Complement System

The complement system, also known as complement cascade, is a part of the immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promote inflammation, and attack the pathogen's cell membrane. It is part of the innate immune system, which is not adaptable and does not change during an individual's lifetime. The complement system can, however, be recruited and brought into action by antibodies generated by the adaptive immune system.

Cat. No.	Product name	CAS No.	Purity
T64388	3-Phenoxybenzaldehyde	39515-51-0	98%
T64388	3-Phenoxybenzaldehyde is a complement (classical pathway) inhibitor with IC50 of 1388μM.
T7497	C3a (70-77)	63555-63-5	98%
T7497	C3a 70-77 is an octapeptide corresponding to the COOH terminus of C3a.
TP2180L	Compstatin control peptide acetate		98%
TP2180L	Compstatin control peptide acetate is an inhibitor of complement protein C3 by binding and inhibiting the cleavage of complement C3.
T17250	W-54011	405098-33-1	98%
T17250	W-54011 is a potent non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils (Ki: 2.2 nM). W-54011 inhibits C5a...
T38332	Complement factor D-IN-2	1903742-34-6	98%
T38332	Complement factor D-IN-2 is an inhibitor of complement factor D extracted from patent WO2015130838A1, compound 190. Complement factor D-IN-2 targets factor D and...
T9915	Eculizumab	219685-50-4
T9915	Eculizumab is a recombinant humanized monoclonal antibody against the complement protein C5
T7776	ADH-503	2055362-74-6	100%
T7776	ADH-503 is a potent agonist of the integrin CD11b to mitigate myeloid cell immunosuppression.
TP1304	Compstatin	206645-99-0	100%
TP1304	Compstatin, a cyclic tridecapeptide, which was originally discovered from phage-display libraries, is a highly potent and selective C3 inhibitor.
T7497L	C3a 70-77 2TFA(63555-63-5(free base))	T7497L	100%
T7497L	C3a 70-77 2TFA is an octapeptide corresponding to the COOH terminus of C3a.
T38287	C3a Receptor Agonist	944997-60-8	97.5%
T38287	C3a Receptor Agonist binds the G protein-coupled C3a receptors (C3aRs) in the immune system complement pathway. Activation of C3aR prevents neutrophils from bein...
T3638	Leukadherin-1	344897-95-6	98.49%
T3638	Leukadherin-1 is an allosteric activator of CD11b/CD18. Increasing CD11b/CD18-dependent cell adhesion to fibrinogen, Decreasing leukocyte motility and transendot...
T12851	SB290157 trifluoroacetate	1140525-25-2	98.93%
T12851	SB290157 trifluoroacetate is a potent and selective antagonist of C3a receptor(IC50 of 200 nM).
T9316	JR14a	2411440-41-8	99.29%
T9316	JR14a is a potent antagonist of human complement C3a receptor.
T12506L1	PMX 205 acetate(514814-49-4 free base)	T12506L1	99.4%
T12506L1	PMX 205 acetate is an antagonist of complement C5a receptor (C5aR; CD88).
T60151	CP-447697	1092847-21-6	99.62%
T60151	CP-447697 is a lipophilic C5a receptor antagonist with an IC50 value of 31 nM. CP-447697 can be used for the research of inflammation.
T9189	Iptacopan hydrochloride	1646321-63-2	99.84%
T9189	LNP023 hydrochloride is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM. LNP023 shows direct, reversible, and...
T0945	Cyclosporin A	59865-13-3	99.85%
T0945	Cyclosporine A is a Calcineurin Inhibitor Immunosuppressant. The mechanism of action of cyclosporine is as a Calcineurin Inhibitor, and Cytochrome P450 3A4 Inhib...
T60161	CP-289	1349637-14-4	99.85%
T60161	CP-289 is a potent C5a receptor antagonist with IC50 of 1 μM.
T8509	Danicopan	1903768-17-1	99.88%
T8509	Danicopan (ACH-4471) is a selective, orally active small molecule factor D inhibitor with high binding affinity to human factor D, with a Kd value of 0.54 nM. Da...
T8223	Avacopan	1346623-17-3	99.9%
T8223	Avacopan is an orally administered small-molecule C5aR ( IC50 : 0.1 nM.)antagonist that blocks the effects of C5a and prevents the development of GN induced by a...