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Hydroxylase

Hydroxylation is a chemical process that introduces a hydroxyl group (-OH) into an organic compound. In biochemistry, hydroxylation reactions are often facilitated by enzymes called hydroxylases. Hydroxylation is the first step in the oxidative degradation of organic compounds in air. It is extremely important in detoxification since hydroxylation converts lipophilic compounds into water-soluble (hydrophilic) products that are more readily removed by the kidneys or liver and excreted. Some drugs (for example, steroids) are activated or deactivated by hydroxylation.
Cat. No. Product name CAS No. Purity Chemical Structure
T10142 P-Ethynylphenylalanine 278605-15-5 98%
p-Ethynylphenylalanine, a tryptophan hydroxylase (TPH) inhibitor, is competitive, effective, selective, and reversible, with a Ki of 32.6 μM.
T6356 (R)-Nepicastat HCl 195881-94-8 98%
(R)-Nepicastat HCl, the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydr...
T15786 LPA2 antagonist 1 1017606-66-4 98%
LPA2 antagonist 1 is an LPA2 antagonist (IC50: 17 nM).
T15426 GSK180 1799725-26-0 98%
GSK180 is a selective competitive inhibitor of kynurenine 3-monooxygenase (KMO; IC50: ~6 nM), an enzyme involved in tryptophan metabolism.
T11470 GSK 366 1953157-39-5 98%
GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor (IC50s: 0.7 nM and 2.3 nM for P. fluorescens-KMO and human KMO).
T7117 Sapropterin dihydrochloride 69056-38-8 98%
Sapropterin dihydrochloride is phenylalanine hydroxylase agonist that is approved for the treatment of BH4 responsive PKU.
T0679 Ketoconazole 65277-42-1 98%
Ketoconazole, a CYP3A4 inhibitor, is an imidazole anti-fungal agent.
T41274 P-Fluoro-L-phenylalanine 1132-68-9 98%
p-Fluoro-L-phenylalanine is a substrate for tyrosine hydroxylase (TH) that can be used to study the regulation of that enzyme. p-Fluoro-L-phenylalanine binds to ...
T21506 Telotristat 1033805-28-5 98%
Telotristat is the active metabolite of LX1606(Telotristat etiprate), which is an orally bioavailable tryptophan hydroxylase (TPH) inhibitor and shows potential ...
T14119 ACT-678689 1783256-96-1 98%
ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1].
T6044 Telotristat Etiprate 1137608-69-5 98%
Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.
T41143 PCPA methyl ester hydrochloride 14173-40-1 98%
pCPA methyl ester hydrochloride is an inhibitor of tryptophan hydroxylase inhibitor and 5-HT synthesis. pCPA methyl ester hydrochloride is permeable across the b...
T15124 Diethyl-pythiDC 1821370-70-0 98%
Diethyl-pythiDC is an collagen prolyl 4-hydroxylase inhibitor.
T1896 Ro 61-8048 199666-03-0 98%
Ro 61-8048 is a potent and selective inhibitor of kynurenine hydroxylase with an IC50 value of 37 nM.
T1447 Fenclonine 7424-00-2 98%
Fenclonine is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fe...
T3268 Mildronate 76144-81-5 98%
Mildronate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption...
T11897 Telotristat ethyl 1033805-22-9 98%
Telotristat ethyl is a orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.
T15796 LX-1031 945976-76-1 98%
LX-1031 is an effective inhibitor of tryptophan 5-hydroxylase. LX-1031 decreases serotonin (5-HT) synthesis peripherally.
T13383 Zamicastat 1080028-80-3 98%
Zamicastat is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73.8 μM and 17.0...
T10142L P-Ethynylphenylalanine hydrochloride 188640-63-3 98%
p-Ethynylphenylalanine hydrochloride is a novel, potent and specific inhibitor of TPH[1]. The potential for p-Ethynylphenylalanine hydrochloride to inhibit selec...
p-Ethynylphenylalanine
T10142
p-Ethynylphenylalanine, a tryptophan hydroxylase (TPH) inhibitor, is competitive, effective, selective, and reversible, with a Ki of 32.6 μM.
(R)-Nepicastat HCl
T6356
(R)-Nepicastat HCl, the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydr...
LPA2 antagonist 1
T15786
LPA2 antagonist 1 is an LPA2 antagonist (IC50: 17 nM).
GSK180
T15426
GSK180 is a selective competitive inhibitor of kynurenine 3-monooxygenase (KMO; IC50: ~6 nM), an enzyme involved in tryptophan metabolism.
GSK 366
T11470
GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor (IC50s: 0.7 nM and 2.3 nM for P. fluorescens-KMO and human KMO).
Sapropterin dihydrochloride
T7117
Sapropterin dihydrochloride is phenylalanine hydroxylase agonist that is approved for the treatment of BH4 responsive PKU.
Ketoconazole
T0679
Ketoconazole, a CYP3A4 inhibitor, is an imidazole anti-fungal agent.
p-Fluoro-L-phenylalanine
T41274
p-Fluoro-L-phenylalanine is a substrate for tyrosine hydroxylase (TH) that can be used to study the regulation of that enzyme. p-Fluoro-L-phenylalanine binds to ...
Telotristat
T21506
Telotristat is the active metabolite of LX1606(Telotristat etiprate), which is an orally bioavailable tryptophan hydroxylase (TPH) inhibitor and shows potential ...
ACT-678689
T14119
ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1].
Telotristat Etiprate
T6044
Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.
pCPA methyl ester hydrochloride
T41143
pCPA methyl ester hydrochloride is an inhibitor of tryptophan hydroxylase inhibitor and 5-HT synthesis. pCPA methyl ester hydrochloride is permeable across the b...
Diethyl-pythiDC
T15124
Diethyl-pythiDC is an collagen prolyl 4-hydroxylase inhibitor.
Ro 61-8048
T1896
Ro 61-8048 is a potent and selective inhibitor of kynurenine hydroxylase with an IC50 value of 37 nM.
Fenclonine
T1447
Fenclonine is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fe...
Mildronate
T3268
Mildronate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption...
Telotristat ethyl
T11897
Telotristat ethyl is a orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.
LX-1031
T15796
LX-1031 is an effective inhibitor of tryptophan 5-hydroxylase. LX-1031 decreases serotonin (5-HT) synthesis peripherally.
Zamicastat
T13383
Zamicastat is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73.8 μM and 17.0...
p-Ethynylphenylalanine hydrochloride
T10142L
p-Ethynylphenylalanine hydrochloride is a novel, potent and specific inhibitor of TPH[1]. The potential for p-Ethynylphenylalanine hydrochloride to inhibit selec...
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