Home Tools
Log in
Cart

ALK

Anaplastic lymphoma kinase (ALK) also known as ALK tyrosine kinase receptor or CD246 (cluster of differentiation 246) is an enzyme that in humans is encoded by the ALK gene.
Cat No. product name
T1900 LDN-212854 LDN-212854, a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors; possesses differences towards ALK2(IC50=1.3 nM) versus...
T1800 GW788388 GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities.
T4257 Belizatinib Belizatinib is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.
T1914 K02288 K02288 is a novel small molecule inhibitor of ALK1/2/3/6.
T2462 SB-505124 SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5.
T1943 ML347 ML347(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.
T3061 Lorlatinib PF-06463922 is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), wit...
T10285 ALK inhibitor 1 ALK inhibitor 1 is a selective ALK kinase inhibitor.
T1661 Crizotinib Crizotinib is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor.
T1791L Ceritinib dihydrochloride Ceritinib dihydrochloride is a selective, orally bioavailable and ATP-competitive inhibitor of ALK tyrosine kinase(IC50 of 200 pM), and also inhibits IGF-1R, Ins...
T1967 AZD-3463 AZD3463, an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.
T2449 D4476 D4476 is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay).
T2251 NVP-TAE 684 NVP-TAE 684 is a excellently effective and specific ALK inhibitor(IC50=3 nM).
T1962 ASP3026 ASP3026 has been used in trials studying the treatment of Solid Tumor, B-Cell Lymphoma, Advanced Malignancies, Positive for Anaplastic Lymphoma Kinase, and Posit...
T3678 Entrectinib Entrectinib is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1.6 nM) and C...
T16708 R-268712 R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor ...
T1935 LDN193189 LDN193189 (DM 3189) is a selective BMP signaling inhibitor, inhibiting the transcriptional activity of ALK2 and ALK3 (IC50s: 0.8/0.8/5.3/16.7 nM for ALK1/2/3/6)....
T22324 Ensartinib hydrochloride Ensartinib dihydrochloride is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of known crizotinib-resistant ALK...
T8399 Crizotinib hydrochloride Crizotinib hydrochloride is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)
T16153 MS4078 MS4078 is an anaplastic lymphoma kinase (ALK) PROTAC. It has a Kd of 19 nM for binding affinity to ALK.
T4975 SM 16 SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).
T3041 ALK inhibitor 2 ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.
T6496 Vactosertib Vactosertib is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also known as act...
T1942 DMH-1 DMH-1 is a potent and selective BMP inhibitor.
T4071 Repotrectinib TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.
T1726 SB-431542 SB-431542 is a potent and selective inhibitor of ALK5 (IC50: 94 nM) and is also an inhibitor of ALK4 (IC50: 140 nM) and ALK7.
T3031 A 83-01 A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 with IC50 values of 12 n...
T2098 A 77-01 A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.
T50042 5-phenylthieno[2,3-d]pyrimidin-4-amine 5-phenylthieno[2,3-d]pyrimidin-4-amine is a chemical compound.
T11254 F-1 F-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. F-1 is a potent ALK and ROS1 dual inhibitor, suppress...
T1944 LDN-214117 LDN-214117 is a potent and selective ALK2 inhibitor.
T13564 AZ7550 AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T13416 ZX-29 ZX-29 is a potent and selective inhibitor of ALK(IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively), and also induces ...
T1791 Ceritinib Ceritinib (LDK378) is a specific ALK inhibitor (IC50: 0.2 nM).
T1936 Alectinib CH5424802 is an orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity.
T2612 CEP-28122 CEP-28122 is a highly potent and selective orally active ALK inhibitor.
T2655 CEP-37440 CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).
T2641 KRCA-0008 KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability.
T8152 6-Demethoxytangeretin 6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa.
T8108 Blu-782 Blu-782 is a activin receptor-like kinase-2 (ALK2) inhibitor ( IC50 of <10 nM)
T9224 CH5424802 analog CH5424802 analog is a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.
T8387 Alectinib hydrochloride Alectinib hydrochloride is a selective, and orally available inhibitor of ALK( IC50 : 1.9 nM)
T13138 TGFBR1-IN-1 TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).
T10759 CEP-28122 mesylate salt (1022958-60-6 free base) CEP-28122 mesylate salt is a highly selective orally active ALK inhibitor (IC50: 1.9 nM in an enzyme-based TRF assay).
T10426 AZ12601011 AZ12601011 is an orally active, selective TGFBR1 kinase inhibitor (IC50: 18 nM; Kd: 2.9 nM) with inhibitory to mammary tumor growth. AZ12601011 inhibits phosphor...
T10442 A 83-01 sodium salt A 83-01 sodium salt is a potent inhibitor of ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50s: 12, 45 and 7.5 nM against the...
T10287 ALK2-IN-2 ALK2-IN-2 is a potent and selective inhibitor of ALK2 (IC50: 9 nM), and over 700-fold selectivity against ALK3.
T10283 ALK-IN-5 ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).
