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Complement System

The complement system, also known as complement cascade, is a part of the immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promote inflammation, and attack the pathogen's cell membrane. It is part of the innate immune system, which is not adaptable and does not change during an individual's lifetime. The complement system can, however, be recruited and brought into action by antibodies generated by the adaptive immune system.
Cat. No. Product name CAS No. Purity Chemical Structure
T11154L EG01377 2HCl 2749438-61-5 98%
EG01377 2HCl is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1) with a Kd value of 1.32 μM and an IC50 value of 609 nM for both EG01377 2HC...
T10863 Complement C5-IN-1 2365402-67-9 98%
Complement C5-IN-1 is a small-molecule inhibitor of complement component 5 protein (C5).
T7497 C3a (70-77) 63555-63-5 98%
C3a 70-77 is an octapeptide corresponding to the COOH terminus of C3a.
T13379 (Z)-Leukadherin-1 2055362-72-4 98%
(Z)-Leukadherin-1 is an allosteric agonist of CD11b.
T9695L POT-4 acetate 98%
POT-4 acetate inhibits Complement C3 activation. POT-4 acetate can be used for studies about age-related macular degeneration.
TP2296L TLQP 21 acetate 98%
TLQP 21 acetate is a potent agonist of G-protein-coupled receptor complement-3a receptor 1 (C3aR1). The EC50 values are 10.3 μM for mouse and 68.8 μM for human...
TP1305L LEP(116-130)(mouse)TFA(258276-95-8 free base) TP1305L 98%
LEP(116-130)(mouse) is a synthetic leptin peptide fragment.
TP2334 PMX 53 acetate(219639-75-5 free base) 852629-88-0 98%
PMX-53 is a potent and orally active CD88 (C5aR) antagonist (IC50: 20 nM) and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 va...
T8509 Danicopan 1903768-17-1 98%
Danicopan (ACH-4471) is a selective, orally active small molecule factor D inhibitor with high binding affinity to human factor D, with a Kd value of 0.54 nM. Da...
T60161 CP-289 1349637-14-4 98%
CP-289 is a potent C5a receptor antagonist with IC50 of 1 μM.
T1076 Dexamethasone 50-02-2 98%
Dexamethasone is a glucocorticoid receptor agonist and an IL receptor modulator.Dexamethasone inhibits production of exosomes containing inflammatory microRNA-15...
T60151 CP-447697 1092847-21-6 98%
CP-447697 is a lipophilic C5a receptor antagonist with an IC50 value of 31 nM. CP-447697 can be used for the research of inflammation.
T12506L1 PMX 205 acetate(514814-49-4 free base) T12506L1 98%
PMX 205 acetate is an antagonist of complement C5a receptor (C5aR; CD88).
T9316 JR14a 2411440-41-8 98%
JR14a is a potent antagonist of human complement C3a receptor.
T12851 SB290157 trifluoroacetate 1140525-25-2 98%
SB290157 trifluoroacetate is a potent and selective antagonist of C3a receptor(IC50 of 200 nM).
T9189 Iptacopan hydrochloride 1646321-63-2 98%
LNP023 hydrochloride is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM. LNP023 shows direct, reversible, and...
T64388 3-Phenoxybenzaldehyde 39515-51-0 98%
3-Phenoxybenzaldehyde is a complement (classical pathway) inhibitor with IC50 of 1388μM.
T3638 Leukadherin-1 344897-95-6 98%
Leukadherin-1 is an allosteric activator of CD11b/CD18. Increasing CD11b/CD18-dependent cell adhesion to fibrinogen, Decreasing leukocyte motility and transendot...
T0945 Cyclosporin A 59865-13-3 98%
Cyclosporine A is a Calcineurin Inhibitor Immunosuppressant. The mechanism of action of cyclosporine is as a Calcineurin Inhibitor, and Cytochrome P450 3A4 Inhib...
T38287 C3a Receptor Agonist 944997-60-8 98%
C3a Receptor Agonist binds the G protein-coupled C3a receptors (C3aRs) in the immune system complement pathway. Activation of C3aR prevents neutrophils from bein...
EG01377 2HCl
T11154L
EG01377 2HCl is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1) with a Kd value of 1.32 μM and an IC50 value of 609 nM for both EG01377 2HC...
Complement C5-IN-1
T10863
Complement C5-IN-1 is a small-molecule inhibitor of complement component 5 protein (C5).
C3a (70-77)
T7497
C3a 70-77 is an octapeptide corresponding to the COOH terminus of C3a.
(Z)-Leukadherin-1
T13379
(Z)-Leukadherin-1 is an allosteric agonist of CD11b.
POT-4 acetate
T9695L
POT-4 acetate inhibits Complement C3 activation. POT-4 acetate can be used for studies about age-related macular degeneration.
TLQP 21 acetate
TP2296L
TLQP 21 acetate is a potent agonist of G-protein-coupled receptor complement-3a receptor 1 (C3aR1). The EC50 values are 10.3 μM for mouse and 68.8 μM for human...
LEP(116-130)(mouse)TFA(258276-95-8 free base)
TP1305L
LEP(116-130)(mouse) is a synthetic leptin peptide fragment.
PMX 53 acetate(219639-75-5 free base)
TP2334
PMX-53 is a potent and orally active CD88 (C5aR) antagonist (IC50: 20 nM) and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 va...
Danicopan
T8509
Danicopan (ACH-4471) is a selective, orally active small molecule factor D inhibitor with high binding affinity to human factor D, with a Kd value of 0.54 nM. Da...
CP-289
T60161
CP-289 is a potent C5a receptor antagonist with IC50 of 1 μM.
Dexamethasone
T1076
Dexamethasone is a glucocorticoid receptor agonist and an IL receptor modulator.Dexamethasone inhibits production of exosomes containing inflammatory microRNA-15...
CP-447697
T60151
CP-447697 is a lipophilic C5a receptor antagonist with an IC50 value of 31 nM. CP-447697 can be used for the research of inflammation.
PMX 205 acetate(514814-49-4 free base)
T12506L1
PMX 205 acetate is an antagonist of complement C5a receptor (C5aR; CD88).
JR14a
T9316
JR14a is a potent antagonist of human complement C3a receptor.
SB290157 trifluoroacetate
T12851
SB290157 trifluoroacetate is a potent and selective antagonist of C3a receptor(IC50 of 200 nM).
Iptacopan hydrochloride
T9189
LNP023 hydrochloride is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM. LNP023 shows direct, reversible, and...
3-Phenoxybenzaldehyde
T64388
3-Phenoxybenzaldehyde is a complement (classical pathway) inhibitor with IC50 of 1388μM.
Leukadherin-1
T3638
Leukadherin-1 is an allosteric activator of CD11b/CD18. Increasing CD11b/CD18-dependent cell adhesion to fibrinogen, Decreasing leukocyte motility and transendot...
Cyclosporin A
T0945
Cyclosporine A is a Calcineurin Inhibitor Immunosuppressant. The mechanism of action of cyclosporine is as a Calcineurin Inhibitor, and Cytochrome P450 3A4 Inhib...
C3a Receptor Agonist
T38287
C3a Receptor Agonist binds the G protein-coupled C3a receptors (C3aRs) in the immune system complement pathway. Activation of C3aR prevents neutrophils from bein...
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