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Complement System

The complement system, also known as complement cascade, is a part of the immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promote inflammation, and attack the pathogen's cell membrane. It is part of the innate immune system, which is not adaptable and does not change during an individual's lifetime. The complement system can, however, be recruited and brought into action by antibodies generated by the adaptive immune system.
Cat No. product name
T9695L POT-4 acetate POT-4 acetate 抑制Complement C3 的活化。 POT-4 acetate 可用于年龄相关性黄斑变性的研究。
T9316 JR14a JR14a is a potent antagonist of human complement C3a receptor.
T9915 Eculizumab Eculizumab is a recombinant humanized monoclonal antibody against the complement protein C5
T0945 Cyclosporin A Cyclosporine A is a Calcineurin Inhibitor Immunosuppressant. The mechanism of action of cyclosporine is as a Calcineurin Inhibitor, and Cytochrome P450 3A4 Inhib...
T1076 Dexamethasone Dexamethasone is a glucocorticoid receptor agonist and an IL receptor modulator.Dexamethasone inhibits production of exosomes containing inflammatory microRNA-15...
TP2296L TLQP 21 acetate TLQP 21 acetate is a potent agonist of G-protein-coupled receptor complement-3a receptor 1 (C3aR1). The EC50 values are 10.3 μM for mouse and 68.8 μM for human...
T38332 Complement factor D-IN-2 Complement factor D-IN-2 is an inhibitor of complement factor D extracted from patent WO2015130838A1, compound 190. Complement factor D-IN-2 targets factor D and...
T12851 SB290157 trifluoroacetate SB290157 trifluoroacetate is a potent and selective antagonist of C3a receptor(IC50 of 200 nM).
T7497 C3a (70-77) C3a 70-77 is an octapeptide corresponding to the COOH terminus of C3a.
T3638 Leukadherin-1 Leukadherin-1 is an allosteric activator of CD11b/CD18. Increasing CD11b/CD18-dependent cell adhesion to fibrinogen, Decreasing leukocyte motility and transendot...
TP2180L Compstatin control peptide acetate Compstatin control peptide acetate is an inhibitor of complement protein C3 by binding and inhibiting the cleavage of complement C3.
T35387 TLQP-21 TFA TLQP-21 TFA (TLQP-21 Trifluoroacetate) 是一种 VGF 衍生肽,可通过结合后折叠机制激活C3aR1 受体。
T7776 ADH-503 ADH-503 is a potent agonist of the integrin CD11b to mitigate myeloid cell immunosuppression.
T7497L C3a 70-77 2TFA(63555-63-5(free base)) C3a 70-77 2TFA is an octapeptide corresponding to the COOH terminus of C3a.
T8509 Danicopan Danicopan (ACH-4471) is a selective, orally active small molecule factor D inhibitor with high binding affinity to human factor D, with a Kd value of 0.54 nM. Da...
T8223 Avacopan Avacopan is an orally administered small-molecule C5aR ( IC50 : 0.1 nM.)antagonist that blocks the effects of C5a and prevents the development of GN induced by a...
T9189 Iptacopan hydrochloride LNP023 hydrochloride is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM. LNP023 shows direct, reversible, and...
T12506L1 PMX 205 acetate(514814-49-4 free base) PMX 205 acetate is an antagonist of complement C5a receptor (C5aR; CD88).
TP1305L LEP(116-130)(mouse)TFA(258276-95-8 free base) LEP(116-130)(mouse) is a synthetic leptin peptide fragment.
TP1304 Compstatin Compstatin, a cyclic tridecapeptide, which was originally discovered from phage-display libraries, is a highly potent and selective C3 inhibitor.
TP2334 PMX 53 acetate(219639-75-5 free base) PMX-53 is a potent and orally active CD88 (C5aR) antagonist (IC50: 20 nM) and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 va...
POT-4 acetate
T9695L
POT-4 acetate 抑制Complement C3 的活化。 POT-4 acetate 可用于年龄相关性黄斑变性的研究。
JR14a
T9316
JR14a is a potent antagonist of human complement C3a receptor.
Eculizumab
T9915
Eculizumab is a recombinant humanized monoclonal antibody against the complement protein C5
Cyclosporin A
T0945
Cyclosporine A is a Calcineurin Inhibitor Immunosuppressant. The mechanism of action of cyclosporine is as a Calcineurin Inhibitor, and Cytochrome P450 3A4 Inhib...
Dexamethasone
T1076
Dexamethasone is a glucocorticoid receptor agonist and an IL receptor modulator.Dexamethasone inhibits production of exosomes containing inflammatory microRNA-15...
TLQP 21 acetate
TP2296L
TLQP 21 acetate is a potent agonist of G-protein-coupled receptor complement-3a receptor 1 (C3aR1). The EC50 values are 10.3 μM for mouse and 68.8 μM for hum...
Complement factor D-IN-2
T38332
Complement factor D-IN-2 is an inhibitor of complement factor D extracted from patent WO2015130838A1, compound 190. Complement factor D-IN-2 targets factor D and...
SB290157 trifluoroacetate
T12851
SB290157 trifluoroacetate is a potent and selective antagonist of C3a receptor(IC50 of 200 nM).
C3a (70-77)
T7497
C3a 70-77 is an octapeptide corresponding to the COOH terminus of C3a.
Leukadherin-1
T3638
Leukadherin-1 is an allosteric activator of CD11b/CD18. Increasing CD11b/CD18-dependent cell adhesion to fibrinogen, Decreasing leukocyte motility and transendot...
Compstatin control peptide acetate
TP2180L
Compstatin control peptide acetate is an inhibitor of complement protein C3 by binding and inhibiting the cleavage of complement C3.
TLQP-21 TFA
T35387
TLQP-21 TFA (TLQP-21 Trifluoroacetate) 是一种 VGF 衍生肽,可通过结合后折叠机制激活C3aR1 受体。
ADH-503
T7776
ADH-503 is a potent agonist of the integrin CD11b to mitigate myeloid cell immunosuppression.
C3a 70-77 2TFA(63555-63-5(free base))
T7497L
C3a 70-77 2TFA is an octapeptide corresponding to the COOH terminus of C3a.
Danicopan
T8509
Danicopan (ACH-4471) is a selective, orally active small molecule factor D inhibitor with high binding affinity to human factor D, with a Kd value of 0.54 nM. Da...
Avacopan
T8223
Avacopan is an orally administered small-molecule C5aR ( IC50 : 0.1 nM.)antagonist that blocks the effects of C5a and prevents the development of GN induced by a...
Iptacopan hydrochloride
T9189
LNP023 hydrochloride is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM. LNP023 shows direct, reversible, and...
PMX 205 acetate(514814-49-4 free base)
T12506L1
PMX 205 acetate is an antagonist of complement C5a receptor (C5aR; CD88).
LEP(116-130)(mouse)TFA(258276-95-8 free base)
TP1305L
LEP(116-130)(mouse) is a synthetic leptin peptide fragment.
Compstatin
TP1304
Compstatin, a cyclic tridecapeptide, which was originally discovered from phage-display libraries, is a highly potent and selective C3 inhibitor.
PMX 53 acetate(219639-75-5 free base)
TP2334
PMX-53 is a potent and orally active CD88 (C5aR) antagonist (IC50: 20 nM) and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 va...