13 nM), less potent to E...		VEGFR , FGFR , FLT , PDGFR , c-Kit
T3570	SU4312	SU 4312,NSC 86429	VEGFR , PDGFR
	SU-4312, also known as DMBI, is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively). SU4312 (SU 4312) unexpectedly protects against MPP(+) -induced neurotox...		VEGFR , PDGFR
T25123	AZ12253801	AZ 12253801,AZ-12253801
	AZ12253801 is a type 1 insulin-like growth factor receptor (IGF-1R) inhibitor.
T39257	Ugodotin
	Ugodotin is an antibody-drug conjugate. Ugodotin can binds IGF-1R with antitumor activity.
T70876	KW-2450 Tosylate
	KW-2450 Tosylate is an orally bioavailable inhibitor of IGF-1R and IR tyrosine kinases with potential antineoplastic activity.
T76800	Dalotuzumab
	Dalotuzumab (MK-0646) is a humanized recombinant monoclonal antibody (IgG1 type) that targets IGF-1R, inhibiting tumor cell proliferation, IGF-1R autophosphorylation, and Akt phosphorylation mediated by IGF-1 and IGF-2. ...
T77071	Lonigutamab
	Lonigutamab (hz208F2-4), a humanized monoclonal antibody targeting IGF-1R, facilitates the creation of antibody-drug conjugates (ADC) [1].
T77044	Istiratumab
	Istiratumab (M-6495), a bispecific monoclonal antibody, targets IGF-1R and ErbB3 receptors and facilitates their degradation via the proteasome pathway, offering potential for cancer research [1] [2] [3].
T78279	Cixutumumab	NSC742460,IMC-A12
	Cixutumumab (IMC-A12), a humanized monoclonal antibody targeting IGF-1R, exhibits high affinity and inhibits ligand-dependent receptor activation, impeding downstream signaling. Additionally, it facilitates the internali...
T68740	NVP-TAC544
	NVP-TAC544 is a novel focal adhesion kinase (FAK) inhibitor, potently blocking kinase activity of FAK along with Aurora A, activated Cdc42-associated kinase 1 (ACK1), Met, insulin receptor (IR), TrkA, and IGF-1R.
T70276	Roridin E
	Roridin E inhibits the receptor tyrosine kinases FGFR3, IGF-1R, PDGFRβ, and TrkB (IC50s = 0.4, 0.4, 1.4, and 1 μM, respectively) and induces cytotoxicity in multiple breast cancer cell lines (IC50s = 0.02-0.05 nM). It al...
T76759	Robatumumab
	Robatumumab (Sch 717454), an anti-human insulin-like growth factor receptor-1 (IGF-1R) antibody, exhibits anti-tumor and anti-proliferative effects on cancer cells. It is applicable in research concerning osteosarcoma an...
T3621	Brigatinib	AP-26113	EGFR , FLT , ROS , IGF-1R , ALK
	Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor.		EGFR , FLT , ROS , IGF-1R , ALK
T83911	CYY292
	CYY292 is a chemical compound acting as an inhibitor of PDGFRα, PDGFRβ, FGFR1, -2, and -3, with respective IC50 values of 5.35, 4.6, 28, 28, and 78 nM. It exhibits selectivity over FGFR4 (IC50 > 1,000 nM) while also targ...
T11654	Indirubin Derivative E804		Others
	Indirubin Derivative E804 is an effective inhibitor of IGF1R, which has an IC50 value of 0.65.		Others
T12102	Mps1-IN-1		Others
	Mps1-IN-1 is a potent, selective and ATP-competitive inhibitor of Mps1 kinase (IC50 : 367 nM )		Others
T13564L2	AZ7550 trimesylate salt	AZ7550 Mesylate,AZ7550 trimesylate salt (1421373-99-0 free base)	MLK
	AZ7550 trimesylate salt (AZ7550 Mesylate) is the active metabolite of ositinib, AZ7550 trimesylate salt inhibits IGF1R activity and can be used in the study of non-small cell lung cancer.		MLK

