Sigma receptor

The sigma receptors σ1 and σ2 bind to ligands such as 4-PPBP (4-phenyl-1-(4-phenylbutyl) piperidine), SA 4503 (cutamesine), ditolylguanidine, dimethyltryptamine, and siramesine. They are named by pharmacological similarities, and are evolutionarily unrelated.

Cat. No.	Product name	CAS No.	Purity
T16445	PD 144418	154130-99-1	98%
T16445	PD 144418 displays potential antipsychotic activity. PD 144418 is a high affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki: 0.08 nM and 1377 nM for...
T19341	Glycerol phenylbutyrate-D15	T19341	98%
T19341	Glycerol phenylbutyrate-D15 is a deuterium-labeled Glycerol phenylbutyrate. Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
T4620	Siramesine	147817-50-3	98%
T4620	Siramesine(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer acti...
T19342	Glycerol phenylbutyrate-D5	T19342	98%
T19342	Glycerol phenylbutyrate-D5 is a deuterium-labeled Glycerol phenylbutyrate. Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
T1865	S1RA	878141-96-9	98%
T1865	S1RA(E-52862) is a potent and selective sigma-1 receptor(σ1R, Ki=17 nM) antagonist, showed good selectivity against σ2R (Ki > 1000 nM).
T22904	L-745870 trihydrochloride	866021-03-6	98%
T22904	highly potent and selective D4 dopamine receptor antagonist
T77340L	AB21 HCl		98%
T77340L	AB21 HCl is a selective antagonist of the σ1 receptor, with Kis of 13 nM for σ1 receptor and 102 nM for σ2 receptor. AB21 HCl is known for its ability to reduce ...
T13510	Sigma-LIGAND-1	139652-01-0	98%
T13510	Sigma-LIGAND-1 is a selective Sigma Receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma-LIGAND-1 has a Ki of 4000...
T12912	Sigma-1 receptor antagonist 3	1639220-17-9	98%
T12912	Sigma-1 receptor antagonist 3 is a potent and selective antagonist of Sigma-1 (σ1) receptor(Ki : 1.14 nM), has the potential for the neuropathic pain.
T1180	Blonanserin	132810-10-7	98%
T1180	Blonanserin is an atypical antipsychotic approved in Japan in January, 2008. Relative to many other antipsychotics, blonanserin has an improved tolerability prof...
T15034	Roluperidone	359625-79-9	98%
T15034	Roluperidone is a novel cyclic amide derivative. It has high equipotent affinities for 5-HT2A and σ2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A and σ2).
T21788	BD 1008 dihydrobromide	138356-09-9	98%
T21788	BD 1008 dihydrobromide is a selective antagonist of the sigma 1 (σ1) receptor (Ki = 2 nM). BD 1008 dihydrobromide have high affinity for sigma1 receptors, modera...
T5969	Ditolylguanidine	97-39-2	98%
T5969	Ditolylguanidine is an agonist of sigma receptor (σ1/σ2 receptor).
T22612	BMY-14802 hydrochloride	105565-55-7	98%
T22612	BMY-14802 hydrochloride is a selective antagonist of σ receptor (IC50 = 112 nM) with antipsychotic effects. BMY-14802 hydrochloride is an agonist of the α1-adren...
T20797	NE-100 hydrochloride	149409-57-4	98%
T20797	NE100 HCl is a potent and selective antagonist of sigma-1 receptor.
T67739	BMY-14802	105565-56-8	98%
T67739	BMY-14802 is a selective and orally active sigma-1 antagonist with an IC50 of 112 nM.
T3597	Cutamesine dihydrochloride	165377-44-6	98%
T3597	Cutamesine dihydrochloride is a selective σ1 receptor agonist (IC50: 17.4 nM). It shows selectivity for σ1 over σ2 receptors, and inhibits angiotensin II-induced...
T72059	S1R agonist 2	150085-21-5	98%
T72059	S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for S2R and 1.1 nM for S1R and is protective against ROS and NMDA-induced neurotoxicity.
T39211	PD 144418 oxalate	1794760-28-3	98%
T39211	PD 144418 oxalate is a highly potent and selective sigma 1 (σ1) receptor ligand, displaying a Ki value of 0.08 nM for σ1 and 1377 nM for σ2. It exhibits negligib...
T4596	4-IBP	155798-08-6	98%
T4596	4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) .