Cationic Bovine Serum Albumin, a protein of 583 amino acids with three homologous alpha structural domains, exhibits significant neuroprotective effects against ischemic stroke when used in conjunction with Tanshinone IIA [1].

GsMTx4 TFA (1209500-46-8 free base) (GsMTx4 TFA) is a spider venom peptide that selectively inhibits cationic permeable mechanically-sensitive channels (MSCs) belonging to the Piezo and TRP channel families.

Nigericin sodium salt is an antibiotic, an NLRP3 activator, and a cationic ion carrier. Nigericin sodium triggers the activation of the NALP3 inflammasome, which inhibits Golgi function and suppresses the growth of Gram-positive bacteria.

DLin-KC2-DMA is a cationic/ionizable lipid. Which is used for siRNA delivery.

D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.

Benzalkonium chloride (Alkyldimethylbenzylammonium chloride) is a cationic surface-acting agent containing the quaternary ammonium group. It has three main categories of use: as a cationic surfactant, a biocide, and phase transfer agent in the chemical industry. This compound is a heterogeneous mixture of alkylbenzyldimethylammonium chlorides of multiple even-numbered alkyl chain lengths.

PNU-177864 hydrochloride is a potent, selective and orally active antagonist of dopamine D3 receptor. PNU-177864 hydrochloride is structurally consistent with a cationic amphiphilic drug (CAD). PNU-177864 hydrochloride induces phospholipidosis in vivo. PNU-177864 hydrochloride exhibits antischizophrenic activity.

DLinDAP (D-LinDAP) is an ionizable cationic lipid used for SiRNA delivery.

SPR741 acetate is a cationic peptide derived from polymyxin B. It exhibits antimicrobial activity against gram-negative bacteria by inhibiting severe gram-negative bacterial sensory by increasing the permeability of the outer membrane of gram-negative bacteria.SPR741 acetate is often used in conjunction with antibiotics for the treatment of a number of diseases.

Kukoamine B mesylate is a novel cationic alkaloid derived from dermatophytes with antioxidant activity, inhibits LPS internalization in Kupffer and RAW 264.7 cells, and can be used to study acute inflammation and diabetes.

Polymyxin B nonapeptide acetate is a cationic cyclic peptide. Polyxin B nonapeptide is a derivative produced by enzymatic cleavage of polyxin B. Compared with polyxin B, polyxin B nonapeptide has low toxicity, lacks bactericidal activity and still has the

PPA-904 FA is a cationic photosensitizer with broad-spectrum antimicrobial activity for use in photodynamic studies (PDT) studies, which can be used to study chronic leg ulcers and diabetic foot ulcers.

Polymyxin B Sulfate (Poly-RX) is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B Sulfate (Poly-RX) is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic.

Polymyxin B nonapeptide, a cationic cyclic peptide derived by enzymatic processing from the naturally occurring peptide polymyxin B, is able to increase the permeability of the outer membrane of Gram-negative bacteria toward hydrophobic antibiotics probab

Cholesterylamine, a cationic lipid, can be incorporated into PLGA to create particles with a charged surface, facilitating its use in drug delivery systems and in the research of autoimmune diseases and allergies [1].

L17E, a cationic amphiphilic peptide with endosomolytic properties, selectively disrupts the membranes of late endosomes (LEs) in an acidic environment and prevents TS5-p45-induced apoptosis in a dose-dependent manner. This peptide is internalized by cells and directed to LEs, where it compromises LE integrity and facilitates the release of their contents into the cytosol. L17E serves as a tool for probing the endosomal protein trafficking pathway [1].

Polymyxin D2 is a cationic lipopeptide antibiotic against many species of Gram-negative bacteria.

Non-competitive nicotinic cholinergic antagonist; selectively inhibits nicotinic-stimulated catecholamine secretion from chromaffin cells and noradrenergic neurons (IC50 ~ 200 nM). Blocks nicotinic-induced cationic signaling (IC50 ~ 200 - 250 nM) and inhi

SPR741, formerly NAB741 (12), is a cationic peptide derived from polymyxin B and is one such potentiator molecule that is under development for the treatment of serious Gram-negative bacterial infections.

Human β-defensin-2 (HβD-2) is a cationic skin-antimicrobial peptide (SAP) characterized by its small size and rich cysteine content. It is produced by various epithelial cells and exhibits potent antimicrobial properties against gram-negative bacteria and Candida. However, it does not effectively target gram-positive Staphylococcus aureus. Given these characteristics, Human β-defensin-2 serves as a valuable tool in colitis research.

Dios-Arg is a steroid-based cationic lipid that contains a diosgenin skeleton coupled to an L-arginine head group. It forms a complex with plasmid DNA and decreases plasmid DNA migration in an agarose-gel retardant assay at charge ratio greater than or equal to 4. Dios-Arg facilitates transfection of plasmid DNA into H1299 and HeLa cells in the presence and absence of fetal bovine serum, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and the caveolae-mediated endocytosis inhibitor genistein . It has been used, coupled to 1,2-dioleoyl-sn-glycero-3-PE , to bind siRNA and plasmid DNA to form cationic lipid nanoparticles for intracellular transport. Dios-Arg is cytotoxic to H1299 and HeLa cells (IC50s = 83.5 and 74.1 μg/ml, respectively).

DOSPA, a cationic lipid, exhibits significant potential when formulated with DNA as a transfection system [1].

MVL5, a non-degradable multivalent cationic lipid, serves as a highly efficient vector for both DNA and siRNA [1].

Fluorescent DOTAP, a cationic lipid, facilitates research in nucleic acid and protein delivery [1].

4A3-SC8 is a modular dendritic macromolecule with cationic and lipophilic groups that enables small RNAs to prolong survival in an aggressive hepatocellular carcinoma model and can be used to synthesize lipid nanoparticles.

BMX-001 is a third-generation, cationic, lipophilic, manganese (Mn), and porphyrin-based mimetic of the human mitochondrial manganese superoxide dismutase (MnSOD). It also has antioxidant and potential chemoprotective activities.

2H-Cho-Arg is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection. It forms a complex with plasmid DNA (pDNA) and decreases pDNA migration in an electrophoretic mobility shift assay at +/- charge ratios of 4 or higher. 2H-Cho-Arg facilitates transfection of a luciferase gene into H1299 cells, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and the caveolae-mediated endocytosis inhibitor genistein , but not by inhibitors of clathrin- or micropinocytosis-mediated endocytosis. It induces cytotoxicity in H1299 cells (IC50 = 92.7 μg/ml).

Dimethyldioctadecylammonium (DDA) is a cationic amphipathic lipid. DDA liposomes containing an Ag85B-ESAT-6 antigen induce antigen deposition at an intramuscular or subcutaneous injection site in mice, increasing immune cell exposure to the antigen. In a guinea pig model of M. tuberculosis infection, spleen bacterial load is reduced and lung and spleen lesion numbers are decreased when the mycobacterial lipid antigens Ac2SGL and PIM2 are administered in liposomes comprised of DDA and a synthetic analog of the mycobacterial cord factor trehalose 6,6-dibehenate (TDB). DDA has also been used in the study of lipid bilayer dynamics.

Human LL-37 is a 37 amino acid cationic (6+) peptide and has been widely studied. LL-37 penetrates the bacterial membrane and forms pores in the membrane.

Elamipretide Triacetate (Elamipretide TriTFA) is an aromatic-cationic tetrapeptide that readily penetrates cell membranes and transiently localizes to the inner mitochondrial membrane where it associates with cardiolipin.It has been used in trials studying the treatment of Leber's Hereditary Optic Neuropathy.

KLA peptide is a cationic amphipathic mitochondrial membrane-disrupting peptide that can induce programmed cell death by targeting mitochondrial membranes, yet it lacks the ability to transverse the plasma membrane.

Human β-defensin-1 (HβD-1) is a cysteine-rich cationic skin-antimicrobial peptide (SAP) produced by epithelial surfaces, circulatory cells, and cells of the reproductive tract. It exhibits antimicrobial activity against a wide range of sperm bacteria.

NRC-16 is a biologically active peptide with characteristics similar to pleurocidin, a cationic antimicrobial peptide (cationic AMP).

18:0 EPC chloride, a synthetic cationic phospholipid, significantly enhances eugenol's inactivation effect on Escherichia coli [1] when used at critical synergistic concentrations ranging from 2.34 to 2.93 μM.

