Cart
Angiogenesis ALK

ALK

Anaplastic lymphoma kinase (ALK) also known as ALK tyrosine kinase receptor or CD246 (cluster of differentiation 246) is an enzyme that in humans is encoded by the ALK gene.The receptor ALK plays a pivotal role in cellular communication and in the normal development and function of the nervous system.
Cat No. product name
T1661 CrizotinibHOT Crizotinib is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor.
T1726 SB 431542HOT SB-431542 is a potent and selective inhibitor of ALK5 (IC50: 94 nM) and is also an inhibitor of ALK4 (IC50: 140 nM) and ALK7.
T1791 LDK378HOT Ceritinib (LDK378) is a specific ALK inhibitor (IC50: 0.2 nM).
T1800 GW 788388 GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities.
T1900 LDN212854 LDN-212854, a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors; possesses differences towards ALK2(IC50=1.3 nM) vers...
T1914 K 02288 K02288 is a novel small molecule inhibitor of ALK1/2/3/6.
T1935 LDN-193189HOT LDN193189 (DM 3189) is a selective BMP signaling inhibitor, inhibiting the transcriptional activity of ALK2 and ALK3 (IC50s: 0.8/0.8/5.3/16.7 nM for ALK1/2/3/6...
T1936 Alectinib CH5424802 is an orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity.
T1942 DMH1 DMH-1 is a potent and selective BMP inhibitor.
T1943 ML347 ML347(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.
T1944 LDN-214117 LDN-214117 is a potent and selective ALK2 inhibitor.
T1962 ASP 3026 ASP3026 has been used in trials studying the treatment of Solid Tumor, B-Cell Lymphoma, Advanced Malignancies, Positive for Anaplastic Lymphoma Kinase, and Posi...
T2098 A77-01 A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.
T2251 TAE684 NVP-TAE 684 is a excellently effective and specific ALK inhibitor(IC50=3 nM).
T2449 D 4476 D4476 is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay).
T2462 SB-505124 SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5.
T2612 CEP-28122 CEP-28122 is a highly potent and selective orally active ALK inhibitor.
T2641 KRCA-0008 KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability.
T2655 CEP37440 CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).
T3031 ALK5 Inhibitor IV A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 with IC50 values of 12...
T3041 ALK inhibitor 2 ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.
T3059 AP26113 Brigatinib is a excellently effective and specific ALK inhibitor( IC50 =0.6 nM).
T3061 Lorlatinib PF-06463922 is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), wi...
T3079 GSK1838705A GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to...
T3550 Ensartinib Ensartinib (X-396) is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplasti...
T3621 Brigatinib Brigatinib is a highly potent and selective ALK inhibitor.
T3678 Entrectinib Entrectinib is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1.6 nM) and ...
T4015 HG-14-10-04 HG-14-10-04 is a potent and specific ALK inhibitor.
T4071 TPX-0005 TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.
T6158 LDN-193189 HCl LDN193189 hydrochloride is a selective BMP type I receptor kinases inhibitor.
T6337 RepSox RepSox is a potent and selective of the TGFβR-1/ALK5 inhibitor.
T6496 Vactosertib Vactosertib is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also known as ac...
T4257 Belizatinib Belizatinib is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.
T4975 SM 16 SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).
T1763 SB525334HOT SB-525334 is a potent and selective inhibitor of the TGF-β1R and ALK5 (IC50: 14.3 nM).
T5197 BIBF0775 BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM).
T8152 6-Demethoxytangeretin 6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa.
T8108 Blu-782 Blu-782 is a activin receptor-like kinase-2 (ALK2) inhibitor ( IC50 of <10 nM)
T8399 Crizotinib hydrochloride Crizotinib hydrochloride is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)
T8387 Alectinib hydrochloride Alectinib hydrochloride is a selective, and orally available inhibitor of ALK( IC50 : 1.9 nM)
T13781 MS4077 MS4077 is an degrader of anaplastic lymphoma kinase (ALK) PROTAC(Kd of 37 nM for binding affinity to ALK).
