Sigma receptor

The sigma receptors σ1 and σ2 bind to ligands such as 4-PPBP (4-phenyl-1-(4-phenylbutyl) piperidine), SA 4503 (cutamesine), ditolylguanidine, dimethyltryptamine, and siramesine. They are named by pharmacological similarities, and are evolutionarily unrelated.

Cat. No.	Product name	CAS No.	Purity
T4620	Siramesine	147817-50-3	98%
T4620	Siramesine(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer acti...
T1865	S1RA	878141-96-9	98%
T1865	S1RA(E-52862) is a potent and selective sigma-1 receptor(σ1R, Ki=17 nM) antagonist, showed good selectivity against σ2R (Ki > 1000 nM).
T19341	Glycerol phenylbutyrate-D15	T19341	98%
T19341	Glycerol phenylbutyrate-D15 is a deuterium-labeled Glycerol phenylbutyrate. Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
T16445	PD 144418	154130-99-1	98%
T16445	PD 144418 displays potential antipsychotic activity. PD 144418 is a high affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki: 0.08 nM and 1377 nM for...
T19342	Glycerol phenylbutyrate-D5	T19342	98%
T19342	Glycerol phenylbutyrate-D5 is a deuterium-labeled Glycerol phenylbutyrate. Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
T12912	Sigma-1 receptor antagonist 3	1639220-17-9	98%
T12912	Sigma-1 receptor antagonist 3 is a potent and selective antagonist of Sigma-1 (σ1) receptor(Ki : 1.14 nM), has the potential for the neuropathic pain.
T12911	Sigma-1 receptor antagonist 2	1639220-15-7	98%
T12911	Sigma-1 receptor antagonist 2 is a potent and selective antagonist of sigma 1 receptor (σ1 R) (σ1 and σ2 receptor with Kis of 3.88 and 1288 nM , respectively).
T22904	L-745870 trihydrochloride	866021-03-6	98%
T22904	highly potent and selective D4 dopamine receptor antagonist
T21788	BD 1008 dihydrobromide	138356-09-9
T21788	BD1008 dihydrobromide is a selective antagonist of the sigma 1 (σ1) receptor (Ki = 2 nM). BD1008 dihydrobromide have high affinity for sigma1 receptors, moderate...
T1180	Blonanserin	132810-10-7	100%
T1180	Blonanserin is an atypical antipsychotic approved in Japan in January, 2008. Relative to many other antipsychotics, blonanserin has an improved tolerability prof...
T15034	Roluperidone	359625-79-9	97.77%
T15034	Roluperidone is a novel cyclic amide derivative. It has high equipotent affinities for 5-HT2A and σ2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A and σ2).
T5969	Ditolylguanidine	97-39-2	98%
T5969	Ditolylguanidine is an agonist of sigma receptor (σ1/σ2 receptor).
T20797	NE-100 hydrochloride	149409-57-4	98.85%
T20797	NE100 HCl is a potent and selective antagonist of sigma-1 receptor.
T3597	Cutamesine dihydrochloride	165377-44-6	99%
T3597	Cutamesine dihydrochloride is a selective σ1 receptor agonist (IC50: 17.4 nM). It shows selectivity for σ1 over σ2 receptors, and inhibits angiotensin II-induced...
T4596	4-IBP	155798-08-6	99.12%
T4596	4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) .
T8834	EST64454 hydrochloride	1950569-11-5	99.15%
T8834	EST64454 is a highly soluble σ1 receptor antagonist (Ki : 22 nM),has the potential for Pain Management.
T7488	BD1063 dhydrochloride	206996-13-6	99.33%
T7488	BD1063 is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM).
T1740	BD-1047 dihydrobromide	138356-21-5	99.39%
T1740	BD-1047 hydrobromide, a selective functional antagonist of sigma receptors, has antipsychotic activity in animal models predictive of efficacy in schizophrenia.
T7952	Noscapine	128-62-1	99.43%
T7952	Noscapine is a Non-addictive Opioid and Microtubule-Inhibitor in Potential Treatment of Glioblastoma.
T3198L	PRE-084 hydrochloride	75136-54-8	99.61%
T3198L	PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).