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FAAH

Fatty acid amide hydrolase or FAAH (oleamide hydrolase, anandamide amidohydrolase) is a member of the serine hydrolase family of enzymes. It was first shown to break down anandamide in 1993. In humans, it is encoded by the gene FAAH.FAAH is an integral membrane hydrolase with a single N-terminal transmembrane domain. In vitro, FAAH has esterase and amidase activity.In vivo, FAAH is the principal catabolic enzyme for a class of bioactive lipids called the fatty acid amides (FAAs).
Cat No. product name
T28353 PDP-EA PDP-EA 是脂肪酸酰胺水解酶 (FAAH) 的激活剂,可增强 FAAH 的酰胺水解酶活性。
TN1965 N-​Benzyllinolenamide N-Benzyllinolenamide is a natural product. It is an inhibitor of fatty acid amide hydrolase (FAAH, IC50 of 41.8 μM).
T3354 BIA 10-2474 BIA10-2474 is a long-acting reversible inhibitor of fatty acid amide hydrolase (FAAH) that increases levels of the neurotransmitter anandamide in the central ner...
T2859 Biochanin A Biochanin A is an isoflavone derivative isolated from red clover Trifolium pratense with anticarcinogenic properties. Biochanin A is a naturally occurring fatty ...
T3215 JNJ-42165279 JNJ-42165279 covalently inactivates the FAAH enzyme but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. JNJ-42165279...
T4859 1-Monomyristin 1-Myristoyl-rac-glycerol, a 1-monoglyceride of myristic acid, has antibacterial activity against several Gram-positive bacterial strains. 1-Myristoyl-rac-glycero...
T6714 URB-597 URB597 is an effective, orally bioavailable FAAH inhibitor (IC50: 4.6 nM), and no effect on other cannabinoid-related targets.
T15268 FAAH-IN-2 FAAH-IN-2 is a potent inhibitor of FAAH(fatty acid amide hydrolase).
T6043 PF-3845 PF-3845 is a potent, selective and irreversible FAAH inhibitor with Ki of 230 nM, showing negligible activity against FAAH2.
T4323 PF-04457845 PF-04457845 is a greatly and effctive FAAH inhibitor, and for hFAAH(IC50=7.2±0.63 nM) and rFAAH(IC50=7.4±0.62 nM).
T2338 JZL195 JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.
T3S2105 N-Benzylpalmitamide N-benzylpalmitamide inhibits fatty acid amide hydrolase (FAAH) in a time-dependent manner and could potentially offer a good alternative for the treatment of pai...
T1325 Carprofen Carprofen is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activities.
T9374 AA38-3 AA38-3 inhibites three SHs (ABHD6, ABHD11, and FAAH)
T2684 JNJ-1661010 JNJ-1661010 is an effective and specific FAAH inhibitor (IC50: 10/ 12 nM for rat/human), shows >100-fold selectivity for FAAH-1 than FAAH-2.
T8646 URB937 URB937 is an inhibitor of FAAH and increases anandamide levels(IC50 : 26.8 nM).
T8927 WWL 154 WWL 154 is an serine hydrolase (SH) and fatty acid amide hydrolase FAAH-4 inhibitor.
T7688 4-Nonylphenylboronic acid 4-Nonylphenylboronic acid is a inhibitor of FAAH.
T12826 SA57 SA57 is a potent, selective inhibitor of FAAH(IC50s of 3.2 nM and 1.9 nM for mouse and human FAAH).
T11255 FAAH-IN-1 FAAH-IN-1 is a fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 145 nM and 650 nM for rat and human FAAH, respectively.
T12139 N-(3-Methoxybenzyl)Palmitamide N-(3-Methoxybenzyl)Palmitamide is a promising FAAH inhibitor, treatment of pain, inflammation and CNS degenerative disorders.
T5357 ARN272 ARN272 is a FAAH-like anandamide transporter (FLAT) inhibitor (IC50: 1.8 μM).
T16847 SA 47 SA 47 is a selective and effective inhibitor of fatty acid amide hydrolase and carbamate.
T16515 PF 750 PF 750 is a selective and covalent fatty acid amide hydrolase inhibitor, It shows IC50s varied from 16.2-595 nM in different pre-incubation times.
