T67707 |
Tyrphostin AG 538
|
133550-18-2
|
98%
|
|
AG 538 is a chalcone compound, an IGF-1 receptor kinase inhibitor (IC₅0 : for 400 nM) that is potent, cell-permeable, reversible, and competitive.
|
T11593 |
I-OMe-Tyrphostin AG 538
|
1094048-77-7
|
98%
|
|
I-OMe-Tyrphostin AG 538 is a specific IGF-1R inhibitor and ATP-competitive inhibitor of PI5P4Kα (IC50: 1 µM).I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated sig...
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T3386 |
Kaempferitrin
|
482-38-2
|
98%
|
|
Kaempferitrin has antidepressant-like effect related to the serotonergic system, principally 5-HT1A. Kaempferitrin exerts cytotoxic and antitumor effects against...
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T37589L |
GIP (3-42), human acetate
|
|
98%
|
|
GIP (3-42), human acetate is an antagonist of a glucose-dependent insulinotropic polypeptide (GIP) receptor and regulates insulin secretion and GIP metabolism in...
|
T14142 |
AGL-2263
|
638213-98-6
|
98%
|
|
AGL-2263 is a blocker of insulin receptor (IR)
|
TN4997 |
Serpentine
|
18786-24-8
|
98%
|
|
Serpentine is an alkaloid found in the roots of Rosa Centifolia that acts as an insulin sensitizer to assist insulin in lowering blood glucose.Serpentine activat...
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T1791L |
Ceritinib dihydrochloride
|
1380575-43-8
|
98%
|
|
Ceritinib dihydrochloride is a selective, orally bioavailable and ATP-competitive inhibitor of ALK tyrosine kinase(IC50 of 200 pM), and also inhibits IGF-1R, Ins...
|
T4324 |
PQ401 hydrochloride (196868-63-0(free base))
|
T4324
|
98%
|
|
PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.
|
T8906 |
NBI-31772
|
374620-70-9
|
98%
|
|
NBI-31772 is the potent inhibitor of insulin-like growth factor-1 binding protein (IGFBP, Ki = 47 nM). NBI-31772 can be used in research on IGF-responsive diseas...
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T6079 |
NVP-ADW742
|
475488-23-4
|
98%
|
|
NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit...
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T60055 |
Chromeceptin
|
331859-86-0
|
98%
|
|
Chromeceptin is an inhibitor of the IGF signaling pathway, decreases the numbers of tumorsphere, and inhibits the AKT/mTOR pathway.
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T3079 |
GSK1838705A
|
1116235-97-2
|
98%
|
|
GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to ...
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T8773 |
MID-1
|
312608-54-1
|
98%
|
|
MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction. It disrupts molecular association of MG53 with IRS-1 and abolishes ...
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T3S0027 |
Picropodophyllotoxin
|
17434-18-3
|
98%
|
|
Picropodophyllin is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth f...
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T6080 |
NVP-AEW541
|
475489-16-8
|
98%
|
|
NVP-AEW541, a potent inhibitor of IGF-1R(IC50=150 nM) and InsR(IC50=140 nM), exhibits excellent efficiency and specificity for IGF-1R in a cell-based assay.
|
T1791 |
Ceritinib
|
1032900-25-6
|
98%
|
|
Ceritinib (LDK378) is a specific ALK inhibitor (IC50: 0.2 nM).
|
T2607 |
MSDC 0160
|
146062-49-9
|
98%
|
|
MSDC-0160 is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease.
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T2693 |
AG1024
|
65678-07-1
|
98%
|
|
AG-1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM), and is less potent for IR(IC50=57 μM).
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T24398 |
Lenaldekar
|
418800-15-4
|
98%
|
|
Lenaldekar is a T-cell expansion and autoimmune encephalomyelitis inhibitor.
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T6419 |
BMS-536924
|
468740-43-4
|
98%
|
|
BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2...
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