Glucagon Receptor

The glucagon receptor is a 62 kDa protein that is activated by glucagon and is a member of the class B G-protein coupled family of receptors, coupled to G alpha i, Gs and to a lesser extent G alpha q. Stimulation of the receptor results in activation of adenylate cyclase and increased levels of intracellular cAMP. In humans, the glucagon receptor is encoded by the GCGR gene.

Cat. No.	Product name	CAS No.	Purity
T40997	GLP-1R modulator C16	875005-43-9	99.6%
T40997	GLP-1R modulator C16 is a variable modulator that significantly increases the binding affinity of GLP-4.
T40279	GLP-1R modulator L7-028	2648317-95-5	98.76%
T40279	GLP-1R modulator L7-028 is a variant modulator that enhances affinity for GLP-1 and cAMP signaling.
T60047	V-0219	878453-71-5	100%
T60047	V-0219 is a positive allosteric modulator of GLP-1 and can be used in studies about obesity-associated diabetes.
TP1148L	Glucagon-like peptide 1 (1-37), human acetate		98%
TP1148L	Glucagon-like peptide 1 (1-37), human acetate is a highly potent the GLP-1 receptor agonist.
TP1452L1	HAEGTFTSD acetate(926018-45-3 free base)	TP1452L1	98%
TP1452L1	HAEGTFTSD acetate is the first N-terminal 1-9 residues of GLP-1 peptide.The GLP-1 (7-36) amide is a product of the preproglucagon gene, which is secreted from in...
T12878	Semaglutide TFA (910463-68-2 free base)	T12878	98%
T12878	Semaglutide TFA is a agonist of glucagon-like peptide-1 (GLP-1) receptor,with a potential for type 2 diabetes treatment.
T35337	Teduglutide	197922-42-2	98%
T35337	Teduglutide is a useful organic compound for research related to life sciences. The catalog number is T35337 and the CAS number is 197922-42-2.
T76279L1	Retatrutide sodium salt		99.97%
T76279L1	Retatrutide sodium salt is a potent triple agonist peptide for glucagon receptor (GCGR), glucose-dependent proinsulinotropic polypeptide receptor (GIPR), and glu...
T14130	Adomeglivant	1488363-78-5	99.97%
T14130	Adomeglivant (LY2409021) is a potent and selective glucagon receptor antagonist. Which is used in clinical trial for type 2 diabetes mellitus.
T9226	CCG-143140	891016-02-7	99.94%
T9226	CCG-143140 is a GLP-1 receptor inverse agonists.
TP1469	Lixisenatide acetate (320367-13-3 free base)	1997361-87-1	99.9%
TP1469	Lixisenatide acetate is a receptor agonist similar to glucagon-like peptide-1 (glp-1) for the treatment of type 2 diabetes mellitus (T2DM).
T3984	GLP-1(7-36), amide	107444-51-9	99.85%
T3984	GLP-1(7-36), amide (MKC 253) is a peptide hormone released from intestinal L-cells upon nutrient consumption. It binds the GLP-1 receptor in the pancreas and dis...
T76559	Survodutide	2805997-46-8	99.83%
T76559	Survodutide (BI 456906) is a dual agonist of glucagon and glucagon-like peptide 1 (GLP-1) receptor (GLP Receptor) that reduces body weight in HbA1c16 diabetes.
T28182	NNC 92-1687	22903-37-3	99.72%
T28182	NNC 92-1687 is a selective glucagon receptor antagonist that can be used to study type 2 diabetes.
T3967	Exendin-4	141758-74-9	99.72%
T3967	Exendin-4 (Exenatide) is a glucagon-like peptide-1 receptor (GLP-1) agonist (IC50: 3.22 nM). Exenatide is a 39 amino acid peptide. Compared to GLP-1, exenatide h...
TP1111L1	Tirzepatide sodium salt		99.69%
TP1111L1	Tirzepatide sodium salt (LY3298176 sodium salt) is a GIP and GLP-1 receptor agonist with neuroprotective activity and can be used to treat obesity.
T61483	GLP-1R modulator C5	421578-93-0	99.59%
T61483	GLP-1R modulator C5 is a small molecule GLP-1R orthosteric modulator that enhances GLP-1 binding to GLP-1R via transmembrane sites and can be used in the study o...
T63166L	(S, R)-LSN 3318839	2765539-92-0	99.57%
T63166L	(S, R)-LSN 3318839 is an allosteric modulator of the glucagon-like peptide-3318839 receptor (GLP-1R) that has demonstrated powerful hypoglycemic effects in anima...
T19850	Semaglutide	910463-68-2	99.56%
T19850	Semaglutide is a glucagon-like peptide 1 receptor (GLP-1R) agonist(EC50 of 6.2 pM in a reporter assay using BHK cells expressing the human receptor).
T36579	GLP-1R Agonist DMB	281209-71-0	99.52%
T36579	GLP-1R Agonist DMB is an agonist of glucagon-like peptide 1 receptor (GLP-1R; KB = 26.3 nM for the recombinant human receptor).