T6937 |
PF-04620110
|
1109276-89-2
|
98%
|
|
PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.
|
T12426 |
PF-06424439
|
1469284-78-3
|
98%
|
|
PF-06424439 is an oral and selective inhibitor of imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) (IC50 of 14 nM).
|
T13373 |
YM17E
|
124900-72-7
|
98%
|
|
YM17E is an inhibitor of ACAT with IC50 of 44 nM in rabbit liver microsomes in vitro.
|
T12767 |
RP 70676
|
136609-26-2
|
98%
|
|
RP 70676 is a potent ACAT inhibitor(rat and rabbit ACAT with IC50 of 25 and 44 nM ).
|
T23521 |
VULM 1457
|
228544-65-8
|
98%
|
|
Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor
|
T10035 |
10,12-Tricosadiynoic acid
|
66990-30-5
|
|
|
10,12-Tricosadiynoic acid is a highly selective and orally active inhibitor of acyl-CoA oxidase-1 (ACOX1). It can treat the high-fat diet- or obesity-induced met...
|
T5544 |
2-Furoic acid
|
88-14-2
|
100%
|
|
2-Furoic acid, an orally active selective human cathepsin K inhibitor, may have the therapeutic potential for the treatment of diseases characterized by excessiv...
|
T16409 |
OSMI-1
|
1681056-61-0
|
96.79%
|
|
OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked...
|
T6365 |
A 922500
|
959122-11-3
|
97.34%
|
|
A922500 is an inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively, good selectivity over related acyltransferases, hERG, and a panel o...
|
T8236 |
RHC 80267
|
83654-05-1
|
98%
|
|
RHC 80267 is a selective inhibitor of DAGL (IC50 : 4 µM in canine platelets)
|
T8314 |
RP-64477
|
135239-65-5
|
99.16%
|
|
RP64477 is the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT) inhibitor.
|
T0504 |
Cyclandelate
|
456-59-7
|
99.21%
|
|
Cyclandelate, a direct-acting smooth muscle relaxant, is used to dilate blood vessels.
|
T12225L |
Nevanimibe hydrochloride
|
133825-81-7
|
99.25%
|
|
Nevanimibe hydrochloride is an orally active and selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) (EC50 of 9 nM).
|
T3342 |
Xanthohumol
|
6754-58-1
|
99.36%
|
|
Xanthohumol, also known as 2', 4, 4'-trihydroxy-6'-methoxy-3'-prenylchalcone or desmethylxanthohumol, is a member of the class of compounds known as 3-prenylated...
|
T22665 |
PD 128042
|
114289-47-3
|
99.44%
|
|
acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor
|
TN1691 |
Glabrol
|
59870-65-4
|
99.72%
|
|
Glabrol is a PTP1B inhibitor, it is also a CYP1B1 inhibitor, it shows inhibition of CYP1B1 in live cell assay with the IC50 value of 15uM.
|
T12425 |
PF-06424439 methanesulfonate
|
1469284-79-4
|
99.79%
|
|
PF-06424439 methanesulfonate is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor(IC50 of 14 nM)[1]. PF-06424439 m...
|
T11733 |
K-604 dihydrochloride
|
217094-32-1
|
99.88%
|
|
K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 inhibitor with an IC50 of 0.45±0.06 μM.
|
T4681 |
T863
|
701232-20-4
|
99.88%
|
|
T-863(DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA bi...
|
T2753 |
Avasimibe
|
166518-60-1
|
99.91%
|
|
Avasimibe is an orally bioavailable inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT, IC50: 3.3 μM) that prevents cholesterol deposition in the ar...
|