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Search Results for " cgmp "

Targets

74

Compounds

11

Natural Products

13

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T14064 8-Bromo-cGMP sodium Calcium Channel , PKA
8-Bromo-cGMP sodium is a PKG activator, a membrane-permeable analog of cGMP. 8-Bromo-cGMP sodium has pain-relieving and vasodilatory effects, significantly inhibits Ca2+ macroscopic currents, and inhibits high K+-stimula...
T68374 8-Nitro-cGMP
8-Nitro-cGMP is a unique cytoprotective mediator which inhibits oxidative stress. 8-Nitro-cGMP is also a probe of the protein S-guanylation.
T11038 Dibutyryl-cGMP sodium Bt2cGMP sodium Others
Dibutyryl-cGMP sodium (Bt2cGMP sodium) is a cell-permeable cGMP analog. Dibutyryl-cGMP sodium preferentially activates cGMP-dependent protein kinase (PKG). Dibutyryl-cGMP sodium inhibits [3H]-arachidonic acid release in ...
T74018 cGMP-HTL
cGMP-HTL contains a HT-ligand, a linker and the Cys-S-cGMP (autophagy tag). cGMP-HTL increases the K63-linked ubiquitination of mitochondria. AUTAC (autophagy-targeting chimera) is a novel targeted-clearance strategy tha...
T82632 Cys-C-cGMP AUTACs
Cys-C-cGMP serves as an autophagy tag for AUTACs (autophagy-targeting chimeras). It enhances K63-linked ubiquitination of mitochondria within HeLa cells [1].
T83402 2′,3′-cGMP triethylamine Guanosine 2',3'-cyclic phosphate triethylamine
Guanosine 2',3'-cyclic phosphate triethylamine, commonly known as 2′,3′-cGMP triethylamine, is an active compound utilizable in numerous research investigations [1].
TP1903 PKG inhibitor peptide cGMP Dependent Kinase Inhibitor Peptide
Competitive inhibitor of cGMP-dependent protein kinase (PKG); analog of a substrate peptide corresponding to a phosphorylation site of histone H2B. Competes with synthetic substrates (Ki = 86 mM) but does not inhibit pho...
T21965 MBCQ PDE
MBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5.
T21607 Ataciguat HMR-1766 Others , Guanylate cyclase
Ataciguat (HMR-1766) (HMR-1766) is a potent and specific soluble guanylate cyclase (sGC) activator.
T13189 TP-10 PDE
TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.
T0096 Vardenafil Vivanza,Levitra,Vardenafil hydrochloride PDE
Vardenafil (Vivanza) is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). Penile erection is a hemod...
T8405 Vardenafil hydrochloride PDE
Vardenafil hydrochloride is a New Phosphodiesterase Type 5(PDE5) Inhibitor, in the Treatment of Erectile Dysfunction in Men With Diabetes
T4097 Vardenafil hydrochloride trihydrate Vardenafil HCl Trihydrate,BAY38-9456 PDE
Vardenafil hydrochloride trihydrate (BAY38-9456) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.
T6888 Methylene Blue methylthioninium chloride,CI-52015,Tetramethylthionine chloride,Basic Blue 9 Guanylate cyclase , Microtubule Associated , NO Synthase , Parasite , Monoamine Oxidase
Methylene Blue (Tetramethylthionine chloride) (IC50 of 1.9 μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.
T0006 Methylene Blue trihydrate Methylthionine chloride,Basic blue 9,Methylene Blue Guanylate cyclase , Microtubule Associated , NO Synthase , Parasite , Monoamine Oxidase
Methylene Blue trihydrate (Basic blue 9) is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene Blue trihydrate...
