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OX Receptor

The orexin receptor is a G-protein-coupled receptor that binds the neuropeptide orexin. There are two variants, OX1 and OX2, each encoded by a different gene (HCRTR1, HCRTR2).
Cat No. product name
TP1973L OXA (17-33) acetate OXA (17-33) acetate is a more potent agonist of orexin-1 receptor (OX1, EC50 = 8.29 nM)) over OX2 (EC50 = 187 nM).
T16096 Filorexant Filorexant is an orally bioavailable effective and selective reversible OX1 and OX2 receptor antagonist (<3 nM in binding).
T16282 Nemorexant Nemorexant is an effective orexin receptor antagonist. It also has IC50s of 2 nM and 3 nM for the Ox1 receptor and Ox2 receptor, respectively.
T1913 MK-3697 MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM).
T2710 TCS 1102 TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors).
T2613 Almorexant Almorexant is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respect...
T11186 EMPA EMPA is a selective, high-affinity and reversible antagonist of orexin OX2 receptor(human and rat OX2-HEK293 membranes with KD values of 1.1 and 1.4 nM respectiv...
T12877L Seltorexant Seltorexant crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. Seltorexant is a high-affinity and selective orexin-2 recep...
TP1045L Orexin B, rat, mouse Acetate Orexin B, rat, mouse Acetate is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.
TQ0237 Lemborexant Lemborexant is a reversible and orally active dual antagonist of the orexin OX1 and OX2 receptors (IC50s: 6.1 nM and 2.6 nM).
T3722 MK-1064 MK-1064 is a selective orexin 2 receptor antagonist (2-SORA).
T3177 Orexin 2 Receptor Agonist Orexin 2 Receptor Agonist is an effective (EC50: 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio: 70) agonist.
T3347 PF3274167 PF-3274167 is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist.
T6658 SB-408124 SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over...
T6155 Almorexant hydrochloride Almorexant HCl (ACT078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 ...
T6140 SB-334867 free base SB-334867 is a selective orexin-1 (OX1) receptor antagonist.
T4965 TCS-OX2-29 TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays >250-fold selectivity for OX2 over OX1.
T5503 IPSU IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors.
T5500 DORA-22 DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory
T5498 SB-649868 SB-649868 is a potent and selective orally active antagonist of orexin(pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively).
OXA (17-33) acetate
TP1973L
OXA (17-33) acetate is a more potent agonist of orexin-1 receptor (OX1, EC50 = 8.29 nM)) over OX2 (EC50 = 187 nM).
Filorexant
T16096
Filorexant is an orally bioavailable effective and selective reversible OX1 and OX2 receptor antagonist (<3 nM in binding).
Nemorexant
T16282
Nemorexant is an effective orexin receptor antagonist. It also has IC50s of 2 nM and 3 nM for the Ox1 receptor and Ox2 receptor, respectively.
MK-3697
T1913
MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM).
TCS 1102
T2710
TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors).
Almorexant
T2613
Almorexant is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respect...
EMPA
T11186
EMPA is a selective, high-affinity and reversible antagonist of orexin OX2 receptor(human and rat OX2-HEK293 membranes with KD values of 1.1 and 1.4 nM respectiv...
Seltorexant
T12877L
Seltorexant crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. Seltorexant is a high-affinity and selective orexin-2 recep...
Orexin B, rat, mouse Acetate
TP1045L
Orexin B, rat, mouse Acetate is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.
Lemborexant
TQ0237
Lemborexant is a reversible and orally active dual antagonist of the orexin OX1 and OX2 receptors (IC50s: 6.1 nM and 2.6 nM).
MK-1064
T3722
MK-1064 is a selective orexin 2 receptor antagonist (2-SORA).
Orexin 2 Receptor Agonist
T3177
Orexin 2 Receptor Agonist is an effective (EC50: 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio: 70) agonist.
PF3274167
T3347
PF-3274167 is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist.
SB-408124
T6658
SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over...
Almorexant hydrochloride
T6155
Almorexant HCl (ACT078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 ...
SB-334867 free base
T6140
SB-334867 is a selective orexin-1 (OX1) receptor antagonist.
TCS-OX2-29
T4965
TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays >250-fold selectivity for OX2 over OX1.
IPSU
T5503
IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors.
DORA-22
T5500
DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory
SB-649868
T5498
SB-649868 is a potent and selective orally active antagonist of orexin(pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively).