vasoconstrictor

Angiotensin II human (Ang II) is a biologically active peptide, a vasoconstrictor. Angiotensin II interacts with AT1R and AT2R to regulate blood pressure, stimulate sympathetic nerves, and increase aldosterone biosynthesis and renal activity in humans.

Kisspeptin-10, human TFA is a potent vasoconstrictor and angiogenesis inhibitor. Kisspeptin-10, human TFA acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression

Urotensin II (114-124), human acetate is an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.

Urotensin II, mouse acetate (9047-55-6 free base) is an endogenous ligand for the orphan GPR14 or SENR. It is a potent vasoconstrictor.

Endothelin 1 (swine, human) acetate is a synthetic peptide with the sequence of human and swine Endothelin 1. Endothelin 1 is a potent endogenous vasoconstrictor and acts through two types of receptors ETA and ETB.

Ornipressin Acetate (POR-8) is a potent vasoconstrictor, hemostatic and renal agent.

Angiotensin II human acetate (DRVYIHPF acetate) is a vasoconstrictor that mainly acts on the AT1 receptor.

Angiotensin I (human, mouse, rat) is the precursor to the vasoconstrictor peptide angiotensin II, cleaved by the angiotensin-converting enzyme (ACE). This peptide hormone causes vasoconstriction and increases blood pressure as part of the renin–angiotensin system, also stimulating aldosterone release from the adrenal cortex to promote sodium retention by the kidneys.

Kisspeptin-10, rat TFA serves as both a potent vasoconstrictor and an inhibitor of angiogenesis, as well as acting as a ligand for the rodent kisspeptin receptor (KISS1, GPR54). Additionally, Kisspeptin-10 TFA demonstrates potential antioxidant properties by reducing Methotrexate-induced reproductive toxicity [1].

Urotensin II, mouse acetate, serves as an endogenous ligand for the orphan G-protein-coupled receptor GPR14 or SENR and acts as a potent vasoconstrictor. Its physiological function extends to the central nervous system [1].

Angiotensin II (5-8) is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II

Felypressin (Octapressin) is a synthetic analog of LYPRESSIN with a PHENYLALANINE substitution at residue 2. Felypressin is a vasoconstrictor with reduced antidiuretic activity.

Angiotensin II human TFA, a potent vasoconstrictor within the renin/angiotensin system, plays a pivotal role in human blood pressure regulation primarily through interactions with the G-protein-coupled receptors Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). It not only prompts sympathetic nervous stimulation, aldosterone biosynthesis, and renal effects but also fosters growth in vascular smooth muscle cells and boosts collagen type I and III synthesis in fibroblasts. This action results in the thickening of the vascular wall and myocardium, alongside fibrosis. Additionally, Angiotensin II human TFA triggers apoptosis and encourages capillary formation from endothelial cells through the LOX-1 dependent redox-sensitive pathway [1] [2] [3] [4].

Endothelin-1 (1-31) (Human) is a potent vasoconstrictor and hypertensive agent, derived from the specific hydrolysis of big ET-1 by chymase [1].

Endothelin 1 (swine, human) (TFA) is a synthetic peptide mirroring the sequence of the potent endogenous vasoconstrictor found in both human and swine Endothelin 1, operating via two receptor types, ET A and ET B [1].

Angiotensin II is a potent direct vasoconstrictor, causing arteries and veins to constrict, so leading to an increase in blood pressure.

Angiotensin-converting enzyme (Kininase II) is a zinc-dependent peptidase and extracellular enzyme that acts as a counterbalance to ACE in the renin-angiotensin system.Angiotensin-converting enzyme is a potent vasoconstrictor used in the study of cardiovascular and immune diseases. Angiotensin-converting enzyme is a potent vasoconstrictor used to study cardiovascular and immune diseases.

Endothelin 1 (swine, human), a synthetic peptide mirroring the sequence of both human and swine Endothelin 1, functions as a robust endogenous vasoconstrictor by interacting with two receptor types, ETA and ETB.

Urotensin II (114-124), human, is an 11-amino acid residue peptide that acts as a potent vasoconstrictor and agonist for the orphan receptor GPR14.

Kisspeptin-10, human TFA, is a potent vasoconstrictor and angiogenesis inhibitor that also suppresses tumor metastasis through its interaction with the receptor GPR54. It is crucial for embryonic kidney development and promotes osteoblast differentiation through NFATc4-mediated BMP2 expression via the Kisspeptin-10/GPR54 signaling pathway [1].

Ornipressin is a vasoconstrictor, haemostatic and renal agent.

