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FAAH

Fatty acid amide hydrolase or FAAH (oleamide hydrolase, anandamide amidohydrolase) is a member of the serine hydrolase family of enzymes. It was first shown to break down anandamide in 1993. In humans, it is encoded by the gene FAAH.FAAH is an integral membrane hydrolase with a single N-terminal transmembrane domain. In vitro, FAAH has esterase and amidase activity.In vivo, FAAH is the principal catabolic enzyme for a class of bioactive lipids called the fatty acid amides (FAAs).
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T78593 JP104 887264-45-1 98%
JP104
JP104 is an aryl carbamate that irreversibly inhibits fatty acid amide hydrolase (FAAH) with a pIC50 value of approximately 8 [1].
T78674 Isopropyl dodec-11-enylfluorophosphonate 623114-64-7 98%
Isopropyl dodec-11-enylfluorophosphonate
Isopropyl dodec-11-enylfluorophosphonate (IDEFP) is an organophosphorus ester functioning as a central cannabinoid receptor (CB1) antagonist and exhibits equipot...
T16847 SA 47 792236-07-8 98%
SA 47
SA 47 is a selective and effective inhibitor of fatty acid amide hydrolase and carbamate.
T12826 SA57 1346169-63-8 98%
SA57
SA57 is a potent, selective inhibitor of FAAH(IC50s of 3.2 nM and 1.9 nM for mouse and human FAAH).
T11255 FAAH-IN-1 1242441-47-9 98%
FAAH-IN-1
FAAH-IN-1 is a fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 145 nM and 650 nM for rat and human FAAH, respectively.
T63536 Dual FAAH/sEH-IN-1 2756099-59-7 99.89%
Dual FAAH/sEH-IN-1
Dual FAAH/sEH-IN-1 is a dual inhibitor of sEH (soluble epoxide hydrolase) (IC50: 9.6 nM) and FAAH (fatty acid amide hydrolase) (IC50: 7 nM) with high affinity an...
T3215 JNJ-42165279 1346528-50-4 99.89%
JNJ-42165279
JNJ-42165279 covalently inactivates the FAAH enzyme but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. JNJ-42165279...
T2684 JNJ-1661010 681136-29-8 99.8%
JNJ-1661010
JNJ-1661010 (Takeda-25) is an effective and specific FAAH inhibitor (IC50: 10/ 12 nM for rat/human), shows >100-fold selectivity for FAAH-1 than FAAH-2.
T3354 BIA 10-2474 1233855-46-3 99.79%
BIA 10-2474
BIA 10-2474 is a long-acting reversible inhibitor of fatty acid amide hydrolase (FAAH) that increases levels of the neurotransmitter anandamide in the central ne...
T2338 JZL195 1210004-12-8 99.78%
JZL195
JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.
T8927 WWL 154 1338574-93-8 99.75%
WWL 154
WWL 154 is an serine hydrolase (SH) and fatty acid amide hydrolase FAAH-4 inhibitor.
T9374 AA38-3 65815-76-1 99.70%
AA38-3
AA38-3 (1-Piperidinecarboxylic acid, 4-nitrophenyl ester) inhibites three SHs (ABHD6, ABHD11, and FAAH)
T12139 N-(3-Methoxybenzyl)Palmitamide 847361-96-0 99.65%
N-(3-Methoxybenzyl)Palmitamide
N-(3-Methoxybenzyl)Palmitamide is a promising FAAH inhibitor, treatment of pain, inflammation and CNS degenerative disorders.
T4859 1-Monomyristin 589-68-4 99.58%
1-Monomyristin
1-Monomyristin (2,3-Dihydroxypropyl tetradecanoate) , a 1-monoglyceride of myristic acid, has antibacterial activity against several Gram-positive bacterial stra...
T8646 URB937 1357160-72-5 99.55%
URB937
URB937 is an inhibitor of FAAH and increases anandamide levels(IC50 : 26.8 nM).
T67745 CB2R/FAAH modulator-2 2876918-68-0 99.52%
CB2R/FAAH modulator-2
CB2R/FAAH modulator-2 (compound 26) is a dual modulator targeting at CB2R and FAAH. CB2R/FAAH modulator-2 acts as a CB2R agonist and FAAH inhibitor, the Ki value...
T77513 2-Chlorophenylboronic acid 3900-89-8 99.42%
2-Chlorophenylboronic acid
2-Chlorophenylboronic acid is a monohalogenated phenylboronic acid, which is an important pharmaceutical intermediate and is widely used in the synthesis of new ...
