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Carbonic Anhydrase

The carbonic anhydrases (or carbonate dehydratases) form a family of enzymes that catalyze the interconversion between carbon dioxide and water and the dissociated ions of carbonic acid (i.e. bicarbonate and hydrogen ions). The active site of most carbonic anhydrases contains a zinc ion. They are therefore classified as metalloenzymes. The enzyme maintains acid-base balance and helps transport carbon dioxide.
Cat. No. Product name CAS No. Purity Chemical Structure
T25372 EMD57033 147527-31-9 98%
EMD57033 is a cardiac troponin C (cTnC) activator, a dominant Ca2+ sensitizer, which functions by binding to cardiac/slow skeletal troponin C heterodimers to pro...
T68136 5-Hexenoic acid, 6-[4-[2-[[(4-chlorophenyl)sulfonyl]amino]ethyl]phenyl]-6-(3-pyridinyl)- 133276-52-5 98%
5-Hexenoic acid, 6-[4-[2-[[(4-chlorophenyl)sulfonyl]amino]ethyl]phenyl]-6-(3-pyridinyl)- shows activity against Carbonic anhydrase and Cyclooxygenase 2.
T0037 Halazone 80-13-7 98%
Halazone is fine white powder with an odor of chlorine. It has been widely used to disinfect drinking water.
TN6707 Methyl 2,4-dihydroxybenzoate 2150-47-2 98%
Methyl 2,4-dihydroxybenzoate is a natural product.
T0267 Zonisamide 68291-97-4 98%
Zonisamide, a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydra...
T8827 EMAC10101d 2561476-24-0 98%
compound EMAC10101d, bearing a 2,4-dichorophenyl substituent in position 4 of the dihydrothiazole ring, was the most potent and selective toward hCA II with an i...
T16960 Sultiame 61-56-3 98%
Sultiame is an inhibitor of carbonic anhydrase. Sultiame can be used in antiepileptic research.
T2616 PIK-93 593960-11-3 98%
PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
T6S0221 Eriocitrin 13463-28-0 98%
1. Eriocitrin is powerful antioxidative flavonoid; (1) Prevents oxidative damages caused by acute exercise-induced oxidative stress.(2) Lipid-lowering effects in...
T0465 Ellagic acid 476-66-4 98%
Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clott...
T67774 Compound CDy9 952306-80-8 98%
Compound CDy9 is a highly selective inhibitor of carbonic anhydrase (CA) with an IC50 value of 0.18 μM for hCA II.
T2530 Levosimendan 141505-33-1 98%
Levosimendan is a calcium sensitizer used in the management of acutely decompensated congestive heart failure. It increases the sensitivity of the heart to calci...
T1999 Taselisib 1282512-48-4 98%
Taselisib is an orally bioavailable inhibitor of the class I phosphatidylinositol 3-kinase (PI3K) alpha isoform (PIK3CA), with potential antineoplastic activity....
T9323 4-Amino-6-(trifluoromethyl)benzene-1,3-disulfonamide 654-62-6 98%
4-Amino-6-(trifluoromethyl)benzene-1,3-disulfonamide is a carbonic anhydrase inhibitor, used as a potential anti-tumor and antiglaucoma drug.
T4321 Indisulam 165668-41-7 98%
Indisulam is a carbonic anhydrase inibitor and Antitumor CDK inhibitor. Indisulam targets the G1 phase of the cell cycle by depleting cyclin E. inducing p53 and ...
T2S0357 6-Hydroxycoumarin 6093-68-1 98%
6-Hydroxycoumarin exhibits cytotoxicity against human HL60, HCT116, COLO205 cells with activity value of 35 uM, 42 uM, 37 respectively. 6-Hydroxycoumarin is a hu...
T21294 Polmacoxib 301692-76-2 98%
Polmacoxib is a first-in-class NSAID drug candidate, is a dual inhibitor of carbonic anhydrase (CA) and COX-2. Polmacoxib inhibits premalignant and malignant col...