DLin-K-C3-DMA, a cationic lipid, facilitates the synthesis of nucleic acid-lipid particles for nucleic acid delivery [1].

G0-C14, an alkyl-modified polyamidoamine (PAMAM) dendrimer with cationic lipid-like properties, is utilized in the development of macrophage-targeted nanoparticles (NPs) for agent and vaccine delivery [1] [2].

Cho-Arg is a steroid-based cationic lipid that contains a cholesterol skeleton coupled to an L-arginine head group. It forms a complex with plasmid DNA and decreases plasmid DNA migration in an agarose-gel retardant assay at charge ratios greater than or equal to 4. Cho-Arg facilitates transfection of plasmid DNA into H1299 and HeLa cells in the presence or absence of fetal bovine serum, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and the caveolae-mediated endocytosis inhibitor genistein . It is cytotoxic to H1299 cells (IC50 = 88.5 μg/ml).

Polymyxin E1, a peptide antibiotic and key component of the cationic lipopeptide antibiotic colistin, was initially extracted from B. polymyxa. It demonstrates effectiveness against P. aeruginosa and E. coli, with minimum inhibitory concentrations (MICs) of 2 µg/ml and 0.8 µg/ml, respectively.

9A1P9, a multi-tail ionizable cationic phospholipid, facilitates membrane destabilization and is applicable for CRISPR-Cas9 gene editing in mice [1].

RCB-02-4-8, an ionizable cationic lipid designed for the formulation of lipid nanoparticles (LNPs), enhances mRNA delivery with proven effectiveness in increasing lung transfection efficiency in mice [1].

CL4F8-6, an ionizable cationic lipid with a pKa of 6.14, is utilized in lipid nanoparticles (LNPs) for mRNA therapeutics. When incorporated into LNPs delivering Cas9 mRNA and sgRNA, CL4F8-6 facilitates CRISPR-mediated gene knockdown in mice [1].

113-O16B, an ionizable cationic lipidoid featuring a disulfide bond, is utilized in producing lipid nanoparticles (LNPs) for mRNA delivery [1].

DOPE (DOPE) is a neutral helper lipid for cationic liposomes.It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery.

Tetradecyltrimethylammonium bromide (MitMAB) is a Dynamin GTPase activity inhibitor and a cationic surfactant with asymmetrical structure.

Cetylpyridinium chloride monohydrate (Hexadecylpyridinium chloride monohydrate) , a cationic quaternary ammonium compound, is used in certain classes of throat sprays, mouthwashes, lozenges, toothpaste, nasal sprays, and breath sprays. Cetylpyridinium chloride monohydrate has also been used as an ingredient in certain pesticides. It is an antiseptic with killing bacteria and other microorganisms. It can be potent in reducing gingivitis and preventing dental plaque. It may result in brown stains between the teeth and on the surface of teeth.

Atiprimod is an orally bioavailable small molecule belonging to the azaspirane class of cationic amphiphilic agents with anti-inflammatory, antineoplastic, and antiangiogenic properties. Atiprimod inhibits the phosphorylation of signal transducer and activator of transcription 3 (STAT3), blocking the signalling pathways of interleukin-6 and vascular endothelial growth factor (VEGF) and downregulating the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1, thereby inhibiting cell proliferation, inducing cell cycle arrest, and inducing apoptosis.

C12-200 is a benchmark ionizable cationic lipidoid along with helper lipids and can be used in the delivery of mRNA.

EDMPC, a cationic lipid, exhibits an enhanced capability for DNA delivery to pulmonary tissues. It facilitates intralobar DNA transfer in rodents [1].

YSK 05, a pH-sensitive cationic lipid, enhances the intracellular trafficking of non-viral vectors, significantly improves gene silencing and hemolytic activities in its modified form YSK 05-MEND, and effectively overcomes the suppression of endosomal escape caused by PEGylation, thereby enhancing siRNA delivery both in vitro and in vivo [1].

Brilliant green, a cationic dye, is utilized for coloring silk and wool. Additionally, it halts the propagation of mold, intestinal parasites, and fungus, proving effective against Gram-positive bacteria [1] [2].