T4015 HG-14-10-04 HG-14-10-04 is a potent and specific ALK inhibitor.
T3079 GSK1838705A GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to ...
LDN-212854
T1900
LDN-212854, a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors; possesses differences towards ALK2(IC50=1.3 nM) versu...
GW788388
T1800
GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities.
Belizatinib
T4257
Belizatinib is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.
K02288
T1914
K02288 is a novel small molecule inhibitor of ALK1/2/3/6.
SB-505124
T2462
SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5.
ML347
T1943
ML347(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.
Lorlatinib
T3061
PF-06463922 is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), wit...
ALK inhibitor 1
T10285
ALK inhibitor 1 is a selective ALK kinase inhibitor.
Crizotinib
T1661
Crizotinib is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor.
Ceritinib dihydrochloride
T1791L
Ceritinib dihydrochloride is a selective, orally bioavailable and ATP-competitive inhibitor of ALK tyrosine kinase(IC50 of 200 pM), and also inhibits IGF-1R, Ins...
AZD-3463
T1967
AZD3463, an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.
D4476
T2449
D4476 is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay).
NVP-TAE 684
T2251
NVP-TAE 684 is a excellently effective and specific ALK inhibitor(IC50=3 nM).
ASP3026
T1962
ASP3026 has been used in trials studying the treatment of Solid Tumor, B-Cell Lymphoma, Advanced Malignancies, Positive for Anaplastic Lymphoma Kinase, and Posit...
Entrectinib
T3678
Entrectinib is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1.6 nM) and C...
R-268712
T16708
R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor...
LDN193189
T1935
LDN193189 (DM 3189) is a selective BMP signaling inhibitor, inhibiting the transcriptional activity of ALK2 and ALK3 (IC50s: 0.8/0.8/5.3/16.7 nM for ALK1/2/3/6)....
Ensartinib hydrochloride
T22324
Ensartinib dihydrochloride is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of known crizotinib-resistant ALK...
Crizotinib hydrochloride
T8399
Crizotinib hydrochloride is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)
MS4078
T16153
MS4078 is an anaplastic lymphoma kinase (ALK) PROTAC. It has a Kd of 19 nM for binding affinity to ALK.
SM 16
T4975
SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).
ALK inhibitor 2
T3041
ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.
Vactosertib
T6496
Vactosertib is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also known as act...
DMH-1
T1942
DMH-1 is a potent and selective BMP inhibitor.
Repotrectinib
T4071
TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.
SB-431542
T1726
SB-431542 is a potent and selective inhibitor of ALK5 (IC50: 94 nM) and is also an inhibitor of ALK4 (IC50: 140 nM) and ALK7.
A 83-01
T3031
A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 with IC50 values of 12 ...
A 77-01
T2098
A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.
5-phenylthieno[2,3-d]pyrimidin-4-amine
T50042
5-phenylthieno[2,3-d]pyrimidin-4-amine is a chemical compound.
F-1
T11254
F-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. F-1 is a potent ALK and ROS1 dual inhibitor, suppres...
LDN-214117
T1944
LDN-214117 is a potent and selective ALK2 inhibitor.
AZ7550
T13564
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
ZX-29
T13416
ZX-29 is a potent and selective inhibitor of ALK(IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively), and also induces ...
Ceritinib
T1791
Ceritinib (LDK378) is a specific ALK inhibitor (IC50: 0.2 nM).
Alectinib
T1936
CH5424802 is an orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity.
CEP-28122
T2612
CEP-28122 is a highly potent and selective orally active ALK inhibitor.
CEP-37440
T2655
CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).
KRCA-0008
T2641
KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability.
6-Demethoxytangeretin
T8152
6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa.
Blu-782
T8108
Blu-782 is a activin receptor-like kinase-2 (ALK2) inhibitor ( IC50 of <10 nM)
CH5424802 analog
T9224
CH5424802 analog is a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.
Alectinib hydrochloride
T8387
Alectinib hydrochloride is a selective, and orally available inhibitor of ALK( IC50 : 1.9 nM)
TGFBR1-IN-1
T13138
TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).
CEP-28122 mesylate salt (1022958-60-6 free base)
T10759
CEP-28122 mesylate salt is a highly selective orally active ALK inhibitor (IC50: 1.9 nM in an enzyme-based TRF assay).
AZ12601011
T10426
AZ12601011 is an orally active, selective TGFBR1 kinase inhibitor (IC50: 18 nM; Kd: 2.9 nM) with inhibitory to mammary tumor growth. AZ12601011 inhibits phosphor...
A 83-01 sodium salt
T10442
A 83-01 sodium salt is a potent inhibitor of ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50s: 12, 45 and 7.5 nM against the...
ALK2-IN-2
T10287
ALK2-IN-2 is a potent and selective inhibitor of ALK2 (IC50: 9 nM), and over 700-fold selectivity against ALK3.
ALK-IN-5
T10283
ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).
HG-14-10-04
T4015
HG-14-10-04 is a potent and specific ALK inhibitor.
GSK1838705A
T3079
GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to ...
1 2