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NOD-like Receptor (NLR)

The nucleotide-binding oligomerization domain-like receptors, or NOD-like receptors (NLRs) (also known as nucleotide-binding leucine-rich repeat receptors), are intracellular sensors of pathogen-associated molecular patterns (PAMPs) that enter the cell via phagocytosis or pores, and damage-associated molecular patterns (DAMPs) that are associated with cell stress. They are types of pattern recognition receptors (PRRs), and play key roles in the regulation of innate immune response. NLRs can cooperate with toll-like receptors (TLRs) and regulate inflammatory and apoptotic response. They are found in lymphocytes, macrophages, dendritic cells and also in non-immune cells, for example in epithelium. NLRs are highly conserved through evolution. Their homologs have been discovered in many different animal species (APAF1) and also in the plant kingdom (disease-resistance R protein).
Cat No. product name
T6454 CORM-3 CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.
T15052 Dapansutrile Dapansutrile is a potent, selective and orally active NLRP3 inflammasome inhibitor, with Anti-inflammatory and analgesic activity.
T3092 Nigericin sodium salt Nigericin sodium salt is an antibiotic from Streptomyces hygroscopicus and is a NLRP3 activator.Nigericin sodium is a cationic ionophore that inhibits Golgi func...
T3587 NOD-IN-1 NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors.
T3230 NLRP3-IN-2 It is a NLRP3 Inflammasome Inhibitor I.
T6591 Nodinitib-1 Nodinitib-1 is a potent and selective NOD1 inhibitor with an IC50 of 0.56 μM.
T2893 Muscone Muscone is an organic compound that is the primary contributor to the odor of musk.
TQ0165 Arglabin Arglabin is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.
T6887 MCC950 sodium MCC950 sodium salt (IC50 of 7.5 nM in BMDMs) is an effective, selective NLRP3 inhibitor.
T1404 Stavudine Stavudine, a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV.
T13375 YQ128 YQ128 is a potent and selective inhibitor of second-generation NLRP3 (NOD-like receptor P3) inflammasome(IC50 of 0.30 µM), with anti-inflammatory activity.
T6S1256 Ruscogenin 1. Ruscogenin has anti-inflammatory activity, suppressed zymosan A-evoked peritoneal total leukocyte migration in mice in a dose-dependent manner, 2. Ruscogenin ...
T4217 INF39 INF39 is a noncytotoxic and irreversible NLRP3 inhibitor.
T9222 Emlenoflast Emlenoflast is a potent and selective inhibitor of NLRP3 inflammasome.
T4164 CY-09 CY-09 is an NLRP3 inhibitor.
T16159 Muramyl dipeptide Muramyl dipeptide is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipe...
T0772 Troxerutin Troxerutin, a natural bioflavonoid, is isolated from Sophora japonica. It has many benefits and medicinal properties.
CORM-3
T6454
CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.
Dapansutrile
T15052
Dapansutrile is a potent, selective and orally active NLRP3 inflammasome inhibitor, with Anti-inflammatory and analgesic activity.
Nigericin sodium salt
T3092
Nigericin sodium salt is an antibiotic from Streptomyces hygroscopicus and is a NLRP3 activator.Nigericin sodium is a cationic ionophore that inhibits Golgi func...
NOD-IN-1
T3587
NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors.
NLRP3-IN-2
T3230
It is a NLRP3 Inflammasome Inhibitor I.
Nodinitib-1
T6591
Nodinitib-1 is a potent and selective NOD1 inhibitor with an IC50 of 0.56 μM.
Muscone
T2893
Muscone is an organic compound that is the primary contributor to the odor of musk.
Arglabin
TQ0165
Arglabin is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.
MCC950 sodium
T6887
MCC950 sodium salt (IC50 of 7.5 nM in BMDMs) is an effective, selective NLRP3 inhibitor.
Stavudine
T1404
Stavudine, a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV.
YQ128
T13375
YQ128 is a potent and selective inhibitor of second-generation NLRP3 (NOD-like receptor P3) inflammasome(IC50 of 0.30 µM), with anti-inflammatory activity.
Ruscogenin
T6S1256
1. Ruscogenin has anti-inflammatory activity, suppressed zymosan A-evoked peritoneal total leukocyte migration in mice in a dose-dependent manner, 2. Ruscogenin ...
INF39
T4217
INF39 is a noncytotoxic and irreversible NLRP3 inhibitor.
Emlenoflast
T9222
Emlenoflast is a potent and selective inhibitor of NLRP3 inflammasome.
CY-09
T4164
CY-09 is an NLRP3 inhibitor.
Muramyl dipeptide
T16159
Muramyl dipeptide is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipe...
Troxerutin
T0772
Troxerutin, a natural bioflavonoid, is isolated from Sophora japonica. It has many benefits and medicinal properties.