Hydroxylase

Hydroxylation is a chemical process that introduces a hydroxyl group (-OH) into an organic compound. In biochemistry, hydroxylation reactions are often facilitated by enzymes called hydroxylases. Hydroxylation is the first step in the oxidative degradation of organic compounds in air. It is extremely important in detoxification since hydroxylation converts lipophilic compounds into water-soluble (hydrophilic) products that are more readily removed by the kidneys or liver and excreted. Some drugs (for example, steroids) are activated or deactivated by hydroxylation.

Cat. No.	Product name	CAS No.	Purity
T15426	GSK180	1799725-26-0	98%
T15426	GSK180 is a selective competitive inhibitor of kynurenine 3-monooxygenase (KMO; IC50: ~6 nM), an enzyme involved in tryptophan metabolism.
T13383	Zamicastat	1080028-80-3	98%
T13383	Zamicastat is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73.8 μM and 17.0...
T15786	LPA2 antagonist 1	1017606-66-4	98%
T15786	LPA2 antagonist 1 is an LPA2 antagonist (IC50: 17 nM).
T10142	P-Ethynylphenylalanine	278605-15-5	98%
T10142	p-Ethynylphenylalanine, a tryptophan hydroxylase (TPH) inhibitor, is competitive, effective, selective, and reversible, with a Ki of 32.6 μM.
T11470	GSK 366	1953157-39-5	98%
T11470	GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor (IC50s: 0.7 nM and 2.3 nM for P. fluorescens-KMO and human KMO).
T6356	(R)-Nepicastat HCl	195881-94-8	98%
T6356	(R)-Nepicastat HCl, the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydr...
T15796	LX-1031	945976-76-1	98%
T15796	LX-1031 is an effective inhibitor of tryptophan 5-hydroxylase. LX-1031 decreases serotonin (5-HT) synthesis peripherally.
T15124	Diethyl-pythiDC	1821370-70-0	98%
T15124	Diethyl-pythiDC is an collagen prolyl 4-hydroxylase inhibitor.
T10142L	P-Ethynylphenylalanine hydrochloride	188640-63-3
T10142L	p-Ethynylphenylalanine hydrochloride is a novel, potent and specific inhibitor of TPH[1]. The potential for p-Ethynylphenylalanine hydrochloride to inhibit selec...
T3268	Mildronate	76144-81-5	98%
T3268	Mildronate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption...
T41143	PCPA methyl ester hydrochloride	14173-40-1	99.08%
T41143	pCPA methyl ester hydrochloride is an inhibitor of tryptophan hydroxylase inhibitor and 5-HT synthesis. pCPA methyl ester hydrochloride is permeable across the b...
T4277	Osilodrostat	928134-65-0	99.12%
T4277	Osilodrostat (LCI699) is an effective inhibitor of human 11β-hydroxylase (IC50: 2.5 nM) and aldosterone synthase (IC50: 0.7 nM).
T6044	Telotristat Etiprate	1137608-69-5	99.36%
T6044	Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.
T14119	ACT-678689	1783256-96-1	99.45%
T14119	ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1].
T21506	Telotristat	1033805-28-5	99.49%
T21506	Telotristat is the active metabolite of LX1606(Telotristat etiprate), which is an orally bioavailable tryptophan hydroxylase (TPH) inhibitor and shows potential ...
T41274	P-Fluoro-L-phenylalanine	1132-68-9	99.53%
T41274	p-Fluoro-L-phenylalanine is a substrate for tyrosine hydroxylase (TH) that can be used to study the regulation of that enzyme. p-Fluoro-L-phenylalanine binds to ...
T0679	Ketoconazole	65277-42-1	99.62%
T0679	Ketoconazole, a CYP3A4 inhibitor, is an imidazole anti-fungal agent.
T11897	Telotristat ethyl	1033805-22-9	99.72%
T11897	Telotristat ethyl is a orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.
T1447	Fenclonine	7424-00-2	99.75%
T1447	Fenclonine is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fe...
T6604	Nepicastat hydrochloride	170151-24-3	99.81%
T6604	Nepicastat (SYN-117) HCl is an effective and specific inhibitor, which is used for bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, respecti...