CaMK

CAMK, also written as CaMK, is an abbreviation for the Ca2+/calmodulin-dependent protein kinase class of enzymes. CAMKs are activated by increases in the concentration of intracellular calcium ions (Ca2+) and calmodulin. When activated, the enzymes transfer phosphates from ATP to defined serine or threonine residues in other proteins, so they are serine/threonine-specific protein kinases. Activated CAMK is involved in the phosphorylation of transcription factors and therefore, in the regulation of expression of responding genes. CAMK also works to regulate the cell life cycle (i.e. programmed cell death), rearrangement of the cell's cytoskeletal network, and mechanisms involved in the learning and memory of an organism.There are 2 common types of CAM Kinase proteins: specialized and multi-functional CAM kinases.

Cat No.	product name
TP1271L	Calmodulin-Dependent Protein Kinase II 290-309 acetate	Calmodulin-Dependent Protein Kinase II 290-309 acetate 是 Ca2+/calmodulin-dependent protein kinase II 的有效拮抗剂（IC50 = 52 nM）。
T3S0807	Berbamine	1. Berbamine has high binding affinity toward the (GGA);G-quadruplex. 2. Berbamine and its derivatives are promising agents to suppress liver cancer growth by ta...
TN1008	Psoralenoside	Psoralenoside is a natural product isolated from the fruits of Psoralea corylifolia, shows estrogen-like activity, osteoblastic proliferation accelerating activi...
T2697	KN-93	KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase.
T4185	Lavendustin C	Lavendustin C is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase.
T1222	Trifluoperazine dihydrochloride	Trifluoperazine Dihydrochloride is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.
T20792	W-7 hydrochloride	W-7 HCl, a calmodulin antagonist, inhibits Ca2+-calmodulin-dependent myosin light chain kinase and phosphodiesterase, W-7 hydrochloride induces apoptosis and has...
TP1909L1	CALP2 acetate(261969-04-4 free base)	CALP2 acetate is an antagonist of calmodulin showing high affinity for binding to the CaM EF-hand/Ca2+-binding site with a Kd of 7.9 µM. CALP2 acetate potently i...
TP2310	Autocamtide-2-related inhibitory peptide	Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.
T6605	NH125	NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.
T3546	STO-609	STO-609 is a specific and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK) for recombinant CaM-KKα/KKβ (Ki: 80/15 ng/mL)....
T2946	Tanshinone IIA sulfonate sodium	Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of tanshinone IIA extracted from Savia miltiorrhiza; a potent negative allosteric modulator o...
TQ0137	A-484954	A 484954 is a highly specific eukaryotic elongation factor-2 (eEF2, IC50: 280 nM) inhibitor.
T14860	CaMKII-IN-1	CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor (IC50: 63 nM). It has significantly high selectivity against CaMKIV, p38a, MLCK, Akt1, and PKC.
T10667	Calmidazolium chloride	Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist (Kd: 3 nM), antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of ...
T14069	A-3 hydrochloride	A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and c...
T8389	Trifluoperazine	Trifluoperazine is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.
T13384L	Y-33075 dihydrochloride	Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).
T3777	Praeruptorin A	Praeruptorin A has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca(2+...
T2694	KN-62	KN-62 is a potent and specific Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor with Ki of 0.9 μM.
T1659	Melatonin	Melatonin is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and...
T1146	Nifedipine	Nifedipine is a dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and va...
T16791	Rottlerin	Rottlerin is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-...
T35328	H-1152 dihydrochloride	H-1152 dihydrochloride (2HCl) 是一种膜渗透性和选择性的Rho-associated protein kinase (ROCK)的抑制剂。 H-1152 可抑制ROCK2、PKA、PKC、PKG、Aurora A和CaMK2的IC50值分别为 0.0120 μM、3.03 μM、5.68 μM...
T2159	CaMKP Inhibitor	CaMKP Inhibitor can inhibit CaMKP.
T2606	KN-93 Phosphate	KN-93 Phosphate is a potent and specific CaMKII inhibitor (Ki: 0.37 μM), no inhibitory for PKC, APK, MLCK or Ca2+-PDE activities.
T8543	KN-92 hydrochloride	KN-92 hydrochloride is an inactive derivative of KN-93. KN-93 is a selective Ca2+/calmodulin-dependent kinase II (CaMKII) inhibitor, competitively blocking CaM b...
T1090	Perphenazine	Perphenazine is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.
T0445	Promethazine	Tafluprost(AFP-168) is an analogue of anti-glaucoma prostaglandin (PG) .
T0364	Dibucaine	Dibucaine, a local anesthetic of the amide type, is now usually used for surface anesthesia.
T1158	Phenoxybenzamine hydrochloride	Phenoxybenzamine Hydrochloride is the hydrochloride salt form of phenoxybenzamine, a synthetic, dibenzamine alpha-adrenergic antagonist with antihypertensive and...
TP1403L	Syntide 2 acetate(108334-68-5 free base)	Syntide-2 acetate is a synthetic peptide recognized as a substrate by Ca2+/calmodulin-dependent protein kinase II (CaMKII; Km = 12 µM).
TP1217L	Autocamtide 2 TFA(129198-88-5 free base)	Autocamtide 2 TFA is a highly selective peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). Autocamtide 2 TFA can be used in the CaMKII...
TP1216	CaM kinase II inhibitor TFA salt	Autocamtide-2-Related Inhibitory Peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.
TP1921L1	Autocamtide-2-related inhibitory peptide, myristoylated acetate(201422-04-0 free base)	Autocamtide-2-related inhibitory peptide, myristoylated acetate is a CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibit...
TP1910L1	CALP1 acetate	CALP1 acetate is a calmodulin (CaM) agonist (Kd of 88 µM) that binds to the CaM EF-hand/Ca2+-binding site. CALP1 blocks calcium influx and apoptosis (IC50 of 44....
T3650	STO-609 acetate	STO-609 acetate is selective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki: 80/15 ng/ml, for CaM-KKα/KKβ); competes for the AT...
T4530	KN-92 phosphate	KN-92 is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to t...
T16752	Rimacalib	Rimacalib is an inhibitor of Ca2+/calmodulin-dependent protein kinase II (IC50s: ~1 μM for CaMKIIα and ~30 μM for CaMKIIγ).