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HIF/HIF Prolyl-Hydroxylase

HIF prolyl-hydroxylase is an enzyme involved in the HIF (Hypoxia-inducible factor) signalling pathways, and is the target for a set of therapeutic drugs called HIF prolyl-hydroxylase inhibitors. Hypoxia-inducible factor (HIF) is an evolutionarily conserved transcription factor that allows the cell to respond physiologically to low concentrations of oxygen. A class of prolyl hydroxylases which act specifically on HIF has been identified; hydroxylation of HIF allows the protein to be targeted for degradation.
Cat No. product name
T29797 AKB-6899 AKB-6899 是脯氨酰羟化酶结构域 3 (PHD3) 的抑制剂,可增加 GM-CSF 处理的巨噬细胞产生的 VEGF 受体的可溶形式 (sVEGFR-1)。 AKB-6899 能稳定 HIF-2α,从而诱导肿瘤相关巨噬细胞产生 sVEGFR-1 并减少肿瘤生长。
T5S1569 AKBA 1. 3-O-Acetyl-11-keto-beta-boswellic acid inhibits 5-lipoxygenase product formation with an IC(5) of 1.5 m muM.
T11561 HIF-2α-IN-2 HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).
T3494 LW6 LW6 is a novel HIF-1 inhibitor.
T5176 Desidustat Desidustat is an inhibitor of HIF hydroxylase.
T3289 Amifostine Amifostine anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.
TL0001 Dencichine Dencichine is a neurotoxic agent. Dencichine is a haemostatic agent, the hemostatic effect relates to modulation of the coagulation system, platelet aggregation ...
T6S0071 Fraxinellone 1. Fraxinellone significantly reduced weight loss and diarrhea in mice and alleviated the macroscopic and microscopic signs of the disease. 2. Fraxinellone exhib...
T6S1315 Oroxylin A 1. Oroxylin A has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting th...
T6961 PX-478 PX-478 2HCl is an orally active, and selective inhibitor of hypoxia-inducible factor-1α (HIF-1α).
T2941 Glucosamine hydrochloride Glucosamine is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.
T13050 SYP-5 SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.
T6381 Amifostine trihydrate Amifostine is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.
T2792 Glucosamine sulfate Extracted from synthetic product;Store the product in sealed, cool and dry condition
T5S2347 Deoxyshikonin 1. Deoxyshikonin may be a new drug candidate for wound healing and treatment of lymphatic diseases. 2. Deoxyshikonin enhances the ability of human dermal lymphat...
T0244 Tilorone dihydrochloride Tilorone dihydrochloride is an orally active interferon inducer, and has antineoplastic and anti-inflammatory actions.
T5684 Ethyl 3,4-dihydroxybenzoate Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.
T3169 KC7F2 KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.
T0429 Glucosamine Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to re...
T0153 Oltipraz Oltipraz is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as g...
T11589 Hydroxycitric acid tripotassium hydrate Potassium citrate monohydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects. Hydroxy...
T5537 IDF-11774 IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).
T12675L PT2399 PT2399 shows effective antitumor activity in vivo. PT2399 is an effective and selective HIF-2α antagonist, which directly binds to the HIF-2α PAS B domain (IC50:...
T7802 M1001 M1001 is a HIF-2α agonist.
T15219 Enarodustat Enarodustat is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.
T2805 Chlorogenic Acid Chlorogenic acid is a naturally occurring phenolic acid which is a carcinogenic inhibitor. It has also been shown to prevent paraquat-induced oxidative stress in...
T13289 EHP-101 VCE-004.8 is a specific dual agonist of PPARγ and CB2 receptor with potent anti-inflammatory activity. VCE-004.8 attenuates adipogenesis and prevents diet-induc...
T9627 PHD-1-IN-1 PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).
T1613 Hydralazine hydrochloride Hydralazine Hydrochloride is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydra...
T1939 DMOG DMOG, an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.
T2488 BAY 87-2243 BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).
T7848 PT-2385 PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).
T001-00000002 Izilendustat Tert-butyl 4-[[1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxopyridin-4-yl]methyl]piperazine-1-carboxylate inhibit of human recombinant EGLN-1 as substrate after 20 m...
T2445 FG-2216 FG-2216 is a potent HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme (IC50: 3.9 uM); orally bioavailable and induced reversible and significant Epo induction...
T1823 IOX2 IOX2 is a selective inhibitor of the Hypoxia Inducible Factor (HIF) Prolyl-Hydroxylases (PHD); active in cells with the IC50 value of 21 nM for PHD2/ELGN-1 and n...
