ALK

Anaplastic lymphoma kinase (ALK) also known as ALK tyrosine kinase receptor or CD246 (cluster of differentiation 246) is an enzyme that in humans is encoded by the ALK gene.

Cat No.	product name
T1900	LDN-212854	LDN-212854, a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors; possesses differences towards ALK2(IC50=1.3 nM) versus...
T1800	GW788388	GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities.
T4257	Belizatinib	Belizatinib is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.
T1914	K02288	K02288 is a novel small molecule inhibitor of ALK1/2/3/6.
T2462	SB-505124	SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5.
T1943	ML347	ML347(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.
T3061	Lorlatinib	PF-06463922 is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), wit...
T10285	ALK inhibitor 1	ALK inhibitor 1 is a selective ALK kinase inhibitor.
T1661	Crizotinib	Crizotinib is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor.
T1791L	Ceritinib dihydrochloride	Ceritinib dihydrochloride is a selective, orally bioavailable and ATP-competitive inhibitor of ALK tyrosine kinase(IC50 of 200 pM), and also inhibits IGF-1R, Ins...
T1967	AZD-3463	AZD3463, an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.
T2449	D4476	D4476 is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay).
T2251	NVP-TAE 684	NVP-TAE 684 is a excellently effective and specific ALK inhibitor(IC50=3 nM).
T1962	ASP3026	ASP3026 has been used in trials studying the treatment of Solid Tumor, B-Cell Lymphoma, Advanced Malignancies, Positive for Anaplastic Lymphoma Kinase, and Posit...
T3678	Entrectinib	Entrectinib is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1.6 nM) and C...
T16708	R-268712	R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor ...
T1935	LDN193189	LDN193189 (DM 3189) is a selective BMP signaling inhibitor, inhibiting the transcriptional activity of ALK2 and ALK3 (IC50s: 0.8/0.8/5.3/16.7 nM for ALK1/2/3/6)....
T22324	Ensartinib hydrochloride	Ensartinib dihydrochloride is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of known crizotinib-resistant ALK...
T8399	Crizotinib hydrochloride	Crizotinib hydrochloride is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)
T16153	MS4078	MS4078 is an anaplastic lymphoma kinase (ALK) PROTAC. It has a Kd of 19 nM for binding affinity to ALK.
T4975	SM 16	SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).
T3041	ALK inhibitor 2	ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.
T6496	Vactosertib	Vactosertib is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also known as act...
T1942	DMH-1	DMH-1 is a potent and selective BMP inhibitor.
T4071	Repotrectinib	TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.
T1726	SB-431542	SB-431542 is a potent and selective inhibitor of ALK5 (IC50: 94 nM) and is also an inhibitor of ALK4 (IC50: 140 nM) and ALK7.
T3031	A 83-01	A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 with IC50 values of 12 n...
T2098	A 77-01	A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.
T50042	5-phenylthieno[2,3-d]pyrimidin-4-amine	5-phenylthieno[2,3-d]pyrimidin-4-amine is a chemical compound.
T11254	F-1	F-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. F-1 is a potent ALK and ROS1 dual inhibitor, suppress...
T1944	LDN-214117	LDN-214117 is a potent and selective ALK2 inhibitor.
T13564	AZ7550	AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T13416	ZX-29	ZX-29 is a potent and selective inhibitor of ALK(IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively), and also induces ...
T1791	Ceritinib	Ceritinib (LDK378) is a specific ALK inhibitor (IC50: 0.2 nM).
T1936	Alectinib	CH5424802 is an orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity.
T2612	CEP-28122	CEP-28122 is a highly potent and selective orally active ALK inhibitor.
T2655	CEP-37440	CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).
T2641	KRCA-0008	KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability.
T8152	6-Demethoxytangeretin	6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa.
T8108	Blu-782	Blu-782 is a activin receptor-like kinase-2 (ALK2) inhibitor ( IC50 of <10 nM)
T9224	CH5424802 analog	CH5424802 analog is a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.
T8387	Alectinib hydrochloride	Alectinib hydrochloride is a selective, and orally available inhibitor of ALK( IC50 : 1.9 nM)
T13138	TGFBR1-IN-1	TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).
T10759	CEP-28122 mesylate salt (1022958-60-6 free base)	CEP-28122 mesylate salt is a highly selective orally active ALK inhibitor (IC50: 1.9 nM in an enzyme-based TRF assay).
T10426	AZ12601011	AZ12601011 is an orally active, selective TGFBR1 kinase inhibitor (IC50: 18 nM; Kd: 2.9 nM) with inhibitory to mammary tumor growth. AZ12601011 inhibits phosphor...
T10442	A 83-01 sodium salt	A 83-01 sodium salt is a potent inhibitor of ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50s: 12, 45 and 7.5 nM against the...
T10287	ALK2-IN-2	ALK2-IN-2 is a potent and selective inhibitor of ALK2 (IC50: 9 nM), and over 700-fold selectivity against ALK3.
T10283	ALK-IN-5	ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).
T4015	HG-14-10-04	HG-14-10-04 is a potent and specific ALK inhibitor.
T3079	GSK1838705A	GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to ...