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PKA

protein kinase A (PKA) is a family of enzymes whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA is also known as cAMP-dependent protein kinase . Protein kinase A has several functions in the cell, including regulation of glycogen, sugar, and lipid metabolism.
Cat No. product name
T14072 A-443654 A-443654 is a pan-Akt inhibitor. It has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
T19836 2-Aminopurine 2-Aminopurine is a double-stranded RNA-dependent protein kinase, protein kinase R (PKR) inhibitor.
T2851 Daphnetin Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM), ...
T7648 HA-100 HA-100 is an inhibitor of protein kinase
T0610 Piceatannol Piceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activat...
T6250 H-89 dihydrochloride H 89 is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 µM, Ki: 48 nM).
T6303 CCT128930 CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM, 28-fold greater selectivity for Akt2 than the closely related PKA kinas...
T6605 NH125 NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.
T0465 Ellagic acid Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clott...
T6680 Staurosporine Staurosporine is a potent PKC inhibitor for PKCα/γ/η (IC50: 2/5/4 nM), less potent to PKCε (73 nM), PKCδ (20 nM) and little action to PKCζ (1086 nM).
T3050 ML-7 hydrochloride ML-7 Hcl is a cell-permeable, reversible, effective, ATP-competitive, and specific inhibitor of myosin light chain kinase (Ki: 300 nM); also inhibits smooth-musc...
T3060 Fasudil hydrochloride Fasudil Hydrochloride is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.
T2205 Acefylline Theophylline-7-acetic acid, a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the...
T1837 BX-912 BX-912 is a specific inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1, IC50: 12 nM). The selectivity of BX-912 is more 10 fold than C-Kit, EGFR, PKA, PKC...
T4S2128 Bilobetin Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.
T1920 Capivasertib Capivasertib (AZD5363) is a new-type orally available inhibitor of the serine/threonine protein kinase AKT (IC50s: 3/7/7 nM for Akt1/2/3).
T4444 A-674563 HCl (552325-73-2(free base)) A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 ...
T6312 R547 R547 is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3α/β, while inactive to other kinases. Phase 1...
T1606 Fasudil Fasudil is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
TN1694 Gliotoxin Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signalin...
T14069 A-3 hydrochloride A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and c...
T3269 Metadoxine Metadoxine is a neurotransmitter stimulant.
T21674L PKA inhibitor fragment (6-22) amide Acetate PKA Inhibitor Fragment (6-22) amide Acetate is a PKA inhibitor with a Ki of 2.8 nM. It can significantly reverse low-level morphine antinociceptive tolerance in ...
T6303L CCT128930 hydrochloride CCT128930 hydrochloride is a potent and selective inhibitor of AKT with IC50 of 6 nM. CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophag...
T2356 Ro-3306 RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases...
T1418 Bucladesine sodium Bucladesine, PKA activator, is a cyclic nucleotide derivative that mimics the action of endogenous cAMP and is capable of permeating the cell membrane. It has va...
T16791 Rottlerin Rottlerin is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-...
T35328 H-1152 dihydrochloride H-1152 dihydrochloride (2HCl) 是一种膜渗透性和选择性的Rho-associated protein kinase (ROCK)的抑制剂。 H-1152 可抑制ROCK2、PKA、PKC、PKG、Aurora A和CaMK2的IC50值分别为 0.0120 μM、3.03 μM、5.68 μM...
TP1351 Kemptide Kemptide is a synthetic heptapeptide, acting as a substrate for cAMP-dependent protein kinase (PK).
T21983L PKI 14-22 amide, myristoylated Acetate PKI 14-22 amide, myristoylated Acetate inhibit cAMP-dependent protein kinase (PKA) and blocks hyperalgesia produced by spinal administration of 8-bromo-cAMP.
T2482 AT13148 AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
TN1542 Cycloheterophyllin Cycloheterophyllin has an antioxidant effect, it is a photoprotective agent that inhibits ultraviolet A (UVA)-induced oxidative stress and damage, and could be u...
T8681 HA-1004 dihydrochloride HA-1004 dihydrochloride is an inhibitor of PKA, PKC, cGKI, MYLK, and calcium channel protein
TN3383 α-Amyrin palmitate alpha-Amyrin palmitate is antiarthritic in the adjuvant model of arthritis in rats. alpha-Amyrin palmitate is a potent non-competitive inhibitor of chymotrypsin ...
TN4317 Isopedicin Isopedicin has anti-inflammatory functions, it inhibits the O(2)(*)(-) production in human neutrophils by an elevation of cellular cAMP and activation of PKA thr...
