ALK

Anaplastic lymphoma kinase (ALK) also known as ALK tyrosine kinase receptor or CD246 (cluster of differentiation 246) is an enzyme that in humans is encoded by the ALK gene.The receptor ALK plays a pivotal role in cellular communication and in the normal development and function of the nervous system.

Cat No.	product name
T1661	CrizotinibHOT	Crizotinib is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor.
T1726	SB 431542HOT	SB-431542 is a potent and selective inhibitor of ALK5 (IC50: 94 nM) and is also an inhibitor of ALK4 (IC50: 140 nM) and ALK7.
T1791	LDK378HOT	Ceritinib (LDK378) is a specific ALK inhibitor (IC50: 0.2 nM).
T1800	GW 788388	GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities.
T1900	LDN212854	LDN-212854, a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors; possesses differences towards ALK2(IC50=1.3 nM) vers...
T1914	K 02288	K02288 is a novel small molecule inhibitor of ALK1/2/3/6.
T1935	LDN-193189HOT	LDN193189 (DM 3189) is a selective BMP signaling inhibitor, inhibiting the transcriptional activity of ALK2 and ALK3 (IC50s: 0.8/0.8/5.3/16.7 nM for ALK1/2/3/6...
T1936	Alectinib	CH5424802 is an orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity.
T1942	DMH1	DMH-1 is a potent and selective BMP inhibitor.
T1943	ML347	ML347(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.
T1944	LDN-214117	LDN-214117 is a potent and selective ALK2 inhibitor.
T1962	ASP 3026	ASP3026 has been used in trials studying the treatment of Solid Tumor, B-Cell Lymphoma, Advanced Malignancies, Positive for Anaplastic Lymphoma Kinase, and Posi...
T2098	A77-01	A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.
T2251	TAE684	NVP-TAE 684 is a excellently effective and specific ALK inhibitor(IC50=3 nM).
T2449	D 4476	D4476 is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay).
T2462	SB-505124	SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5.
T2612	CEP-28122	CEP-28122 is a highly potent and selective orally active ALK inhibitor.
T2641	KRCA-0008	KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability.
T2655	CEP37440	CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).
T3031	ALK5 Inhibitor IV	A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 with IC50 values of 12...
T3041	ALK inhibitor 2	ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.
T3059	AP26113	Brigatinib is a excellently effective and specific ALK inhibitor( IC50 =0.6 nM).
T3061	Lorlatinib	PF-06463922 is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), wi...
T3079	GSK1838705A	GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to...
T3550	Ensartinib	Ensartinib (X-396) is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplasti...
T3621	Brigatinib	Brigatinib is a highly potent and selective ALK inhibitor.
T3678	Entrectinib	Entrectinib is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1.6 nM) and ...
T4015	HG-14-10-04	HG-14-10-04 is a potent and specific ALK inhibitor.
T4071	TPX-0005	TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.
T6158	LDN-193189 HCl	LDN193189 hydrochloride is a selective BMP type I receptor kinases inhibitor.
T6337	RepSox	RepSox is a potent and selective of the TGFβR-1/ALK5 inhibitor.
T6496	Vactosertib	Vactosertib is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also known as ac...
T4257	Belizatinib	Belizatinib is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.
T4975	SM 16	SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).
T1763	SB525334HOT	SB-525334 is a potent and selective inhibitor of the TGF-β1R and ALK5 (IC50: 14.3 nM).
T5197	BIBF0775	BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM).
T8152	6-Demethoxytangeretin	6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa.
T8108	Blu-782	Blu-782 is a activin receptor-like kinase-2 (ALK2) inhibitor ( IC50 of <10 nM)
T8399	Crizotinib hydrochloride	Crizotinib hydrochloride is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)
T8387	Alectinib hydrochloride	Alectinib hydrochloride is a selective, and orally available inhibitor of ALK( IC50 : 1.9 nM)
T13781	MS4077	MS4077 is an degrader of anaplastic lymphoma kinase (ALK) PROTAC(Kd of 37 nM for binding affinity to ALK).
T10442	A 83-01 sodium salt	A 83-01 sodium salt is a potent inhibitor of ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50s: 12, 45 and 7.5 nM against th...
T10287	ALK2-IN-2	ALK2-IN-2 is a potent and selective inhibitor of ALK2 (IC50: 9 nM), and over 700-fold selectivity against ALK3.
T10283	ALK-IN-5	ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).
T10426	AZ12601011	AZ12601011 is an orally active, selective TGFBR1 kinase inhibitor (IC50: 18 nM; Kd: 2.9 nM) with inhibitory to mammary tumor growth. AZ12601011 inhibits phospho...
T15262	Vactosertib Hydrochloride	Vactosertib Hydrochloride is an orally active and ATP-competitive ALK5 inhibitor (IC50: 12.9 nM). It has potently antimetastatic activity and anticancer effect....
T13138	TGFBR1-IN-1	TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).
T15572	IN-1130	IN-1130 inhibits ALK5 phosphorylation of casein (IC50=36 nM) and p38α mitogen-activated protein kinase (IC50=4.3 μM). IN-1130 is a highly selective inhibitor ...
T16708	R-268712	R-268712 is an effective and selective inhibitor of ALK5 IC50: 2.5 nM).
T13352	Wy 49051	Wy 49051 is an orally active antagonist of H1 receptor(IC50 of 44 nM).