T10442 A 83-01 sodium salt A 83-01 sodium salt is a potent inhibitor of ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50s: 12, 45 and 7.5 nM against th...
T10287 ALK2-IN-2 ALK2-IN-2 is a potent and selective inhibitor of ALK2 (IC50: 9 nM), and over 700-fold selectivity against ALK3.
T10283 ALK-IN-5 ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).
T10426 AZ12601011 AZ12601011 is an orally active, selective TGFBR1 kinase inhibitor (IC50: 18 nM; Kd: 2.9 nM) with inhibitory to mammary tumor growth. AZ12601011 inhibits phospho...
T15262 Vactosertib Hydrochloride Vactosertib Hydrochloride is an orally active and ATP-competitive ALK5 inhibitor (IC50: 12.9 nM). It has potently antimetastatic activity and anticancer effect....
T13138 TGFBR1-IN-1 TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).
T15572 IN-1130 IN-1130 inhibits ALK5 phosphorylation of casein (IC50=36 nM) and p38α mitogen-activated protein kinase (IC50=4.3 μM). IN-1130 is a highly selective inhibitor ...
T16708 R-268712 R-268712 is an effective and selective inhibitor of ALK5 IC50: 2.5 nM).
T13352 Wy 49051 Wy 49051 is an orally active antagonist of H1 receptor(IC50 of 44 nM).
Crizotinib HOT
T1661CAS 877399-52-5
Crizotinib is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor.
SB 431542 HOT
T1726CAS 301836-41-9
SB-431542 is a potent and selective inhibitor of ALK5 (IC50: 94 nM) and is also an inhibitor of ALK4 (IC50: 140 nM) and ALK7.
LDK378 HOT
T1791CAS 1032900-25-6
Ceritinib (LDK378) is a specific ALK inhibitor (IC50: 0.2 nM).
GW 788388
T1800CAS 452342-67-5
GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities.
LDN212854
T1900CAS 1432597-26-6
LDN-212854, a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors; possesses differences towards ALK2(IC50=1.3 nM) vers...
K 02288
T1914CAS 1431985-92-0
K02288 is a novel small molecule inhibitor of ALK1/2/3/6.
LDN-193189 HOT
T1935CAS 1062368-24-4
LDN193189 (DM 3189) is a selective BMP signaling inhibitor, inhibiting the transcriptional activity of ALK2 and ALK3 (IC50s: 0.8/0.8/5.3/16.7 nM for ALK1/2/3/6...
Alectinib
T1936CAS 1256580-46-7
CH5424802 is an orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity.
DMH1
T1942CAS 1206711-16-1
DMH-1 is a potent and selective BMP inhibitor.
ML347
T1943CAS 1062368-49-3
ML347(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.
LDN-214117
T1944CAS 1627503-67-6
LDN-214117 is a potent and selective ALK2 inhibitor.
ASP 3026
T1962CAS 1097917-15-1
ASP3026 has been used in trials studying the treatment of Solid Tumor, B-Cell Lymphoma, Advanced Malignancies, Positive for Anaplastic Lymphoma Kinase, and Posi...
A77-01
T2098CAS 607737-87-1
A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.
TAE684
T2251CAS 761439-42-3
NVP-TAE 684 is a excellently effective and specific ALK inhibitor(IC50=3 nM).
D 4476
T2449CAS 301836-43-1
D4476 is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay).
SB-505124
T2462CAS 694433-59-5
SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5.
CEP-28122
T2612CAS 1022958-60-6
CEP-28122 is a highly potent and selective orally active ALK inhibitor.
KRCA-0008
T2641CAS 1472795-20-2
KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability.
CEP37440
T2655CAS 1391712-60-9
CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).
ALK5 Inhibitor IV
T3031CAS 909910-43-6
A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 with IC50 values of 12...