T15802 LY2183240 LY2183240 inhibits fatty acid amide hydrolase (FAAH) activity (IC50 = 12.4 nM). LY2183240 is a novel and highly effective blocker of anandamide uptake (IC50 = 27...
PDP-EA
T28353
PDP-EA 是脂肪酸酰胺水解酶 (FAAH) 的激活剂,可增强 FAAH 的酰胺水解酶活性。
N-​Benzyllinolenamide
TN1965
N-Benzyllinolenamide is a natural product. It is an inhibitor of fatty acid amide hydrolase (FAAH, IC50 of 41.8 μM).
BIA 10-2474
T3354
BIA10-2474 is a long-acting reversible inhibitor of fatty acid amide hydrolase (FAAH) that increases levels of the neurotransmitter anandamide in the central ner...
Biochanin A
T2859
Biochanin A is an isoflavone derivative isolated from red clover Trifolium pratense with anticarcinogenic properties. Biochanin A is a naturally occurring fatty ...
JNJ-42165279
T3215
JNJ-42165279 covalently inactivates the FAAH enzyme but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. JNJ-42165279...
1-Monomyristin
T4859
1-Myristoyl-rac-glycerol, a 1-monoglyceride of myristic acid, has antibacterial activity against several Gram-positive bacterial strains. 1-Myristoyl-rac-glycero...
URB-597
T6714
URB597 is an effective, orally bioavailable FAAH inhibitor (IC50: 4.6 nM), and no effect on other cannabinoid-related targets.
FAAH-IN-2
T15268
FAAH-IN-2 is a potent inhibitor of FAAH(fatty acid amide hydrolase).
PF-3845
T6043
PF-3845 is a potent, selective and irreversible FAAH inhibitor with Ki of 230 nM, showing negligible activity against FAAH2.
PF-04457845
T4323
PF-04457845 is a greatly and effctive FAAH inhibitor, and for hFAAH(IC50=7.2±0.63 nM) and rFAAH(IC50=7.4±0.62 nM).
JZL195
T2338
JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.
N-Benzylpalmitamide
T3S2105
N-benzylpalmitamide inhibits fatty acid amide hydrolase (FAAH) in a time-dependent manner and could potentially offer a good alternative for the treatment of pai...
Carprofen
T1325
Carprofen is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activities.
AA38-3
T9374
AA38-3 inhibites three SHs (ABHD6, ABHD11, and FAAH)
JNJ-1661010
T2684
JNJ-1661010 is an effective and specific FAAH inhibitor (IC50: 10/ 12 nM for rat/human), shows >100-fold selectivity for FAAH-1 than FAAH-2.
URB937
T8646
URB937 is an inhibitor of FAAH and increases anandamide levels(IC50 : 26.8 nM).
WWL 154
T8927
WWL 154 is an serine hydrolase (SH) and fatty acid amide hydrolase FAAH-4 inhibitor.
4-Nonylphenylboronic acid
T7688
4-Nonylphenylboronic acid is a inhibitor of FAAH.
SA57
T12826
SA57 is a potent, selective inhibitor of FAAH(IC50s of 3.2 nM and 1.9 nM for mouse and human FAAH).
FAAH-IN-1
T11255
FAAH-IN-1 is a fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 145 nM and 650 nM for rat and human FAAH, respectively.
N-(3-Methoxybenzyl)Palmitamide
T12139
N-(3-Methoxybenzyl)Palmitamide is a promising FAAH inhibitor, treatment of pain, inflammation and CNS degenerative disorders.
ARN272
T5357
ARN272 is a FAAH-like anandamide transporter (FLAT) inhibitor (IC50: 1.8 μM).
SA 47
T16847
SA 47 is a selective and effective inhibitor of fatty acid amide hydrolase and carbamate.
PF 750
T16515
PF 750 is a selective and covalent fatty acid amide hydrolase inhibitor, It shows IC50s varied from 16.2-595 nM in different pre-incubation times.
LY2183240
T15802
LY2183240 inhibits fatty acid amide hydrolase (FAAH) activity (IC50 = 12.4 nM). LY2183240 is a novel and highly effective blocker of anandamide uptake (IC50 = 27...