Compounds

Synonym: IGF-1R Inhibitor II

Target: Apoptosis, IGF-1R

NBI-31772

T8906

Synonym: NBI31772,NBI 31772

Target: Trk receptor, c-Met/HGFR, IGF-1R

XL228

T17267

Synonym:

Target: IGF-1R, Bcr-Abl, Src, Aurora Kinase

GSK1904529A

T6003

Synonym: GSK 4529

Target: Apoptosis, Raf, VEGFR, IGF-1R, Syk

Target: MLK, FAK, EGFR, FLT, Tyrosine Kinases, PYK2, MNK, IGF-1R, ACK, BTK, ALK, Drug Metabolite

GSK1838705A

T3079

Synonym:

Target: IGF-1R, JNK, S6 Kinase, ALK

MAZ51

T8496

Synonym:

Target: Apoptosis, VEGFR

NVP-AEW541

T6080

Synonym: AEW541

Target: FLT, Tyrosine Kinases, IGF-1R, Autophagy

Ceritinib

T1791

Synonym: LDK378

Target: Serine Protease, IGF-1R, ALK

NVP-TAE 226

T1918

Synonym: TAE226

Target: Apoptosis, FAK, c-Met/HGFR, PYK2, IGF-1R

ALK inhibitor 1

T10285

Synonym:

Target: FAK, IGF-1R, ALK

AZD-3463

T1967

Synonym: ALK/IGF1R inhibitor

Target: Apoptosis, IGF-1R, ALK, Autophagy

NVP-ADW742

T6079

Synonym: ADW742,ADW,GSK 552602A

Target: Apoptosis, IGF-1R

Ceritinib dihydrochloride

T1791L

Synonym: LDK378 dihydrochloride

Target: IGF-1R, ALK

AZ7550 hydrochloride

T13564L

Synonym: AZ7550 hydrochloride (1421373-99-0 free base)

Target: EGFR, IGF-1R

BMS-536924

T6419

Synonym: HY-10262,BMS 536924,CS-0117

Target: Apoptosis, FAK, MEK, IGF-1R, Src

AG1024

T2693

Synonym: Tyrphostin AG 1024,Tyrphostin,AGS 200

Target: Apoptosis, IGF-1R

PQ401 hydrochloride (196868-63-0(free base))

Target: IGF-1R, Src

I-OMe-Tyrphostin AG 538

T11593

Synonym: I-OMe-AG 538

Target: IGF-1R, PI3K

Teprotumumab

T76727

Synonym: R 1507,HZN 001

Target: TSH Receptor, IGF-1R

Target: Apoptosis, FGFR, FLT, JAK, Bcr-Abl, Src, c-Kit, Aurora Kinase

Aurora kinase inhibitor-3

T5524

Synonym: Aurora Kinase Inhibitor III

Target: Aurora Kinase

NT157

T4605

Synonym:

Target: IGF-1R, STAT

Orantinib

T6184

Synonym: SU6668,TSU-68,NSC 702827

Target: Apoptosis, VEGFR, FGFR, PDGFR

Dovitinib

T6289

Synonym: TKI258,CHIR-258

Target: VEGFR, FGFR, FLT, PDGFR, c-Kit

SU4312

T3570

Synonym: SU 4312,NSC 86429

Target: VEGFR, PDGFR

AZ12253801

T25123

Synonym: AZ 12253801,AZ-12253801

Synonym: NSC742460,IMC-A12

Target: EGFR, FLT, ROS, IGF-1R, ALK

Indirubin Derivative E804

AZ7550 trimesylate salt

T13564L2

Synonym: AZ7550 Mesylate,AZ7550 trimesylate salt (1421373-99-0 free base)