ALK inhibitor 2
T3041CAS 761438-38-4
ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.
AP26113
T3059CAS 1197958-12-5
Brigatinib is a excellently effective and specific ALK inhibitor( IC50 =0.6 nM).
Lorlatinib
T3061CAS 1454846-35-5
PF-06463922 is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), wi...
GSK1838705A
T3079CAS 1116235-97-2
GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to...
Ensartinib
T3550CAS 1365267-27-1
Ensartinib (X-396) is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplasti...
Brigatinib
T3621CAS 1197953-54-0
Brigatinib is a highly potent and selective ALK inhibitor.
Entrectinib
T3678CAS 1108743-60-7
Entrectinib is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1.6 nM) and ...
HG-14-10-04
T4015CAS 1356962-34-9
HG-14-10-04 is a potent and specific ALK inhibitor.
TPX-0005
T4071CAS 1802220-02-5
TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.
LDN-193189 HCl
T6158CAS 1062368-62-0
LDN193189 hydrochloride is a selective BMP type I receptor kinases inhibitor.
RepSox
T6337CAS 446859-33-2
RepSox is a potent and selective of the TGFβR-1/ALK5 inhibitor.
Vactosertib
T6496CAS 1352608-82-2
Vactosertib is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also known as ac...
Belizatinib
T4257CAS 1357920-84-3
Belizatinib is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.
SM 16
T4975CAS 614749-78-9
SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).
SB525334 HOT
T1763CAS 356559-20-1
SB-525334 is a potent and selective inhibitor of the TGF-β1R and ALK5 (IC50: 14.3 nM).
BIBF0775
T5197CAS 334951-90-5
BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM).
6-Demethoxytangeretin
T8152CAS 6601-66-7
6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa.
Blu-782
T8108CAS 2141955-96-4
Blu-782 is a activin receptor-like kinase-2 (ALK2) inhibitor ( IC50 of <10 nM)
Crizotinib hydrochloride
T8399CAS 1415560-69-8
Crizotinib hydrochloride is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)
Alectinib hydrochloride
T8387CAS 1256589-74-8
Alectinib hydrochloride is a selective, and orally available inhibitor of ALK( IC50 : 1.9 nM)
MS4077
T13781CAS 2230077-10-6
MS4077 is an degrader of anaplastic lymphoma kinase (ALK) PROTAC(Kd of 37 nM for binding affinity to ALK).
A 83-01 sodium salt
T10442CAS
A 83-01 sodium salt is a potent inhibitor of ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50s: 12, 45 and 7.5 nM against th...
ALK2-IN-2
T10287CAS 2254409-25-9
ALK2-IN-2 is a potent and selective inhibitor of ALK2 (IC50: 9 nM), and over 700-fold selectivity against ALK3.
ALK-IN-5
T10283CAS 2351929-66-1
ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).
AZ12601011
T10426CAS
AZ12601011 is an orally active, selective TGFBR1 kinase inhibitor (IC50: 18 nM; Kd: 2.9 nM) with inhibitory to mammary tumor growth. AZ12601011 inhibits phospho...
Vactosertib Hydrochloride
T15262CAS 1352610-25-3
Vactosertib Hydrochloride is an orally active and ATP-competitive ALK5 inhibitor (IC50: 12.9 nM). It has potently antimetastatic activity and anticancer effect....
TGFBR1-IN-1
T13138CAS 2170830-26-7
TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).
IN-1130
T15572CAS 868612-83-3
IN-1130 inhibits ALK5 phosphorylation of casein (IC50=36 nM) and p38α mitogen-activated protein kinase (IC50=4.3 μM). IN-1130 is a highly selective inhibitor ...
R-268712
T16708CAS 879487-87-3
R-268712 is an effective and selective inhibitor of ALK5 IC50: 2.5 nM).
Wy 49051
T13352CAS 113418-56-7
Wy 49051 is an orally active antagonist of H1 receptor(IC50 of 44 nM).