ROR|Targetmol

Cat No.	product name
T0760	Cholesterol	Cholesterol is the primary sterol in mammals. The significance of Cholesterol is becoming more appreciated in fundamental cellular processes.
T10210	A-9758	A-9758 is a RORγ ligand and a selective RORγt inverse agonist (IC50: 5 nM) and exhibits robust potency against IL-17A release. It is effective in suppressing ...
T11308	FM26	FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells. FM26 is a potent and allosteric retinoic acid receptor...
T12754	RORγt Inverse agonist 8	RORγt Inverse agonist 8 is a potent, selective, orally bioavailable RORγt inverse agonist(human RORγt-LBD with an IC50 of 19 nM).
T13067	TAK-828F	TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (IC50=1.9 nM, reporter gene IC...
T13172	TMP780	TMP780 is an inverse RORγt agonist(IC50 of 13 nM). RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders.
T14369	AZD-0284	AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].
T1659	Melatonin	Melatonin is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness an...
T16787	Vimirogant	Vimirogant is a RORγ inhibitor (Ki: <100 nM).
T16832	S18-000003	S18-000003 is an effective orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t inhibitor (IC50: 29 nM). S18-000003 inhibits IL-17 product...
T16929	SR2211	SR2211 is a potent and selective synthetic RORγ modulator (Ki: 105 nM and an IC50: ~320 nM).
T17108	TMP920	TMP920 inhibits RORγt binding to the SRC1 peptide (IC50: 0.03 μM). TMP920 is a highly potent and selective RORγt antagonist.
T19606	Xylan	Xylan represents the main hemicellulose component in the secondary plant cell walls of flowering plants.
T4050	GSK2981278	GSK2981278 is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma).
T4594	SR 1078	SR1078 is an agonist of retinoic acid receptor-related orphan receptor (ROR)α/γ.
T4670	SR0987	SR0987 is a RORγt agonist,
T5160	SR3335	SR 3335 is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM).
T5163	SR1001	SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM).
T7388	GSK805	GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor's putative ligand bin...
TQ0007	Cintirorgon	Cintirorgon (LYC-55716) is a selective, oral agonist of RORγ. Cintirorgon modulates gene expression of RORγ expressing T lymphocyte immune cells.

Cat No.

product name

Cholesterol is the primary sterol in mammals. The significance of Cholesterol is becoming more appreciated in fundamental cellular processes.

T10210

A-9758

A-9758 is a RORγ ligand and a selective RORγt inverse agonist (IC50: 5 nM) and exhibits robust potency against IL-17A release. It is effective in suppressing ...

T11308

FM26

FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells. FM26 is a potent and allosteric retinoic acid receptor...

T12754

RORγt Inverse agonist 8

RORγt Inverse agonist 8 is a potent, selective, orally bioavailable RORγt inverse agonist(human RORγt-LBD with an IC50 of 19 nM).

T13067

TAK-828F

TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (IC50=1.9 nM, reporter gene IC...

T13172

TMP780

TMP780 is an inverse RORγt agonist(IC50 of 13 nM). RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders.

T14369

AZD-0284

AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].

T1659

Melatonin

Melatonin is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness an...

T16787

Vimirogant

Vimirogant is a RORγ inhibitor (Ki: <100 nM).

T16832

S18-000003

S18-000003 is an effective orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t inhibitor (IC50: 29 nM). S18-000003 inhibits IL-17 product...

T16929

SR2211

SR2211 is a potent and selective synthetic RORγ modulator (Ki: 105 nM and an IC50: ~320 nM).

T17108

TMP920

TMP920 inhibits RORγt binding to the SRC1 peptide (IC50: 0.03 μM). TMP920 is a highly potent and selective RORγt antagonist.

T19606

Xylan

Xylan represents the main hemicellulose component in the secondary plant cell walls of flowering plants.

T4050

GSK2981278

GSK2981278 is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma).

T4594

SR 1078

SR1078 is an agonist of retinoic acid receptor-related orphan receptor (ROR)α/γ.

T4670

SR0987

SR0987 is a RORγt agonist,

T5160

SR3335

SR 3335 is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM).

T5163

SR1001

SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM).

T7388

GSK805

GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor's putative ligand bin...

TQ0007

Cintirorgon

Cintirorgon (LYC-55716) is a selective, oral agonist of RORγ. Cintirorgon modulates gene expression of RORγ expressing T lymphocyte immune cells.

Cholesterol

T0760CAS 57-88-5

Cholesterol is the primary sterol in mammals. The significance of Cholesterol is becoming more appreciated in fundamental cellular processes.

A-9758

T10210CAS 2055271-22-0

A-9758 is a RORγ ligand and a selective RORγt inverse agonist (IC50: 5 nM) and exhibits robust potency against IL-17A release. It is effective in suppressing ...

FM26

T11308CAS 2407981-35-3

FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells. FM26 is a potent and allosteric retinoic acid receptor...