Hydroxylase

Hydroxylation is a chemical process that introduces a hydroxyl group (-OH) into an organic compound. In biochemistry, hydroxylation reactions are often facilitated by enzymes called hydroxylases. Hydroxylation is the first step in the oxidative degradation of organic compounds in air. It is extremely important in detoxification since hydroxylation converts lipophilic compounds into water-soluble (hydrophilic) products that are more readily removed by the kidneys or liver and excreted. Some drugs (for example, steroids) are activated or deactivated by hydroxylation.

Cat No.	product name
T0679	Ketoconazole	Ketoconazole, a CYP3A4 inhibitor, is an imidazole anti-fungal agent.
T1896	Ro 61-8048	Ro 61-8048 is a potent and selective inhibitor of kynurenine hydroxylase with an IC50 value of 37 nM.
T3268	Mildronate	Mildronate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorptio...
T6004	Tetrahydropapaverine hydrochloride	Tetrahydropapaverine, an analogue of salsolinol and tetrahydropapaveroline, has neurotoxicity on dopamine neurons.
T6044	Telotristat Etiprate	Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.
T6356	(R)-Nepicastat HCl	(R)-Nepicastat HCl, the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hy...
T6604	Nepicastat HCl	Nepicastat (SYN-117) HCl is an effective and specific inhibitor, which is used for bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, respec...
T4277	Osilodrostat	Osilodrostat (LCI699) is an effective inhibitor of human 11β-hydroxylase (IC50: 2.5 nM) and aldosterone synthase (IC50: 0.7 nM).
T11470	GSK 366	GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor with IC50s of 0.7 nM and 2.3 nM for P. fluorescens-KMO (Pf-KMO) and human KMO, respectively.
T15426	GSK180	GSK180 rapidly changes levels of kynurenine pathway metabolites, and acts as a useful tool to probe the therapeutic potential of KMO inhibition. GSK180 is a sel...
T15786	LPA2 antagonist 1	LPA2 antagonist 1 is an LPA2 antagonist (IC50: 17 nM).