Home Tools
Log in
Cart

IGF-1R

The insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF-1 plays an important role in growth and continues to have anabolic effects in adults – meaning that it can induce hypertrophy of skeletal muscle and other target tissues. Mice lacking the IGF-1 receptor die late in development, and show a dramatic reduction in body mass, testifying to the strong growth-promoting effect of this receptor.
Cat. No. Product name CAS No. Purity Chemical Structure
T67707 Tyrphostin AG 538 133550-18-2 98%
AG 538 is a chalcone compound, an IGF-1 receptor kinase inhibitor (IC₅0 : for 400 nM) that is potent, cell-permeable, reversible, and competitive.
T11593 I-OMe-Tyrphostin AG 538 1094048-77-7 98%
I-OMe-Tyrphostin AG 538 is a specific IGF-1R inhibitor and ATP-competitive inhibitor of PI5P4Kα (IC50: 1 µM).I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated sig...
T3386 Kaempferitrin 482-38-2 98%
Kaempferitrin has antidepressant-like effect related to the serotonergic system, principally 5-HT1A. Kaempferitrin exerts cytotoxic and antitumor effects against...
T37589L GIP (3-42), human acetate 98%
GIP (3-42), human acetate is an antagonist of a glucose-dependent insulinotropic polypeptide (GIP) receptor and regulates insulin secretion and GIP metabolism in...
T14142 AGL-2263 638213-98-6 98%
AGL-2263 is a blocker of insulin receptor (IR)
TN4997 Serpentine 18786-24-8 98%
Serpentine is an alkaloid found in the roots of Rosa Centifolia that acts as an insulin sensitizer to assist insulin in lowering blood glucose.Serpentine activat...
T1791L Ceritinib dihydrochloride 1380575-43-8 98%
Ceritinib dihydrochloride is a selective, orally bioavailable and ATP-competitive inhibitor of ALK tyrosine kinase(IC50 of 200 pM), and also inhibits IGF-1R, Ins...
T4324 PQ401 hydrochloride (196868-63-0(free base)) T4324 98%
PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.
T8906 NBI-31772 374620-70-9 98%
NBI-31772 is the potent inhibitor of insulin-like growth factor-1 binding protein (IGFBP, Ki = 47 nM). NBI-31772 can be used in research on IGF-responsive diseas...
T6079 NVP-ADW742 475488-23-4 98%
NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit...
T60055 Chromeceptin 331859-86-0 98%
Chromeceptin is an inhibitor of the IGF signaling pathway, decreases the numbers of tumorsphere, and inhibits the AKT/mTOR pathway.
T3079 GSK1838705A 1116235-97-2 98%
GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to ...
T8773 MID-1 312608-54-1 98%
MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction. It disrupts molecular association of MG53 with IRS-1 and abolishes ...
T3S0027 Picropodophyllotoxin 17434-18-3 98%
Picropodophyllin is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth f...
T6080 NVP-AEW541 475489-16-8 98%
NVP-AEW541, a potent inhibitor of IGF-1R(IC50=150 nM) and InsR(IC50=140 nM), exhibits excellent efficiency and specificity for IGF-1R in a cell-based assay.
T1791 Ceritinib 1032900-25-6 98%
Ceritinib (LDK378) is a specific ALK inhibitor (IC50: 0.2 nM).
T2607 MSDC 0160 146062-49-9 98%
MSDC-0160 is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease.
T2693 AG1024 65678-07-1 98%
AG-1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM), and is less potent for IR(IC50=57 μM).
T24398 Lenaldekar 418800-15-4 98%
Lenaldekar is a T-cell expansion and autoimmune encephalomyelitis inhibitor.
T6419 BMS-536924 468740-43-4 98%
BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2...
Tyrphostin AG 538
T67707
AG 538 is a chalcone compound, an IGF-1 receptor kinase inhibitor (IC₅0 : for 400 nM) that is potent, cell-permeable, reversible, and competitive.
I-OMe-Tyrphostin AG 538
T11593
I-OMe-Tyrphostin AG 538 is a specific IGF-1R inhibitor and ATP-competitive inhibitor of PI5P4Kα (IC50: 1 µM).I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated sig...
Kaempferitrin
T3386
Kaempferitrin has antidepressant-like effect related to the serotonergic system, principally 5-HT1A. Kaempferitrin exerts cytotoxic and antitumor effects against...
GIP (3-42), human acetate
T37589L
GIP (3-42), human acetate is an antagonist of a glucose-dependent insulinotropic polypeptide (GIP) receptor and regulates insulin secretion and GIP metabolism in...
AGL-2263
T14142
AGL-2263 is a blocker of insulin receptor (IR)
Serpentine
TN4997
Serpentine is an alkaloid found in the roots of Rosa Centifolia that acts as an insulin sensitizer to assist insulin in lowering blood glucose.Serpentine activat...
Ceritinib dihydrochloride
T1791L
Ceritinib dihydrochloride is a selective, orally bioavailable and ATP-competitive inhibitor of ALK tyrosine kinase(IC50 of 200 pM), and also inhibits IGF-1R, Ins...
PQ401 hydrochloride (196868-63-0(free base))
T4324
PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.
NBI-31772
T8906
NBI-31772 is the potent inhibitor of insulin-like growth factor-1 binding protein (IGFBP, Ki = 47 nM). NBI-31772 can be used in research on IGF-responsive diseas...
NVP-ADW742
T6079
NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit...
Chromeceptin
T60055
Chromeceptin is an inhibitor of the IGF signaling pathway, decreases the numbers of tumorsphere, and inhibits the AKT/mTOR pathway.
GSK1838705A
T3079
GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to ...
MID-1
T8773
MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction. It disrupts molecular association of MG53 with IRS-1 and abolishes ...
Picropodophyllotoxin
T3S0027
Picropodophyllin is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth f...
NVP-AEW541
T6080
NVP-AEW541, a potent inhibitor of IGF-1R(IC50=150 nM) and InsR(IC50=140 nM), exhibits excellent efficiency and specificity for IGF-1R in a cell-based assay.
Ceritinib
T1791
Ceritinib (LDK378) is a specific ALK inhibitor (IC50: 0.2 nM).
MSDC 0160
T2607
MSDC-0160 is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease.
AG1024
T2693
AG-1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM), and is less potent for IR(IC50=57 μM).
Lenaldekar
T24398
Lenaldekar is a T-cell expansion and autoimmune encephalomyelitis inhibitor.
BMS-536924
T6419
BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2...
1 2 3