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HIF/HIF Prolyl-Hydroxylase

HIF prolyl-hydroxylase is an enzyme involved in the HIF (Hypoxia-inducible factor) signalling pathways, and is the target for a set of therapeutic drugs called HIF prolyl-hydroxylase inhibitors. Hypoxia-inducible factor (HIF) is an evolutionarily conserved transcription factor that allows the cell to respond physiologically to low concentrations of oxygen. A class of prolyl hydroxylases which act specifically on HIF has been identified; hydroxylation of HIF allows the protein to be targeted for degradation.
Cat. No. Product name CAS No. Purity Chemical Structure
T67831 HIF-2α agonist 2 2750141-15-0 98%
HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α. HIF-2α agonist 2 can promote the stability of the ARNT A/B ring in the 3z structu...
T64336 Izilendustat 1303512-02-8 98%
Tert-butyl 4-[[1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxopyridin-4-yl]methyl]piperazine-1-carboxylate inhibit of human recombinant EGLN-1 as substrate after 20 m...
T2763 Panaxadiol 19666-76-3 98%
Panaxadiol is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.
T0244 Tilorone dihydrochloride 27591-69-1 98%
Tilorone dihydrochloride is an orally active interferon inducer, and has antineoplastic and anti-inflammatory actions.
T1823 IOX2 931398-72-0 98%
IOX2 is a selective inhibitor of the Hypoxia Inducible Factor (HIF) Prolyl-Hydroxylases (PHD); active in cells with the IC50 value of 21 nM for PHD2/ELGN-1 and n...
T5761 Notoginsenoside Ft1 155683-00-4 98%
Notoginsenoside Ft1 is a saponin originally isolated from P. notoginseng with diverse biological activities
T1205 Chloramphenicol 56-75-7 98%
Chloramphenicol, a broad-spectrum antibiotic, blocks bacterial protein synthesis.
T0429 Glucosamine 3416-24-8 98%
Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to re...
T6S1315 Oroxylin A 480-11-5 98%
1. Oroxylin A has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting th...
T2488 BAY 87-2243 1227158-85-1 98%
BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).
T5S2347 Deoxyshikonin 43043-74-9 98%
1. Deoxyshikonin may be a new drug candidate for wound healing and treatment of lymphatic diseases. 2. Deoxyshikonin enhances the ability of human dermal lymphat...
T0153 Oltipraz 64224-21-1 98%
Oltipraz is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as g...
T2792 Glucosamine sulfate 29031-19-4 98%
Extracted from synthetic product;Store the product in sealed, cool and dry condition
T5392 TP0463518 1558021-37-6 98%
TP-0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor (IC50s: 13 nM and 18 nM for human and rat PHD2, respectively).
T6S0071 Fraxinellone 28808-62-0 98%
1. Fraxinellone significantly reduced weight loss and diarrhea in mice and alleviated the macroscopic and microscopic signs of the disease. 2. Fraxinellone exhib...
T13289 EHP-101 1818428-24-8 98%
VCE-004.8 is a specific dual agonist of PPARγ and CB2 receptor with potent anti-inflammatory activity. VCE-004.8 attenuates adipogenesis and prevents diet-induc...
T15219 Enarodustat 1262132-81-9 98%
Enarodustat is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.
T3169 KC7F2 927822-86-4 98%
KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.
T13050 SYP-5 1384268-04-5 98%
SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.
T1613 Hydralazine hydrochloride 304-20-1 98%
Hydralazine Hydrochloride is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydra...
HIF-2α agonist 2
T67831
HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α. HIF-2α agonist 2 can promote the stability of the ARNT A/B ring in the 3z structu...
Izilendustat
T64336
Tert-butyl 4-[[1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxopyridin-4-yl]methyl]piperazine-1-carboxylate inhibit of human recombinant EGLN-1 as substrate after 20 m...
Panaxadiol
T2763
Panaxadiol is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.
Tilorone dihydrochloride
T0244
Tilorone dihydrochloride is an orally active interferon inducer, and has antineoplastic and anti-inflammatory actions.
IOX2
T1823
IOX2 is a selective inhibitor of the Hypoxia Inducible Factor (HIF) Prolyl-Hydroxylases (PHD); active in cells with the IC50 value of 21 nM for PHD2/ELGN-1 and n...
Notoginsenoside Ft1
T5761
Notoginsenoside Ft1 is a saponin originally isolated from P. notoginseng with diverse biological activities
Chloramphenicol
T1205
Chloramphenicol, a broad-spectrum antibiotic, blocks bacterial protein synthesis.
Glucosamine
T0429
Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to re...
Oroxylin A
T6S1315
1. Oroxylin A has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting th...
BAY 87-2243
T2488
BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).
Deoxyshikonin
T5S2347
1. Deoxyshikonin may be a new drug candidate for wound healing and treatment of lymphatic diseases. 2. Deoxyshikonin enhances the ability of human dermal lymphat...
Oltipraz
T0153
Oltipraz is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as g...
Glucosamine sulfate
T2792
Extracted from synthetic product;Store the product in sealed, cool and dry condition
TP0463518
T5392
TP-0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor (IC50s: 13 nM and 18 nM for human and rat PHD2, respectively).
Fraxinellone
T6S0071
1. Fraxinellone significantly reduced weight loss and diarrhea in mice and alleviated the macroscopic and microscopic signs of the disease. 2. Fraxinellone exhib...
EHP-101
T13289
VCE-004.8 is a specific dual agonist of PPARγ and CB2 receptor with potent anti-inflammatory activity. VCE-004.8 attenuates adipogenesis and prevents diet-induc...
Enarodustat
T15219
Enarodustat is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.
KC7F2
T3169
KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.
SYP-5
T13050
SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.
Hydralazine hydrochloride
T1613
Hydralazine Hydrochloride is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydra...
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