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HIF/HIF Prolyl-Hydroxylase

HIF prolyl-hydroxylase is an enzyme involved in the HIF (Hypoxia-inducible factor) signalling pathways, and is the target for a set of therapeutic drugs called HIF prolyl-hydroxylase inhibitors. Hypoxia-inducible factor (HIF) is an evolutionarily conserved transcription factor that allows the cell to respond physiologically to low concentrations of oxygen. A class of prolyl hydroxylases which act specifically on HIF has been identified; hydroxylation of HIF allows the protein to be targeted for degradation.
Cat. No. Product name CAS No. Purity Chemical Structure
T3289 Amifostine 20537-88-6 98%
Amifostine anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.
T29797 AKB-6899 1007377-55-0 98%
AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macr...
T9627 PHD-1-IN-1 2009343-14-8 98%
PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).
T6823 E3330 136164-66-4 98%
E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.
T21653 1,4-DPCA 331830-20-7 98%
1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HI...
T13289 EHP-101 1818428-24-8
VCE-004.8 is a specific dual agonist of PPARγ and CB2 receptor with potent anti-inflammatory activity. VCE-004.8 attenuates adipogenesis and prevents diet-induc...
T11589 Hydroxycitric acid tripotassium hydrate 6100-05-6
Potassium citrate monohydrate effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation, and anti-tumor effects. Hydr...
T50099 HIF-2α-IN-4 882268-69-1
HIF-2a translation inhibitor is a compound used as a molecular building block.
T1141 Fenbendazole 43210-67-9 100%
Fenbendazole is an antinematodal benzimidazole used in veterinary medicine.
T7802 M1001 874590-32-6 100%
M1001 is a HIF-2α agonist.
T3S2344 β,β-Dimethylacrylshikonin 24502-79-2 93.42%
1. Dimethylacrylshikonin is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combine...
T0153 Oltipraz 64224-21-1 95.91%
Oltipraz is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as g...
T5176 Desidustat 1616690-16-4 96.91%
Desidustat is an inhibitor of HIF hydroxylase.
T5S1569 AKBA 67416-61-9 97.85%
1. 3-O-Acetyl-11-keto-beta-boswellic acid inhibits 5-lipoxygenase product formation with an IC(5) of 1.5 m muM.
T6961 PX-478 685898-44-6 97.93%
PX-478 2HCl is an orally active, and selective inhibitor of hypoxia-inducible factor-1α (HIF-1α).
TL0001 Dencichine 5302-45-4 98%
Dencichine is a neurotoxic agent. Dencichine is a haemostatic agent, the hemostatic effect relates to modulation of the coagulation system, platelet aggregation ...
T5684 Ethyl 3,4-dihydroxybenzoate 3943-89-3 98%
Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.
T1939 DMOG 89464-63-1 98%
DMOG, an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.
T0256 Citric acid trilithium salt tetrahydrate 6080-58-6 98%
Lithium Citrate, the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways and me...
T5537 IDF-11774 1429054-28-3 98%
IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).
Amifostine
T3289
Amifostine anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.
AKB-6899
T29797
AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macr...
PHD-1-IN-1
T9627
PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).
E3330
T6823
E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.
1,4-DPCA
T21653
1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HI...
EHP-101
T13289
VCE-004.8 is a specific dual agonist of PPARγ and CB2 receptor with potent anti-inflammatory activity. VCE-004.8 attenuates adipogenesis and prevents diet-induc...
Hydroxycitric acid tripotassium hydrate
T11589
Potassium citrate monohydrate effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation, and anti-tumor effects. Hydr...
HIF-2α-IN-4
T50099
HIF-2a translation inhibitor is a compound used as a molecular building block.
Fenbendazole
T1141
Fenbendazole is an antinematodal benzimidazole used in veterinary medicine.
M1001
T7802
M1001 is a HIF-2α agonist.
β,β-Dimethylacrylshikonin
T3S2344
1. Dimethylacrylshikonin is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combine...
Oltipraz
T0153
Oltipraz is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as g...
Desidustat
T5176
Desidustat is an inhibitor of HIF hydroxylase.
AKBA
T5S1569
1. 3-O-Acetyl-11-keto-beta-boswellic acid inhibits 5-lipoxygenase product formation with an IC(5) of 1.5 m muM.
PX-478
T6961
PX-478 2HCl is an orally active, and selective inhibitor of hypoxia-inducible factor-1α (HIF-1α).
dencichine
TL0001
Dencichine is a neurotoxic agent. Dencichine is a haemostatic agent, the hemostatic effect relates to modulation of the coagulation system, platelet aggregation ...
Ethyl 3,4-dihydroxybenzoate
T5684
Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.
DMOG
T1939
DMOG, an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.
Citric acid trilithium salt tetrahydrate
T0256
Lithium Citrate, the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways and me...
IDF-11774
T5537
IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).
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