T4480 Vardenafil dihydrochloride Levitra,Vardenafil Hydrochloride PDE
Vardenafil dihydrochloride (Levitra) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.
T23252 Rp-8-Br-PET-cGMPS Others
cGMP-dependent protein kinase (PKG) inhibitor
T7321 MBP146-78 Parasite
MBP146-78 is a potent and selective cGMP inhibitor dependent protein kinases.
T1398 Tadalafil Cialis,IC-351 Apoptosis , PDE
Tadalafil (IC-351) is a carboline-based compound with vasodilatory activity. Tadalafil selectively inhibits the cyclic guanosine monophosphate (cGMP)-specific type 5 phosphodiesterase- (PDE-5)-mediated degradation of cGM...
T60500 AP-C5 Parasite
AP-C5 is a compound with selective inhibition of guanosine 3',5' cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII), with a Pic50 value of 7.2 for cGMP, and can be used in the study of diarrheal diseases.
TP1523 PKG inhibitor peptide TFA (82801-73-8 free base) PKG inhibitor peptide TFA PKA
PKG inhibitor peptide TFA (82801-73-8 free base) is an inhibitor of ATP-competitive cGMP-dependent protein kinase (PKG).
T15381 Gisadenafil UK-369003 PDE
Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.
T28881 Sulmazole Vardax,AR-L 115BS,AR-L 115-BS PDE , Parasite , Adenosine Receptor
Sulmazole (AR-L 115-BS) is a small molecule Sulmazole is a small molecule cGMP-PDE inhibitor.Sulmazole is a competitive inhibitor of A1 adenosine receptors.Sulmazole has been shown to improve cardiac index, low pulmonary...
T77570 AP-C2 PKA
AP-C2 is a potent small molecule guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC50 of 5.2 for cGKII.
T16164 MY-5445 N-(3-chlorophenyl)-4-phenylphthalazin-1-amine PDE
MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) is a specific inhibitor of phosphodiesterase type 5 (PDE5). MY-5445 selectively inhibits cGMP PDE (Ki:1.3 μM).
T23411L T-0156 T 0156 PDE , Parasite
T-0156 is a novel, potent and selective phosphodiesterase type 5 inhibitor that inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) with low affinity for PDE6, PDE1, PDE2, PDE3 and PDE4.
TP1787L PKG Substrate acetate(81187-14-6 free base) PKA
PKG Substrate acetate is a selective substrate for cGMP-dependent protein kinase (PKG).PKG Substrate is a selective substrate for protein kinase G (PKG) with a strong preference for PKG Iα (Km = 59 μM) over PKG II (Km = ...
T0467 Sildenafil citrate UK-92480 citrate Apoptosis , PDE , Autophagy
Sildenafil citrate (UK-92480 citrate) , a cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) Inhibitor, is used extensively for erectile dysfunction and less commonly for pulmonary hypertensio...
T2129 Zaprinast PDE
Zaprinast is a cGMP-selective phosphodiesterase (PDE) inhibitor and a GPR35 agonist. It has a strong activating effect on rat GPR35 and a certain activating effect on human GPR35. It reduces vascular remodeling through a...
T0459 Sulindac Arthrocine,MK-231,Clinoril,Sulindac sulfoxide COX , Autophagy
Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cycl...
T0075 Nicorandil SG-75 Potassium Channel
Nicorandil (SG-75)(Ikorel) acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system. It undertakes this through two methods. Firstly, by activating potassium channels, and secondly b...
