ALK

Anaplastic lymphoma kinase (ALK) also known as ALK tyrosine kinase receptor or CD246 (cluster of differentiation 246) is an enzyme that in humans is encoded by the ALK gene.

Cat. No.	Product name	CAS No.	Purity
T13781	MS4077	2230077-10-6	98%
T13781	MS4077 is an degrader of anaplastic lymphoma kinase (ALK) PROTAC(Kd of 37 nM for binding affinity to ALK).
T10426	AZ12601011	T10426	98%
T10426	AZ12601011 is an orally active, selective TGFBR1 kinase inhibitor with an IC 50 of 18 nM and a K d of 2.9 nM. AZ12601011 inhibits phosphorylation of SMAD2 via se...
T10442	A 83-01 sodium salt	T10442	98%
T10442	Transforming growth factor (TGF)-beta signaling facilitates tumor growth and metastasis in advanced cancer. Use of inhibitors of TGF-beta signaling may thus be a...
T10283	ALK-IN-5	2351929-66-1	98%
T10283	ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).
T15572	IN-1130	868612-83-3	98%
T15572	IN-1130 is a selective inhibitor of ALK5 with IC50 values of 5.3 nM, 36 nM, and 4.3 μM for phosphorylation of ALK5-mediated Smad3, ALK5 phosphorylation of casein...
T10287	ALK2-IN-2	2254409-25-9	98%
T10287	ALK2-IN-2 is a potent and selective inhibitor of ALK2 (IC50: 9 nM), and over 700-fold selectivity against ALK3.
T13138	TGFBR1-IN-1	2170830-26-7	98%
T13138	TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).
T13421	(-)-Cevimeline hydrochloride hemihydrate	T13421	98%
T13421	(-)-Cevimeline hydrochloride hemihydrate ((-)-SNI-2011), a novel muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrom...
T15262	Vactosertib Hydrochloride	1352610-25-3	98%
T15262	Vactosertib Hydrochloride is an orally active and ATP-competitive ALK5 inhibitor (IC50: 12.9 nM). It has potently antimetastatic activity and anticancer effect. ...
T9837	N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-bromoaniline	1352608-94-6	98%
T9837	Compound 12d is a potent ALK5 inhibitor with an IC50 of 7nM.
T13564	AZ7550	1421373-99-0	98%
T13564	AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T15612	JH-VIII-157-02	1639422-97-1	98%
T15612	JH-VIII-157-02 is an inhibitor of ALK and inhibits echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) with IC50s of 2 nM for EML4-ALK G1202R, EML4-A...
T50042	5-phenylthieno[2,3-d]pyrimidin-4-amine	195193-10-3
T50042	5-phenylthieno[2,3-d]pyrimidin-4-amine is a chemical compound.
T2641	KRCA-0008	1472795-20-2	96.19%
T2641	KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability.
T3059	ALK-IN-1	1197958-12-5	97.66%
T3059	AP26113 is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. P...
T3031	A 83-01	909910-43-6	98%
T3031	A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 with IC50 values of 12 n...
T1962	ASP3026	1097917-15-1	98%
T1962	ASP3026 has been used in trials studying the treatment of Solid Tumor, B-Cell Lymphoma, Advanced Malignancies, Positive for Anaplastic Lymphoma Kinase, and Posit...
T1800	GW788388	452342-67-5	98%
T1800	GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities.
T3550	X-376	1365267-27-1	98.29%
T3550	Ensartinib (X-396) is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic...
T9224	CH5424802 analog	1256577-71-5	98.31%
T9224	CH5424802 analog is a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.