T0760 |
Cholesterol |
Cholesterol is the primary sterol in mammals. The significance of Cholesterol is becoming more appreciated in fundamental cellular processes. |
T10210 |
A-9758 |
A-9758 is a RORγ ligand and a selective RORγt inverse agonist (IC50: 5 nM) and exhibits robust potency against IL-17A release. It is effective in suppressing ...
|
T11308 |
FM26 |
FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells. FM26 is a potent and allosteric retinoic acid receptor...
|
T12754 |
RORγt Inverse agonist 8 |
RORγt Inverse agonist 8 is a potent, selective, orally bioavailable RORγt inverse agonist(human RORγt-LBD with an IC50 of 19 nM). |
T13067 |
TAK-828F |
TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (IC50=1.9 nM, reporter gene IC...
|
T13172 |
TMP780 |
TMP780 is an inverse RORγt agonist(IC50 of 13 nM). RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders. |
T14369 |
AZD-0284 |
AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1]. |
T1659 |
Melatonin |
Melatonin is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness an...
|
T16787 |
Vimirogant |
Vimirogant is a RORγ inhibitor (Ki: <100 nM). |
T16832 |
S18-000003 |
S18-000003 is an effective orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t inhibitor (IC50: 29 nM). S18-000003 inhibits IL-17 product...
|
T16929 |
SR2211 |
SR2211 is a potent and selective synthetic RORγ modulator (Ki: 105 nM and an IC50: ~320 nM). |
T17108 |
TMP920 |
TMP920 inhibits RORγt binding to the SRC1 peptide (IC50: 0.03 μM). TMP920 is a highly potent and selective RORγt antagonist. |
T19606 |
Xylan |
Xylan represents the main hemicellulose component in the secondary plant cell walls of flowering plants. |
T4050 |
GSK2981278 |
GSK2981278 is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma). |
T4594 |
SR 1078 |
SR1078 is an agonist of retinoic acid receptor-related orphan receptor (ROR)α/γ. |
T4670 |
SR0987 |
SR0987 is a RORγt agonist, |
T5160 |
SR3335 |
SR 3335 is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM). |
T5163 |
SR1001 |
SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM). |
T7388 |
GSK805 |
GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor's putative ligand bin...
|
TQ0007 |
Cintirorgon |
Cintirorgon (LYC-55716) is a selective, oral agonist of RORγ. Cintirorgon modulates gene expression of RORγ expressing T lymphocyte immune cells. |