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Carbonic Anhydrase

The carbonic anhydrases (or carbonate dehydratases) form a family of enzymes that catalyze the interconversion between carbon dioxide and water and the dissociated ions of carbonic acid (i.e. bicarbonate and hydrogen ions). The active site of most carbonic anhydrases contains a zinc ion. They are therefore classified as metalloenzymes. The enzyme maintains acid-base balance and helps transport carbon dioxide.
Cat No. product name
T1026 Mafenide hydrochloride Mafenide hydrochloride is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.
T6581 Methyclothiazide Methyclothiazide is a substituted benzothiadiazide, used to treat high blood pressure and fluid retention caused by various conditions including heart disease.
T2616 PIK-93 PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
T23782 Benzolamide Benzolamide is an inhibitor of carbonic anhydrase. Benzolamide inhibits low-threshold calcium currents in hippocampal pyramidal neurons.
T2S0357 6-Hydroxycoumarin 6-Hydroxycoumarin exhibits cytotoxicity against human HL60, HCT116, COLO205 cells with activity value of 35 uM, 42 uM, 37 respectively. 6-Hydroxycoumarin is a hu...
T0037 Halazone Halazone is fine white powder with an odor of chlorine. It has been widely used to disinfect drinking water.
T0465 Ellagic acid Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clott...
T6503 Fluorometholone Acetate Fluorometholone Acetate is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye.
T2530 Levosimendan Levosimendan is a calcium sensitizer used in the management of acutely decompensated congestive heart failure. It increases the sensitivity of the heart to calci...
T6S0221 Eriocitrin 1. Eriocitrin is powerful antioxidative flavonoid; (1) Prevents oxidative damages caused by acute exercise-induced oxidative stress.(2) Lipid-lowering effects in...
T1409 Methocarbamol Methocarbamol is a centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of muscu...
T5012 Ethoxzolamide Ethoxzolamide is a carbonic anhydrase inhibitor.
T0675 Topiramate Topiramate is a unique antiseizure medication that is used in the treatment of partial and generalized seizures. Topiramate has been rarely associated with hepat...
T0738 Urea Urea is formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end metabolite of protein catabolism and accounts for ab...
T2187 2-Aminobenzenesulfonamide 2-Aminobenzenesulfonamide is a molecule containing the sulfonamide functional group attached to an aniline.
T8611 2,3-dihydro-1H-indene-5-sulfonamide 2,3-dihydro-1H-indene-5-sulfonamide is Carbonic anhydrase 12 (human) inhibitor.
T2017 U-104 U-104 is an effective carbonic anhydrase (CA) inhibitor for CA IX( Ki=45.1 nM) and CA XII(Ki=4.5 nM).
T1999 Taselisib Taselisib is an orally bioavailable inhibitor of the class I phosphatidylinositol 3-kinase (PI3K) alpha isoform (PIK3CA), with potential antineoplastic activity....
T2134 Dorzolamide hydrochloride Dorzolamide Hydrochloride is the hydrochloride salt form of dorzolamide, an inhibitor of carbonic anhydrase, a zinc-containing enzyme that catalyzes the rapid co...
T21294 Polmacoxib Polmacoxib is a first-in-class NSAID drug candidate, is a dual inhibitor of carbonic anhydrase (CA) and COX-2. Polmacoxib inhibits premalignant and malignant col...
T8827 EMAC10101d compound EMAC10101d, bearing a 2,4-dichorophenyl substituent in position 4 of the dihydrothiazole ring, was the most potent and selective toward hCA II with an i...
T9323 4-Amino-6-(trifluoromethyl)benzene-1,3-disulfonamide 4-Amino-6-(trifluoromethyl)benzene-1,3-disulfonamide is a carbonic anhydrase inhibitor, used as a potential anti-tumor and antiglaucoma drug.
T0515 Tioxolone Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor.
T0267 Zonisamide Zonisamide, a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydra...
T0782 Benzthiazide Benzthiazide is used in the therapy of edema and hypertension. Like other thiazides, benzthiazide accelerates water loss from the body (diuretics). They inhibit ...
TN6707 Methyl 2,4-dihydroxybenzoate Methyl 2,4-dihydroxybenzoate is a natural product.
T6469 Dichlorphenamide Dichlorphenamide is a carbonic anhydrase inhibitor that is used in the treatment of glaucoma.
T6781 Benzenesulfonamide Benzenesulfonamide ia an inhibitor of carbonic anhydrases.
T4S2354 Dimethylfraxetin Dimethylfraxetin is a Carbonic anhydrase inhibitor(Ki:0.0097 μM)
T4321 Indisulam Indisulam is a carbonic anhydrase inibitor and Antitumor CDK inhibitor. Indisulam targets the G1 phase of the cell cycle by depleting cyclin E. inducing p53 and ...
T0142 Brinzolamide Brinzolamide is a Carbonic Anhydrase Inhibitor. The mechanism of action of brinzolamide is as a Carbonic Anhydrase Inhibitor.
T0106 Methazolamide Methazolamide is a carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.
T0114 Trichlormethiazide Trichlormethiazide is a short-acting, 3-dichloromethyl derivative of hydrochlorothiazide, belonging to the class of thiazide diuretics. Trichlormethiazide appear...
T16960 Sultiame Sultiame 是一种碳酸酐酶抑制剂。 Sultiame 可用于抗癫痫研究。
Mafenide hydrochloride
T1026
Mafenide hydrochloride is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.
Methyclothiazide
T6581
Methyclothiazide is a substituted benzothiadiazide, used to treat high blood pressure and fluid retention caused by various conditions including heart disease.
PIK-93
T2616
PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
Benzolamide
T23782
Benzolamide is an inhibitor of carbonic anhydrase. Benzolamide inhibits low-threshold calcium currents in hippocampal pyramidal neurons.
6-Hydroxycoumarin
T2S0357
6-Hydroxycoumarin exhibits cytotoxicity against human HL60, HCT116, COLO205 cells with activity value of 35 uM, 42 uM, 37 respectively. 6-Hydroxycoumarin is a hu...
Halazone
T0037
Halazone is fine white powder with an odor of chlorine. It has been widely used to disinfect drinking water.
Ellagic acid
T0465
Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clott...
Fluorometholone Acetate
T6503
Fluorometholone Acetate is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye.
Levosimendan
T2530
Levosimendan is a calcium sensitizer used in the management of acutely decompensated congestive heart failure. It increases the sensitivity of the heart to calci...
Eriocitrin
T6S0221
1. Eriocitrin is powerful antioxidative flavonoid; (1) Prevents oxidative damages caused by acute exercise-induced oxidative stress.(2) Lipid-lowering effects in...
Methocarbamol
T1409
Methocarbamol is a centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of muscu...
Ethoxzolamide
T5012
Ethoxzolamide is a carbonic anhydrase inhibitor.
Topiramate
T0675
Topiramate is a unique antiseizure medication that is used in the treatment of partial and generalized seizures. Topiramate has been rarely associated with hepat...
Urea
T0738
Urea is formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end metabolite of protein catabolism and accounts for ab...
2-Aminobenzenesulfonamide
T2187
2-Aminobenzenesulfonamide is a molecule containing the sulfonamide functional group attached to an aniline.
2,3-dihydro-1H-indene-5-sulfonamide
T8611
2,3-dihydro-1H-indene-5-sulfonamide is Carbonic anhydrase 12 (human) inhibitor.
U-104
T2017
U-104 is an effective carbonic anhydrase (CA) inhibitor for CA IX( Ki=45.1 nM) and CA XII(Ki=4.5 nM).
Taselisib
T1999
Taselisib is an orally bioavailable inhibitor of the class I phosphatidylinositol 3-kinase (PI3K) alpha isoform (PIK3CA), with potential antineoplastic activity....
Dorzolamide hydrochloride
T2134
Dorzolamide Hydrochloride is the hydrochloride salt form of dorzolamide, an inhibitor of carbonic anhydrase, a zinc-containing enzyme that catalyzes the rapid co...
Polmacoxib
T21294
Polmacoxib is a first-in-class NSAID drug candidate, is a dual inhibitor of carbonic anhydrase (CA) and COX-2. Polmacoxib inhibits premalignant and malignant col...
EMAC10101d
T8827
compound EMAC10101d, bearing a 2,4-dichorophenyl substituent in position 4 of the dihydrothiazole ring, was the most potent and selective toward hCA II with an i...
4-Amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
T9323
4-Amino-6-(trifluoromethyl)benzene-1,3-disulfonamide is a carbonic anhydrase inhibitor, used as a potential anti-tumor and antiglaucoma drug.
Tioxolone
T0515
Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor.
Zonisamide
T0267
Zonisamide, a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydra...
Benzthiazide
T0782
Benzthiazide is used in the therapy of edema and hypertension. Like other thiazides, benzthiazide accelerates water loss from the body (diuretics). They inhibit ...
Methyl 2,4-dihydroxybenzoate
TN6707
Methyl 2,4-dihydroxybenzoate is a natural product.
Dichlorphenamide
T6469
Dichlorphenamide is a carbonic anhydrase inhibitor that is used in the treatment of glaucoma.
Benzenesulfonamide
T6781
Benzenesulfonamide ia an inhibitor of carbonic anhydrases.
Dimethylfraxetin
T4S2354
Dimethylfraxetin is a Carbonic anhydrase inhibitor(Ki:0.0097 μM)
Indisulam
T4321
Indisulam is a carbonic anhydrase inibitor and Antitumor CDK inhibitor. Indisulam targets the G1 phase of the cell cycle by depleting cyclin E. inducing p53 and ...
Brinzolamide
T0142
Brinzolamide is a Carbonic Anhydrase Inhibitor. The mechanism of action of brinzolamide is as a Carbonic Anhydrase Inhibitor.
Methazolamide
T0106
Methazolamide is a carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.
Trichlormethiazide
T0114
Trichlormethiazide is a short-acting, 3-dichloromethyl derivative of hydrochlorothiazide, belonging to the class of thiazide diuretics. Trichlormethiazide appear...
Sultiame
T16960
Sultiame 是一种碳酸酐酶抑制剂。 Sultiame 可用于抗癫痫研究。