FAAH

Fatty acid amide hydrolase or FAAH (oleamide hydrolase, anandamide amidohydrolase) is a member of the serine hydrolase family of enzymes. It was first shown to break down anandamide in 1993. In humans, it is encoded by the gene FAAH.FAAH is an integral membrane hydrolase with a single N-terminal transmembrane domain. In vitro, FAAH has esterase and amidase activity.In vivo, FAAH is the principal catabolic enzyme for a class of bioactive lipids called the fatty acid amides (FAAs).

Cat No.	product name
T2338	JZL195	JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.
T2684	JNJ-1661010	JNJ-1661010 is an effective and specific FAAH inhibitor (IC50: 10/ 12 nM for rat/human), shows >100-fold selectivity for FAAH-1 than FAAH-2.
T2859	Biochanin A	Biochanin A is an isoflavone derivative isolated from red clover Trifolium pratense with anticarcinogenic properties. Biochanin A is a naturally occurring fatty...
T3215	JNJ-42165279	JNJ-42165279 covalently inactivates the FAAH enzyme but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. JNJ-4216527...
T3354	BIA10-2474	BIA10-2474 is a long-acting reversible inhibitor of fatty acid amide hydrolase (FAAH) that increases levels of the neurotransmitter anandamide in the central ne...
T6043	PF-3845	PF-3845 is a potent, selective and irreversible FAAH inhibitor with Ki of 230 nM, showing negligible activity against FAAH2.
T6714	URB597	URB597 is an effective, orally bioavailable FAAH inhibitor (IC50: 4.6 nM), and no effect on other cannabinoid-related targets.
T4323	PF-04457845	PF-04457845 is a greatly and effctive FAAH inhibitor,and for hFAAH(IC50=7.2±0.63 nM) and rFAAH(IC50=7.4±0.62 nM).
T7688	4-Nonylphenylboronic acid	4-Nonylphenylboronic acid is a inhibitor of FAAH.
T12826	SA57	SA57 is a potent, selective inhibitor of FAAH(IC50s of 3.2 nM and 1.9 nM for mouse and human FAAH).
T11255	FAAH-IN-1	FAAH-IN-1 is a fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 145 nM and 650 nM for rat and human FAAH, respectively.
T16515	PF 750	PF 750 is a selective and covalent fatty acid amide hydrolase inhibitor, It shows IC50s varied from 16.2-595 nM in different pre-incubation times.
T16847	SA 47	SA 47 is a selective and effective inhibitor of fatty acid amide hydrolase and carbamate.
T8646	URB937	URB937 is an inhibitor of FAAH and increases anandamide levels(IC50 : 26.8 nM).

Cat No.

product name

T2338

JZL195

JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.

T2684

JNJ-1661010

JNJ-1661010 is an effective and specific FAAH inhibitor (IC50: 10/ 12 nM for rat/human), shows >100-fold selectivity for FAAH-1 than FAAH-2.

T2859

Biochanin A

Biochanin A is an isoflavone derivative isolated from red clover Trifolium pratense with anticarcinogenic properties. Biochanin A is a naturally occurring fatty...

T3215

JNJ-42165279

JNJ-42165279 covalently inactivates the FAAH enzyme but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. JNJ-4216527...

T3354

BIA10-2474

BIA10-2474 is a long-acting reversible inhibitor of fatty acid amide hydrolase (FAAH) that increases levels of the neurotransmitter anandamide in the central ne...

T6043

PF-3845

PF-3845 is a potent, selective and irreversible FAAH inhibitor with Ki of 230 nM, showing negligible activity against FAAH2.

T6714

URB597

URB597 is an effective, orally bioavailable FAAH inhibitor (IC50: 4.6 nM), and no effect on other cannabinoid-related targets.

T4323

PF-04457845

PF-04457845 is a greatly and effctive FAAH inhibitor,and for hFAAH(IC50=7.2±0.63 nM) and rFAAH(IC50=7.4±0.62 nM).

T7688

4-Nonylphenylboronic acid

4-Nonylphenylboronic acid is a inhibitor of FAAH.

T12826

SA57

SA57 is a potent, selective inhibitor of FAAH(IC50s of 3.2 nM and 1.9 nM for mouse and human FAAH).

T11255

FAAH-IN-1

FAAH-IN-1 is a fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 145 nM and 650 nM for rat and human FAAH, respectively.

T16515

PF 750

PF 750 is a selective and covalent fatty acid amide hydrolase inhibitor, It shows IC50s varied from 16.2-595 nM in different pre-incubation times.

T16847

SA 47

SA 47 is a selective and effective inhibitor of fatty acid amide hydrolase and carbamate.

T8646

URB937

URB937 is an inhibitor of FAAH and increases anandamide levels(IC50 : 26.8 nM).