T7355 IC87201 Others , iGluR
IC87201 is a nNOS-PDZ/PSD-95-PDZ inhibitor. IC87201 showed great promise in cellular experiments and animal models of ischemic stroke and pain.
T9080 Plecanatide Guanylate cyclase
Plecanatide acetate is an analogue of Uroguanylin. It is an orally active guanylate cyclase-C (GC-C) receptor agonist.
T8462 Enoximone PDE
Enoximone is a selective inhibitor of phosphodiesterase III (PDE3), with treatment of congestive heart failure.
T63838 AZD5462 RXFP receptor
AZD5462 is a potent orally available relaxin receptor RXFP1 agonist for the study of heart failure and cancer.
T69593 Sildenafil nitrate
Sildenafil nitrate is a selective inhibitor of PDE5 (type 5 cGMP phosphodiesterase) which catalyzes the hydrolysis of 3',5'-cyclic guanosine monophosphate (cGMP).
T24568 OMS-824 OMS 824
OMS-824 is a phosphodiesterase-10 inhibitor that slows or stops the hydrolysis of cAMP and cGMP.
T32406 KMUP-4 KMUP 4
Kmup-4 is an enhancer of cGMP activity and an aortic smooth muscle relaxant.
T32405 KMUP-3 KMUP 3,KMUP3
KMUP-3 is an enhancer of cGMP activity, and acts as an aortic smooth muscle relaxant.
T24163 IMR687 IMR-687,IMR 687
IMR687 is a PDE9 inhibitor that slows or stops the hydrolysis of cGMP. IMR687 can be regarded as a highly promising drug against Alzheimer's for improving memory.
T69171 Etazolate
Etazolate is an inhibitor of phosphodiesterase IV that is about 8 times more active for cAMP than cGMP.
T63311 PfPKG-IN-1
PfPKG-IN-1 is an imidazole-based inhibitor of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG).
T16482 PF-05085727 PDE
PF-05085727 inhibits PDE2A >4,000-fold selectivity over PDE1 and PDE3-11. PF-05085727 is an effective, selective and brain penetrant inhibitor of cGMP-dependent PDE2A (IC50=2 nM) .
T24615 PF04677490 PF-04677490,PF 04677490
PF04677490 is an effective PDE1 inhibitor. PF04677490 efficaciously inhibits cAMP- and cGMP-hydrolytic activity in preparations from human myocardium at concentrations selective for PDE1.
T27408 Gea 3162 Gea3162,Gea-3162
Gea 3162 is a potent inhibitor of ADP-induced platelet aggregation in platelet rich plasma (PRP). GEA 3162 stimulates cGMP production in granulocytes, platelets, and polymorphonuclear leukocytes.
T11400 Gisadenafil besylate UK 369003-26 Others
Gisadenafil besylate (UK 369003-26) is a specific, orally active phosphodiesterase 5 (PDE5) inhibitor ,prevents degradation of cyclic guanosine monophosphate (cGMP), with an IC50 of 3.6 nM .
T69949 CGP-78608
CGP-78608 is a glycine site-specific N-methyl-D-aspartate receptor antagonist prevents activation of the NMDA/NO/CGMP pathway by ammonia.
T82988 AP-C7
AP-C7 is a selective inhibitor of cGMP-dependent protein kinase II (cGKII) with a pIC50 value of 5.0, demonstrating only weak inhibition of cGKII-dependent anion secretion [1].
T82990 AP-C4
AP-C4 is a selective inhibitor targeting guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII), exhibiting a pIC50 value of 5.2. Conversely, AP-C3 does not inhibit cGKII-mediated anion secretion...
T82525 DT-2
DT-2 serves as a potent, selective inhibitor of cGMP-dependent protein kinase (PKG), with a Ki of 12.5 nM, effectively hindering PKG-catalyzed phosphorylation [1].

Compounds

8-Bromo-cGMP sodium
T14064
Synonym:
Target: Calcium Channel, PKA
8-Nitro-cGMP
T68374
Synonym:
Target:
Dibutyryl-cGMP sodium
T11038
Synonym: Bt2cGMP sodium
Target: Others
cGMP-HTL
T74018
Synonym:
Target:
Cys-C-cGMP
T82632
Synonym:
Target: AUTACs
2′,3′-cGMP triethylamine
T83402
Synonym: Guanosine 2',3'-cyclic phosphate triethylamine
Target:
PKG inhibitor peptide
TP1903
Synonym: cGMP Dependent Kinase Inhibitor Peptide
Target:
MBCQ
T21965
Synonym:
Target: PDE
Ataciguat
T21607
Synonym: HMR-1766
Target: Others, Guanylate cyclase
TP-10
T13189
Synonym:
Target: PDE
Vardenafil
T0096
Synonym: Vivanza,Levitra,Vardenafil hydrochloride
Target: PDE
Vardenafil hydrochloride
T8405
Synonym:
Target: PDE
Vardenafil hydrochloride trihydrate
T4097
Synonym: Vardenafil HCl Trihydrate,BAY38-9456
Target: PDE
Methylene Blue
T6888
Synonym: methylthioninium chloride,CI-52015,Tetramethylthionine chloride,Basic Blue 9
Target: Guanylate cyclase, Microtubule Associated, NO Synthase, Parasite, Monoamine Oxidase
Methylene Blue trihydrate
T0006
Synonym: Methylthionine chloride,Basic blue 9,Methylene Blue
Target: Guanylate cyclase, Microtubule Associated, NO Synthase, Parasite, Monoamine Oxidase
Vardenafil dihydrochloride
T4480
Synonym: Levitra,Vardenafil Hydrochloride
Target: PDE
Rp-8-Br-PET-cGMPS
T23252
Synonym:
Target: Others
MBP146-78
T7321
Synonym:
Target: Parasite
Tadalafil
T1398
Synonym: Cialis,IC-351
Target: Apoptosis, PDE
AP-C5
T60500
Synonym:
Target: Parasite
PKG inhibitor peptide TFA (82801-73-8 free base)
TP1523
Synonym: PKG inhibitor peptide TFA
Target: PKA
Gisadenafil
T15381
Synonym: UK-369003
Target: PDE
Sulmazole
T28881
Synonym: Vardax,AR-L 115BS,AR-L 115-BS
Target: PDE, Parasite, Adenosine Receptor
AP-C2
T77570
Synonym:
Target: PKA
MY-5445
T16164
Synonym: N-(3-chlorophenyl)-4-phenylphthalazin-1-amine
Target: PDE
T-0156
T23411L
Synonym: T 0156
Target: PDE, Parasite
PKG Substrate acetate(81187-14-6 free base)
TP1787L
Synonym:
Target: PKA
Sildenafil citrate
T0467
Synonym: UK-92480 citrate
Target: Apoptosis, PDE, Autophagy
Zaprinast
T2129
Synonym:
Target: PDE
Sulindac
T0459
Synonym: Arthrocine,MK-231,Clinoril,Sulindac sulfoxide
Target: COX, Autophagy
Nicorandil
T0075
Synonym: SG-75
Target: Potassium Channel
IC87201
T7355
Synonym:
Target: Others, iGluR
Plecanatide
T9080
Synonym:
Target: Guanylate cyclase
Enoximone
T8462
Synonym:
Target: PDE
AZD5462
T63838
Synonym:
Target: RXFP receptor
Sildenafil nitrate
T69593
Synonym:
Target:
OMS-824
T24568
Synonym: OMS 824
Target:
KMUP-4
T32406
Synonym: KMUP 4
Target:
KMUP-3
T32405
Synonym: KMUP 3,KMUP3
Target:
IMR687
T24163
Synonym: IMR-687,IMR 687
Target:
Etazolate
T69171
Synonym:
Target:
PfPKG-IN-1
T63311
Synonym:
Target:
PF-05085727
T16482
Synonym:
Target: PDE
PF04677490
T24615
Synonym: PF-04677490,PF 04677490
Target:
Gea 3162
T27408
Synonym: Gea3162,Gea-3162
Target:
Gisadenafil besylate
T11400
Synonym: UK 369003-26
Target: Others
CGP-78608
T69949
Synonym:
Target:
AP-C7
T82988
Synonym:
Target:
AP-C4
T82990
Synonym:
Target:
DT-2
T82525
Synonym:
Target:
1 2
Cat No. Product Name Synonyms Targets
T5065 GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD Monosodium-GMP,cGMP sodium salt,Cyclic GMP PKA
GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD (cGMP sodium salt) , also known as cGMP, is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, inc...
TN1266 3-O-Methylquercetin IL Receptor , cAMP , PDE
3-O-Methylquercetin is a selective and competitive PDE3/PDE4 inhibitor, and inhibits PDE3 than PDE4 with a low K(m) value; it inhibits total cAMP- and cGMP-phosphodiesterase (PDE) of guinea pig trachealis at low concentr...
T3S0870 Paederosidic acid methyl ester ATPase , Potassium Channel , NO Synthase
Paederosidic acid methyl ester has antinociception, is possibly related to the pathway of NO-cGMP-ATP sensitive K(+) channels.
T17199 Udenafil PDE
Udenafil is an inhibitor of PDE5 .
T4S1637 Gamma-Mangostin Normangostin Others , 5-HT Receptor
1. gamma-Mangostin (Normangostin) as a preventive agent of the metabolic syndrome. 2. Gamma-Mangostin has free radical scavenging activity, and antiproliferative and apoptotic activity in HepG2 cells. 3. Gamma-Mangostin ...
T8061 Citronellal (±)-Citronellal Others
Citronellal ((±)-Citronellal) is a monoterpene predominantly formed by the secondary metabolism of plants, producing antithrombotic, antiplatelet, and antihypertensive activities.
T3794 Pentagalloylglucose Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose Influenza Virus
1, 2, 3, 4, 6-Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) and gallic acid from Pistacia lentiscus have antimutagenic and antioxidant activities. 2. 1, 2, 3, 4, 6-Penta-O-galloyl-beta-D-glucose (PGG) possesses poten...
T27436 GS 389 GS-389,GS389
GS 389 is a novel tetrahydroisoquinoline analog with vasorelaxant properties. GS-389 significantly inhibited cGMP phosphodiesterase from the rabbit brain and increased cGMP levels in the rat aorta.
TN4397 Kuraridine PDE , Parasite
Kuraridine is measured against cGMP PDE5 to identify potent cGMP specific phosphodiesterase type 5 inhibitory constituents.
TN1843 Kushenol K PDE , HSV
Kushenol K is a potent and Selective Inhibitor of cGMP Phosphodiesterase 5, it also has inhibitory effects on diacylglycerol acyltransferase (DGAT). Kushenol K shows weak antiviral activity against Herpes simplex virus t...
TN2918 3-Acetoxy-8(17),13E-labdadien-15-oic acid cAMP , Potassium Channel , Calcium Channel
ent-3-Acetoxy-labda-8(17),13-dien-15-oic acid have vasorelaxant and hypotensive actions, the mechanisms underlying the cardiovascular actions of the labdane involve the activation of the endothelial NO-cGMP pathway, the ...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPJ-01112 PRKG1 Protein, Human, Recombinant (His) Human Human Cells
cGMP-Dependent Protein Kinase 1 (PRKG1) belongs to the protein kinase superfamily and AGC Ser/Thr protein kinase family. PRKG1 contains one AGC-kinase C-terminal domain, two cyclic nucleotide-binding domains, and one pro...
TMPY-02081 PDE2A Protein, Human, Recombinant (aa 215-900, His) Human Baculovirus-Insect Cells
cGMP-dependent 3',5'-cyclic phosphodiesterase, also known as cyclic GMP-stimulated phosphodiesterase and PDE2A, is a peripheral membrane protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE2 sub...
TMPH-02316 YJEFN3 Protein, Human, Recombinant Human E. coli
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-gen...
TMPY-01922 PDE9A Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, also known as PDE9A, is a member of the cyclic nucleotide phosphodiesterase family and PDE9 subfamily. PDE9A is expressed in all tissues examined (testis, br...
TMPY-01921 PDE9A Protein, Human, Recombinant (His) Human E. coli
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, also known as PDE9A, is a member of the cyclic nucleotide phosphodiesterase family and PDE9 subfamily. PDE9A is expressed in all tissues examined (testis, br...
TMPH-01423 GNAZ Protein, Human, Recombinant (His & SUMO) Human E. coli
GNAZ mutations are associated with melanoma. PMID: 20424519 cGMP-phosphodiesterase 6 can be activated by another cancer-retina antigen, transducin, through Wnt5a-Frizzled-2 cascade, which leads to a lowering of cGMP and ...
TMPH-00171 PBP 4A Protein, Bacillus subtilis, Recombinant (His & SUMO) Bacillus subtilis E. coli
GNAZ mutations are associated with melanoma. PMID: 20424519 cGMP-phosphodiesterase 6 can be activated by another cancer-retina antigen, transducin, through Wnt5a-Frizzled-2 cascade, which leads to a lowering of cGMP and ...
TMPY-02977 PDE1C Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
PDE1C belongs to the cyclic nucleotide phosphodiesterase family, PDE1 subfamily. Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds ...
TMPH-03017 CYP51 Protein, Mycobacterium tuberculosis, Recombinant (His & Myc) Mycobacterium tuberculosis Baculovirus
Hormone that acts as a ligand for natriuretic peptide receptor NPR3/NPR-C and promotes bone growth and physical endurance in muscle. Acts as a regulator of osteoblast differentiation and bone growth by binding to natriur...
TMPY-01819 PDE1B Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, also known as Cam-PDE 1B and PDE1B, is a cytoplasm protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE1 subfamily. Pho...
TMPJ-00875 NPPB Protein, Human, Recombinant (His) Human E. coli
Human Natriuretic peptides B acts as a cardiac hormone; it is associated with many biological actions, such as diuresis, natriuresis, vasorelaxation, which inhibits the secretion of rennin and aldosterone. It acts as a p...
TMPY-03554 GCAP1 Protein, Human, Recombinant Human Baculovirus-Insect Cells
GCAP 1 gene plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messenger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by ...
TMPY-03463 GCAP1 Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
GCAP 1 gene plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messenger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by ...
TargetMol