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Metabolism Hydroxylase

Hydroxylase

Hydroxylation is a chemical process that introduces a hydroxyl group (-OH) into an organic compound. In biochemistry, hydroxylation reactions are often facilitated by enzymes called hydroxylases. Hydroxylation is the first step in the oxidative degradation of organic compounds in air. It is extremely important in detoxification since hydroxylation converts lipophilic compounds into water-soluble (hydrophilic) products that are more readily removed by the kidneys or liver and excreted. Some drugs (for example, steroids) are activated or deactivated by hydroxylation.
Cat No. product name
T0679 Ketoconazole Ketoconazole, a CYP3A4 inhibitor, is an imidazole anti-fungal agent.
T1896 Ro 61-8048 Ro 61-8048 is a potent and selective inhibitor of kynurenine hydroxylase with an IC50 value of 37 nM.
T3268 Mildronate Mildronate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorptio...
T6004 Tetrahydropapaverine hydrochloride Tetrahydropapaverine, an analogue of salsolinol and tetrahydropapaveroline, has neurotoxicity on dopamine neurons.
T6044 Telotristat Etiprate Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.
T6356 (R)-Nepicastat HCl (R)-Nepicastat HCl, the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hy...
T6604 Nepicastat HCl Nepicastat (SYN-117) HCl is an effective and specific inhibitor, which is used for bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, respec...
T4277 Osilodrostat Osilodrostat (LCI699) is an effective inhibitor of human 11β-hydroxylase (IC50: 2.5 nM) and aldosterone synthase (IC50: 0.7 nM).
T11470 GSK 366 GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor with IC50s of 0.7 nM and 2.3 nM for P. fluorescens-KMO (Pf-KMO) and human KMO, respectively.
T15426 GSK180 GSK180 rapidly changes levels of kynurenine pathway metabolites, and acts as a useful tool to probe the therapeutic potential of KMO inhibition. GSK180 is a sel...
T15786 LPA2 antagonist 1 LPA2 antagonist 1 is an LPA2 antagonist (IC50: 17 nM).
Ketoconazole
T0679CAS 65277-42-1
Ketoconazole, a CYP3A4 inhibitor, is an imidazole anti-fungal agent.
Ro 61-8048
T1896CAS 199666-03-0
Ro 61-8048 is a potent and selective inhibitor of kynurenine hydroxylase with an IC50 value of 37 nM.
Mildronate
T3268CAS 76144-81-5
Mildronate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorptio...
Tetrahydropapaverine hydrochloride
T6004CAS 6429-04-5
Tetrahydropapaverine, an analogue of salsolinol and tetrahydropapaveroline, has neurotoxicity on dopamine neurons.
Telotristat Etiprate
T6044CAS 1137608-69-5
Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.
(R)-Nepicastat HCl
T6356CAS 195881-94-8
(R)-Nepicastat HCl, the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hy...
Nepicastat HCl
T6604CAS 170151-24-3
Nepicastat (SYN-117) HCl is an effective and specific inhibitor, which is used for bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, respec...
Osilodrostat
T4277CAS 928134-65-0
Osilodrostat (LCI699) is an effective inhibitor of human 11β-hydroxylase (IC50: 2.5 nM) and aldosterone synthase (IC50: 0.7 nM).
GSK 366
T11470CAS 1953157-39-5
GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor with IC50s of 0.7 nM and 2.3 nM for P. fluorescens-KMO (Pf-KMO) and human KMO, respectively.
GSK180
T15426CAS 1799725-26-0
GSK180 rapidly changes levels of kynurenine pathway metabolites, and acts as a useful tool to probe the therapeutic potential of KMO inhibition. GSK180 is a sel...
LPA2 antagonist 1
T15786CAS 1017606-66-4
LPA2 antagonist 1 is an LPA2 antagonist (IC50: 17 nM).