T36758 CAIX Inhibitor S4 1330061-67-0 98%
CAIX Inhibitor S4 is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively. The Kis for CA II and CA I are 546 and 5600 nM...
T4S2354 Dimethylfraxetin 6035-49-0 98%
Dimethylfraxetin is a Carbonic anhydrase inhibitor(Ki:0.0097 μM)
T0738 Urea 57-13-6 98%
Urea is formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end metabolite of protein catabolism and accounts for ab...
EMD57033
T25372
EMD57033 is a cardiac troponin C (cTnC) activator, a dominant Ca2+ sensitizer, which functions by binding to cardiac/slow skeletal troponin C heterodimers to pro...
5-Hexenoic acid, 6-[4-[2-[[(4-chlorophenyl)sulfonyl]amino]ethyl]phenyl]-6-(3-pyridinyl)-
T68136
5-Hexenoic acid, 6-[4-[2-[[(4-chlorophenyl)sulfonyl]amino]ethyl]phenyl]-6-(3-pyridinyl)- shows activity against Carbonic anhydrase and Cyclooxygenase 2.
Halazone
T0037
Halazone is fine white powder with an odor of chlorine. It has been widely used to disinfect drinking water.
Methyl 2,4-dihydroxybenzoate
TN6707
Methyl 2,4-dihydroxybenzoate is a natural product.
Zonisamide
T0267
Zonisamide, a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydra...
EMAC10101d
T8827
compound EMAC10101d, bearing a 2,4-dichorophenyl substituent in position 4 of the dihydrothiazole ring, was the most potent and selective toward hCA II with an i...
Sultiame
T16960
Sultiame is an inhibitor of carbonic anhydrase. Sultiame can be used in antiepileptic research.
PIK-93
T2616
PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
Eriocitrin
T6S0221
1. Eriocitrin is powerful antioxidative flavonoid; (1) Prevents oxidative damages caused by acute exercise-induced oxidative stress.(2) Lipid-lowering effects in...
Ellagic acid
T0465
Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clott...
Compound CDy9
T67774
Compound CDy9 is a highly selective inhibitor of carbonic anhydrase (CA) with an IC50 value of 0.18 μM for hCA II.
Levosimendan
T2530
Levosimendan is a calcium sensitizer used in the management of acutely decompensated congestive heart failure. It increases the sensitivity of the heart to calci...
Taselisib
T1999
Taselisib is an orally bioavailable inhibitor of the class I phosphatidylinositol 3-kinase (PI3K) alpha isoform (PIK3CA), with potential antineoplastic activity....
4-Amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
T9323
4-Amino-6-(trifluoromethyl)benzene-1,3-disulfonamide is a carbonic anhydrase inhibitor, used as a potential anti-tumor and antiglaucoma drug.
Indisulam
T4321
Indisulam is a carbonic anhydrase inibitor and Antitumor CDK inhibitor. Indisulam targets the G1 phase of the cell cycle by depleting cyclin E. inducing p53 and ...
6-Hydroxycoumarin
T2S0357
6-Hydroxycoumarin exhibits cytotoxicity against human HL60, HCT116, COLO205 cells with activity value of 35 uM, 42 uM, 37 respectively. 6-Hydroxycoumarin is a hu...
Polmacoxib
T21294
Polmacoxib is a first-in-class NSAID drug candidate, is a dual inhibitor of carbonic anhydrase (CA) and COX-2. Polmacoxib inhibits premalignant and malignant col...
CAIX Inhibitor S4
T36758
CAIX Inhibitor S4 is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively. The Kis for CA II and CA I are 546 and 5600 nM...
Dimethylfraxetin
T4S2354
Dimethylfraxetin is a Carbonic anhydrase inhibitor(Ki:0.0097 μM)
Urea
T0738
Urea is formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end metabolite of protein catabolism and accounts for ab...
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