T7880 IOX4 IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)
T5392 TP0463518 TP-0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor (IC50s: 13 nM and 18 nM for human and rat PHD2, respectively).
T3180 JNJ-42041935 JNJ-42041935 is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.
T4106 MK-8617 MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM).
AKB-6899
T29797
AKB-6899 是脯氨酰羟化酶结构域 3 (PHD3) 的抑制剂,可增加 GM-CSF 处理的巨噬细胞产生的 VEGF 受体的可溶形式 (sVEGFR-1)。 AKB-6899...
AKBA
T5S1569
1. 3-O-Acetyl-11-keto-beta-boswellic acid inhibits 5-lipoxygenase product formation with an IC(5) of 1.5 m muM.
HIF-2α-IN-2
T11561
HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).
LW6
T3494
LW6 is a novel HIF-1 inhibitor.
Desidustat
T5176
Desidustat is an inhibitor of HIF hydroxylase.
Amifostine
T3289
Amifostine anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.
dencichine
TL0001
Dencichine is a neurotoxic agent. Dencichine is a haemostatic agent, the hemostatic effect relates to modulation of the coagulation system, platelet aggregation ...
Fraxinellone
T6S0071
1. Fraxinellone significantly reduced weight loss and diarrhea in mice and alleviated the macroscopic and microscopic signs of the disease. 2. Fraxinellone exhib...
Oroxylin A
T6S1315
1. Oroxylin A has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting th...
PX-478
T6961
PX-478 2HCl is an orally active, and selective inhibitor of hypoxia-inducible factor-1α (HIF-1α).
Glucosamine hydrochloride
T2941
Glucosamine is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.
SYP-5
T13050
SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.
Amifostine trihydrate
T6381
Amifostine is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.
Glucosamine sulfate
T2792
Extracted from synthetic product;Store the product in sealed, cool and dry condition
Deoxyshikonin
T5S2347
1. Deoxyshikonin may be a new drug candidate for wound healing and treatment of lymphatic diseases. 2. Deoxyshikonin enhances the ability of human dermal lymphat...
Tilorone dihydrochloride
T0244
Tilorone dihydrochloride is an orally active interferon inducer, and has antineoplastic and anti-inflammatory actions.
Ethyl 3,4-dihydroxybenzoate
T5684
Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.
KC7F2
T3169
KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.
Glucosamine
T0429
Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to re...
Oltipraz
T0153
Oltipraz is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as g...
Hydroxycitric acid tripotassium hydrate
T11589
Potassium citrate monohydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects. Hydroxy...
IDF-11774
T5537
IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).
PT2399
T12675L
PT2399 shows effective antitumor activity in vivo. PT2399 is an effective and selective HIF-2α antagonist, which directly binds to the HIF-2α PAS B domain (IC5...
M1001
T7802
M1001 is a HIF-2α agonist.
Enarodustat
T15219
Enarodustat is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.
Chlorogenic Acid
T2805
Chlorogenic acid is a naturally occurring phenolic acid which is a carcinogenic inhibitor. It has also been shown to prevent paraquat-induced oxidative stress in...
EHP-101
T13289
VCE-004.8 is a specific dual agonist of PPARγ and CB2 receptor with potent anti-inflammatory activity. VCE-004.8 attenuates adipogenesis and prevents diet-indu...
PHD-1-IN-1
T9627
PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).
Hydralazine hydrochloride
T1613
Hydralazine Hydrochloride is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydra...
DMOG
T1939
DMOG, an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.
BAY 87-2243
T2488
BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).
PT-2385
T7848
PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).
Izilendustat
T001-00000002
Tert-butyl 4-[[1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxopyridin-4-yl]methyl]piperazine-1-carboxylate inhibit of human recombinant EGLN-1 as substrate after 20 m...
FG-2216
T2445
FG-2216 is a potent HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme (IC50: 3.9 uM); orally bioavailable and induced reversible and significant Epo induction...
IOX2
T1823
IOX2 is a selective inhibitor of the Hypoxia Inducible Factor (HIF) Prolyl-Hydroxylases (PHD); active in cells with the IC50 value of 21 nM for PHD2/ELGN-1 and n...
IOX4
T7880
IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)
TP0463518
T5392
TP-0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor (IC50s: 13 nM and 18 nM for human and rat PHD2, respectively).
JNJ-42041935
T3180
JNJ-42041935 is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.
MK-8617
T4106
MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM).