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Metabolism FAAH

FAAH

Fatty acid amide hydrolase or FAAH (oleamide hydrolase, anandamide amidohydrolase) is a member of the serine hydrolase family of enzymes. It was first shown to break down anandamide in 1993. In humans, it is encoded by the gene FAAH.FAAH is an integral membrane hydrolase with a single N-terminal transmembrane domain. In vitro, FAAH has esterase and amidase activity.In vivo, FAAH is the principal catabolic enzyme for a class of bioactive lipids called the fatty acid amides (FAAs).
Cat No. product name
T2338 JZL195 JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.
T2684 JNJ-1661010 JNJ-1661010 is an effective and specific FAAH inhibitor (IC50: 10/ 12 nM for rat/human), shows >100-fold selectivity for FAAH-1 than FAAH-2.
T2859 Biochanin A Biochanin A is an isoflavone derivative isolated from red clover Trifolium pratense with anticarcinogenic properties. Biochanin A is a naturally occurring fatty...
T3215 JNJ-42165279 JNJ-42165279 covalently inactivates the FAAH enzyme but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. JNJ-4216527...
T3354 BIA10-2474 BIA10-2474 is a long-acting reversible inhibitor of fatty acid amide hydrolase (FAAH) that increases levels of the neurotransmitter anandamide in the central ne...
T6043 PF-3845 PF-3845 is a potent, selective and irreversible FAAH inhibitor with Ki of 230 nM, showing negligible activity against FAAH2.
T6714 URB597 URB597 is an effective, orally bioavailable FAAH inhibitor (IC50: 4.6 nM), and no effect on other cannabinoid-related targets.
T4323 PF-04457845 PF-04457845 is a greatly and effctive FAAH inhibitor,and for hFAAH(IC50=7.2±0.63 nM) and rFAAH(IC50=7.4±0.62 nM).
T7688 4-Nonylphenylboronic acid 4-Nonylphenylboronic acid is a inhibitor of FAAH.
T12826 SA57 SA57 is a potent, selective inhibitor of FAAH(IC50s of 3.2 nM and 1.9 nM for mouse and human FAAH).
T11255 FAAH-IN-1 FAAH-IN-1 is a fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 145 nM and 650 nM for rat and human FAAH, respectively.
T16515 PF 750 PF 750 is a selective and covalent fatty acid amide hydrolase inhibitor, It shows IC50s varied from 16.2-595 nM in different pre-incubation times.
T16847 SA 47 SA 47 is a selective and effective inhibitor of fatty acid amide hydrolase and carbamate.
T8646 URB937 URB937 is an inhibitor of FAAH and increases anandamide levels(IC50 : 26.8 nM).
JZL195
T2338CAS 1210004-12-8
JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.
JNJ-1661010
T2684CAS 681136-29-8
JNJ-1661010 is an effective and specific FAAH inhibitor (IC50: 10/ 12 nM for rat/human), shows >100-fold selectivity for FAAH-1 than FAAH-2.
Biochanin A
T2859CAS 491-80-5
Biochanin A is an isoflavone derivative isolated from red clover Trifolium pratense with anticarcinogenic properties. Biochanin A is a naturally occurring fatty...
JNJ-42165279
T3215CAS 1346528-50-4
JNJ-42165279 covalently inactivates the FAAH enzyme but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. JNJ-4216527...
BIA10-2474
T3354CAS 1233855-46-3
BIA10-2474 is a long-acting reversible inhibitor of fatty acid amide hydrolase (FAAH) that increases levels of the neurotransmitter anandamide in the central ne...
PF-3845
T6043CAS 1196109-52-0
PF-3845 is a potent, selective and irreversible FAAH inhibitor with Ki of 230 nM, showing negligible activity against FAAH2.
URB597
T6714CAS 546141-08-6
URB597 is an effective, orally bioavailable FAAH inhibitor (IC50: 4.6 nM), and no effect on other cannabinoid-related targets.
PF-04457845
T4323CAS 1020315-31-4
PF-04457845 is a greatly and effctive FAAH inhibitor,and for hFAAH(IC50=7.2±0.63 nM) and rFAAH(IC50=7.4±0.62 nM).
4-Nonylphenylboronic acid
T7688CAS 256383-45-6
4-Nonylphenylboronic acid is a inhibitor of FAAH.
SA57
T12826CAS 1346169-63-8
SA57 is a potent, selective inhibitor of FAAH(IC50s of 3.2 nM and 1.9 nM for mouse and human FAAH).
FAAH-IN-1
T11255CAS 1242441-47-9
FAAH-IN-1 is a fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 145 nM and 650 nM for rat and human FAAH, respectively.
PF 750
T16515CAS 959151-50-9
PF 750 is a selective and covalent fatty acid amide hydrolase inhibitor, It shows IC50s varied from 16.2-595 nM in different pre-incubation times.
SA 47
T16847CAS 792236-07-8
SA 47 is a selective and effective inhibitor of fatty acid amide hydrolase and carbamate.
URB937
T8646CAS 1357160-72-5
URB937 is an inhibitor of FAAH and increases anandamide levels(IC50 : 26.8 nM).