IGF-1R

The insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF-1 plays an important role in growth and continues to have anabolic effects in adults – meaning that it can induce hypertrophy of skeletal muscle and other target tissues. Mice lacking the IGF-1 receptor die late in development, and show a dramatic reduction in body mass, testifying to the strong growth-promoting effect of this receptor.

Cat. No.	Product name	CAS No.	Purity
T67707	Tyrphostin AG 538	133550-18-2	98%
T67707	AG 538 is a chalcone compound, an IGF-1 receptor kinase inhibitor (IC₅0 : for 400 nM) that is potent, cell-permeable, reversible, and competitive.
T11593	I-OMe-Tyrphostin AG 538	1094048-77-7	98%
T11593	I-OMe-Tyrphostin AG 538 is a specific IGF-1R inhibitor and ATP-competitive inhibitor of PI5P4Kα (IC50: 1 µM).I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated sig...
T3386	Kaempferitrin	482-38-2	98%
T3386	Kaempferitrin has antidepressant-like effect related to the serotonergic system, principally 5-HT1A. Kaempferitrin exerts cytotoxic and antitumor effects against...
T37589L	GIP (3-42), human acetate		98%
T37589L	GIP (3-42), human acetate is an antagonist of a glucose-dependent insulinotropic polypeptide (GIP) receptor and regulates insulin secretion and GIP metabolism in...
T14142	AGL-2263	638213-98-6	98%
T14142	AGL-2263 is a blocker of insulin receptor (IR)
TN4997	Serpentine	18786-24-8	98%
TN4997	Serpentine is an alkaloid found in the roots of Rosa Centifolia that acts as an insulin sensitizer to assist insulin in lowering blood glucose.Serpentine activat...
T1791L	Ceritinib dihydrochloride	1380575-43-8	98%
T1791L	Ceritinib dihydrochloride is a selective, orally bioavailable and ATP-competitive inhibitor of ALK tyrosine kinase(IC50 of 200 pM), and also inhibits IGF-1R, Ins...
T4324	PQ401 hydrochloride (196868-63-0(free base))	T4324	98%
T4324	PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.
T8906	NBI-31772	374620-70-9	98%
T8906	NBI-31772 is the potent inhibitor of insulin-like growth factor-1 binding protein (IGFBP, Ki = 47 nM). NBI-31772 can be used in research on IGF-responsive diseas...
T6079	NVP-ADW742	475488-23-4	98%
T6079	NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit...
T60055	Chromeceptin	331859-86-0	98%
T60055	Chromeceptin is an inhibitor of the IGF signaling pathway, decreases the numbers of tumorsphere, and inhibits the AKT/mTOR pathway.
T3079	GSK1838705A	1116235-97-2	98%
T3079	GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to ...
T8773	MID-1	312608-54-1	98%
T8773	MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction. It disrupts molecular association of MG53 with IRS-1 and abolishes ...
T3S0027	Picropodophyllotoxin	17434-18-3	98%
T3S0027	Picropodophyllin is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth f...
T6080	NVP-AEW541	475489-16-8	98%
T6080	NVP-AEW541, a potent inhibitor of IGF-1R(IC50=150 nM) and InsR(IC50=140 nM), exhibits excellent efficiency and specificity for IGF-1R in a cell-based assay.
T1791	Ceritinib	1032900-25-6	98%
T1791	Ceritinib (LDK378) is a specific ALK inhibitor (IC50: 0.2 nM).
T2607	MSDC 0160	146062-49-9	98%
T2607	MSDC-0160 is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease.
T2693	AG1024	65678-07-1	98%
T2693	AG-1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM), and is less potent for IR(IC50=57 μM).
T24398	Lenaldekar	418800-15-4	98%
T24398	Lenaldekar is a T-cell expansion and autoimmune encephalomyelitis inhibitor.
T6419	BMS-536924	468740-43-4	98%
T6419	BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2...