T77594 VU534 923509-20-0 99.22%
VU534
VU534 is a NAPE-PLD agonist with an EC50 of 0.30 μM.VU534 is a dual inhibitor of FAAH and sEH, with an IC50 of 1.2 μM for sEH.VU534 is used in diseases related t...
T15268 FAAH-IN-2 184475-71-6 99.18%
FAAH-IN-2
FAAH-IN-2 (O-Desmorpholinopropyl Gefitinib) is a potent inhibitor of FAAH(fatty acid amide hydrolase).
T7688 4-Nonylphenylboronic acid 256383-45-6 99.13%
4-Nonylphenylboronic acid
4-Nonylphenylboronic acid is a inhibitor of FAAH.
JP104
T78593
JP104 is an aryl carbamate that irreversibly inhibits fatty acid amide hydrolase (FAAH) with a pIC50 value of approximately 8 [1].
Isopropyl dodec-11-enylfluorophosphonate
T78674
Isopropyl dodec-11-enylfluorophosphonate (IDEFP) is an organophosphorus ester functioning as a central cannabinoid receptor (CB1) antagonist and exhibits equipot...
SA 47
T16847
SA 47 is a selective and effective inhibitor of fatty acid amide hydrolase and carbamate.
SA57
T12826
SA57 is a potent, selective inhibitor of FAAH(IC50s of 3.2 nM and 1.9 nM for mouse and human FAAH).
FAAH-IN-1
T11255
FAAH-IN-1 is a fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 145 nM and 650 nM for rat and human FAAH, respectively.
Dual FAAH/sEH-IN-1
T63536
Dual FAAH/sEH-IN-1 is a dual inhibitor of sEH (soluble epoxide hydrolase) (IC50: 9.6 nM) and FAAH (fatty acid amide hydrolase) (IC50: 7 nM) with high affinity an...
JNJ-42165279
T3215
JNJ-42165279 covalently inactivates the FAAH enzyme but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. JNJ-42165279...
JNJ-1661010
T2684
JNJ-1661010 (Takeda-25) is an effective and specific FAAH inhibitor (IC50: 10/ 12 nM for rat/human), shows >100-fold selectivity for FAAH-1 than FAAH-2.
BIA 10-2474
T3354
BIA 10-2474 is a long-acting reversible inhibitor of fatty acid amide hydrolase (FAAH) that increases levels of the neurotransmitter anandamide in the central ne...
JZL195
T2338
JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.
WWL 154
T8927
WWL 154 is an serine hydrolase (SH) and fatty acid amide hydrolase FAAH-4 inhibitor.
AA38-3
T9374
AA38-3 (1-Piperidinecarboxylic acid, 4-nitrophenyl ester) inhibites three SHs (ABHD6, ABHD11, and FAAH)
N-(3-Methoxybenzyl)Palmitamide
T12139
N-(3-Methoxybenzyl)Palmitamide is a promising FAAH inhibitor, treatment of pain, inflammation and CNS degenerative disorders.
1-Monomyristin
T4859
1-Monomyristin (2,3-Dihydroxypropyl tetradecanoate) , a 1-monoglyceride of myristic acid, has antibacterial activity against several Gram-positive bacterial stra...
URB937
T8646
URB937 is an inhibitor of FAAH and increases anandamide levels(IC50 : 26.8 nM).
CB2R/FAAH modulator-2
T67745
CB2R/FAAH modulator-2 (compound 26) is a dual modulator targeting at CB2R and FAAH. CB2R/FAAH modulator-2 acts as a CB2R agonist and FAAH inhibitor, the Ki value...
2-Chlorophenylboronic acid
T77513
2-Chlorophenylboronic acid is a monohalogenated phenylboronic acid, which is an important pharmaceutical intermediate and is widely used in the synthesis of new ...
VU534
T77594
VU534 is a NAPE-PLD agonist with an EC50 of 0.30 μM.VU534 is a dual inhibitor of FAAH and sEH, with an IC50 of 1.2 μM for sEH.VU534 is used in diseases related t...
FAAH-IN-2
T15268
FAAH-IN-2 (O-Desmorpholinopropyl Gefitinib) is a potent inhibitor of FAAH(fatty acid amide hydrolase).
4-Nonylphenylboronic acid
T7688
4-Nonylphenylboronic acid is a inhibitor of FAAH.
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TargetMol