TN4277 Isocupressic acid Isocupressic acid induces abortion in pregnant cows when ingested primarily during the last trimester, it decrease affects the angiogenesis of the female reprodu...
TN4114 Gardenin A Gardenin A has antihyperlipidemic and hepatoprotective effects , it also promotes neuritogenesis through the activation of MAPK/ERK-, PKC-, and PKA-dependent, bu...
TP1957L PKI (5-24) Acetate(99534-03-9 free base) PKI (5-24) Acetate is a high affinity PKA inhibitor (Ki = 2.3 nM).
TP1876L CREBtide acetate(149155-45-3 free base) CREBtide acetate is a synthetic substrate for PKA (Km=3.9 µM), which is based on the phosphorylation sequence in d-CREB (cAMP response element binding protein).
TP1789L Malantide acetate(86555-35-3 free base) Malantide acetate is a dodecapeptide phosphorylated by cyclic AMP-dependent protein kinase (PKA), and increases PKA activity.Malantide is a synthetic peptide tha...
TP1787L PKG Substrate acetate(81187-14-6 free base) PKG Substrate acetate is a selective substrate for cGMP-dependent protein kinase (PKG).PKG Substrate is a selective substrate for protein kinase G (PKG) with a s...
TP1523 PKG inhibitor peptide TFA (82801-73-8 free base) PKG inhibitor peptide TFA is an inhibitor of atp-competitive cGMP-dependent protein kinase (PKG), Ki 86 μM.
TQ0072 Warangalone Warangalone is an anti-malarial compound that can inhibit the growth of both strains of parasite 3D7 (chloroquine-sensitive) and K1 (chloroquine-resistant) with ...
T5065 GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE, also known as cGMP, is a cellular regulatory agent and has been described as a second messenger. Its levels increase in res...
T6304 AT7867 AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively; little activity outside the...
T6315 MLN8054 MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.
T6139L A-674563 2HCl(552325-73-2(fb-2hcl)) A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.
T6139 A-674563 A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.
T6747 8-Bromo-cAMP sodium salt 8-Bromo-cAMP is a long-acting derivative of cyclic AMP. It is an activator of cyclic AMP-dependent protein kinase, but resistant to degradation by cyclic AMP pho...
T3498 CCG215022 CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, 5 and 1, respectively.
A-443654
T14072
A-443654 is a pan-Akt inhibitor. It has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
2-Aminopurine
T19836
2-Aminopurine is a double-stranded RNA-dependent protein kinase, protein kinase R (PKR) inhibitor.
Daphnetin
T2851
Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM...
HA-100
T7648
HA-100 is an inhibitor of protein kinase
Piceatannol
T0610
Piceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activa...
H-89 dihydrochloride
T6250
H 89 is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 µM, Ki: 48 nM).
CCT128930
T6303
CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM, 28-fold greater selectivity for Akt2 than the closely related PKA kinas...
NH125
T6605
NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.
Ellagic acid
T0465
Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clott...
Staurosporine
T6680
Staurosporine is a potent PKC inhibitor for PKCα/γ/η (IC50: 2/5/4 nM), less potent to PKCε (73 nM), PKCδ (20 nM) and little action to PKCζ (1086 nM).
ML-7 hydrochloride
T3050
ML-7 Hcl is a cell-permeable, reversible, effective, ATP-competitive, and specific inhibitor of myosin light chain kinase (Ki: 300 nM); also inhibits smooth-musc...
Fasudil hydrochloride
T3060
Fasudil Hydrochloride is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.
Acefylline
T2205
Theophylline-7-acetic acid, a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the...
BX-912
T1837
BX-912 is a specific inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1, IC50: 12 nM). The selectivity of BX-912 is more 10 fold than C-Kit, EGFR, PKA, PKC...
Bilobetin
T4S2128
Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.
Capivasertib
T1920
Capivasertib (AZD5363) is a new-type orally available inhibitor of the serine/threonine protein kinase AKT (IC50s: 3/7/7 nM for Akt1/2/3).
A-674563 HCl (552325-73-2(free base))
T4444
A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 ...
R547
T6312
R547 is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3α/β, while inactive to other kinases. Phase...
Fasudil
T1606
Fasudil is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
Gliotoxin
TN1694
Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signalin...
A-3 hydrochloride
T14069
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and c...
Metadoxine
T3269
Metadoxine is a neurotransmitter stimulant.
PKA inhibitor fragment (6-22) amide Acetate
T21674L
PKA Inhibitor Fragment (6-22) amide Acetate is a PKA inhibitor with a Ki of 2.8 nM. It can significantly reverse low-level morphine antinociceptive tolerance in ...
CCT128930 hydrochloride
T6303L
CCT128930 hydrochloride is a potent and selective inhibitor of AKT with IC50 of 6 nM. CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophag...
Ro-3306
T2356
RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases...
Bucladesine sodium
T1418
Bucladesine, PKA activator, is a cyclic nucleotide derivative that mimics the action of endogenous cAMP and is capable of permeating the cell membrane. It has va...
Rottlerin
T16791
Rottlerin is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,...
H-1152 dihydrochloride
T35328
H-1152 dihydrochloride (2HCl) 是一种膜渗透性和选择性的Rho-associated protein kinase (ROCK)的抑制剂。 H-1152 可抑制ROCK2、PKA、PKC、PKG、A...
Kemptide
TP1351
Kemptide is a synthetic heptapeptide, acting as a substrate for cAMP-dependent protein kinase (PK).
PKI 14-22 amide, myristoylated Acetate
T21983L
PKI 14-22 amide, myristoylated Acetate inhibit cAMP-dependent protein kinase (PKA) and blocks hyperalgesia produced by spinal administration of 8-bromo-cAMP.
AT13148
T2482
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
Cycloheterophyllin
TN1542
Cycloheterophyllin has an antioxidant effect, it is a photoprotective agent that inhibits ultraviolet A (UVA)-induced oxidative stress and damage, and could be u...
HA-1004 dihydrochloride
T8681
HA-1004 dihydrochloride is an inhibitor of PKA, PKC, cGKI, MYLK, and calcium channel protein
α-Amyrin palmitate
TN3383
alpha-Amyrin palmitate is antiarthritic in the adjuvant model of arthritis in rats. alpha-Amyrin palmitate is a potent non-competitive inhibitor of chymotrypsin ...
Isopedicin
TN4317
Isopedicin has anti-inflammatory functions, it inhibits the O(2)(*)(-) production in human neutrophils by an elevation of cellular cAMP and activation of PKA thr...
Isocupressic acid
TN4277
Isocupressic acid induces abortion in pregnant cows when ingested primarily during the last trimester, it decrease affects the angiogenesis of the female reprodu...
Gardenin A
TN4114
Gardenin A has antihyperlipidemic and hepatoprotective effects , it also promotes neuritogenesis through the activation of MAPK/ERK-, PKC-, and PKA-dependent, bu...
PKI (5-24) Acetate(99534-03-9 free base)
TP1957L
PKI (5-24) Acetate is a high affinity PKA inhibitor (Ki = 2.3 nM).
CREBtide acetate(149155-45-3 free base)
TP1876L
CREBtide acetate is a synthetic substrate for PKA (Km=3.9 µM), which is based on the phosphorylation sequence in d-CREB (cAMP response element binding protein)....
Malantide acetate(86555-35-3 free base)
TP1789L
Malantide acetate is a dodecapeptide phosphorylated by cyclic AMP-dependent protein kinase (PKA), and increases PKA activity.Malantide is a synthetic peptide tha...
PKG Substrate acetate(81187-14-6 free base)
TP1787L
PKG Substrate acetate is a selective substrate for cGMP-dependent protein kinase (PKG).PKG Substrate is a selective substrate for protein kinase G (PKG) with a s...
PKG inhibitor peptide TFA (82801-73-8 free base)
TP1523
PKG inhibitor peptide TFA is an inhibitor of atp-competitive cGMP-dependent protein kinase (PKG), Ki 86 μM.
Warangalone
TQ0072
Warangalone is an anti-malarial compound that can inhibit the growth of both strains of parasite 3D7 (chloroquine-sensitive) and K1 (chloroquine-resistant) with ...
GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD
T5065
GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE, also known as cGMP, is a cellular regulatory agent and has been described as a second messenger. Its levels increase in res...
AT7867
T6304
AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively; little activity outside the...
MLN8054
T6315
MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.
A-674563 2HCl(552325-73-2(fb-2hcl))
T6139L
A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.
A-674563
T6139
A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.
8-Bromo-cAMP sodium salt
T6747
8-Bromo-cAMP is a long-acting derivative of cyclic AMP. It is an activator of cyclic AMP-dependent protein kinase, but resistant to degradation by cyclic AMP pho...
CCG215022
T3498
CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, 5 and 1, respectively.
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