Target: MLK

Cat No.	Product Name	Synonyms	Targets
T6S1487	Ginsenoside Rg5		NF-κB , COX , IGF-1R
	1. Ginsenoside Rg5 could be a beneficial agent for the treatment of Alzheimer's disease. 2. Ginsenoside Rg5 suppresses LPS-induced nitric oxide (NO) production and proinflammatory TNF-α secretion. 3. Ginsenoside Rg5 can ...		NF-κB , COX , IGF-1R
T6943	Picropodophyllin	AXL1717,Picropodophyllin (PPP),Picropodophyllotoxin,PPP	Apoptosis , IGF-1R
	Picropodophyllin (Picropodophyllin (PPP)) (PPP) is a specific IGF-1R inhibitor (IC50: 1 nM). Picropodophyllin specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with...		Apoptosis , IGF-1R
T3923	Calycosin	Cyclosin,3'-Hydroxyformononetin	Apoptosis , Tyrosinase
	Calycosin (Cyclosin) acts as a selective estrogen receptor modulator. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Calycosin suppresses breast cancer c...		Apoptosis , Tyrosinase

Natural Products

Ginsenoside Rg5

T6S1487

Synonym:

Target: NF-κB, COX, IGF-1R

Picropodophyllin

T6943

Synonym: AXL1717,Picropodophyllin (PPP),Picropodophyllotoxin,PPP

Target: Apoptosis, IGF-1R

Calycosin

T3923

Synonym: Cyclosin,3'-Hydroxyformononetin

Target: Apoptosis, Tyrosinase

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPK-00455	IGF1R/CD221 Protein, Human, Recombinant (His & Avi)	Human	HEK293
	The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, prot...
TMPK-00658	IGF1R/CD221 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, prot...
TMPK-00456	IGF1R/CD221 Protein, Human, Recombinant (aa 31-932, His & Avi), Biotinylated	Human	HEK293
	The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, prot...
TMPY-06195	IGF1R/CD221 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	The insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase involved in several biological processes including cell proliferation, differentiation, DNA repair, and cell survival. This a disulfide...
TMPY-00150	IGF2/IGF-II Protein, Human, Recombinant	Human	Yeast
	Insulin-like growth factor 2 (IGF-2/IGF-II) is a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele,...
TMPK-00083	IGF1/IGF-I Protein, Human, Recombinant (hFc)	Human	HEK293
	The insulin family consists of insulin, insulin-like growth factor 1 (IGF-1), insulin-like growth factor 2 (IGF-2), their receptors (IR, IGF-1R and IGF-2R), and their binding proteins.Insulin-like growth factor I (IGF-I)...
TMPK-00061	IGF2/IGF-II Protein, Human, Recombinant (hFc)	Human	HEK293
	The insulin family consists of insulin, insulin-like growth factor 1 (IGF-1), insulin-like growth factor 2 (IGF-2), their receptors (IR, IGF-1R and IGF-2R), and their binding proteins. All three ligands are involved in c...
TMPY-06596	Claudin-18.2 Protein-VLP, Human, Recombinant	Human	HEK293
	Claudins family member Claudin18 (CLDN18) is a four-pass transmembrane protein with two extracellular loops and cytoplasmic N- and C-tails found in tight junctions. CLDN18 modulates paracellular permeability, polarity, a...
TMPY-06942	Claudin-18 Protein, Human, Recombinant (His & Strep)	Human	HEK293
	Claudins family member Claudin18 (CLDN18) is a four-pass transmembrane protein with two extracellular loops and cytoplasmic N- and C-tails found in tight junctions. CLDN18 modulates paracellular permeability, polarity, a...
TMPY-06822	Claudin-18 Protein, Human, Recombinant (CLDN18.2), Fluorescent	Human	HEK293
	Claudins family member Claudin18 (CLDN18) is a four-pass transmembrane protein with two extracellular loops and cytoplasmic N- and C-tails found in tight junctions. CLDN18 modulates paracellular permeability, polarity, a...
TMPY-06828	Claudin-18 Protein, Human, Recombinant (CLDN18.1)	Human	HEK293
	Claudins family member Claudin18 (CLDN18) is a four-pass transmembrane protein with two extracellular loops and cytoplasmic N- and C-tails found in tight junctions. CLDN18 modulates paracellular permeability, polarity, a...