NOD-like Receptor (NLR)

The nucleotide-binding oligomerization domain-like receptors, or NOD-like receptors (NLRs) (also known as nucleotide-binding leucine-rich repeat receptors), are intracellular sensors of pathogen-associated molecular patterns (PAMPs) that enter the cell via phagocytosis or pores, and damage-associated molecular patterns (DAMPs) that are associated with cell stress. They are types of pattern recognition receptors (PRRs), and play key roles in the regulation of innate immune response. NLRs can cooperate with toll-like receptors (TLRs) and regulate inflammatory and apoptotic response. They are found in lymphocytes, macrophages, dendritic cells and also in non-immune cells, for example in epithelium. NLRs are highly conserved through evolution. Their homologs have been discovered in many different animal species (APAF1) and also in the plant kingdom (disease-resistance R protein).

Cat. No.	Product name	CAS No.	Purity
T78168	NLRP3-IN-17	2254432-75-0	98%
T78168	NLRP3-IN-17 is a potent, selective, and orally active inhibitor of the NLRP3 inflammasome, demonstrating an IC50 of 7 nM. It effectively inhibits NLRP3-dependent...
T78180	NLRP3-IN-18	2769040-06-2	98%
T78180	NLRP3-IN-18, also known as compound 13, is a potent inhibitor of NLRP3, demonstrating an IC50 value of ≤1.0 µM [1].
T78613	Selnoflast calcium	2887416-19-3	98%
T78613	Selnoflast calcium (example 6), an NLRP3 inhibitor (extracted from patent WO2019008025) [1], is a chemical compound designed to suppress the activity of the NLRP...
T78614	Selnoflast potassium		98%
T78614	Selnoflast (potassium) (example 6), is an NLRP3 inhibitor.
T78822	JT002	2238820-43-2	98%
T78822	JT002 is an orally active NLRP3 inflammasome inhibitor that decreases the production of NLRP3-dependent proinflammatory cytokines (such as IL-1β, IL-1α, IL-18) a...
T78894	NLRP3-IN-21	2956791-61-8	98%
T78894	NLRP3-IN-21 (compound L38) is an inhibitor of the NLRP3 inflammasome that possesses anti-inflammatory properties. It suppresses the activation of the NLRP3 infla...
T79446	INF200		98%
T79446	INF200 (compound 5), a sulfonylurea-based inhibitor of NLRP3 and associated pyroptosis, exhibits cardiometabolic benefits in a rat model of high-fat diet (HFD)-i...
T79590	Anti-neuroinflammation agent 1		98%
T79590	Anti-neuroinflammation Agent 1 effectively modulates BV2 microglia cell polarization, shifting from an M1 to an M2 phenotype [1].
T79695	NLRP3-IN-19	2238819-65-1	98%
T79695	JT001 (NLRP3-IN-19) is a potent, specific, and orally active NLRP3 inhibitor that impedes the assembly of the NLRP3 inflammasome. This action results in the supp...
T79696	JT001 sodium		98%
T79696	JT001 (NLRP3-IN-19) sodium is a potent, specific, and orally active NLRP3 inhibitor that impedes the assembly of the NLRP3 inflammasome, thus curbing cytokine re...
T79733	NLRP3-IN-20	2428478-22-0	98%
T79733	NLRP3-IN-20 (compound 11) is an orally administered inhibitor targeting the NLRP3 inflammasome, exhibiting potent inhibition with an IC50 of 25 nM against IL-1β ...
T79864	Usnoflast	2455519-86-3	98%
T79864	Usnoflast functions as an NLRP3 modulator and also serves as a non-steroidal anti-inflammatory agent (NSAID) [1].
T80267	TriDAP	877462-71-0	98%
T80267	TriDAP (L-Ala-γ-D-Glu-meso-diaminopimelic acid), a biologically active peptide, functions as a specific Nod1 activator.
T80268	IE-DAP	592520-07-5	98%
T80268	iE-DAP is a biologically active peptide that functions as a NOD1 agonist.
T80273	M-TriDAP	60230-21-9	98%
T80273	M-TriDAP (N-Acetylmuramyl-L-Ala-γ-D-Glu-meso-diaminopimelic acid) is a bioactive peptide functioning as a NOD1/2 agonist.
T81637	NT-0796	2272917-13-0	98%
T81637	NT-0796, a selective CNS-penetrant NLRP3 inflammasome inhibitor, exhibits potent inhibitory activity with an IC50 of 0.32 nM in PBMC assays. As an isopropyl este...
T81665	NLRP3-IN-23		98%
T81665	NLRP3-IN-23 (Compound 15C) is an inhibitor that significantly impedes heme-mediated activation of the NLRP3 inflammasome at a concentration of 0.1 μM [1].
T81666	NLRP3-IN-22	1193329-98-4	98%
T81666	NLRP3-IN-22 (Compound II-4) is an inhibitor of NLRP3, exhibiting a 67% inhibition rate at a concentration of 10 μM [1].
T81667	NLRP3 agonist 2		98%
T81667	NLRP3 agonist 2 (compound 22) is an orally active agent that activates Caspase-1 in THP1 cells [1].
T81668	NLRP3 agonist 1	2454019-69-1	98%
T81668	NLRP3 agonist 1 (compound 23) serves as a potent, orally active agent that activates Caspase-1 enzyme, leading to the cleavage of proinflammatory cytokines pro-I...