T14064 |
8-Bromo-cGMP sodium
|
51116-01-9
|
98%
|
|
8-Bromo-cGMP sodium is a PKG activator, a membrane-permeable analog of cGMP. 8-Bromo-cGMP sodium has pain-relieving and vasodilatory effects, significantly inhib...
|
TN1542 |
Cycloheterophyllin
|
36545-53-6
|
98%
|
|
Cycloheterophyllin has an antioxidant effect, it is a photoprotective agent that inhibits ultraviolet A (UVA)-induced oxidative stress and damage, and could be u...
|
TN1694 |
Gliotoxin
|
67-99-2
|
98%
|
|
Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signalin...
|
TN3383 |
α-Amyrin palmitate
|
22255-10-3
|
98%
|
|
alpha-Amyrin palmitate is antiarthritic in the adjuvant model of arthritis in rats. alpha-Amyrin palmitate is a potent non-competitive inhibitor of chymotrypsin ...
|
T15669 |
KT5720
|
108068-98-0
|
98%
|
|
KT5720 is a cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase A (PKA) (Ki: 60 nM).
|
TN4277 |
Isocupressic acid
|
1909-91-7
|
98%
|
|
Isocupressic acid induces abortion in pregnant cows when ingested primarily during the last trimester, it decrease affects the angiogenesis of the female reprodu...
|
TP1351 |
Kemptide
|
65189-71-1
|
98%
|
|
Kemptide is a synthetic heptapeptide, acting as a substrate for cAMP-dependent protein kinase (PK).
|
TN4317 |
Isopedicin
|
4431-42-9
|
98%
|
|
Isopedicin has anti-inflammatory functions, it inhibits the O(2)(*)(-) production in human neutrophils by an elevation of cellular cAMP and activation of PKA thr...
|
T6139 |
A-674563
|
552325-73-2
|
98%
|
|
A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.
|
T15798 |
LX7101
|
1192189-69-7
|
98%
|
|
LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).
|
TQ0072 |
Warangalone
|
4449-55-2
|
98%
|
|
Warangalone is an anti-malarial compound that can inhibit the growth of both strains of parasite 3D7 (chloroquine-sensitive) and K1 (chloroquine-resistant) with ...
|
T2205 |
Acefylline
|
652-37-9
|
98%
|
|
Theophylline-7-acetic acid, a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the...
|
T6747 |
8-Bromo-cAMP sodium salt
|
76939-46-3
|
98%
|
|
8-Bromo-cAMP is a long-acting derivative of cyclic AMP. It is an activator of cyclic AMP-dependent protein kinase, but resistant to degradation by cyclic AMP pho...
|
T6680 |
Staurosporine
|
62996-74-1
|
98%
|
|
Staurosporine is a potent PKC inhibitor for PKCα/γ/η (IC50: 2/5/4 nM), less potent to PKCε (73 nM), PKCδ (20 nM) and little action to PKCζ (1086 nM).
|
T14069 |
A-3 hydrochloride
|
78957-85-4
|
98%
|
|
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and c...
|
T0465 |
Ellagic acid
|
476-66-4
|
98%
|
|
Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clott...
|
T4S2128 |
Bilobetin
|
521-32-4
|
98%
|
|
Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.
|
T7648 |
HA-100
|
84468-24-6
|
98%
|
|
HA-100 is an inhibitor of protein kinase
|
T6304 |
AT7867
|
857531-00-1
|
98%
|
|
AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively; little activity outside the...
|
T3050 |
ML-7 hydrochloride
|
110448-33-4
|
98%
|
|
ML-7 Hcl is a cell-permeable, reversible, effective, ATP-competitive, and specific inhibitor of myosin light chain kinase (Ki: 300 nM); also inhibits smooth-musc...
|