ROR|Targetmol

Cat No.	product name
T0760	Cholesterol	Cholesterol is the primary sterol in mammals. The significance of Cholesterol is becoming more appreciated in fundamental cellular processes.
T1659	Melatonin	Melatonin is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness an...
T4050	GSK2981278	GSK2981278 is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma).
T4594	SR 1078	SR1078 is an agonist of retinoic acid receptor-related orphan receptor (ROR)α/γ.
T4670	SR0987	SR0987 is a RORγt agonist,
T5163	SR1001	SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM).
T5160	SR3335	SR 3335 is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM).
T7388	GSK805	GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor's putative ligand bin...
TQ0007	Cintirorgon	Cintirorgon (LYC-55716) is a selective, oral agonist of RORγ. Cintirorgon modulates gene expression of RORγ expressing T lymphocyte immune cells.
T10210	A-9758	A-9758 is a RORγ ligand and a selective RORγt inverse agonist (IC50: 5 nM) and exhibits robust potency against IL-17A release. It is effective in suppressing ...
T14369	AZD-0284	AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].
T12754	RORγt Inverse agonist 8	RORγt Inverse agonist 8 is a potent, selective, orally bioavailable RORγt inverse agonist(human RORγt-LBD with an IC50 of 19 nM).
T13067	TAK-828F	TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (IC50=1.9 nM, reporter gene IC...
T11308	FM26	FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells. FM26 is a potent and allosteric retinoic acid receptor...
T13172	TMP780	TMP780 is an inverse RORγt agonist(IC50 of 13 nM). RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders.
T19606	Xylan	Xylan represents the main hemicellulose component in the secondary plant cell walls of flowering plants.
T16787	Vimirogant	Vimirogant is a RORγ inhibitor (Ki: <100 nM).
T16832	S18-000003	S18-000003 is an effective orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t inhibitor (IC50: 29 nM). S18-000003 inhibits IL-17 product...
T16929	SR2211	SR2211 is a potent and selective synthetic RORγ modulator (Ki: 105 nM and an IC50: ~320 nM).
T17108	TMP920	TMP920 inhibits RORγt binding to the SRC1 peptide (IC50: 0.03 μM). TMP920 is a highly potent and selective RORγt antagonist.

Cat No.

product name

Cholesterol is the primary sterol in mammals. The significance of Cholesterol is becoming more appreciated in fundamental cellular processes.

T1659

Melatonin

Melatonin is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness an...

T4050

GSK2981278

GSK2981278 is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma).

T4594

SR 1078

SR1078 is an agonist of retinoic acid receptor-related orphan receptor (ROR)α/γ.

T4670

SR0987

SR0987 is a RORγt agonist,

T5163

SR1001

SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM).

T5160

SR3335

SR 3335 is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM).

T7388

GSK805

GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor's putative ligand bin...

TQ0007

Cintirorgon

Cintirorgon (LYC-55716) is a selective, oral agonist of RORγ. Cintirorgon modulates gene expression of RORγ expressing T lymphocyte immune cells.

T10210

A-9758

A-9758 is a RORγ ligand and a selective RORγt inverse agonist (IC50: 5 nM) and exhibits robust potency against IL-17A release. It is effective in suppressing ...

T14369

AZD-0284

AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].

T12754

RORγt Inverse agonist 8

RORγt Inverse agonist 8 is a potent, selective, orally bioavailable RORγt inverse agonist(human RORγt-LBD with an IC50 of 19 nM).

T13067

TAK-828F

TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (IC50=1.9 nM, reporter gene IC...

T11308

FM26

FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells. FM26 is a potent and allosteric retinoic acid receptor...

T13172

TMP780

TMP780 is an inverse RORγt agonist(IC50 of 13 nM). RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders.

T19606

Xylan

Xylan represents the main hemicellulose component in the secondary plant cell walls of flowering plants.

T16787

Vimirogant

Vimirogant is a RORγ inhibitor (Ki: <100 nM).

T16832

S18-000003

S18-000003 is an effective orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t inhibitor (IC50: 29 nM). S18-000003 inhibits IL-17 product...

T16929

SR2211

SR2211 is a potent and selective synthetic RORγ modulator (Ki: 105 nM and an IC50: ~320 nM).

T17108

TMP920

TMP920 inhibits RORγt binding to the SRC1 peptide (IC50: 0.03 μM). TMP920 is a highly potent and selective RORγt antagonist.

Cholesterol

T0760CAS 57-88-5

Cholesterol is the primary sterol in mammals. The significance of Cholesterol is becoming more appreciated in fundamental cellular processes.

Melatonin

T1659CAS 73-31-4

Melatonin is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness an...