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Metabolism ROR

ROR

Cat No. product name
T0760 Cholesterol Cholesterol is the primary sterol in mammals. The significance of Cholesterol is becoming more appreciated in fundamental cellular processes.
T1659 Melatonin Melatonin is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness an...
T4050 GSK2981278 GSK2981278 is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma).
T4594 SR 1078 SR1078 is an agonist of retinoic acid receptor-related orphan receptor (ROR)α/γ.
T4670 SR0987 SR0987 is a RORγt agonist,
T5163 SR1001 SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM).
T5160 SR3335 SR 3335 is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM).
T7388 GSK805 GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor's putative ligand bin...
TQ0007 Cintirorgon Cintirorgon (LYC-55716) is a selective, oral agonist of RORγ. Cintirorgon modulates gene expression of RORγ expressing T lymphocyte immune cells.
T10210 A-9758 A-9758 is a RORγ ligand and a selective RORγt inverse agonist (IC50: 5 nM) and exhibits robust potency against IL-17A release. It is effective in suppressing ...
T14369 AZD-0284 AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].
T12754 RORγt Inverse agonist 8 RORγt Inverse agonist 8 is a potent, selective, orally bioavailable RORγt inverse agonist(human RORγt-LBD with an IC50 of 19 nM).
T13067 TAK-828F TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (IC50=1.9 nM, reporter gene IC...
T11308 FM26  FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells. FM26  is a potent and allosteric retinoic acid receptor...
T13172 TMP780 TMP780 is an inverse RORγt agonist(IC50 of 13 nM). RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders.
T19606 Xylan Xylan represents the main hemicellulose component in the secondary plant cell walls of flowering plants.
T16787 Vimirogant Vimirogant is a RORγ inhibitor (Ki: <100 nM).
T16832 S18-000003 S18-000003 is an effective orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t inhibitor (IC50: 29 nM). S18-000003 inhibits IL-17 product...
T16929 SR2211 SR2211 is a potent and selective synthetic RORγ modulator (Ki: 105 nM and an IC50: ~320 nM).
T17108 TMP920 TMP920 inhibits RORγt binding to the SRC1 peptide (IC50: 0.03 μM). TMP920 is a highly potent and selective RORγt antagonist.
Cholesterol
T0760CAS 57-88-5
Cholesterol is the primary sterol in mammals. The significance of Cholesterol is becoming more appreciated in fundamental cellular processes.
Melatonin
T1659CAS 73-31-4
Melatonin is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness an...
GSK2981278
T4050CAS 1474110-21-8
GSK2981278 is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma).
SR 1078
T4594CAS 1246525-60-9
SR1078 is an agonist of retinoic acid receptor-related orphan receptor (ROR)α/γ.
SR0987
T4670CAS 303126-97-8
SR0987 is a RORγt agonist,
SR1001
T5163CAS 1335106-03-0
SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM).
SR3335
T5160CAS 293753-05-6
SR 3335 is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM).
GSK805
T7388CAS 1426802-50-7
GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor's putative ligand bin...
Cintirorgon
TQ0007CAS 2055536-64-4
Cintirorgon (LYC-55716) is a selective, oral agonist of RORγ. Cintirorgon modulates gene expression of RORγ expressing T lymphocyte immune cells.
A-9758
T10210CAS 2055271-22-0
A-9758 is a RORγ ligand and a selective RORγt inverse agonist (IC50: 5 nM) and exhibits robust potency against IL-17A release. It is effective in suppressing ...
AZD-0284
T14369CAS 2101291-07-8
AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].
RORγt Inverse agonist 8
T12754CAS 2079892-79-6
RORγt Inverse agonist 8 is a potent, selective, orally bioavailable RORγt inverse agonist(human RORγt-LBD with an IC50 of 19 nM).
TAK-828F
T13067CAS 1854901-94-2
TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (IC50=1.9 nM, reporter gene IC...
FM26
T11308CAS 2407981-35-3
 FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells. FM26  is a potent and allosteric retinoic acid receptor...
TMP780
T13172CAS 1422053-03-9
TMP780 is an inverse RORγt agonist(IC50 of 13 nM). RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders.
Xylan
T19606CAS 9014-63-5
Xylan represents the main hemicellulose component in the secondary plant cell walls of flowering plants.
Vimirogant
T16787CAS 1802706-04-2
Vimirogant is a RORγ inhibitor (Ki: <100 nM).
S18-000003
T16832CAS 2068119-11-7
S18-000003 is an effective orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t inhibitor (IC50: 29 nM). S18-000003 inhibits IL-17 product...
SR2211
T16929CAS 1359164-11-6
SR2211 is a potent and selective synthetic RORγ modulator (Ki: 105 nM and an IC50: ~320 nM).
TMP920
T17108CAS 1421837-45-7
TMP920 inhibits RORγt binding to the SRC1 peptide (IC50: 0.03 μM). TMP920 is a highly potent and selective RORγt antagonist.