HIF/HIF Prolyl-Hydroxylase

HIF prolyl-hydroxylase is an enzyme involved in the HIF (Hypoxia-inducible factor) signalling pathways, and is the target for a set of therapeutic drugs called HIF prolyl-hydroxylase inhibitors. Hypoxia-inducible factor (HIF) is an evolutionarily conserved transcription factor that allows the cell to respond physiologically to low concentrations of oxygen. A class of prolyl hydroxylases which act specifically on HIF has been identified; hydroxylation of HIF allows the protein to be targeted for degradation.

Cat. No.	Product name	CAS No.	Purity
T67831	HIF-2α agonist 2	2750141-15-0	98%
T67831	HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α. HIF-2α agonist 2 can promote the stability of the ARNT A/B ring in the 3z structu...
T64336	Izilendustat	1303512-02-8	98%
T64336	Tert-butyl 4-[[1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxopyridin-4-yl]methyl]piperazine-1-carboxylate inhibit of human recombinant EGLN-1 as substrate after 20 m...
T2763	Panaxadiol	19666-76-3	98%
T2763	Panaxadiol is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.
T0244	Tilorone dihydrochloride	27591-69-1	98%
T0244	Tilorone dihydrochloride is an orally active interferon inducer, and has antineoplastic and anti-inflammatory actions.
T1823	IOX2	931398-72-0	98%
T1823	IOX2 is a selective inhibitor of the Hypoxia Inducible Factor (HIF) Prolyl-Hydroxylases (PHD); active in cells with the IC50 value of 21 nM for PHD2/ELGN-1 and n...
T5761	Notoginsenoside Ft1	155683-00-4	98%
T5761	Notoginsenoside Ft1 is a saponin originally isolated from P. notoginseng with diverse biological activities
T1205	Chloramphenicol	56-75-7	98%
T1205	Chloramphenicol, a broad-spectrum antibiotic, blocks bacterial protein synthesis.
T0429	Glucosamine	3416-24-8	98%
T0429	Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to re...
T6S1315	Oroxylin A	480-11-5	98%
T6S1315	1. Oroxylin A has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting th...
T2488	BAY 87-2243	1227158-85-1	98%
T2488	BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).
T5S2347	Deoxyshikonin	43043-74-9	98%
T5S2347	1. Deoxyshikonin may be a new drug candidate for wound healing and treatment of lymphatic diseases. 2. Deoxyshikonin enhances the ability of human dermal lymphat...
T0153	Oltipraz	64224-21-1	98%
T0153	Oltipraz is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as g...
T2792	Glucosamine sulfate	29031-19-4	98%
T2792	Extracted from synthetic product;Store the product in sealed, cool and dry condition
T5392	TP0463518	1558021-37-6	98%
T5392	TP-0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor (IC50s: 13 nM and 18 nM for human and rat PHD2, respectively).
T6S0071	Fraxinellone	28808-62-0	98%
T6S0071	1. Fraxinellone significantly reduced weight loss and diarrhea in mice and alleviated the macroscopic and microscopic signs of the disease. 2. Fraxinellone exhib...
T13289	EHP-101	1818428-24-8	98%
T13289	VCE-004.8 is a specific dual agonist of PPARγ and CB2 receptor with potent anti-inflammatory activity. VCE-004.8 attenuates adipogenesis and prevents diet-induc...
T15219	Enarodustat	1262132-81-9	98%
T15219	Enarodustat is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.
T3169	KC7F2	927822-86-4	98%
T3169	KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.
T13050	SYP-5	1384268-04-5	98%
T13050	SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.
T1613	Hydralazine hydrochloride	304-20-1	98%
T1613	Hydralazine Hydrochloride is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydra...