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Hydroxylase

Hydroxylation is a chemical process that introduces a hydroxyl group (-OH) into an organic compound. In biochemistry, hydroxylation reactions are often facilitated by enzymes called hydroxylases. Hydroxylation is the first step in the oxidative degradation of organic compounds in air. It is extremely important in detoxification since hydroxylation converts lipophilic compounds into water-soluble (hydrophilic) products that are more readily removed by the kidneys or liver and excreted. Some drugs (for example, steroids) are activated or deactivated by hydroxylation.
Cat No. product name
T41143 PCPA methyl ester hydrochloride pCPA methyl ester hydrochloride 是色氨酸羟化酶抑制剂和5-HT合成的抑制剂。 pCPA methyl ester hydrochloride 可穿过血脑屏障并降低 5-HT 中枢可用性。
T15796 LX-1031 LX-1031 是一种有效的色氨酸 5-羟化酶抑制剂。 LX-1031 减少外周5-羟色胺的合成。
T15124 Diethyl-pythiDC Diethyl-pythiDC 是一种胶原蛋白脯氨酰 4-羟化酶抑制剂。
T4277 Osilodrostat Osilodrostat (LCI699) is an effective inhibitor of human 11β-hydroxylase (IC50: 2.5 nM) and aldosterone synthase (IC50: 0.7 nM).
T0679 Ketoconazole Ketoconazole, a CYP3A4 inhibitor, is an imidazole anti-fungal agent.
T13383 Zamicastat Zamicastat is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73.8 μM and 17.0...
T10142L P-Ethynylphenylalanine hydrochloride p-Ethynylphenylalanine hydrochloride is a novel, potent and specific inhibitor of TPH[1]. The potential for p-Ethynylphenylalanine hydrochloride to inhibit selec...
T1896 Ro 61-8048 Ro 61-8048 is a potent and selective inhibitor of kynurenine hydroxylase with an IC50 value of 37 nM.
T21506 Telotristat Telotristat is the active metabolite of LX1606(Telotristat etiprate), which is an orally bioavailable tryptophan hydroxylase (TPH) inhibitor and shows potential ...
T7117 Sapropterin dihydrochloride Sapropterin dihydrochloride is phenylalanine hydroxylase agonist that is approved for the treatment of BH4 responsive PKU.
T11897 Telotristat ethyl Telotristat ethyl is a orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.
T11470 GSK 366 GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor (IC50s: 0.7 nM and 2.3 nM for P. fluorescens-KMO and human KMO).
T3268 Mildronate Mildronate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption...
T6004 Tetrahydropapaverine hydrochloride Tetrahydropapaverine, an analogue of salsolinol and tetrahydropapaveroline, has neurotoxicity on dopamine neurons.
T6044 Telotristat Etiprate Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.
T6356 (R)-Nepicastat HCl (R)-Nepicastat HCl, the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydr...
T6604 Nepicastat hydrochloride Nepicastat (SYN-117) HCl is an effective and specific inhibitor, which is used for bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, respecti...
T15786 LPA2 antagonist 1 LPA2 antagonist 1 is an LPA2 antagonist (IC50: 17 nM).
T14119 ACT-678689 ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1].
T1447 Fenclonine Fenclonine is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fe...
T15426 GSK180 GSK180 is a selective competitive inhibitor of kynurenine 3-monooxygenase (KMO; IC50: ~6 nM), an enzyme involved in tryptophan metabolism.
pCPA methyl ester hydrochloride
T41143
LX-1031
T15796
LX-1031 是一种有效的色氨酸 5-羟化酶抑制剂。 LX-1031 减少外周5-羟色胺的合成。
Diethyl-pythiDC
T15124
Diethyl-pythiDC 是一种胶原蛋白脯氨酰 4-羟化酶抑制剂。
Osilodrostat
T4277
Osilodrostat (LCI699) is an effective inhibitor of human 11β-hydroxylase (IC50: 2.5 nM) and aldosterone synthase (IC50: 0.7 nM).
Ketoconazole
T0679
Ketoconazole, a CYP3A4 inhibitor, is an imidazole anti-fungal agent.
Zamicastat
T13383
Zamicastat is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73.8 μM and 17...
p-Ethynylphenylalanine hydrochloride
T10142L
p-Ethynylphenylalanine hydrochloride is a novel, potent and specific inhibitor of TPH[1]. The potential for p-Ethynylphenylalanine hydrochloride to inhibit selec...
Ro 61-8048
T1896
Ro 61-8048 is a potent and selective inhibitor of kynurenine hydroxylase with an IC50 value of 37 nM.
Telotristat
T21506
Telotristat is the active metabolite of LX1606(Telotristat etiprate), which is an orally bioavailable tryptophan hydroxylase (TPH) inhibitor and shows potential ...
Sapropterin dihydrochloride
T7117
Sapropterin dihydrochloride is phenylalanine hydroxylase agonist that is approved for the treatment of BH4 responsive PKU.
Telotristat ethyl
T11897
Telotristat ethyl is a orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.
GSK 366
T11470
GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor (IC50s: 0.7 nM and 2.3 nM for P. fluorescens-KMO and human KMO).
Mildronate
T3268
Mildronate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption...
Tetrahydropapaverine hydrochloride
T6004
Tetrahydropapaverine, an analogue of salsolinol and tetrahydropapaveroline, has neurotoxicity on dopamine neurons.
Telotristat Etiprate
T6044
Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.
(R)-Nepicastat HCl
T6356
(R)-Nepicastat HCl, the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hyd...
Nepicastat hydrochloride
T6604
Nepicastat (SYN-117) HCl is an effective and specific inhibitor, which is used for bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, respect...
LPA2 antagonist 1
T15786
LPA2 antagonist 1 is an LPA2 antagonist (IC50: 17 nM).
ACT-678689
T14119
ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1].
Fenclonine
T1447
Fenclonine is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fe...
GSK180
T15426
GSK180 is a selective competitive inhibitor of kynurenine 3-monooxygenase (KMO; IC50: ~6 nM), an enzyme involved in tryptophan metabolism.