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Epoxide Hydrolase

Epoxide hydrolases (EH's), also known as epoxide hydratases, are enzymes that metabolize compounds that contain an epoxide residue; they convert this residue to two hydroxyl residues through an epoxide hydrolysis reaction to form diol products. Several enzymes possess EH activity. Microsomal epoxide hydrolase (epoxide hydrolase 1, EH1, or mEH), soluble epoxide hydrolase (sEH, epoxide hydrolase 2, EH2, or cytoplasmic epoxide hydrolase), and the more recently discovered but not as yet well defined functionally, epoxide hydrolase 3 (EH3) and epoxide hydrolase 4 (EH4) are structurally closely related isozymes. Other enzymes with epoxide hydrolase activity include leukotriene A4 hydrolase, Cholesterol-5,6-oxide hydrolase, MEST (gene) (Peg1/MEST), and Hepoxilin-epoxide hydrolase. The hydrolases are distinguished from each other by their substrate preferences and, directly related to this, their functions.
Cat No. product name
T15430 GSK2256294A GSK2256294A 是重组人、大鼠和小鼠 sEH 的有效特异性抑制剂,IC50 分别为 27 pM、61 pM 和 189 pM。
T7898 AUDA AUDA is an inhibitor of sEH(IC50 values of 18 and 69 nM for the mouse and human enzymes, respectively)
T10900 CUDA CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases the a...
T2716 1,3-Diphenylurea 1, 3-Diphenylurea is involved with Epoxide hydrolase activity.
T11147 EC5026 EC5026 has the potential to relieve pain by stabilizing natural analgesic and anti-inflammatory mediators.
T7199 TPPU TPPU is a potent inhibitor of both human and mouse sEH (IC50 of 3.7 and 2.8 nM, respectively)
T12580 PTUPB PTUPB is a potent and dual inhibitor of sEH and COX-2 enzymes(IC50 of 0.9 nM and 1.26 μM, respectively).
T14557 BI-1935 BI-1935 is an inhibitor of soluble epoxide hydrolase (sEH). For diseases related to cardiovascular disease.
T21859 ARM1 ARM1 is a potent inhibitor of aminopeptidase and epoxide hydrolase. The IC50 values are 7.61 µM for aminopeptidase and 12.4 µM for epoxide hydrolase.
T8315 1-Cyclohexyl-3-dodecyl urea 1-Cyclohexyl-3-dodecyl urea is a highly selective soluble epoxide hydrolase (sEH) inhibitor.
T17196 UC-1728 UC-1728 is an effective rabbit soluble epoxide hydrolase inhibitor (IC50: 2 nM on rabbit liver).
T17158 Trans-AUCB trans-AUCB is an effective and selective soluble epoxide hydrolase inhibitor (IC50s: 1.3 nM, 8 nM, 8 nM for hsEH, mouse sEH and rat sEH, respectively).
T0355 Valpromide Valpromide is a carboxamide derivative of valproic acid, used in the treatment of epilepsy and some affective disorders.
T8844 Diflapolin Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and ...
T23044 N,N'-Dicyclohexylurea soluble epoxide hydrolase (sEH) inhibitor
T14315 AR-9281 AR9281 is a potent and selective inhibitor of soluble epoxide hydrolase (s-EH) potentially for the treatment of hypertension and type 2 diabetes
GSK2256294A
T15430
GSK2256294A 是重组人、大鼠和小鼠 sEH 的有效特异性抑制剂,IC50 分别为 27 pM、61 pM 和 189 pM。
AUDA
T7898
AUDA is an inhibitor of sEH(IC50 values of 18 and 69 nM for the mouse and human enzymes, respectively)
CUDA
T10900
CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases the a...
1,3-Diphenylurea
T2716
1, 3-Diphenylurea is involved with Epoxide hydrolase activity.
EC5026
T11147
EC5026 has the potential to relieve pain by stabilizing natural analgesic and anti-inflammatory mediators.
TPPU
T7199
TPPU is a potent inhibitor of both human and mouse sEH (IC50 of 3.7 and 2.8 nM, respectively)
PTUPB
T12580
PTUPB is a potent and dual inhibitor of sEH and COX-2 enzymes(IC50 of 0.9 nM and 1.26 μM, respectively).
BI-1935
T14557
BI-1935 is an inhibitor of soluble epoxide hydrolase (sEH). For diseases related to cardiovascular disease.
ARM1
T21859
ARM1 is a potent inhibitor of aminopeptidase and epoxide hydrolase. The IC50 values are 7.61 µM for aminopeptidase and 12.4 µM for epoxide hydrolase.
1-Cyclohexyl-3-dodecyl urea
T8315
1-Cyclohexyl-3-dodecyl urea is a highly selective soluble epoxide hydrolase (sEH) inhibitor.
UC-1728
T17196
UC-1728 is an effective rabbit soluble epoxide hydrolase inhibitor (IC50: 2 nM on rabbit liver).
trans-AUCB
T17158
trans-AUCB is an effective and selective soluble epoxide hydrolase inhibitor (IC50s: 1.3 nM, 8 nM, 8 nM for hsEH, mouse sEH and rat sEH, respectively).
Valpromide
T0355
Valpromide is a carboxamide derivative of valproic acid, used in the treatment of epilepsy and some affective disorders.
Diflapolin
T8844
Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and ...
N,N'-Dicyclohexylurea
T23044
soluble epoxide hydrolase (sEH) inhibitor
AR-9281
T14315
AR9281 is a potent and selective inhibitor of soluble epoxide hydrolase (s-EH) potentially for the treatment of hypertension and type 2 diabetes