Neuromedin U (NMU) is a neuropeptide first demonstrated to drive smooth muscle contraction.1Translated as a 174 amino acid propeptide, NMU is cleaved to different lengths in different animals. It has diverse receptor-mediated rolesin vivo, as it regulates feeding, vasoconstriction, nociception, and bone remodeling and contributes to obesity, cancer and septic shock.2,2NMU-25 is the active form of NMU in humans. It binds with high affinity to receptors on human left ventricle and coronary artery (KDs = 0.26 and 0.11 nM, respectively), eliciting endothelium-independent vasoconstriction.3NMU-25 also suppresses glucose-stimulated insulin secretion in human islets, and this effect is lost in NMU R165W mutants, resulting in early-onset obesity.4 1.Mitchell, J.D., Maguire, J.J., and Davenport, A.P.Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin SBritish Journal of Pharmacology15887-103(2009) 2.Greenwood, H.C., Bloom, S.R., and Murphy, K.G.Peptides and their potential role in the treatment of diabetes and obesityRev.Diabet.Stud.8(3)355-368(2011) 3.Mitchell, J.D., Maguire, J.J., Kuc, R.E., et al.Expression and vasoconstrictor function of anorexigenic peptides neuromedin U-25 and S in the human cardiovascular systemCardiovascular Research81353-361(2009) 4.Alfa, R.W., Park, S., Skelly, K.R., et al.Suppression of insulin production and secretion by a decretin hormoneCell Metabolism21(2)323-333(2015)

Angiotensin II is a potent direct vasoconstrictor, causing arteries and veins to constrict, so leading to an increase in blood pressure. Angiotensin also potentiates the release of norepinephrine by a direct action on postganglionic sympathetic fibers.

Angiotensin 1/2 (1-8) amide (H2N-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-amide) is a peptide analog to angiotensin II that is used as a vasopressor agent in the treatment of certain types of shock and circulatory collapse. It is a potent vasoconstrictor and is us

Felypressin acetate (PLV-2) is an agonist of vasopressin 1 and acts on all arginine vasopressin receptors 1AS. Felypressin acetate can be used in dental procedures.

Kisspeptin-10, human is an effective vasoconstrictor and inhibitor of angiogenesis.

Endothelin-1 (1-31) (Human) acetate, a potent vasoconstrictor and hypertensive agent, is produced through the selective hydrolysis of big ET-1 by chymase [1].

Endothelin-3 (human, mouse, rabbit, rat) is a cyclic 21-amino acid peptide, acting as an endogenous neuropeptide and potent vasoconstrictor.

Jump to search UTS2 Identifiers Aliases UTS2, PRO1068, U-II, UCN2, UII, urotensin 2 External IDs OMIM: 604097 MGI: 1346329 HomoloGene: 4939 GeneCards: UTS2 hide Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.23 Start 7,843,083 bp[1] En

Endothelin 1 (swine, human), Alexa Fluor 488-labeled, is a synthetic peptide mirroring human and swine Endothelin 1, an endogenous vasoconstrictor, and is tagged with Alexa Fluor 488 for fluorescence, operating via two receptor types, ET A and ET B [1].

The big endothelins comprise residues 53-90 (human big ET-1) and 53-91 (porcine big ET-1) of the endothelin precursor (preproendothelin). Compared to the mature endothelin-1 (ET-1), both peptides show less vasoconstrictor activity in vitro, but similar pressor effects in vivo. Former CAS-number 121014-54-8.

Urotensin II (114-124), human TFA, is an 11-amino acid peptide with a potent vasoconstrictor effect and acts as an agonist for the orphan receptor GPR14.

Terlipressin is a potent vasoconstrictor that acts via V1 receptors on arteriolar smooth muscle cells.

Terlipressin Acetate, a highly selective vasopressin V1 receptor agonist, on oxygen and glucose deprivation re-oxygenation (OGD R)-induced damage in intestinal epithelial cells (IEC-6).Terlipressin acetate exerts anti-inflammatory and anti-oxidative effects. Terlipressin acetate has the potential for hepatorenal syndrome and norepinephrine-resistant septic shock research.

Human Big ET-1 comprises residues 53-90 of the endothelin precursor (preproendothelin). Compared to the mature endothelin-1 (hET-1), the peptide show less vasoconstrictor activity in vitro, but similar pressor effects in vivo. Former CAS-number 121014-53-7.

Urotensin II, mouse TFA is an endogenous ligand for the orphan GPR14 or SENR. It is a potent vasoconstrictor.