ROR

The RAR-related orphan receptors (RORs) are members of the nuclear receptor family of intracellular transcription factors. There are three forms of ROR, ROR-α, -β, and -γ and each is encoded by a separate gene RORA, RORB, and RORC respectively. The RORs are somewhat unusual in that they appear to bind as monomers to hormone response elements as opposed to the majority of other nuclear receptors which bind as dimers. They bind to DNA elements called ROR response elements (RORE).

Cat. No.	Product name	CAS No.	Purity
T17108	TMP920	1421837-45-7	98%
T17108	TMP920 inhibits RORγt binding to the SRC1 peptide (IC50: 0.03 μM). TMP920 is a highly potent and selective RORγt antagonist.
T13172	TMP780	1422053-03-9	98%
T13172	TMP780 is an inverse RORγt agonist (IC50: 13 nM). RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders.
T13067	TAK-828F	1854901-94-2	98%
T13067	TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (IC50=1.9 nM, reporter gene IC50=...
T12754	RORγt Inverse agonist 8	2079892-79-6	98%
T12754	RORγt Inverse agonist 8 is a potent, selective, orally bioavailable RORγt inverse agonist(human RORγt-LBD with an IC50 of 19 nM).
T9635	Cedirogant	2055496-11-0	98%
T9635	Cedirogant is an orally active retinoid-related orphan receptor-γt(RORγt) inverse agonist that is used for psoriasis study.
T10210	A-9758	2055271-22-0	98%
T10210	A-9758 is a RORγ ligand and a selective RORγt inverse agonist (IC50: 5 nM) and exhibits robust potency against IL-17A release. It is effective in suppressing bot...
T11308	FM26	2407981-35-3	98%
T11308	FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells. FM26 is a potent and allosteric retinoic acid receptor-rela...
T16929	SR2211	1359164-11-6	98%
T16929	SR2211 is a potent and selective synthetic RORγ modulator (Ki: 105 nM and an IC50: ~320 nM).
T16787	Vimirogant	1802706-04-2	98%
T16787	Vimirogant is a RORγ inhibitor (Ki: <100 nM).
T12753	RORγt Inverse agonist 6	1887161-80-9	98%
T12753	RORγt Inverse agonist 6 is an agonist of RORγt inverse. RORγt Inverse agonist 6 can be used in research on Th17-driven autoimmune diseases.
T13502	3-Oxo-5β-cholanoic acid	1553-56-6	98%
T13502	3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) is a bile acid metabolite and inhibits the differentiation of TH17 cells by directly binding to the key transcr...
T13172L1	TMP-778	1422171-08-1	98%
T13172L1	TMP-778 is a selective inverse agonist of RORγt.
T9623	RORγt inverse agonist 13	2170477-75-3	98%
T9623	RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist (IC50=63.8 nM), with improved drug-like properties[1].
T7388	GSK805	1426802-50-7	98%
T7388	GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor's putative ligand bindi...
T4594	SR1078	1246525-60-9	98.74%
T4594	SR1078 is an agonist of retinoic acid receptor-related orphan receptor (ROR)α/γ.
T39250	Bevurogant	1817773-66-2	98.78%
T39250	Bevurogant is an antagonist of RORγt receptor and can be used in studies about the treatment of chronic inflammatory diseases.
T13362	XY101	2349368-16-5	98.81%
T13362	XY101 is a selective, metabolically stable and orally available agonist of RORγ inverse(IC50 of 30 nM and a Kd of 380 nM).
TQ0007	Cintirorgon	2055536-64-4	98.85%
TQ0007	Cintirorgon is a selective, oral agonist of RORγ. Cintirorgon modulates gene expression of RORγ expressing T lymphocyte immune cells.
T2834	Nobiletin	478-01-3	98.88%
T2834	Nobiletin is a natural polymethoxylated flavone isolated from citrus peels with anti-inflammatory and anti-tumor activities. Nobiletin is practically insoluble (...
T5163	SR1001	1335106-03-0	99.04%
T5163	SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM).