Hydroxylase

Hydroxylation is a chemical process that introduces a hydroxyl group (-OH) into an organic compound. In biochemistry, hydroxylation reactions are often facilitated by enzymes called hydroxylases. Hydroxylation is the first step in the oxidative degradation of organic compounds in air. It is extremely important in detoxification since hydroxylation converts lipophilic compounds into water-soluble (hydrophilic) products that are more readily removed by the kidneys or liver and excreted. Some drugs (for example, steroids) are activated or deactivated by hydroxylation.

Cat No.	product name
T41143	PCPA methyl ester hydrochloride	pCPA methyl ester hydrochloride 是色氨酸羟化酶抑制剂和5-HT合成的抑制剂。 pCPA methyl ester hydrochloride 可穿过血脑屏障并降低 5-HT 中枢可用性。
T15796	LX-1031	LX-1031 是一种有效的色氨酸 5-羟化酶抑制剂。 LX-1031 减少外周5-羟色胺的合成。
T15124	Diethyl-pythiDC	Diethyl-pythiDC 是一种胶原蛋白脯氨酰 4-羟化酶抑制剂。
T4277	Osilodrostat	Osilodrostat (LCI699) is an effective inhibitor of human 11β-hydroxylase (IC50: 2.5 nM) and aldosterone synthase (IC50: 0.7 nM).
T0679	Ketoconazole	Ketoconazole, a CYP3A4 inhibitor, is an imidazole anti-fungal agent.
T13383	Zamicastat	Zamicastat is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73.8 μM and 17.0...
T10142L	P-Ethynylphenylalanine hydrochloride	p-Ethynylphenylalanine hydrochloride is a novel, potent and specific inhibitor of TPH[1]. The potential for p-Ethynylphenylalanine hydrochloride to inhibit selec...
T1896	Ro 61-8048	Ro 61-8048 is a potent and selective inhibitor of kynurenine hydroxylase with an IC50 value of 37 nM.
T21506	Telotristat	Telotristat is the active metabolite of LX1606(Telotristat etiprate), which is an orally bioavailable tryptophan hydroxylase (TPH) inhibitor and shows potential ...
T7117	Sapropterin dihydrochloride	Sapropterin dihydrochloride is phenylalanine hydroxylase agonist that is approved for the treatment of BH4 responsive PKU.
T11897	Telotristat ethyl	Telotristat ethyl is a orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.
T11470	GSK 366	GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor (IC50s: 0.7 nM and 2.3 nM for P. fluorescens-KMO and human KMO).
T3268	Mildronate	Mildronate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption...
T6004	Tetrahydropapaverine hydrochloride	Tetrahydropapaverine, an analogue of salsolinol and tetrahydropapaveroline, has neurotoxicity on dopamine neurons.
T6044	Telotristat Etiprate	Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.
T6356	(R)-Nepicastat HCl	(R)-Nepicastat HCl, the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydr...
T6604	Nepicastat hydrochloride	Nepicastat (SYN-117) HCl is an effective and specific inhibitor, which is used for bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, respecti...
T15786	LPA2 antagonist 1	LPA2 antagonist 1 is an LPA2 antagonist (IC50: 17 nM).
T14119	ACT-678689	ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1].
T1447	Fenclonine	Fenclonine is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fe...
T15426	GSK180	GSK180 is a selective competitive inhibitor of kynurenine 3-monooxygenase (KMO; IC50: ~6 nM), an enzyme involved in tryptophan metabolism.

Cat No.

product name

T41143

PCPA methyl ester hydrochloride

pCPA methyl ester hydrochloride 是色氨酸羟化酶抑制剂和5-HT合成的抑制剂。 pCPA methyl ester hydrochloride 可穿过血脑屏障并降低 5-HT 中枢可用性。

T15796

LX-1031

LX-1031 是一种有效的色氨酸 5-羟化酶抑制剂。 LX-1031 减少外周5-羟色胺的合成。

T15124

Diethyl-pythiDC

Diethyl-pythiDC 是一种胶原蛋白脯氨酰 4-羟化酶抑制剂。

T4277

Osilodrostat

Osilodrostat (LCI699) is an effective inhibitor of human 11β-hydroxylase (IC50: 2.5 nM) and aldosterone synthase (IC50: 0.7 nM).

T0679

Ketoconazole

Ketoconazole, a CYP3A4 inhibitor, is an imidazole anti-fungal agent.

T13383

Zamicastat

Zamicastat is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73.8 μM and 17.0...

T10142L

P-Ethynylphenylalanine hydrochloride

p-Ethynylphenylalanine hydrochloride is a novel, potent and specific inhibitor of TPH[1]. The potential for p-Ethynylphenylalanine hydrochloride to inhibit selec...

T1896

Ro 61-8048

Ro 61-8048 is a potent and selective inhibitor of kynurenine hydroxylase with an IC50 value of 37 nM.

T21506

Telotristat

Telotristat is the active metabolite of LX1606(Telotristat etiprate), which is an orally bioavailable tryptophan hydroxylase (TPH) inhibitor and shows potential ...

T7117

Sapropterin dihydrochloride

Sapropterin dihydrochloride is phenylalanine hydroxylase agonist that is approved for the treatment of BH4 responsive PKU.

T11897

Telotristat ethyl

Telotristat ethyl is a orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.

T11470

GSK 366

GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor (IC50s: 0.7 nM and 2.3 nM for P. fluorescens-KMO and human KMO).

T3268

Mildronate

Mildronate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption...

T6004

Tetrahydropapaverine hydrochloride

Tetrahydropapaverine, an analogue of salsolinol and tetrahydropapaveroline, has neurotoxicity on dopamine neurons.

T6044

Telotristat Etiprate

Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.

T6356

(R)-Nepicastat HCl

(R)-Nepicastat HCl, the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydr...

T6604

Nepicastat hydrochloride

Nepicastat (SYN-117) HCl is an effective and specific inhibitor, which is used for bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, respecti...

T15786

LPA2 antagonist 1

LPA2 antagonist 1 is an LPA2 antagonist (IC50: 17 nM).

T14119

ACT-678689

ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1].

T1447

Fenclonine

Fenclonine is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fe...

T15426

GSK180

GSK180 is a selective competitive inhibitor of kynurenine 3-monooxygenase (KMO; IC50: ~6 nM), an enzyme involved in tryptophan metabolism.