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Sigma receptor

The sigma receptors σ1 and σ2 bind to ligands such as 4-PPBP (4-phenyl-1-(4-phenylbutyl) piperidine), SA 4503 (cutamesine), ditolylguanidine, dimethyltryptamine, and siramesine. They are named by pharmacological similarities, and are evolutionarily unrelated.
Cat. No. Product name CAS No. Purity Chemical Structure
T16445 PD 144418 154130-99-1 98%
PD 144418 displays potential antipsychotic activity. PD 144418 is a high affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki: 0.08 nM and 1377 nM for...
T19341 Glycerol phenylbutyrate-D15 T19341 98%
Glycerol phenylbutyrate-D15 is a deuterium-labeled Glycerol phenylbutyrate. Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
T4620 Siramesine 147817-50-3 98%
Siramesine(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer acti...
T19342 Glycerol phenylbutyrate-D5 T19342 98%
Glycerol phenylbutyrate-D5 is a deuterium-labeled Glycerol phenylbutyrate. Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
T1865 S1RA 878141-96-9 98%
S1RA(E-52862) is a potent and selective sigma-1 receptor(σ1R, Ki=17 nM) antagonist, showed good selectivity against σ2R (Ki > 1000 nM).
T22904 L-745870 trihydrochloride 866021-03-6 98%
highly potent and selective D4 dopamine receptor antagonist
T77340L AB21 HCl 98%
AB21 HCl is a selective antagonist of the σ1 receptor, with Kis of 13 nM for σ1 receptor and 102 nM for σ2 receptor. AB21 HCl is known for its ability to reduce ...
T13510 Sigma-LIGAND-1 139652-01-0 98%
Sigma-LIGAND-1 is a selective Sigma Receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma-LIGAND-1 has a Ki of 4000...
T12912 Sigma-1 receptor antagonist 3 1639220-17-9 98%
Sigma-1 receptor antagonist 3 is a potent and selective antagonist of Sigma-1 (σ1) receptor(Ki : 1.14 nM), has the potential for the neuropathic pain.
T1180 Blonanserin 132810-10-7 98%
Blonanserin is an atypical antipsychotic approved in Japan in January, 2008. Relative to many other antipsychotics, blonanserin has an improved tolerability prof...
T15034 Roluperidone 359625-79-9 98%
Roluperidone is a novel cyclic amide derivative. It has high equipotent affinities for 5-HT2A and σ2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A and σ2).
T21788 BD 1008 dihydrobromide 138356-09-9 98%
BD 1008 dihydrobromide is a selective antagonist of the sigma 1 (σ1) receptor (Ki = 2 nM). BD 1008 dihydrobromide have high affinity for sigma1 receptors, modera...
T5969 Ditolylguanidine 97-39-2 98%
Ditolylguanidine is an agonist of sigma receptor (σ1/σ2 receptor).
T22612 BMY-14802 hydrochloride 105565-55-7 98%
BMY-14802 hydrochloride is a selective antagonist of σ receptor (IC50 = 112 nM) with antipsychotic effects. BMY-14802 hydrochloride is an agonist of the α1-adren...
T20797 NE-100 hydrochloride  149409-57-4 98%
NE100 HCl is a potent and selective antagonist of sigma-1 receptor.
T67739 BMY-14802 105565-56-8 98%
BMY-14802 is a selective and orally active sigma-1 antagonist with an IC50 of 112 nM.
T3597 Cutamesine dihydrochloride 165377-44-6 98%
Cutamesine dihydrochloride is a selective σ1 receptor agonist (IC50: 17.4 nM). It shows selectivity for σ1 over σ2 receptors, and inhibits angiotensin II-induced...
T72059 S1R agonist 2 150085-21-5 98%
S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for S2R and 1.1 nM for S1R and is protective against ROS and NMDA-induced neurotoxicity.
T39211 PD 144418 oxalate 1794760-28-3 98%
PD 144418 oxalate is a highly potent and selective sigma 1 (σ1) receptor ligand, displaying a Ki value of 0.08 nM for σ1 and 1377 nM for σ2. It exhibits negligib...
T4596 4-IBP 155798-08-6 98%
4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) .
PD 144418
T16445
PD 144418 displays potential antipsychotic activity. PD 144418 is a high affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki: 0.08 nM and 1377 nM for...
Glycerol phenylbutyrate-D15
T19341
Glycerol phenylbutyrate-D15 is a deuterium-labeled Glycerol phenylbutyrate. Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
Siramesine
T4620
Siramesine(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer acti...
Glycerol phenylbutyrate-D5
T19342
Glycerol phenylbutyrate-D5 is a deuterium-labeled Glycerol phenylbutyrate. Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
S1RA
T1865
S1RA(E-52862) is a potent and selective sigma-1 receptor(σ1R, Ki=17 nM) antagonist, showed good selectivity against σ2R (Ki > 1000 nM).
L-745870 trihydrochloride
T22904
highly potent and selective D4 dopamine receptor antagonist
AB21 HCl
T77340L
AB21 HCl is a selective antagonist of the σ1 receptor, with Kis of 13 nM for σ1 receptor and 102 nM for σ2 receptor. AB21 HCl is known for its ability to reduce ...
Sigma-LIGAND-1
T13510
Sigma-LIGAND-1 is a selective Sigma Receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma-LIGAND-1 has a Ki of 4000...
Sigma-1 receptor antagonist 3
T12912
Sigma-1 receptor antagonist 3 is a potent and selective antagonist of Sigma-1 (σ1) receptor(Ki : 1.14 nM), has the potential for the neuropathic pain.
Blonanserin
T1180
Blonanserin is an atypical antipsychotic approved in Japan in January, 2008. Relative to many other antipsychotics, blonanserin has an improved tolerability prof...
Roluperidone
T15034
Roluperidone is a novel cyclic amide derivative. It has high equipotent affinities for 5-HT2A and σ2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A and σ2).
BD 1008 dihydrobromide
T21788
BD 1008 dihydrobromide is a selective antagonist of the sigma 1 (σ1) receptor (Ki = 2 nM). BD 1008 dihydrobromide have high affinity for sigma1 receptors, modera...
Ditolylguanidine
T5969
Ditolylguanidine is an agonist of sigma receptor (σ1/σ2 receptor).
BMY-14802 hydrochloride
T22612
BMY-14802 hydrochloride is a selective antagonist of σ receptor (IC50 = 112 nM) with antipsychotic effects. BMY-14802 hydrochloride is an agonist of the α1-adren...
NE-100 hydrochloride 
T20797
NE100 HCl is a potent and selective antagonist of sigma-1 receptor.
BMY-14802
T67739
BMY-14802 is a selective and orally active sigma-1 antagonist with an IC50 of 112 nM.
Cutamesine dihydrochloride
T3597
Cutamesine dihydrochloride is a selective σ1 receptor agonist (IC50: 17.4 nM). It shows selectivity for σ1 over σ2 receptors, and inhibits angiotensin II-induced...
S1R agonist 2
T72059
S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for S2R and 1.1 nM for S1R and is protective against ROS and NMDA-induced neurotoxicity.
PD 144418 oxalate
T39211
PD 144418 oxalate is a highly potent and selective sigma 1 (σ1) receptor ligand, displaying a Ki value of 0.08 nM for σ1 and 1377 nM for σ2. It exhibits negligib...
4-IBP
T4596
4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) .
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