ROR

The RAR-related orphan receptors (RORs) are members of the nuclear receptor family of intracellular transcription factors. There are three forms of ROR, ROR-α, -β, and -γ and each is encoded by a separate gene RORA, RORB, and RORC respectively. The RORs are somewhat unusual in that they appear to bind as monomers to hormone response elements as opposed to the majority of other nuclear receptors which bind as dimers. They bind to DNA elements called ROR response elements (RORE).

Cat. No.	Product name	CAS No.	Purity
T37587	ML 209	1334526-14-5	98%
T37587	ML-209 is an antagonist of retinoic acid receptor-related orphan receptor γt (RORγt; IC50= 1.1 μM in a reporter assay).1It inhibits RORγt-induced transcription i...
T11923	Methyl-3β-hydroxycholenate	20231-57-6	98%
T11923	Methyl-3β-hydroxycholenate is a modulator of RORγ.
T13067	TAK-828F	1854901-94-2	98%
T13067	TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (IC50=1.9 nM, reporter gene IC50=...
T16787	Vimirogant	1802706-04-2	98%
T16787	Vimirogant is a RORγ inhibitor (Ki: <100 nM).
T11308	FM26	2407981-35-3	98%
T11308	FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells. FM26 is a potent and allosteric retinoic acid receptor-rela...
T17108	TMP920	1421837-45-7	98%
T17108	TMP920 inhibits RORγt binding to the SRC1 peptide (IC50: 0.03 μM). TMP920 is a highly potent and selective RORγt antagonist.
T12754	RORγt Inverse agonist 8	2079892-79-6	98%
T12754	RORγt Inverse agonist 8 is a potent, selective, orally bioavailable RORγt inverse agonist(human RORγt-LBD with an IC50 of 19 nM).
T35321	Zymostenol	566-97-2	98%
T35321	Zymostenol is a RORγ agonist with an EC50 of 1 μM.Zymostenol is a late stage precursor of cholesterol biosynthesis.
T13172	TMP780	1422053-03-9	98%
T13172	TMP780 is an inverse RORγt agonist (IC50: 13 nM). RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders.
T10210	A-9758	2055271-22-0	98%
T10210	A-9758 is a RORγ ligand and a selective RORγt inverse agonist (IC50: 5 nM) and exhibits robust potency against IL-17A release. It is effective in suppressing bot...
T0760	Cholesterol	57-88-5	98%
T0760	Cholesterol is the primary sterol in mammals. The significance of Cholesterol is becoming more appreciated in fundamental cellular processes.
T4050	GSK2981278	1474110-21-8	98%
T4050	GSK2981278 is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma).
T14369	AZD-0284	2101291-07-8	98%
T14369	AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].
T9635	Cedirogant	2055496-11-0	98%
T9635	Cedirogant is an orally active retinoid-related orphan receptor-γt(RORγt) inverse agonist that is used for psoriasis study.
T3S1251	Neoruscogenin	17676-33-4	98%
T3S1251	1. Neoruscogenin represents a universal pharmacological tool for RORα research due to its specific selectivity profile versus other nuclear receptors.
T6690	T0901317	293754-55-9	98%
T6690	T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).
T5160	SR3335	293753-05-6	98%
T5160	SR 3335 is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM).
T5163	SR1001	1335106-03-0	98%
T5163	SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM).
T2834	Nobiletin	478-01-3	98%
T2834	Nobiletin is a natural polymethoxylated flavone isolated from citrus peels with anti-inflammatory and anti-tumor activities. Nobiletin is practically insoluble (...
TQ0007	Cintirorgon	2055536-64-4	98%
TQ0007	Cintirorgon is a selective, oral agonist of RORγ. Cintirorgon modulates gene expression of RORγ expressing T lymphocyte immune cells.