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Signaling Pathways Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling
DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation JAK/STAT signaling MAPK Membrane transporter/Ion channel
Metabolism Microbiology/Virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome
Stem Cells Tyrosine Kinase/Adaptors Ubiquitination
Focused Bioactive Libraries Characteristic Bioactive Libraries Target / Pathway Focused Disease Focused Approved / Repurposing
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AhR

The aryl hydrocarbon receptor (AHR) is a member of the basic helix-loop-helix-period-aryl hydrocarbon receptor nuclear translocator-single-minded (bHLH-PAS) family of transcription factors, which act as biological sensors by initiating gene expression programs in response to endogenous and exogenous signals.
Cat No. product name
T4928 L-Kynurenine L-Kynurenine is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppress...
T2448 CH-223191 CH-223191 is a potent and specific antagonist for aryl hydrocarbon receptor (AhR).
T1159 Leflunomide Leflunomide is an immunomodulatory agent used in the therapy of rheumatoid arthritis and psoriatic arthritis.
T1831 StemRegenin 1 StemRegenin 1 is an aryl hydrocarbon receptor (AhR) inhibitor.
T4644 Tapinarof Tapinarof is targeted as a topical cream treatment for psoriasis, a chronic autoimmune skin disease.
T5281 Skatole Skatole is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.
T1960 YL-109 YL-109, a novel anticancer agent, can inhibit breast Y cell growth and invasiveness in vitro and in vivo.
T4608 PDM2 PDM 2 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist.
T20625 Prochloraz Prochloraz, a broad-spectrum contact imidazole fungicide, is used against several diseases in wheat, barley, and oleaginous plants but also for the treatment of ...
T4938 Potassium 1H-indol-3-yl sulfate Indoxyl sulfate (potassium salt) is an agonist for the human aryl hydrocarbon receptor (AHR). The aryl hydrocarbon receptor (AhR) has recently emerged as a patho...
T0343 Nimodipine Nimodipine, a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells.
TN1451 Brevifolincarboxylic acid Brevifolincarboxylic acid is a natural product isolated from Polygonum capitatum, it has inhibitory effect on the aryl hydrocarbon receptor (AhR). Brevifolincarb...
T5622 BAY-218 AHR antagonist 1 is an aryl hydrocarbon receptor (AHR) antagonist , has an IC50 of 39.9 nM in human cell line.
T4607 CAY 10465 CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM).
T7202 ITE ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR) (Ki : 3 nM), has immunosuppressive activity.
T9112 (-)-Perillaldehyde (-)-Perillaldehyde shows antibacterial activity.
T1046 Mexiletine hydrochloride Mexiletine Hydrochloride is the hydrochloride salt form of mexiletine, a local anesthetic and antiarrhythmic (Class IB) agent structurally related to lidocaine. ...
T10007 1,4-Chrysenequinone 1,4-Chrysenequinone acts as an activator of aryl hydrocarbon receptor (AhR).
T5541 PDM11 PDM 11 is an antagonist of aryl hydrocarbon receptor (AhR)
L-Kynurenine
T4928
L-Kynurenine is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppress...
CH-223191
T2448
CH-223191 is a potent and specific antagonist for aryl hydrocarbon receptor (AhR).
Leflunomide
T1159
Leflunomide is an immunomodulatory agent used in the therapy of rheumatoid arthritis and psoriatic arthritis.
StemRegenin 1
T1831
StemRegenin 1 is an aryl hydrocarbon receptor (AhR) inhibitor.
Tapinarof
T4644
Tapinarof is targeted as a topical cream treatment for psoriasis, a chronic autoimmune skin disease.
Skatole
T5281
Skatole is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.
YL-109
T1960
YL-109, a novel anticancer agent, can inhibit breast Y cell growth and invasiveness in vitro and in vivo.
PDM2
T4608
PDM 2 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist.
Prochloraz
T20625
Prochloraz, a broad-spectrum contact imidazole fungicide, is used against several diseases in wheat, barley, and oleaginous plants but also for the treatment of ...
Potassium 1H-indol-3-yl sulfate
T4938
Indoxyl sulfate (potassium salt) is an agonist for the human aryl hydrocarbon receptor (AHR). The aryl hydrocarbon receptor (AhR) has recently emerged as a patho...
Nimodipine
T0343
Nimodipine, a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells.
Brevifolincarboxylic acid
TN1451
Brevifolincarboxylic acid is a natural product isolated from Polygonum capitatum, it has inhibitory effect on the aryl hydrocarbon receptor (AhR). Brevifolincarb...
BAY-218
T5622
AHR antagonist 1 is an aryl hydrocarbon receptor (AHR) antagonist , has an IC50 of 39.9 nM in human cell line.
CAY 10465
T4607
CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM).
ITE
T7202
ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR) (Ki : 3 nM), has immunosuppressive activity.
(-)-Perillaldehyde
T9112
(-)-Perillaldehyde shows antibacterial activity.
Mexiletine hydrochloride
T1046
Mexiletine Hydrochloride is the hydrochloride salt form of mexiletine, a local anesthetic and antiarrhythmic (Class IB) agent structurally related to lidocaine. ...
1,4-Chrysenequinone
T10007
1,4-Chrysenequinone acts as an activator of aryl hydrocarbon receptor (AhR).
PDM11
T5541
PDM 11 is an antagonist of aryl hydrocarbon receptor (AhR)
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